SitesBLAST
Comparing AO353_27065 AO353_27065 cytochrome C oxidase Cbb3 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
Q47945 Alcohol dehydrogenase (quinone), cytochrome c subunit; ADH; Alcohol dehydrogenase (quinone), subunit II; Cytochrome c-553; Cytochrome c553; Ethanol:Q2 reductase; G3-ADH subunit II; Quinohemoprotein-cytochrome c complex; Ubiquinol oxidase; EC 1.1.5.5 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
37% identity, 99% coverage: 3:411/415 of query aligns to 9:441/478 of Q47945
- Q37 (= Q25) modified: Pyrrolidone carboxylic acid
Sites not aligning to the query:
8gy2B Cryo-em structure of membrane-bound alcohol dehydrogenase from gluconobacter oxydans
37% identity, 93% coverage: 27:411/415 of query aligns to 1:403/433 of 8gy2B
- binding heme c: C18 (= C44), C21 (= C47), H22 (= H48), T46 (= T72), I48 (= I74), Y59 (= Y85), L68 (= L94), R73 (= R99), V79 (≠ L105), Y80 (= Y106), M83 (= M109), F88 (≠ Y114), R126 (= R151), H165 (= H189), C166 (= C190), C169 (= C193), H170 (= H194), I201 (≠ L218), A202 (= A219), P203 (= P220), L205 (= L222), W216 (= W232), F224 (= F240), A234 (≠ T250), V235 (≠ M251), F236 (= F252), F236 (= F252), M239 (= M255), N301 (≠ V311), C302 (= C312), C305 (= C315), H306 (= H316), M316 (≠ I326), F317 (≠ A327), P318 (≠ V328), L320 (≠ M330), P324 (≠ T334), G342 (≠ I352), S352 (≠ R362), V354 (≠ Q364), M356 (= M366), F359 (= F369), M375 (≠ L385)
- binding ubiquinone-10: C21 (= C47), L34 (= L60), P39 (= P65), P81 (= P107), L129 (= L154), W132 (= W157), E168 (= E192), R173 (= R197), I197 (≠ L214), D241 (≠ P257)
Sites not aligning to the query:
7w2jC Cryo-em structure of membrane-bound fructose dehydrogenase from gluconobacter japonicus
36% identity, 90% coverage: 32:406/415 of query aligns to 1:387/418 of 7w2jC
- binding heme c: C13 (= C44), C16 (= C47), H17 (= H48), T42 (= T72), I44 (= I74), Y55 (= Y85), L75 (= L105), Y76 (= Y106), A78 (= A108), M79 (= M109), R122 (= R151), H161 (= H189), C162 (= C190), C165 (= C193), H166 (= H194), A191 (= A219), P192 (= P220), R223 (≠ T250), P227 (≠ E254), M228 (= M255), V289 (= V311), C290 (= C312), C293 (= C315), H294 (= H316), Y305 (≠ I326), Y306 (≠ A327), P307 (≠ V328), L309 (≠ M330), N312 (= N333), T313 (= T334), T314 (= T335), D322 (≠ N343), I327 (= I348), V331 (≠ I352), R333 (≠ Q355), I340 (≠ R362), M342 (≠ Q364), P343 (= P365), F345 (≠ P367)
8jejC Cryo-em structure of na-dithionite reduced membrane-bound fructose dehydrogenase from gluconobacter japonicus
35% identity, 90% coverage: 32:406/415 of query aligns to 1:401/413 of 8jejC
- binding heme c: C13 (= C44), C16 (= C47), H17 (= H48), T42 (= T72), I44 (= I74), F60 (= F90), L64 (= L94), L75 (= L105), Y76 (= Y106), M79 (= M109), P80 (= P110), Y84 (= Y114), R122 (= R151), C162 (= C190), C165 (= C193), H166 (= H194), I186 (≠ L214), W189 (≠ Y217), A191 (= A219), P192 (= P220), I194 (≠ L222), W205 (= W232), Y213 (≠ F240), R223 (≠ T250), M228 (= M255), V303 (= V311), C304 (= C312), C307 (= C315), H308 (= H316), Y320 (≠ A327), P321 (≠ V328), L323 (≠ M330), T327 (= T334), T328 (= T335), D336 (≠ N343), I341 (= I348), V345 (≠ I352), R347 (≠ Q355), I354 (≠ R362), M356 (≠ Q364), F359 (≠ P367), I376 (≠ L381)
- binding ubiquinone-10: M36 (≠ F66), P77 (= P107), S124 (≠ G153), W128 (= W157), C165 (= C193), L173 (≠ G201)
Sites not aligning to the query:
8gy3A Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
30% identity, 90% coverage: 15:387/415 of query aligns to 24:409/440 of 8gy3A
- binding heme c: Y52 (≠ D43), C53 (= C44), C56 (= C47), H57 (= H48), S84 (≠ T72), I86 (= I74), W97 (≠ Y85), F102 (= F90), L117 (= L105), F121 (≠ M109), F126 (≠ Y114), R163 (= R151), C203 (= C190), C206 (= C193), H207 (= H194), A232 (= A219), P233 (= P220), L235 (= L222), W245 (= W232), Y253 (≠ F240), L254 (= L241), G263 (= G249), S264 (≠ T250), M269 (= M255), Y292 (≠ L278), C337 (= C312), C340 (= C315), H341 (= H316), P353 (= P324), L355 (≠ I326), N358 (= N333), N359 (≠ T334), V372 (= V347), I377 (= I352), G382 (= G359), Q383 (≠ F360), I386 (≠ M363), M388 (= M366), F391 (= F369)
- binding ubiquinone-10: E55 (≠ A46), T76 (≠ S64), F78 (= F66), Y118 (= Y106), P119 (= P107), I160 (≠ F148), G166 (≠ L154), Q167 (≠ M155), F169 (vs. gap), W170 (= W157), H202 (= H189), R210 (= R197), L213 (≠ P200)
8hddB Complex structure of catalytic, small, and a partial electron transfer subunits from burkholderia cepacia fad glucose dehydrogenase
30% identity, 24% coverage: 308:405/415 of query aligns to 26:121/121 of 8hddB
- binding protoporphyrin ix containing fe: C30 (= C312), C33 (= C315), H34 (= H316), Y46 (≠ A327), P47 (≠ V328), T54 (= T335), V66 (= V347), I67 (= I348), R73 (≠ K356), I80 (≠ M363), M82 (= M366), P83 (= P367)
Query Sequence
>AO353_27065 AO353_27065 cytochrome C oxidase Cbb3
MKRLLSSLGTAVGLAVSLMAIQQAQAADQQQIKRGEYLARAADCMACHTAPGGAPYAGGL
PIVSPFGTIYGTNITPDKDHGIGQYSDDEFFAALTEGKRRDGANLYPAMPYTSYHLMPRE
DSDAIHAYLQTVAPINRAAPVTRLSFPFNVRLGLMGWNMLYGKDVKLTPAEGKSEDWKRG
QYLVDVLGHCGECHTPRGLPGAMQQDKRLTGGLLNGYLAPSLLANDLAARGWTHQDLSSF
LKHGMSAQGTMFNEMFPVFHNSTQNLNEPDLASMATFLLGDPPPQARVLSEVPLDKMTES
ARRGRQDYLNVCAGCHGVNGEGKPHIAVAMQGNTTLRLEDPRNLLRVIEDGIGEQKFAGF
ERMQPMPGFADKLSNQQMTDLISYLRQAWGGQPADLLIGQIEQLKADAPVEHKAH
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory