SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing AO356_00370 FitnessBrowser__pseudo5_N2C3_1:AO356_00370 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6agmA Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy- d-arabino-heptulosonate-7-phosphate synthase from escherichia coli (see paper)
53% identity, 91% coverage: 29:352/356 of query aligns to 19:326/334 of 6agmA

query
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6agmA

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binding tyrosine: P145 (= P155), Q149 (≠ S159), S178 (≠ G188), F207 (≠ H217), I210 (≠ V220), L219 (≠ I229)

4hsoA Crystal structure of s213g variant dah7ps from neisseria meningitidis (see paper)
51% identity, 88% coverage: 32:345/356 of query aligns to 21:331/345 of 4hsoA

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binding manganese (ii) ion: C58 (= C69), H265 (= H277), E299 (= E311), D319 (= D333)
binding phosphoenolpyruvate: R89 (= R100), A161 (= A172), R162 (= R173), K183 (= K194), R231 (= R242), H265 (= H277)
binding tyrosine: Q148 (≠ S159), L172 (≠ M183), L176 (= L187), S177 (≠ G188)

4umbA Structural analysis of substrate-mimicking inhibitors in complex with neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water (see paper)
51% identity, 88% coverage: 32:345/356 of query aligns to 11:321/335 of 4umbA

query
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4umbA

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binding (2R)-2-(phosphonooxy)propanoic acid: R79 (= R100), K84 (= K105), A151 (= A172), R152 (= R173), K173 (= K194), R221 (= R242), H255 (= H277)
binding manganese (ii) ion: C48 (= C69), H255 (= H277), E289 (= E311), D309 (= D333)

5dcbC Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase regulated and complexed with pep
51% identity, 88% coverage: 32:345/356 of query aligns to 25:335/348 of 5dcbC

query
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5dcbC

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R

-

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

G

S

A

T

T

E

E

Q

E

L

L

binding manganese (ii) ion: C62 (= C69), K98 (= K105), H269 (= H277), E303 (= E311), D323 (= D333)
binding phosphoenolpyruvate: R93 (= R100), Y95 (= Y102), E144 (= E151), K187 (= K194), R235 (= R242), H269 (= H277)
binding phenylalanine: Q152 (≠ S159), A155 (≠ D162), L180 (= L187), S181 (≠ G188), F210 (≠ H217), S212 (≠ G219), V222 (≠ I229)

4umcA Structural analysis of substrate-mimicking inhibitors in complex with neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water (see paper)
51% identity, 88% coverage: 32:345/356 of query aligns to 11:321/334 of 4umcA

query
sites
4umcA

H

Y

Q

E

L

L

P

P

L

I

S

S

T

K

A

E

L

A

S

S

H

G

Q

L

V

V

S

H

A

R

H

T

R

R

Q

Q

A

E

I

I

R

S

A

D

I

L

L

V

N

H

G

G

E

R

D

D

A

K

R

R

L

L

V

V

I

I

V

I

G

G

P

P

C
|
C

S

S

I

I

H

H

D

D

P

P

K

K

S

A

A

A

L

L

E

E

Y

Y

A

A

A

E

N

R

L

L

A

L

R

K

V

L

A

R

H

K

E

Q

V

Y

S

E

D

N

S

E

M

L

F

L

L

I

V

V

M

M

R
|
R

A

V

Y

Y

V

F

E

E

K
|
K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

L

D

D

G

G

S

T

D

F

D

D

M

I

A

N

A

F

G

G

L

L

T

R

L

Q

S

A

R

R

E

S

L

L

M

L

R

L

E

S

M

L

L

N

Q

N

L

M

G

G

L

M

P

P

V

A

A

S

T

T

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S

Q

Y

Y

F

Y

D

A

D

D

L

L

L

I

S

S

W

W

V

G

A

A

I

I

G
|
G

A

A

R
|
R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L

L

G

S

M

C

P

P

V

V

G

G

F

F

K
|
K

N

N

G

G

T

T

D

D

G

G

G

N

V

L

G

K

I

I

A

A

C

I

D

D

A

A

M

I

R

G

S

A

A

A

A

S

H

H

P

S

H

H

R

H

H

F

F

L

G

S

V

V

D

T

S

K

Q

A

G

G

H

H

P

S

A

A

I

I

I

V

Q

H

T

T

P

G

G

G

N

N

P

P

D

D

T

C

H

H

L

V

V

I

L

L

R
|
R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

D

R

A

Q

E

S

H

V

V

T

S

Q

E

I

A

H

A

S

E

D

Q

L

L

T

R

R

A

L

A

K

G

I

V

P

T

A

D

R

K

I

L

M

M

V

I

D

D

C

C

S

S

H
|
H

A

A

N

N

S

S

G

R

K

K

D

D

P

Y

L

T

R

R

Q

Q

P

M

Q

E

V

V

F

A

D

Q

D

D

V

I

L

A

E

A

Q

Q

R

L

L

E

Q

Q

G

D

N

G

R

G

S

N

L

I

I

M

G

G

M

V

M

M

L

V

E
|
E

S

S

H

H

L

L

F

V

E

E

G

G

C

R

Q

Q

P

D

L

-

G

K

P

P

S

E

M

V

R

-

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

G

S

A

T

T

E

E

Q

E

L

L

binding manganese (ii) ion: C48 (= C69), H255 (= H277), E289 (= E311), D309 (= D333)
binding l-phospholactate: R79 (= R100), K84 (= K105), G150 (= G171), R152 (= R173), K173 (= K194), R221 (= R242), H255 (= H277)

5dcdA Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase regulated (tyrosine)
51% identity, 88% coverage: 32:345/356 of query aligns to 23:333/346 of 5dcdA

query
sites
5dcdA

H

Y

Q

E

L

L

P

P

L

I

S

S

T

K

A

E

L

A

S

S

H

G

Q

L

V

V

S

H

A

R

H

T

R

R

Q

Q

A

E

I

I

R

S

A

D

I

L

L

V

N

H

G

G

E

R

D

D

A

K

R

R

L

L

V

V

I

I

V

I

G

G

P

P

C
|
C

S

S

I

I

H

H

D

D

P

P

K

K

S

A

A

A

L

L

E

E

Y

Y

A

A

A

E

N

R

L

L

A

L

R

K

V

L

A

R

H

K

E

Q

V

Y

S

E

D

N

S

E

M

L

F

L

L

I

V

V

M

M

R

R

A

V

Y

Y

V

F

E

E

K

K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

L

D

D

G

G

S

T

D

F

D

D

M

I

A

N

A

F

G

G

L

L

T

R

L

Q

S

A

R

R

E

S

L

L

M

L

R

L

E

S

M

L

L

N

Q

N

L

M

G

G

L

M

P

P

V

A

A

S

T

T

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S
x
Q

Y

Y

F

Y

D
x
A

D

D

L

L

L

I

S

S

W

W

V

G

A

A

I

I

G

G

A
|
A

R

R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L
|
L

G
x
S

M

C

P

P

V

V

G

G

F

F

K
|
K

N

N

G

G

T

T

D

D

G

G

G

N

V

L

G

K

I

I

A

A

C

I

D

D

A

A

M

I

R

G

S

A

A

A

A

S

H

H

P

S

H

H

R

H

H

F

F

L

G
x
S

V

V

D

T

S

K

Q

A

G

G

H

H

P

S

A

A

I

I

I
x
V

Q

H

T

T

P

G

G

G

N

N

P

P

D

D

T

C

H

H

L

V

V

I

L

L

R
|
R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

D

R

A

Q

E

S

H

V

V

T

S

Q

E

I

A

H

A

S

E

D

Q

L

L

T

R

R

A

L

A

K

G

I

V

P

T

A

D

R

K

I

L

M

M

V

I

D

D

C

C

S

S

H
|
H

A

A

N

N

S

S

G

R

K

K

D

D

P

Y

L

T

R

R

Q

Q

P

M

Q

E

V

V

F

A

D

Q

D

D

V

I

L

A

E

A

Q

Q

R

L

L

E

Q

Q

G

D

N

G

R

G

S

N

L

I

I

M

G

G

M

V

M

M

L

V

E
|
E

S

S

H

H

L

L

F

V

E

E

G

G

C

R

Q

Q

P

D

L

-

G

K

P

P

S

E

M

V

R

-

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

G

S

A

T

T

E

E

Q

E

L

L

binding manganese (ii) ion: C60 (= C69), H267 (= H277), E301 (= E311), D321 (= D333)
binding trimethylamine oxide: A163 (= A172), K185 (= K194), R233 (= R242), H267 (= H277)
binding tyrosine: Q150 (≠ S159), A153 (≠ D162), L178 (= L187), S179 (≠ G188), S210 (≠ G219), V220 (≠ I229)

5dceA Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase regulated (tryptophan) (see paper)
51% identity, 88% coverage: 32:345/356 of query aligns to 21:331/344 of 5dceA

query
sites
5dceA

H

Y

Q

E

L

L

P

P

L

I

S

S

T

K

A

E

L

A

S

S

H

G

Q

L

V

V

S

H

A

R

H

T

R

R

Q

Q

A

E

I

I

R

S

A

D

I

L

L

V

N

H

G

G

E

R

D

D

A

K

R

R

L

L

V

V

I

I

V

I

G

G

P

P

C
|
C

S

S

I

I

H

H

D

D

P

P

K

K

S

A

A

A

L

L

E

E

Y

Y

A

A

A

E

N

R

L

L

A

L

R

K

V

L

A

R

H

K

E

Q

V

Y

S

E

D

N

S

E

M

L

F

L

L

I

V

V

M

M

R

R

A

V

Y

Y

V

F

E

E

K

K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

L

D

D

G

G

S

T

D

F

D

D

M

I

A

N

A

F

G

G

L

L

T

R

L

Q

S

A

R

R

E

S

L

L

M

L

R

L

E

S

M

L

L

N

Q

N

L

M

G

G

L

M

P

P

V

A

A

S

T

T

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S
x
Q

Y

Y

F

Y

D

A

D

D

L

L

L

I

S

S

W

W

V

G

A

A

I

I

G

G

A

A

R

R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L
|
L

G
x
S

M

C

P

P

V

V

G

G

F

F

K

K

N

N

G

G

T

T

D

D

G

G

G

N

V

L

G

K

I

I

A

A

C

I

D

D

A

A

M

I

R

G

S

A

A

A

A

S

H

H

P

S

H

H

R

H

H

F

F

L

G
x
S

V
|
V

D

T

S

K

Q

A

G

G

H

H

P

S

A

A

I

I

I
x
V

Q

H

T

T

P

G

G

G

N

N

P

P

D

D

T

C

H

H

L

V

V

I

L

L

R

R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

D

R

A

Q

E

S

H

V

V

T

S

Q

E

I

A

H

A

S

E

D

Q

L

L

T

R

R

A

L

A

K

G

I

V

P

T

A

D

R

K

I

L

M

M

V

I

D

D

C

C

S

S

H
|
H

A

A

N

N

S

S

G

R

K

K

D

D

P

Y

L

T

R

R

Q

Q

P

M

Q

E

V

V

F

A

D

Q

D

D

V

I

L

A

E

A

Q

Q

R

L

L

E

Q

Q

G

D

N

G

R

G

S

N

L

I

I

M

G

G

M

V

M

M

L

V

E
|
E

S

S

H

H

L

L

F

V

E

E

G

G

C

R

Q

Q

P

D

L

-

G

K

P

P

S

E

M

V

R

-

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

G

S

A

T

T

E

E

Q

E

L

L

binding manganese (ii) ion: C58 (= C69), H265 (= H277), E299 (= E311), D319 (= D333)
binding tryptophan: Q148 (≠ S159), L176 (= L187), S177 (≠ G188), S208 (≠ G219), V209 (= V220), V218 (≠ I229)

4umaA Structural analysis of substrate-mimicking inhibitors in complex with neisseria meningitidis 3 deoxy d arabino heptulosonate 7 phosphate synthase the importance of accommodating the active site water (see paper)
51% identity, 88% coverage: 32:345/356 of query aligns to 10:320/333 of 4umaA

query
sites
4umaA

H

Y

Q

E

L

L

P

P

L

I

S

S

T

K

A

E

L

A

S

S

H

G

Q

L

V

V

S

H

A

R

H

T

R

R

Q

Q

A

E

I

I

R

S

A

D

I

L

L

V

N

H

G

G

E

R

D

D

A

K

R

R

L

L

V

V

I

I

V

I

G

G

P

P

C
|
C

S

S

I

I

H

H

D

D

P

P

K

K

S

A

A

A

L

L

E

E

Y

Y

A

A

A

E

N

R

L

L

A

L

R

K

V

L

A

R

H

K

E

Q

V

Y

S

E

D

N

S

E

M

L

F

L

L

I

V

V

M

M

R
|
R

A

V

Y

Y

V

F

E

E

K
|
K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

L

D

D

G

G

S

T

D

F

D

D

M

I

A

N

A

F

G

G

L

L

T

R

L

Q

S

A

R

R

E

S

L

L

M

L

R

L

E

S

M

L

L

N

Q

N

L

M

G

G

L

M

P

P

V

A

A

S

T

T

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S

Q

Y

Y

F

Y

D

A

D

D

L

L

L

I

S

S

W

W

V

G

A

A

I

I

G
|
G

A
|
A

R
|
R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L

L

G

S

M

C

P

P

V

V

G

G

F

F

K
|
K

N

N

G

G

T

T

D

D

G

G

G

N

V

L

G

K

I

I

A

A

C

I

D

D

A

A

M

I

R

G

S

A

A

A

A

S

H

H

P

S

H

H

R

H

H

F

F

L

G

S

V

V

D

T

S

K

Q

A

G

G

H

H

P

S

A

A

I

I

I

V

Q

H

T

T

P

G

G

G

N

N

P

P

D

D

T

C

H

H

L

V

V

I

L

L

R
|
R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

D

R

A

Q

E

S

H

V

V

T

S

Q

E

I

A

H

A

S

E

D

Q

L

L

T

R

R

A

L

A

K

G

I

V

P

T

A

D

R

K

I

L

M

M

V

I

D

D

C

C

S

S

H
|
H

A

A

N

N

S

S

G

R

K

K

D

D

P

Y

L

T

R

R

Q

Q

P

M

Q

E

V

V

F

A

D

Q

D

D

V

I

L

A

E

A

Q

Q

R

L

L

E

Q

Q

G

D

N

G

R

G

S

N

L

I

I

M

G

G

M

V

M

M

L

V

E
|
E

S

S

H

H

L

L

F

V

E

E

G

G

C

R

Q

Q

P

D

L

-

G

K

P

P

S

E

M

V

R

-

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

G

S

A

T

T

E

E

Q

E

L

L

binding (e)-2-methyl-3-phosphonoacrylate: R78 (= R100), K83 (= K105), G149 (= G171), A150 (= A172), R151 (= R173), K172 (= K194), R220 (= R242), H254 (= H277)
binding manganese (ii) ion: C47 (= C69), H254 (= H277), E288 (= E311), D308 (= D333)

1kflA Crystal structure of phenylalanine-regulated 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase (dahp synthase) from e.Coli complexed with mn2+, pep, and phe (see paper)
47% identity, 94% coverage: 13:347/356 of query aligns to 1:340/350 of 1kflA

query
sites
1kflA

L

M

N

N

P

Y

A

Q

N

N

E

D

A

D

L

L

T

R

L

I

R

K

L

E

P

I

S

K

S

E

L

L

-

L

-

P

-

V

Q

A

L

L

K

L

H

E

Q

K

L

F

P

P

L

A

S

T

T

E

A

N

L

A

S

A

H

N

Q

T

V

V

S

A

A

H

H

A

R

R

Q

K

A

A

I

I

R

H

A

K

I

I

L

L

N

K

G

G

E

N

D

D

A

D

R

R

L

L

V

V

I

V

V

I

G

G

P

P

C
|
C

S

S

I

I

H

H

D

D

P

P

K

V

S

A

A

A

L

K

E

E

Y

Y

A

A

A

T

N

R

L

L

A

L

R

A

V

L

A

R

H

E

E

E

V

L

S

K

D

D

S

E

M

L

F

E

L

I

V

V

M

M

R
|
R

A

V

Y

Y

V

F

E

E

K
|
K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

M

D

D

G

N

S

S

D

F

D

Q

M

I

A

N

A

D

G

G

L

L

T

R

L

I

S

A

R

R

E

K

L

L

M

L

R

L

E

D

M

I

L

N

Q

D

L

S

G

G

L

L

P

P

V

A

A

A

T

G

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S
x
Q

Y

Y

F

L

D
x
A

D

D

L

L

L

M

S

S

W

W

V

G

A

A

I

I

G

G

A

A

R

R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L
|
L

G
x
S

M

C

P

P

V

V

G

G

F

F

K
|
K

N

N

G

G

T

T

D

D

G

G

G

T

V

I

G

K

I

V

A

A

C

I

D

D

A

A

M

I

R

N

S

A

A

A

A

G

H

A

P

P

H

H

R

C

H
x
F

F

L

G
x
S

V

V

D

T

S

K

Q

W

G

G

H

H

P

S

A

A

I

I

I
x
V

Q

N

T

T

P

S

G

G

N

N

P

G

D

D

T

C

H

H

L

I

V

I

L

L

R
|
R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

S

R

A

Q

K

S

H

V

V

T

A

Q

E

I

V

H

K

S

E

D

G

L

L

T

N

R

K

L

A

K

G

I

L

P

P

A

A

R

Q

I

V

M

M

V

I

D

D

C

F

S

S

H
|
H

A

A

N

N

S

S

G

S

K

K

D

Q

P

F

L

K

R

K

Q

Q

P

M

Q

D

V

V

F

C

D

A

D

D

V

V

L

C

E

Q

Q

Q

R

I

L

A

Q

G

G

G

N

E

R

K

S

A

L

I

I

I

G

G

M

V

M

M

L

V

E
|
E

S

S

H

H

L

L

F

V

E

E

G

G

C

N

Q

Q

P

S

L

L

-

E

-

S

G

G

P

E

S

P

M

L

R

A

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

E

S

D

T

T

E

D

Q

A

L

L

R

R

E

Q

binding manganese (ii) ion: C61 (= C69), K97 (= K105), H268 (= H277), E302 (= E311), D326 (= D333)
binding phosphoenolpyruvate: R92 (= R100), K186 (= K194), R234 (= R242), H268 (= H277)
binding phenylalanine: Q151 (≠ S159), A154 (≠ D162), L179 (= L187), S180 (≠ G188), F209 (≠ H217), S211 (≠ G219), V221 (≠ I229)

P0AB91 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54 from Escherichia coli (strain K12) (see paper)
47% identity, 94% coverage: 13:347/356 of query aligns to 1:340/350 of P0AB91

query
sites
P0AB91

L

M

N

N

P

Y

A

Q

N

N

E

D

A

D

L

L

T

R

L

I

R

K

L

E

P

I

S

K

S

E

L

L

-

L

-

P

-

V

Q

A

L

L

K

L

H

E

Q

K

L

F

P

P

L

A

S

T

T

E

A

N

L

A

S

A

H

N

Q

T

V

V

S

A

A

H

H

A

R

R

Q

K

A

A

I

I

R

H

A

K

I

I

L

L

N

K

G

G

E

N

D

D

A

D

R

R

L

L

V

V

I

V

V

I

G

G

P

P

C

C

S

S

I

I

H

H

D

D

P

P

K

V

S

A

A

A

L

K

E

E

Y

Y

A

A

A

T

N

R

L

L

A

L

R

A

V

L

A

R

H

E

E

E

V

L

S

K

D

D

S

E

M

L

F

E

L

I

V

V

M

M

R

R

A

V

Y

Y

V

F

E

E

K

K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

M

D

D

G

N

S

S

D

F

D

Q

M

I

A

N

A

D

G

G

L

L

T

R

L

I

S

A

R

R

E

K

L

L

M

L

R

L

E

D

M

I

L

N

Q

D

L

S

G

G

L

L

P

P

V

A

A

A

T

G

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S

Q

Y

Y

F

L

D

A

D

D

L

L

L

M

S

S

W

W

V

G

A

A

I

I

G

G

A

A

R

R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L

L

G

S

M

C

P

P

V

V

G

G

F

F

K

K

N

N

G

G

T

T

D

D

G

G

G

T

V

I

G

K

I

V

A

A

C

I

D

D

A

A

M

I

R

N

S

A

A

A

A

G

H

A

P

P

H

H

R

C

H

F

F

L

G

S

V

V

D

T

S

K

Q

W

G

G

H

H

P

S

A

A

I

I

I

V

Q

N

T

T

P

S

G

G

N

N

P

G

D

D

T

C

H

H

L

I

V

I

L

L

R

R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

S

R

A

Q
x
K

S

H

V

V

T

A

Q

E

I

V

H

K

S

E

D

G

L

L

T

N

R

K

L

A

K

G

I

L

P

P

A

A

R

Q

I

V

M

M

V

I

D

D

C

F

S

S

H

H

A

A

N

N

S

S

G

S

K

K

D

Q

P

F

L

K

R

K

Q

Q

P

M

Q

D

V

V

F

C

D

A

D

D

V

V

L

C

E

Q

Q

Q

R

I

L

A

Q

G

G

G

N

E

R

K

S

A

L

I

I

I

G

G

M

V

M

M

L

V

E

E

S

S

H

H

L

L

F

V

E

E

G

G

C

N

Q

Q

P

S

L

L

-

E

-

S

G

G

P

E

S

P

M

L

R

A

Y

Y

G

G

V

K

S

S

V

I

T

T

D

D

G

A

C

C

L

I

G

G

W

W

E

E

S

D

T

T

E

D

Q

A

L

L

R

R

E

Q

K244 (≠ Q253) modified: N6-acetyllysine

8e0sD Dahp (3-deoxy-d-arabinoheptulosonate-7-phosphate) synthase complexed with dahp oxime in unbound:(bound)2:unbound conformations (see paper)
49% identity, 90% coverage: 28:347/356 of query aligns to 14:334/343 of 8e0sD

query
sites
8e0sD

L

V

Q

A

L

L

K

L

H

E

Q

K

L

F

P

P

L

A

S

T

T

E

A

N

L

A

S

A

H

N

Q

T

V

V

S

A

A

H

H

A

R

R

Q

K

A

A

I

I

R

H

A

K

I

I

L

L

N

K

G

G

E

N

D

D

A

D

R

R

L

L

V

V

I

V

V

I

G

G

P

P

C

C

S

S

I

I

H

H

D

D

P

P

K

V

S

A

A

A

L

K

E
|
E

Y

Y

A

A

A

T

N
x
R

L

L

A

L

R

A

V

L

A

R

H

E

E

E

V

L

S

K

D

D

S

E

M

L

F

E

L

I

V

V

M

M

R

R

A

V

Y

Y

V

F

E

E

K

K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

M

D

D

G

N

S

S

D

F

D

Q

M

I

A

N

A

D

G

G

L

L

T

R

L

I

S

A

R

R

E

K

L

L

M

L

R

L

E

D

M

I

L

N

Q

D

L

S

G

G

L

L

P

P

V

A

A

A

T

G

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S

Q

Y

Y

F

L

D

A

D

D

L

L

L

M

S

S

W

W

V

G

A

A

I

I

G

G

A

A

R

R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L

L

G

S

M

C

P

P

V

V

G

G

F

F

K

K

N

N

G

G

T

T

D

D

G

G

G

T

V

I

G

K

I

V

A

A

C

I

D

D

A

A

M

I

R

N

S

A

A

A

A

G

H

A

P

P

H

H

R

C

H

F

F

L

G

S

V

V

D

T

S

K

Q

W

G

G

H

H

P

S

A

A

I

I

I

V

Q

N

T

T

P

S

G

G

N

N

P

G

D

D

T

C

H

H

L

I

V

I

L

L

R

R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

S

R

A

Q

K

S

H

V

V

T

A

Q

E

I

V

H

K

S

E

D

G

L

L

T

N

R

K

L

A

K

G

I

L

P

P

A

A

R

Q

I

V

M

M

V

I

D

D

C

F

S

S

H

H

A

A

N

N

S

S

G

S

K

K

D

Q

P

F

L

K

R

K

Q

Q

P

M

Q

D

V

V

F

C

D

A

D

D

V

V

L

C

E

Q

Q

Q

R

I

L

A

Q

G

G

G

N

E

R

K

S

A

L

I

I

I

G

G

M

V

M

M

L

V

E

E

S

S

H

H

L
|
L

F

V

E

E

G

G

C

N

Q

Q

P

S

L

L

-

E

-

S

G

G

P

E

S

P

M

L

R

A

Y

Y

G

G

V

K

S

S

V

I

T

T

D

D

G

A

C

C

L

I

G

G

W

W

E

E

S

D

T

T

E

D

Q

A

L

L

R

R

E

Q

binding beta-D-glucopyranose: E65 (= E79), R69 (≠ N83), L299 (= L314)

7rudB Dahp synthase complex with trifluoropyruvate oxime (see paper)
49% identity, 90% coverage: 28:347/356 of query aligns to 14:334/343 of 7rudB

query
sites
7rudB

L

V

Q

A

L

L

K

L

H

E

Q

K

L

F

P

P

L

A

S

T

T

E

A

N

L

A

S

A

H

N

Q

T

V

V

S

A

A

H

H

A

R

R

Q

K

A

A

I

I

R

H

A

K

I

I

L

L

N

K

G

G

E

N

D

D

A

D

R

R

L

L

V

V

I

V

V

I

G

G

P

P

C

C

S

S

I

I

H

H

D

D

P

P

K

V

S

A

A

A

L

K

E

E

Y

Y

A

A

A

T

N

R

L

L

A

L

R

A

V

L

A

R

H

E

E

E

V

L

S

K

D

D

S

E

M

L

F

E

L

I

V

V

M

M

R

R

A

V

Y

Y

V

F

E

E

K

K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

M

D

D

G

N

S

S

D

F

D

Q

M

I

A

N

A

D

G

G

L

L

T

R

L

I

S

A

R

R

E

K

L

L

M

L

R

L

E

D

M

I

L

N

Q

D

L

S

G

G

L

L

P

P

V

A

A

A

T

G

E
|
E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S

Q

Y

Y

F

L

D

A

D

D

L

L

L

M

S

S

W

W

V

G

A

A

I

I

G
|
G

A
|
A

R

R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L

L

G

S

M

C

P

P

V

V

G

G

F

F

K
|
K

N

N

G

G

T

T

D

D

G

G

G

T

V

I

G

K

I

V

A

A

C

I

D

D

A

A

M

I

R

N

S

A

A

A

A

G

H

A

P

P

H

H

R

C

H

F

F

L

G

S

V

V

D

T

S

K

Q

W

G

G

H

H

P

S

A

A

I

I

I

V

Q

N

T

T

P

S

G

G

N

N

P

G

D

D

T

C

H

H

L

I

V

I

L

L

R
|
R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

S

R

A

Q

K

S

H

V

V

T

A

Q

E

I

V

H

K

S

E

D

G

L

L

T

N

R

K

L

A

K

G

I

L

P

P

A

A

R

Q

I

V

M

M

V

I

D

D

C

F

S

S

H
|
H

A

A

N

N

S

S

G

S

K

K

D

Q

P

F

L

K

R

K

Q

Q

P

M

Q

D

V

V

F

C

D

A

D

D

V

V

L

C

E

Q

Q

Q

R

I

L

A

Q

G

G

G

N

E

R

K

S

A

L

I

I

I

G

G

M

V

M

M

L

V

E

E

S

S

H

H

L

L

F

V

E

E

G

G

C

N

Q

Q

P

S

L

L

-

E

-

S

G

G

P

E

S

P

M

L

R

A

Y

Y

G

G

V

K

S

S

V

I

T

T

D

D

G

A

C

C

L

I

G

G

W

W

E

E

S

D

T

T

E

D

Q

A

L

L

R

R

E

Q

binding (2Z)-3,3,3-trifluoro-2-(hydroxyimino)propanoic acid: E137 (= E151), G157 (= G171), A158 (= A172), K180 (= K194), R228 (= R242), H262 (= H277)

5cksB Dahp (3-deoxy-d-arabinoheptulosonate-7-phosphate) synthase in complex with dahp oxime. (see paper)
49% identity, 90% coverage: 28:347/356 of query aligns to 15:335/345 of 5cksB

query
sites
5cksB

L

V

Q

A

L

L

K

L

H

E

Q

K

L

F

P

P

L

A

S

T

T

E

A

N

L

A

S

A

H

N

Q

T

V

V

S

A

A

H

H

A

R

R

Q

K

A

A

I

I

R

H

A

K

I

I

L

L

N

K

G

G

E

N

D

D

A

D

R

R

L

L

V

V

I

V

V

I

G

G

P

P

C

C

S

S

I

I

H

H

D

D

P

P

K

V

S

A

A

A

L
x
K

E

E

Y

Y

A

A

A

T

N

R

L

L

A

L

R

A

V

L

A

R

H

E

E

E

V

L

S

K

D

D

S

E

M

L

F

E

L

I

V

V

M

M

R
|
R

A

V

Y
|
Y

V

F

E

E

K
|
K

P
|
P

R
|
R

T
|
T

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

M

D

D

G

N

S

S

D

F

D

Q

M

I

A

N

A

D

G

G

L

L

T

R

L

I

S

A

R

R

E

K

L

L

M

L

R

L

E
x
D

M

I

L

N

Q

D

L

S

G

G

L

L

P

P

V

A

A

A

T

G

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S

Q

Y

Y

F

L

D

A

D

D

L

L

L

M

S

S

W

W

V

G

A

A

I

I

G

G

A

A

R

R

T

T

E

E

S

S

Q
|
Q

I

V

H

H

R

R

E
|
E

M

L

A

A

S

S

G

G

L

L

G

S

M

C

P

P

V

V

G

G

F

F

K
|
K

N

N

G

G

T

T

D

D

G

G

G

T

V

I

G

K

I

V

A

A

C

I

D

D

A

A

M

I

R

N

S

A

A

A

A

G

H

A

P

P

H

H

R

C

H
x
F

F
x
L

G

S

V

V

D

T

S

K

Q

W

G

G

H

H

P

S

A

A

I

I

I

V

Q

N

T

T

P

S

G

G

N

N

P

G

D

D

T

C

H

H

L

I

V

I

L

L

R

R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

S

R

A

Q

K

S

H

V

V

T

A

Q

E

I

V

H

K

S

E

D

G

L

L

T

N

R

K

L

A

K

G

I

L

P

P

A

A

R

Q

I

V

M

M

V

I

D

D

C

F

S

S

H
|
H

A

A

N

N

S

S

G

S

K

K

D

Q

P

F

L

K

R

K

Q

Q

P

M

Q

D

V

V

F

C

D

A

D

D

V

V

L

C

E

Q

Q

Q

R

I

L

A

Q

G

G

G

N

E

R

K

S

A

L

I

I

I

G

G

M

V

M

M

L

V

E

E

S

S

H

H

L

L

F

V

E

E

G

G

C

N

Q

Q

P

S

L

L

-

E

-

S

G

G

P

E

S

P

M

L

R

A

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

E

S

D

T

T

E

D

Q

A

L

L

R

R

E

Q

binding DAHP Oxime: R87 (= R100), Y89 (= Y102), K92 (= K105), P93 (= P106), R94 (= R107), T95 (= T108), K181 (= K194), H263 (= H277), D321 (= D333)
binding beta-D-galactopyranose: K65 (≠ L78), D127 (≠ E140), Q165 (= Q178), E169 (= E182), F204 (≠ H217), L205 (≠ F218)

1qr7A Crystal structure of phenylalanine-regulated 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase from escherichia coli complexed with pb2+ and pep (see paper)
49% identity, 90% coverage: 28:347/356 of query aligns to 13:328/338 of 1qr7A

query
sites
1qr7A

L

V

Q

A

L

L

K

L

H

E

Q

K

L

F

P

P

L

A

S

T

T

E

A

N

L

A

S

A

H

N

Q

T

V

V

S

A

A

H

H

A

R

R

Q

K

A

A

I

I

R

H

A

K

I

I

L

L

N

K

G

G

E

N

D

D

A

D

R

R

L

L

V

V

I

V

V

I

G

G

P

P

C
|
C

S

S

I

I

H

H

D

D

P

P

K

V

S

A

A

A

L

K

E

E

Y

Y

A

A

A

T

N

R

L

L

A

L

R

A

V

L

A

R

H

E

E

E

V

L

S

K

D

D

S

E

M

L

F

E

L

I

V

V

M

M

R
|
R

A

V

Y
|
Y

V

F

E

E

K

K

P

P

R

R

T

T

V

V

G

G

W

W

K

K

G

G

L

L

A

I

Y

N

D

D

P

P

G

H

L

M

D

D

G

N

S

S

D

F

D

Q

M

I

A

N

A

D

G

G

L

L

T

R

L

I

S

A

R

R

E

K

L

L

M

L

R

L

E

D

M

I

L

N

Q

D

L

S

G

G

L

L

P

P

V

A

A

A

T

G

E

E

L

F

L

L

Q

D

P

M

M

I

A

T

A

P

S

Q

Y

Y

F

L

D

A

D

D

L

L

L

M

S

S

W

W

V

G

A

A

I

I

G

G

A

A

R
|
R

T

T

E

E

S

S

Q

Q

I

V

H

H

R

R

E

E

M

L

A

A

S

S

G

G

L

L

G

S

M

C

P

P

V

V

G

G

F

F

K
|
K

N

N

G

G

T

T

D

D

G

G

G

T

V

I

G

K

I

V

A

A

C

I

D

D

A

A

M

I

R

N

S

A

A

A

A

G

H

A

P

P

H

H

R

C

H

F

F

L

G

S

V

V

D

T

S

K

Q

W

G

G

H

H

P

S

A

A

I

I

I

V

Q

N

T

T

P

S

G

G

N

N

P

G

D

D

T

C

H

H

L

I

V

I

L

L

R
|
R

G

G

H

-

R

K

G

E

P

P

N

N

Y

Y

D

S

R

A

Q

K

S

H

V

V

T

A

Q

E

I

V

H

K

S

E

D

G

L

L

T

N

R

K

L

A

K

G

I

L

P

P

A

A

R

Q

I

V

M

M

V

I

D

D

C

F

S

S

H
|
H

A

A

N

N

S

S

G

S

K

K

D

Q

P

F

L

K

R

K

Q

Q

P

M

Q

D

V

V

F

C

D

A

D

D

V

V

L

C

E

Q

Q

Q

R

I

L

A

Q

G

G

G

N

E

R

K

S

A

L

I

I

I

G

G

M

V

M

M

L

V

E
|
E

S

S

H

H

L

L

F

V

E

E

G

G

C

N

Q

Q

P

S

L

L

G

-

P

-

S

-

M

L

R

A

Y

Y

G

G

V

K

S

S

V

I

T

T

D
|
D

G

A

C

C

L

I

G

G

W

W

E

E

S

D

T

T

E

D

Q

A

L

L

R

R

E

Q

binding lead (ii) ion: C54 (= C69), H261 (= H277)