Comparing AO356_09240 FitnessBrowser__pseudo5_N2C3_1:AO356_09240 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
Q2YLF3 4-hydroxyproline epimerase; Hydroxyproline-2-epimerase; HyPRE; EC 5.1.1.8 from Brucella abortus (strain 2308) (see paper)
57% identity, 100% coverage: 2:332/332 of query aligns to 3:333/333 of Q2YLF3
8a3fAAA Proline racemase A (AsProR)
38% identity, 99% coverage: 3:331/332 of query aligns to 5:335/335 of 8a3fAAA
6r77A Crystal structure of trans-3-hydroxy-l-proline dehydratase in complex with substrate - closed conformation (see paper)
34% identity, 98% coverage: 7:331/332 of query aligns to 22:347/348 of 6r77A
6j7cA Crystal structure of proline racemase-like protein from thermococcus litoralis in complex with proline (see paper)
35% identity, 98% coverage: 5:331/332 of query aligns to 7:330/331 of 6j7cA
Q4DA80 Proline racemase A; TcPA45-A; TcPRACA; rTcPA45; EC 5.1.1.4 from Trypanosoma cruzi (strain CL Brener) (see 2 papers)
34% identity, 100% coverage: 1:331/332 of query aligns to 72:421/423 of Q4DA80
1w61A Proline racemase in complex with 2 molecules of pyrrole-2- carboxylic acid (holo form) (see paper)
34% identity, 100% coverage: 1:331/332 of query aligns to 1:350/353 of 1w61A
6hjeA Trypanosoma cruzi proline racemase in complex with inhibitor ng-p27 (see paper)
34% identity, 100% coverage: 1:331/332 of query aligns to 5:354/357 of 6hjeA
6hjgB Trypanosoma cruzi proline racemase in complex with inhibitor oxopa (see paper)
34% identity, 100% coverage: 1:331/332 of query aligns to 22:371/376 of 6hjgB
Q9I476 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; Hydroxyproline-2-epimerase; PaHyPRE; EC 5.1.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
36% identity, 97% coverage: 8:330/332 of query aligns to 7:313/314 of Q9I476
Q96EM0 Trans-3-hydroxy-L-proline dehydratase; Trans-L-3-hydroxyproline dehydratase; EC 4.2.1.77 from Homo sapiens (Human) (see paper)
31% identity, 98% coverage: 8:331/332 of query aligns to 23:353/354 of Q96EM0
4j9xA Crystal structure of the complex of a hydroxyproline epimerase (target efi-506499, pseudomonas fluorescens pf-5) with trans-4-hydroxy-l- proline
36% identity, 98% coverage: 3:329/332 of query aligns to 2:308/310 of 4j9xA
4j9wA Crystal structure of the complex of a hydroxyproline epimerase (target efi-506499, pseudomonas fluorescens pf-5) with the inhibitor pyrrole- 2-carboxylate
36% identity, 98% coverage: 3:329/332 of query aligns to 2:308/310 of 4j9wA
Q4KGU2 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; EC 5.1.1.8 from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
36% identity, 98% coverage: 3:329/332 of query aligns to 2:308/310 of Q4KGU2
4q60A Crystal structure of a 4-hydroxyproline epimerase from burkholderia multivorans atcc 17616, target efi-506586, open form, with bound pyrrole-2-carboxylate
36% identity, 97% coverage: 8:329/332 of query aligns to 12:310/311 of 4q60A
4q2hA Crystal structure of probable proline racemase from agrobacterium radiobacter k84, target efi-506561, with bound carbonate
32% identity, 99% coverage: 2:331/332 of query aligns to 5:335/346 of 4q2hA
4k7gD Crystal structure of a 3-hydroxyproline dehydratse from agrobacterium vitis, target efi-506470, with bound pyrrole 2-carboxylate, ordered active site
29% identity, 100% coverage: 2:332/332 of query aligns to 14:346/352 of 4k7gD
B9K4G4 Trans-3-hydroxy-L-proline dehydratase; T3LHyp dehydratase; t3HypD; Trans-L-3-hydroxyproline dehydratase; EC 4.2.1.77 from Allorhizobium ampelinum (strain ATCC BAA-846 / DSM 112012 / S4) (Agrobacterium vitis (strain S4)) (see paper)
29% identity, 100% coverage: 2:332/332 of query aligns to 4:336/342 of B9K4G4
4lb0B Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans-4-oh-l-proline
28% identity, 99% coverage: 2:331/332 of query aligns to 5:335/347 of 4lb0B
B9JQV3 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; EC 5.1.1.8 from Allorhizobium ampelinum (strain ATCC BAA-846 / DSM 112012 / S4) (Agrobacterium vitis (strain S4)) (see paper)
28% identity, 99% coverage: 2:331/332 of query aligns to 4:334/347 of B9JQV3
>AO356_09240 FitnessBrowser__pseudo5_N2C3_1:AO356_09240
MRRSFFCIDSHACGNPVRVVAGGGPLLPSVSMAERREIFVRDHDWVRTALMFEPRGHDIM
SGVIIYPSTREDCDFGALFIEVSGCLPMCGAGTIGLSTVVIEEGLVTPKEPGKLAIETPA
GRVDVEYTLDGEYVESIKLFNVASYLHSADVVVQVPGVGQLTVDIAYGGNFYAVVEPQQC
WPGLDGHSTADIVGLSVKLRAALAGICNPLHPENERITGVHHVIWCDKPQNSTADGRCAV
FYGDKAIDRSPGGTGTSARMAQLFGKGRLKVGDTYRHESPIGTLYEGKVEAAIKVGEFDG
IRPSITGWAQVTGYNTLFVDDRDPLAHGFQLA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory