SitesBLAST
Comparing AO356_09270 AO356_09270 aldehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
73% identity, 98% coverage: 1:496/505 of query aligns to 1:496/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (= V165), L166 (= L166), P167 (= P167), W168 (= W168), K192 (= K192), G225 (= G225), G229 (= G229), F243 (= F243), G245 (= G245), S246 (= S246), T249 (= T249), L252 (≠ R252), F253 (= F253), Y256 (= Y256), C269 (= C269), G270 (= G270), C303 (= C303), H350 (= H350), K353 (= K353), F400 (= F400)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
48% identity, 97% coverage: 5:495/505 of query aligns to 2:495/495 of 5iuwA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E398), D476 (= D476)
- binding 1h-indol-3-ylacetic acid: F167 (= F170), M170 (≠ L173), C300 (= C303), D457 (≠ G456), F465 (= F464)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V165), V163 (≠ L166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), G222 (= G225), G226 (= G229), K227 (≠ E230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (≠ T249), Y253 (= Y256), E265 (= E268), A266 (≠ C269), C300 (= C303), E399 (= E398), F401 (= F400)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
48% identity, 97% coverage: 5:495/505 of query aligns to 2:495/495 of 5iuvA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E398), D476 (= D476)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V165), V163 (≠ L166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), S191 (≠ A194), G222 (= G225), G226 (= G229), K227 (≠ E230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (≠ T249), Y253 (= Y256), E265 (= E268), A266 (≠ C269), C300 (= C303), E399 (= E398), F401 (= F400)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
48% identity, 97% coverage: 5:495/505 of query aligns to 2:495/495 of 7jsoA
- active site: N166 (= N169), E265 (= E268), A300 (≠ C303), D476 (= D476)
- binding 1h-indol-3-ylacetic acid: F167 (= F170), W174 (= W177), V299 (≠ N302), A300 (≠ C303), T301 (≠ S304), D457 (≠ G456), F465 (= F464)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ V165), V163 (≠ L166), P164 (= P167), W165 (= W168), K189 (= K192), E192 (= E195), G222 (= G225), G226 (= G229), K227 (≠ E230), F240 (= F243), G242 (= G245), S243 (= S246), I246 (≠ T249), A266 (≠ C269), G267 (= G270), A300 (≠ C303), E399 (= E398), F401 (= F400)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
45% identity, 93% coverage: 24:491/505 of query aligns to 14:484/494 of 4pz2B
- active site: N159 (= N169), K182 (= K192), E258 (= E268), C292 (= C303), E392 (= E398), D469 (= D476)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ V165), I156 (≠ L166), P157 (= P167), W158 (= W168), N159 (= N169), M164 (= M174), K182 (= K192), A184 (= A194), E185 (= E195), G215 (= G225), G219 (= G229), F233 (= F243), T234 (= T244), G235 (= G245), S236 (= S246), V239 (≠ T249), E258 (= E268), L259 (≠ C269), C292 (= C303), E392 (= E398), F394 (= F400)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
42% identity, 93% coverage: 24:491/505 of query aligns to 23:491/501 of Q56YU0
- G152 (≠ T152) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A415) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
43% identity, 93% coverage: 24:491/505 of query aligns to 9:476/486 of 4pxlA
- active site: N154 (= N169), K177 (= K192), E253 (= E268), C287 (= C303), E384 (= E398), D461 (= D476)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ V165), V151 (≠ L166), P152 (= P167), W153 (= W168), K177 (= K192), E180 (= E195), G210 (= G225), G214 (= G229), A215 (≠ E230), F228 (= F243), G230 (= G245), S231 (= S246), V234 (≠ T249), E253 (= E268), G255 (= G270), C287 (= C303), Q334 (≠ H350), K337 (= K353), E384 (= E398), F386 (= F400)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 14:495/496 of 4fr8C
- active site: N165 (= N169), K188 (= K192), Q264 (≠ E268), C298 (= C303), E395 (= E398), E472 (≠ D476)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V165), I162 (≠ L166), W164 (= W168), K188 (= K192), G221 (= G225), G225 (= G229), A226 (≠ E230), F239 (= F243), G241 (= G245), S242 (= S246), I245 (≠ T249), Q345 (≠ H350), E395 (= E398), F397 (= F400)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 11:492/493 of 4fr8A
- active site: N162 (= N169), K185 (= K192), Q261 (≠ E268), C295 (= C303), E392 (= E398), E469 (≠ D476)
- binding nicotinamide-adenine-dinucleotide: I158 (≠ V165), I159 (≠ L166), W161 (= W168), K185 (= K192), G218 (= G225), G222 (= G229), A223 (≠ E230), F236 (= F243), G238 (= G245), S239 (= S246), I242 (≠ T249), Q342 (≠ H350), K345 (= K353), E392 (= E398), F394 (= F400)
- binding propane-1,2,3-triyl trinitrate: F163 (= F170), L166 (= L173), W170 (= W177), F289 (≠ W297), S294 (≠ N302), C295 (= C303), D450 (≠ G456), F452 (≠ G458)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 5l13A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F170), M168 (= M174), W171 (= W177), F290 (≠ W297), C295 (≠ N302), C296 (= C303), C297 (≠ S304), D451 (≠ G456), F453 (≠ G458)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 4kwgA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F170), M168 (= M174), C295 (≠ N302), C296 (= C303), C297 (≠ S304), D451 (≠ G456), F453 (≠ G458)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 4kwfA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F170), M168 (= M174), W171 (= W177), E262 (= E268), C295 (≠ N302), C296 (= C303), C297 (≠ S304), D451 (≠ G456), F453 (≠ G458), F459 (= F464)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 3sz9A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F170), C295 (≠ N302), C296 (= C303), D451 (≠ G456), F453 (≠ G458), F459 (= F464)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 3injA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ D124), F164 (= F170), L167 (= L173), F286 (≠ N293), F290 (≠ W297), D451 (≠ G456), F453 (≠ G458)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 2vleA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding daidzin: M118 (≠ D124), F164 (= F170), M168 (= M174), W171 (= W177), F286 (≠ N293), F290 (≠ W297), C295 (≠ N302), C296 (= C303), D451 (≠ G456), V452 (≠ E457), F453 (≠ G458)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 1o01B
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding (2e)-but-2-enal: C296 (= C303), C297 (≠ S304), F453 (≠ G458)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V165), I160 (≠ L166), P161 (= P167), W162 (= W168), K186 (= K192), E189 (= E195), G219 (= G225), G223 (= G229), A224 (≠ E230), F237 (= F243), G239 (= G245), S240 (= S246), I243 (≠ T249), L263 (≠ C269), G264 (= G270), C296 (= C303), Q343 (≠ H350), E393 (= E398), F395 (= F400)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
43% identity, 95% coverage: 19:499/505 of query aligns to 12:493/494 of 1cw3A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E398), E470 (≠ D476)
- binding magnesium ion: V34 (= V41), D103 (= D109), Q190 (= Q196)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V165), I160 (≠ L166), P161 (= P167), W162 (= W168), K186 (= K192), G219 (= G225), G223 (= G229), A224 (≠ E230), F237 (= F243), G239 (= G245), S240 (= S246), I243 (≠ T249), L263 (≠ C269), G264 (= G270), C296 (= C303), Q343 (≠ H350), K346 (= K353), E393 (= E398), F395 (= F400)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 93% coverage: 24:495/505 of query aligns to 20:490/491 of 5gtlA
- active site: N165 (= N169), K188 (= K192), E263 (= E268), C297 (= C303), E394 (= E398), E471 (≠ D476)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ V165), P163 (= P167), K188 (= K192), A190 (= A194), E191 (= E195), Q192 (= Q196), G221 (= G225), G225 (= G229), G241 (= G245), S242 (= S246), T245 (= T249), L264 (≠ C269), C297 (= C303), E394 (= E398), F396 (= F400)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 93% coverage: 24:495/505 of query aligns to 20:490/491 of 5gtkA
- active site: N165 (= N169), K188 (= K192), E263 (= E268), C297 (= C303), E394 (= E398), E471 (≠ D476)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V165), I162 (≠ L166), P163 (= P167), W164 (= W168), K188 (= K192), E191 (= E195), G221 (= G225), G225 (= G229), A226 (≠ E230), F239 (= F243), G241 (= G245), S242 (= S246), T245 (= T249), Y248 (≠ R252), L264 (≠ C269), C297 (= C303), Q344 (≠ H350), R347 (≠ K353), E394 (= E398), F396 (= F400)
5teiA Structure of human aldh1a1 with inhibitor cm039
42% identity, 94% coverage: 24:499/505 of query aligns to 16:492/493 of 5teiA
- active site: N162 (= N169), K185 (= K192), E261 (= E268), C295 (= C303), E392 (= E398), E469 (≠ D476)
- binding 6-{[(3-fluorophenyl)methyl]sulfanyl}-5-(2-methylphenyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: S113 (≠ V120), F163 (= F170), H285 (≠ N293), G286 (= G294), Y289 (≠ W297), C295 (= C303), G450 (= G456), V452 (≠ G458), F458 (= F464)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (≠ V165), I159 (≠ L166), P160 (= P167), W161 (= W168), N162 (= N169), K185 (= K192), E188 (= E195), G218 (= G225), G222 (= G229), A223 (≠ E230), F236 (= F243), T237 (= T244), G238 (= G245), S239 (= S246), V242 (≠ T249), C295 (= C303), Q342 (≠ H350), K345 (= K353), E392 (= E398), F394 (= F400)
Query Sequence
>AO356_09270 AO356_09270 aldehyde dehydrogenase
MRDLLTAAEYAAIAKSMSFPNTAFINGAFKPAISGNTFATVNPATGELLTEVSACAAEDV
DYAVSKAREAFEDGRWRLLPPGERKAVLLKFAKLLEKNRHELAVLESLDSGKPVRECQLV
DVPDTIHTLRWHAEVIDKLYDHTAPVGNDALTMVVREPIGVVGCVLPWNFPLLMLAWKIG
PALAAGCSVIVKPAEQTTLTTLRVAELAFDAGVPAGVLNIVTGTGKDVGEPLGLHKDVDM
VSFTGSTATGRRFLHYAADSNLKRVVLECGGKNPAVVMDDAEDLDLVAEQVVNGAFWNMG
ENCSATSRLLVHASVKDELLKRMGAYIREWKMGDPLDPQNRVGALVSSDHFEKVKSYLDY
ASASNLEAVYGGDTHDGAFIQPTVIDGVDRDSRLFQEEIFGPVLSVTTFNSICEAIALAN
DTHYGLAASVYTGNLRRAIKLAREIRAGIVTVNCFGEGDASTPFGGYKESGFGGRDKSVF
AHDQYTEIKTIWIDVSDRSVDETVK
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory