SitesBLAST – Find functional sites

 

SitesBLAST

Comparing AO356_09710 AO356_09710 chorismate mutase to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 5 hits to proteins with known functional sites (download)

Q7CHH5 Secreted chorismate mutase; CM; *YpCM; EC 5.4.99.5 from Yersinia pestis (see paper)
32% identity, 74% coverage: 5:143/187 of query aligns to 22:143/186 of Q7CHH5

query
sites
Q7CHH5
F
 
F
K
 
F
L
 
L
C
 
S
L
 
L
A
 
A
L
 
V
S
 
Q
A
 
A
A
 
Q
L
 
Q
L
x
C
A
 
G
S
 
Q
T
 
T
A
 
A
A
 
-
A
 
-
A
 
-
S
 
-
T
 
-
P
 
-
A
 
-
P
 
-
E
 
-
A
 
-
L
 
-
T
 
-
P
 
P
L
 
L
L
 
I
N
 
N
A
 
-
I
 
-
G
 
-
E
 
E
R
 
R
L
 
L
A
 
S
I
 
Y
A
 
M
D
 
K
Q
 
D
V
 
V
A
 
A
L
 
G
S
 
Y
K
 
K
W
 
A
D
 
E
S
 
N
G
 
H
K
 
L
P
 
P
V
 
I
E
 
E
D
 
D
R
 
R
Q
 
I
R
 
Q
E
 
E
R
 
E
E
 
K
V
 
V
I
 
I
A
 
N
A
 
S
A
 
A
V
 
M
A
 
A
Q
 
Q
A
 
A
P
 
E
A
 
S
Y
 
L
K
 
G
L
 
L
S
 
N
N
 
G
E
 
E
T
 
S
V
 
I
E
 
K
A
 
P
F
 
L
F
 
M
A
 
V
A
 
A
Q
 
Q
I
 
I
E
 
N
A
 
A
N
 
A
K
 
K
M
 
A
V
 
I
Q
 
Q
Y
 
Y
I
 
R
N
 
Y
L
 
R
S
 
A
D
 
D
W
 
W
A
 
L
L
 
S
D
 
Q
G
 
P
K
 
E
A
 
P
P
 
G
D
 
W
L
 
Q
P
 
P
R
 
K
P
 
P
D
 
-
L
 
-
V
 
L
G
 
D
Q
 
D
I
 
V
R
 
R
P
 
A
Q
 
N
L
 
I
D
 
G
R
 
E
L
 
L
Q
 
S
K
 
T
R
 
K
L
 
I
L
 
L
Q
 
E
Q
 
Q
L
 
I
A
 
A
D
 
E

Sites not aligning to the query:

P9WIB9 Secreted chorismate mutase; CM; *MtCM; EC 5.4.99.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
31% identity, 94% coverage: 7:182/187 of query aligns to 10:193/199 of P9WIB9

query
sites
P9WIB9
L
|
L
C
x
A
L
x
T
A
|
A
L
x
V
S
|
S
A
x
I
A
x
G
L
x
I
L
|
L
A
x
L
S
|
S
T
x
L
A
x
I
A
|
A
A
x
P
A
x
L
S
x
G
T
x
P
P
|
P
A
x
L
P
x
A
E
x
R
A
|
A
-
 
D
-
 
G
-
 
T
-
 
S
-
 
Q
L
 
L
T
 
A
P
 
E
L
 
L
L
 
V
N
 
D
A
 
A
I
 
A
G
 
A
E
 
E
R
|
R
L
 
L
A
 
E
I
 
V
A
 
A
D
 
D
Q
 
P
V
 
V
A
 
A
L
 
A
S
 
F
K
|
K
W
 
W
D
 
R
S
 
A
G
 
Q
K
 
L
P
 
P
V
 
I
E
 
E
D
|
D
R
 
S
Q
 
G
R
|
R
E
 
V
R
 
E
E
 
Q
V
 
Q
I
 
L
A
 
A
A
 
K
A
 
L
V
 
G
A
 
E
Q
 
D
A
 
A
P
 
R
A
 
S
Y
 
Q
K
 
H
L
 
I
S
 
D
N
 
P
E
 
D
T
 
Y
V
 
V
E
 
T
A
 
R
F
 
V
F
 
F
A
 
D
A
 
D
Q
 
Q
I
 
I
E
 
R
A
 
A
N
x
T
K
 
E
M
 
A
V
 
I
Q
x
E
Y
 
Y
I
 
S
N
 
R
L
 
F
S
 
S
D
 
D
W
 
W
A
 
K
L
 
L
D
 
N
-
 
P
G
 
A
K
 
S
A
 
A
P
 
P
D
 
P
L
 
E
P
 
P
R
 
-
P
 
P
D
 
D
L
 
L
V
 
S
G
 
A
Q
 
S
I
 
-
R
|
R
P
 
S
Q
 
A
L
 
I
D
 
D
R
 
S
L
 
L
Q
 
N
K
 
N
R
 
R
L
 
M
L
 
L
Q
 
S
Q
 
Q
L
 
I
A
 
W
D
 
S
F
 
H
A
 
W
P
 
S
Y
 
L
R
 
L
T
 
S
D
 
A
P
 
P
Q
 
S
C
|
C
P
 
A
Q
 
A
W
 
Q
L
 
L
A
 
D
H
 
R
A
 
A
T
 
K
-
 
R
-
 
D
-
 
I
-
 
V
-
 
R
-
 
S
-
 
R
H
 
H
H
 
L
D
 
D
K
 
S
Q
 
-
H
 
-
P
 
-
V
 
L
H
 
Y
R
 
Q
L
 
R
A
 
A
L
 
L
I
 
T
R
 
T
A
 
A
T
 
T
A
 
Q
E
 
S
L
 
Y
C
|
C

Sites not aligning to the query:

2ao2B The 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactions (see paper)
32% identity, 81% coverage: 31:182/187 of query aligns to 5:159/165 of 2ao2B

query
sites
2ao2B
L
 
L
T
 
A
P
 
E
L
 
L
L
 
V
N
 
D
A
 
A
I
 
A
G
 
A
E
 
E
R
|
R
L
 
L
A
 
E
I
 
V
A
 
A
D
 
D
Q
 
P
V
 
V
A
 
A
L
 
A
S
 
F
K
|
K
W
 
W
D
 
R
S
 
A
G
 
Q
K
x
L
P
|
P
V
x
I
E
|
E
D
|
D
R
 
S
Q
 
G
R
|
R
E
 
V
R
 
E
E
 
Q
V
x
Q
I
 
L
A
 
A
A
 
K
A
 
L
V
 
G
A
 
E
Q
 
D
A
 
A
P
 
R
A
 
S
Y
 
Q
K
 
H
L
 
I
S
 
D
N
 
P
E
 
D
T
 
Y
V
 
V
E
 
T
A
 
R
F
 
V
F
 
F
A
 
D
A
 
D
Q
 
Q
I
 
I
E
 
R
A
 
A
N
x
T
K
x
E
M
 
A
V
 
I
Q
x
E
Y
 
Y
I
 
S
N
 
R
L
 
F
S
 
S
D
 
D
W
 
W
A
 
K
L
 
L
D
 
N
-
 
P
G
 
A
K
 
S
A
 
A
P
 
P
D
 
P
L
 
E
P
 
P
R
 
-
P
 
P
D
 
D
L
 
L
V
 
S
G
 
A
Q
 
S
I
 
-
R
|
R
P
 
S
Q
 
A
L
 
I
D
 
D
R
 
S
L
 
L
Q
 
N
K
 
N
R
 
R
L
 
M
L
 
L
Q
 
S
Q
 
Q
L
 
I
A
 
W
D
 
S
F
 
H
A
 
W
P
 
S
Y
 
L
R
 
L
T
 
S
D
 
A
P
 
P
Q
 
S
C
 
C
P
 
A
Q
 
A
W
 
Q
L
 
L
A
 
D
H
 
R
A
 
A
T
 
K
-
 
R
-
 
D
-
 
I
-
 
V
-
 
R
-
 
S
-
 
R
H
 
H
H
 
L
D
 
D
K
 
S
Q
 
-
H
 
-
P
 
-
V
 
L
H
 
Y
R
 
Q
L
 
R
A
 
A
L
 
L
I
 
T
R
 
T
A
 
A
T
 
T
A
 
Q
E
 
S
L
 
Y
C
 
C

2ao2A The 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactions (see paper)
32% identity, 81% coverage: 31:182/187 of query aligns to 5:159/165 of 2ao2A

query
sites
2ao2A
L
 
L
T
 
A
P
 
E
L
 
L
L
 
V
N
 
D
A
 
A
I
 
A
G
 
A
E
 
E
R
|
R
L
 
L
A
 
E
I
 
V
A
 
A
D
 
D
Q
 
P
V
 
V
A
 
A
L
 
A
S
 
F
K
|
K
W
 
W
D
 
R
S
 
A
G
 
Q
K
 
L
P
 
P
V
 
I
E
 
E
D
|
D
R
 
S
Q
 
G
R
|
R
E
 
V
R
 
E
E
 
Q
V
 
Q
I
 
L
A
 
A
A
 
K
A
 
L
V
 
G
A
 
E
Q
 
D
A
 
A
P
 
R
A
 
S
Y
 
Q
K
 
H
L
 
I
S
 
D
N
 
P
E
 
D
T
 
Y
V
 
V
E
 
T
A
 
R
F
 
V
F
 
F
A
 
D
A
 
D
Q
 
Q
I
 
I
E
 
R
A
 
A
N
x
T
K
x
E
M
 
A
V
 
I
Q
x
E
Y
 
Y
I
 
S
N
 
R
L
 
F
S
 
S
D
 
D
W
 
W
A
 
K
L
 
L
D
 
N
-
 
P
G
 
A
K
 
S
A
 
A
P
 
P
D
 
P
L
 
E
P
 
P
R
 
-
P
 
P
D
 
D
L
 
L
V
 
S
G
 
A
Q
 
S
I
 
-
R
|
R
P
 
S
Q
 
A
L
 
I
D
 
D
R
 
S
L
 
L
Q
 
N
K
 
N
R
 
R
L
 
M
L
 
L
Q
 
S
Q
 
Q
L
 
I
A
 
W
D
 
S
F
 
H
A
 
W
P
 
S
Y
 
L
R
 
L
T
 
S
D
 
A
P
 
P
Q
 
S
C
 
C
P
 
A
Q
 
A
W
 
Q
L
 
L
A
 
D
H
 
R
A
 
A
T
 
K
-
 
R
-
 
D
-
 
I
-
 
V
-
 
R
-
 
S
-
 
R
H
 
H
H
 
L
D
 
D
K
 
S
Q
 
-
H
 
-
P
 
-
V
 
L
H
 
Y
R
 
Q
L
 
R
A
 
A
L
 
L
I
 
T
R
 
T
A
 
A
T
 
T
A
 
Q
E
 
S
L
 
Y
C
 
C

2fp2B Secreted chorismate mutase from mycobacterium tuberculosis (see paper)
32% identity, 81% coverage: 31:182/187 of query aligns to 3:157/163 of 2fp2B

query
sites
2fp2B
L
 
L
T
 
A
P
 
E
L
 
L
L
 
V
N
 
D
A
 
A
I
 
A
G
 
A
E
 
E
R
|
R
L
 
L
A
 
E
I
 
V
A
 
A
D
 
D
Q
 
P
V
 
V
A
 
A
L
 
A
S
 
F
K
|
K
W
 
W
D
 
R
S
 
A
G
 
Q
K
 
L
P
 
P
V
x
I
E
|
E
D
|
D
R
 
S
Q
 
G
R
|
R
E
 
V
R
 
E
E
 
Q
V
x
Q
I
 
L
A
 
A
A
 
K
A
 
L
V
 
G
A
 
E
Q
 
D
A
 
A
P
 
R
A
 
S
Y
 
Q
K
 
H
L
 
I
S
 
D
N
 
P
E
 
D
T
 
Y
V
 
V
E
 
T
A
 
R
F
 
V
F
 
F
A
 
D
A
 
D
Q
 
Q
I
|
I
E
 
R
A
 
A
N
x
T
K
x
E
M
 
A
V
 
I
Q
x
E
Y
 
Y
I
 
S
N
 
R
L
 
F
S
 
S
D
 
D
W
 
W
A
 
K
L
 
L
D
 
N
-
 
P
G
 
A
K
 
S
A
 
A
P
 
P
D
 
P
L
 
E
P
 
P
R
 
-
P
 
P
D
 
D
L
 
L
V
 
S
G
 
A
Q
 
S
I
 
-
R
|
R
P
 
S
Q
 
A
L
 
I
D
 
D
R
 
S
L
 
L
Q
 
N
K
 
N
R
 
R
L
 
M
L
 
L
Q
 
S
Q
 
Q
L
 
I
A
 
W
D
 
S
F
 
H
A
 
W
P
 
S
Y
 
L
R
 
L
T
 
S
D
 
A
P
 
P
Q
 
S
C
 
C
P
 
A
Q
 
A
W
 
Q
L
 
L
A
 
D
H
 
R
A
 
A
T
 
K
-
 
R
-
 
D
-
 
I
-
 
V
-
 
R
-
 
S
-
 
R
H
 
H
H
 
L
D
 
D
K
 
S
Q
 
-
H
 
-
P
 
-
V
 
L
H
 
Y
R
 
Q
L
 
R
A
 
A
L
 
L
I
 
T
R
 
T
A
 
A
T
 
T
A
 
Q
E
 
S
L
 
Y
C
 
C

Query Sequence

>AO356_09710 AO356_09710 chorismate mutase
MTLRFKLCLALSAALLASTAAAASTPAPEALTPLLNAIGERLAIADQVALSKWDSGKPVE
DRQREREVIAAAVAQAPAYKLSNETVEAFFAAQIEANKMVQYINLSDWALDGKAPDLPRP
DLVGQIRPQLDRLQKRLLQQLADFAPYRTDPQCPQWLAHATHHDKQHPVHRLALIRATAE
LCISTKA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory