SitesBLAST – Find functional sites

 

SitesBLAST

Comparing AO356_18175 FitnessBrowser__pseudo5_N2C3_1:AO356_18175 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 11 hits to proteins with known functional sites (download)

3ab9A Crystal structure of lipoylated e. Coli h-protein (reduced form) (see paper)
51% identity, 95% coverage: 2:122/127 of query aligns to 4:125/127 of 3ab9A

query
sites
3ab9A
S
 
A
E
 
E
L
 
L
R
 
K
F
 
Y
T
 
S
E
 
K
D
 
E
H
 
H
E
 
E
W
 
W
L
 
L
R
 
R
T
 
K
E
 
E
A
 
A
D
 
D
G
 
G
S
 
T
V
 
Y
T
 
T
V
 
V
G
 
G
I
 
I
T
 
T
A
 
E
F
 
H
A
 
A
Q
 
Q
N
 
E
A
 
L
L
 
L
G
 
G
D
 
D
V
 
M
V
 
V
F
 
F
V
 
V
Q
x
D
L
|
L
P
 
P
E
 
E
L
 
V
Q
 
G
A
 
A
-
 
T
Y
 
V
D
 
S
K
 
A
G
 
G
A
 
D
E
 
D
A
 
C
S
 
A
T
 
V
V
 
A
E
 
E
S
 
S
V
 
V
K
 
K
A
 
A
A
 
A
S
 
S
G
 
D
V
 
I
Y
 
Y
M
 
A
P
 
P
L
 
V
D
 
S
G
 
G
E
 
E
V
 
I
L
 
V
E
 
A
V
 
V
N
 
N
D
 
D
K
 
A
L
 
L
D
 
S
A
 
D
S
 
S
P
 
P
E
 
E
L
 
L
V
 
V
N
 
N
E
 
S
D
 
E
P
 
P
L
 
Y
G
 
A
E
 
G
G
 
G
W
 
W
F
 
I
F
 
F
R
 
K
F
 
I
K
 
K
P
 
A
T
 
S
D
 
D
A
 
E
D
 
S
A
 
E
V
 
L
A
 
E
K
 
S
L
 
L
L
 
L
D
 
D
Q
 
A
D
 
T
A
 
A
Y
 
Y
D
 
E
R
 
A
L
 
L
I
 
L
K
 
E

Q5SKW9 Glycine cleavage system H protein from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
50% identity, 94% coverage: 6:125/127 of query aligns to 9:128/128 of Q5SKW9

query
sites
Q5SKW9
F
 
Y
T
 
T
E
 
K
D
 
T
H
 
H
E
 
E
W
 
W
L
 
A
R
 
L
T
 
P
E
 
E
A
 
G
D
 
D
G
 
-
S
 
T
V
 
V
T
 
L
V
 
V
G
 
G
I
 
I
T
 
T
A
 
D
F
 
Y
A
 
A
Q
 
Q
N
 
D
A
 
A
L
 
L
G
 
G
D
 
D
V
 
V
V
 
V
F
 
Y
V
 
V
Q
 
E
L
 
L
P
 
P
E
 
E
L
 
V
-
 
G
Q
 
R
A
 
V
Y
 
V
D
 
E
K
 
K
G
 
G
A
 
E
E
 
A
A
 
V
S
 
A
T
 
V
V
 
V
E
 
E
S
 
S
V
 
V
K
|
K
A
 
T
A
 
A
S
 
S
G
 
D
V
 
I
Y
 
Y
M
 
A
P
 
P
L
 
V
D
 
A
G
 
G
E
 
E
V
 
I
L
 
V
E
 
E
V
 
V
N
 
N
D
 
L
K
 
A
L
 
L
D
 
E
A
 
K
S
 
T
P
 
P
E
 
E
L
 
L
V
 
V
N
 
N
E
 
Q
D
 
D
P
 
P
L
 
Y
G
 
G
E
 
E
G
 
G
W
 
W
F
 
I
F
 
F
R
 
R
F
 
L
K
 
K
P
 
P
T
 
R
D
 
D
A
 
M
D
 
G
A
 
D
V
 
L
A
 
D
K
 
E
L
 
L
L
 
L
D
 
D
Q
 
A
D
 
G
A
 
G
Y
 
Y
D
 
Q
R
 
E
L
 
V
I
 
L
K
 
E
A
 
S
N
 
E
A
 
A

P23434 Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein from Homo sapiens (Human) (see 4 papers)
44% identity, 97% coverage: 1:123/127 of query aligns to 48:170/173 of P23434

query
sites
P23434
M
 
L
S
 
S
E
 
V
L
 
R
R
 
K
F
 
F
T
 
T
E
 
E
D
 
K
H
|
H
E
 
E
W
 
W
L
 
V
R
 
T
T
 
T
E
 
E
A
 
-
D
 
N
G
 
G
S
 
I
V
 
G
T
 
T
V
 
V
G
 
G
I
 
I
T
 
S
A
x
N
F
 
F
A
 
A
Q
|
Q
N
x
E
A
|
A
L
|
L
G
|
G
D
|
D
V
|
V
V
|
V
F
x
Y
V
x
C
Q
x
S
L
|
L
P
|
P
E
|
E
L
x
V
-
x
G
Q
x
T
A
x
K
Y
x
L
D
x
N
K
|
K
G
x
Q
A
x
D
E
|
E
A
x
F
S
x
G
T
x
A
V
x
L
E
|
E
S
|
S
V
|
V
K
|
K
A
|
A
A
|
A
S
|
S
G
x
E
V
x
L
Y
|
Y
M
x
S
P
|
P
L
|
L
D
x
S
G
|
G
E
|
E
V
|
V
L
x
T
E
|
E
V
x
I
N
|
N
D
x
E
K
x
A
L
|
L
D
x
A
A
x
E
S
x
N
P
|
P
E
x
G
L
|
L
V
|
V
N
|
N
E
x
K
D
x
S
P
x
C
L
x
Y
G
x
E
E
x
D
G
|
G
W
|
W
F
x
L
F
x
I
R
x
K
F
x
M
K
x
T
P
x
L
T
x
S
D
x
N
A
x
P
D
x
S
A
x
E
V
x
L
A
x
D
K
x
E
L
|
L
L
x
M
D
x
S
Q
x
E
D
x
E
A
|
A
Y
|
Y
D
x
E
R
x
K
L
x
Y
I
|
I
K
|
K
A
x
S

Sites not aligning to the query:

P20821 Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein from Bos taurus (Bovine) (see 3 papers)
44% identity, 97% coverage: 1:123/127 of query aligns to 48:170/173 of P20821

query
sites
P20821
M
x
L
S
 
S
E
 
V
L
 
R
R
 
K
F
 
F
T
 
T
E
 
E
D
 
K
H
 
H
E
 
E
W
 
W
L
 
V
R
 
T
T
 
T
E
 
E
A
 
-
D
 
N
G
 
G
S
 
V
V
 
G
T
 
T
V
 
V
G
 
G
I
 
I
T
 
S
A
 
N
F
 
F
A
 
A
Q
 
Q
N
 
E
A
 
A
L
 
L
G
 
G
D
 
D
V
 
V
V
 
V
F
 
Y
V
 
C
Q
 
S
L
 
L
P
 
P
E
 
E
L
 
V
-
 
G
Q
 
T
A
 
K
Y
 
L
D
 
N
K
 
K
G
 
Q
A
 
E
E
 
E
A
 
F
S
 
G
T
 
A
V
 
L
E
 
E
S
 
S
V
 
V
K
|
K
A
 
A
A
 
A
S
 
S
G
 
E
V
 
L
Y
 
Y
M
 
S
P
 
P
L
 
L
D
 
S
G
 
G
E
 
E
V
 
V
L
 
T
E
 
E
V
 
I
N
 
N
D
 
K
K
 
A
L
 
L
D
 
A
A
 
E
S
 
N
P
 
P
E
 
G
L
 
L
V
 
V
N
 
N
E
 
K
D
 
S
P
 
C
L
 
Y
G
 
E
E
 
D
G
 
G
W
 
W
F
 
L
F
 
I
R
 
K
F
 
M
K
 
T
P
 
F
T
 
S
D
 
N
A
 
P
D
 
S
A
 
E
V
 
L
A
 
D
K
 
E
L
 
L
L
 
M
D
 
S
Q
 
E
D
 
E
A
 
A
Y
 
Y
D
 
E
R
 
K
L
 
Y
I
 
I
K
 
K
A
 
S

Sites not aligning to the query:

P16048 Glycine cleavage system H protein, mitochondrial from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
45% identity, 94% coverage: 4:122/127 of query aligns to 41:159/165 of P16048

query
sites
P16048
L
 
L
R
 
K
F
 
Y
T
 
A
E
 
P
D
 
S
H
 
H
E
 
E
W
 
W
L
 
V
R
 
K
T
 
H
E
 
E
A
 
-
D
 
-
G
 
G
S
 
S
V
 
V
-
 
A
T
 
T
V
 
I
G
 
G
I
 
I
T
 
T
A
 
D
F
 
H
A
 
A
Q
 
Q
N
 
D
A
 
H
L
 
L
G
 
G
D
 
E
V
 
V
V
 
V
F
 
F
V
 
V
Q
 
E
L
 
L
P
 
P
E
 
E
L
 
P
Q
 
G
-
 
V
A
 
S
Y
 
V
D
 
T
K
 
K
G
 
G
A
 
K
E
 
G
A
 
F
S
 
G
T
 
A
V
 
V
E
 
E
S
 
S
V
 
V
K
|
K
A
 
A
A
 
T
S
 
S
G
 
D
V
 
V
Y
 
N
M
 
S
P
 
P
L
 
I
D
 
S
G
 
G
E
 
E
V
 
V
L
 
I
E
 
E
V
 
V
N
 
N
D
 
T
K
 
G
L
 
L
D
 
T
A
 
G
S
 
K
P
 
P
E
 
G
L
 
L
V
 
I
N
 
N
E
 
S
D
 
S
P
 
P
L
 
Y
G
 
E
E
 
D
G
 
G
W
 
W
F
 
M
F
 
I
R
 
K
F
 
I
K
 
K
P
 
P
T
 
T
D
 
S
A
 
P
D
 
D
A
 
E
V
 
L
A
 
E
K
 
S
L
 
L
L
 
L
D
 
G
Q
 
A
D
 
K
A
 
E
Y
 
Y
D
 
T
R
 
K
L
 
F
I
 
C
K
 
E

1htpA Refined structures at 2 angstroms and 2.2 angstroms of the two forms of the h-protein, a lipoamide-containing protein of the glycine decarboxylase complex (see paper)
45% identity, 94% coverage: 4:122/127 of query aligns to 7:125/131 of 1htpA

query
sites
1htpA
L
 
L
R
 
K
F
 
Y
T
 
A
E
 
P
D
x
S
H
|
H
E
|
E
W
 
W
L
 
V
R
 
K
T
 
H
E
 
E
A
 
-
D
 
-
G
 
G
S
 
S
V
 
V
-
 
A
T
 
T
V
 
I
G
 
G
I
 
I
T
 
T
A
 
D
F
 
H
A
 
A
Q
 
Q
N
 
D
A
x
H
L
 
L
G
 
G
D
 
E
V
 
V
V
 
V
F
 
F
V
 
V
Q
 
E
L
 
L
P
 
P
E
 
E
L
 
P
Q
 
G
-
 
V
A
 
S
Y
 
V
D
 
T
K
 
K
G
 
G
A
 
K
E
 
G
A
 
F
S
 
G
T
 
A
V
 
V
E
 
E
S
 
S
V
 
V
K
|
K
A
 
A
A
 
T
S
 
S
G
 
D
V
 
V
Y
 
N
M
 
S
P
 
P
L
 
I
D
 
S
G
 
G
E
 
E
V
 
V
L
 
I
E
 
E
V
 
V
N
 
N
D
 
T
K
 
G
L
 
L
D
 
T
A
 
G
S
 
K
P
 
P
E
 
G
L
 
L
V
 
I
N
 
N
E
 
S
D
 
S
P
 
P
L
 
Y
G
 
E
E
 
D
G
 
G
W
 
W
F
 
M
F
 
I
R
 
K
F
 
I
K
 
K
P
 
P
T
 
T
D
 
S
A
 
P
D
 
D
A
 
E
V
 
L
A
 
E
K
 
S
L
 
L
L
 
L
D
 
G
Q
 
A
D
 
K
A
 
E
Y
 
Y
D
 
T
R
 
K
L
 
F
I
 
C
K
 
E

Sites not aligning to the query:

1hpcB Refined structures at 2 angstroms and 2.2 angstroms of the two forms of the h-protein, a lipoamide-containing protein of the glycine decarboxylase (see paper)
45% identity, 94% coverage: 4:122/127 of query aligns to 7:125/131 of 1hpcB

query
sites
1hpcB
L
 
L
R
 
K
F
 
Y
T
 
A
E
 
P
D
 
S
H
 
H
E
 
E
W
 
W
L
 
V
R
 
K
T
 
H
E
 
E
A
 
-
D
 
-
G
 
G
S
 
S
V
 
V
-
 
A
T
 
T
V
 
I
G
 
G
I
 
I
T
 
T
A
 
D
F
 
H
A
 
A
Q
 
Q
N
 
D
A
x
H
L
 
L
G
 
G
D
 
E
V
 
V
V
 
V
F
 
F
V
 
V
Q
 
E
L
 
L
P
 
P
E
 
E
L
 
P
Q
 
G
-
 
V
A
 
S
Y
 
V
D
 
T
K
 
K
G
 
G
A
 
K
E
 
G
A
 
F
S
 
G
T
 
A
V
 
V
E
 
E
S
 
S
V
 
V
K
|
K
A
 
A
A
 
T
S
 
S
G
 
D
V
 
V
Y
 
N
M
 
S
P
 
P
L
 
I
D
 
S
G
 
G
E
 
E
V
 
V
L
 
I
E
 
E
V
 
V
N
 
N
D
 
T
K
 
G
L
 
L
D
 
T
A
 
G
S
 
K
P
 
P
E
 
G
L
 
L
V
 
I
N
 
N
E
 
S
D
 
S
P
 
P
L
 
Y
G
 
E
E
 
D
G
 
G
W
 
W
F
 
M
F
 
I
R
 
K
F
 
I
K
 
K
P
 
P
T
 
T
D
 
S
A
 
P
D
 
D
A
 
E
V
 
L
A
 
E
K
 
S
L
 
L
L
 
L
D
 
G
Q
 
A
D
 
K
A
 
E
Y
 
Y
D
 
T
R
 
K
L
 
F
I
 
C
K
 
E

1hpcA Refined structures at 2 angstroms and 2.2 angstroms of the two forms of the h-protein, a lipoamide-containing protein of the glycine decarboxylase (see paper)
45% identity, 94% coverage: 4:122/127 of query aligns to 7:125/131 of 1hpcA

query
sites
1hpcA
L
 
L
R
 
K
F
 
Y
T
 
A
E
 
P
D
 
S
H
 
H
E
 
E
W
 
W
L
 
V
R
 
K
T
 
H
E
 
E
A
 
-
D
 
-
G
 
G
S
 
S
V
 
V
-
 
A
T
 
T
V
 
I
G
 
G
I
 
I
T
 
T
A
 
D
F
 
H
A
 
A
Q
 
Q
N
 
D
A
x
H
L
 
L
G
 
G
D
 
E
V
 
V
V
 
V
F
 
F
V
 
V
Q
 
E
L
 
L
P
 
P
E
 
E
L
 
P
Q
 
G
-
 
V
A
 
S
Y
 
V
D
 
T
K
 
K
G
 
G
A
 
K
E
 
G
A
 
F
S
 
G
T
 
A
V
 
V
E
 
E
S
 
S
V
 
V
K
|
K
A
 
A
A
 
T
S
 
S
G
 
D
V
 
V
Y
 
N
M
 
S
P
 
P
L
 
I
D
 
S
G
 
G
E
 
E
V
 
V
L
 
I
E
 
E
V
 
V
N
 
N
D
 
T
K
 
G
L
 
L
D
 
T
A
 
G
S
 
K
P
 
P
E
 
G
L
 
L
V
 
I
N
 
N
E
 
S
D
 
S
P
 
P
L
 
Y
G
 
E
E
 
D
G
 
G
W
 
W
F
 
M
F
 
I
R
 
K
F
 
I
K
 
K
P
 
P
T
 
T
D
 
S
A
 
P
D
 
D
A
 
E
V
 
L
A
 
E
K
 
S
L
 
L
L
 
L
D
 
G
Q
 
A
D
 
K
A
 
E
Y
 
Y
D
 
T
R
 
K
L
 
F
I
 
C
K
 
E

1dxmA Reduced form of the h protein from glycine decarboxylase complex (see paper)
45% identity, 94% coverage: 4:122/127 of query aligns to 7:125/131 of 1dxmA

query
sites
1dxmA
L
 
L
R
 
K
F
 
Y
T
 
A
E
 
P
D
 
S
H
 
H
E
 
E
W
 
W
L
 
V
R
 
K
T
 
H
E
 
E
A
 
-
D
 
-
G
 
G
S
 
S
V
 
V
-
 
A
T
 
T
V
 
I
G
 
G
I
 
I
T
 
T
A
 
D
F
 
H
A
 
A
Q
 
Q
N
 
D
A
x
H
L
|
L
G
 
G
D
 
E
V
 
V
V
 
V
F
 
F
V
 
V
Q
 
E
L
 
L
P
 
P
E
 
E
L
 
P
Q
 
G
-
 
V
A
 
S
Y
 
V
D
 
T
K
 
K
G
 
G
A
 
K
E
 
G
A
 
F
S
 
G
T
 
A
V
 
V
E
 
E
S
 
S
V
 
V
K
|
K
A
 
A
A
 
T
S
 
S
G
 
D
V
 
V
Y
 
N
M
 
S
P
 
P
L
 
I
D
 
S
G
 
G
E
 
E
V
 
V
L
 
I
E
 
E
V
 
V
N
 
N
D
 
T
K
 
G
L
 
L
D
 
T
A
 
G
S
 
K
P
 
P
E
 
G
L
 
L
V
 
I
N
 
N
E
 
S
D
 
S
P
 
P
L
 
Y
G
 
E
E
 
D
G
 
G
W
 
W
F
 
M
F
 
I
R
 
K
F
 
I
K
 
K
P
 
P
T
 
T
D
 
S
A
 
P
D
 
D
A
 
E
V
 
L
A
 
E
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S
L
 
L
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A
D
 
K
A
 
E
Y
 
Y
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T
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K
L
 
F
I
 
C
K
 
E

Sites not aligning to the query:

Q9HDV9 Putative glycine cleavage system H protein, mitochondrial; Glycine decarboxylase complex subunit H from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
43% identity, 95% coverage: 2:122/127 of query aligns to 43:163/169 of Q9HDV9

query
sites
Q9HDV9
S
 
S
E
 
T
L
 
K
R
 
H
F
 
F
T
 
T
E
 
K
D
 
E
H
 
H
E
 
E
W
 
W
L
 
V
R
 
K
T
 
V
E
 
D
A
 
G
D
 
D
G
 
V
S
 
G
V
 
-
T
 
T
V
 
V
G
 
G
I
 
I
T
 
T
A
 
S
F
 
Y
A
 
A
Q
 
A
N
 
N
A
 
A
L
 
L
G
 
G
D
 
E
V
 
V
V
 
V
F
 
F
V
 
V
Q
 
E
L
 
L
P
 
P
E
 
E
L
 
P
Q
 
E
A
 
T
-
 
T
Y
 
V
D
 
S
K
 
V
G
 
G
A
 
D
E
 
G
A
 
I
S
 
G
T
 
A
V
 
V
E
 
E
S
 
S
V
 
V
K
 
K
A
 
S
A
 
A
S
 
S
G
 
D
V
 
V
Y
 
Y
M
 
S
P
 
P
L
 
V
D
 
S
G
 
G
E
 
T
V
 
V
L
 
T
E
 
S
V
 
I
N
 
N
D
 
E
K
 
S
L
 
L
D
 
G
A
 
D
S
 
S
P
 
P
E
 
D
L
 
K
V
 
V
N
 
S
E
 
S
D
x
S
P
 
P
L
 
E
G
 
E
E
 
E
G
 
G
W
 
W
F
 
I
F
 
C
R
 
K
F
 
I
K
 
K
P
 
L
T
 
S
D
 
S
A
 
P
D
 
D
A
 
E
V
 
L
A
 
K
K
 
S
L
 
L
L
 
L
D
 
N
Q
 
D
D
 
E
A
 
S
Y
 
Y
D
 
A
R
 
Q
L
 
F
I
 
C
K
 
K

P11183 Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein from Gallus gallus (Chicken) (see paper)
44% identity, 97% coverage: 1:123/127 of query aligns to 39:161/164 of P11183

query
sites
P11183
M
x
L
S
 
S
E
 
A
L
 
R
R
 
K
F
 
F
T
 
T
E
 
D
D
 
K
H
 
H
E
 
E
W
 
W
L
 
I
R
 
S
T
 
V
E
 
E
A
 
-
D
 
N
G
 
G
S
 
I
V
 
G
T
 
T
V
 
V
G
 
G
I
 
I
T
 
S
A
 
N
F
 
F
A
 
A
Q
 
Q
N
 
E
A
 
A
L
 
L
G
 
G
D
 
D
V
 
V
V
 
V
F
 
Y
V
 
C
Q
 
S
L
 
L
P
 
P
E
 
E
L
 
I
-
 
G
Q
 
T
A
 
K
Y
 
L
D
 
N
K
 
K
G
 
D
A
 
D
E
 
E
A
 
F
S
 
G
T
 
A
V
 
L
E
 
E
S
 
S
V
 
V
K
|
K
A
 
A
A
 
A
S
 
S
G
 
E
V
 
L
Y
 
Y
M
 
S
P
 
P
L
 
L
D
 
T
G
 
G
E
 
E
V
 
V
L
 
T
E
 
D
V
 
I
N
 
N
D
 
A
K
 
A
L
 
L
D
 
A
A
 
D
S
 
N
P
 
P
E
 
G
L
 
L
V
 
V
N
 
N
E
 
K
D
 
S
P
 
C
L
 
Y
G
 
Q
E
 
D
G
 
G
W
 
W
F
 
L
F
 
I
R
 
K
F
 
M
-
 
T
-
 
V
-
 
E
K
 
K
P
 
P
T
 
A
D
 
E
A
 
L
D
 
D
A
 
-
V
 
-
A
 
-
K
 
E
L
 
L
L
 
M
D
 
S
Q
 
E
D
 
D
A
 
A
Y
 
Y
D
 
E
R
 
K
L
 
Y
I
 
I
K
 
K
A
 
S

Sites not aligning to the query:

Query Sequence

>AO356_18175 FitnessBrowser__pseudo5_N2C3_1:AO356_18175
MSELRFTEDHEWLRTEADGSVTVGITAFAQNALGDVVFVQLPELQAYDKGAEASTVESVK
AASGVYMPLDGEVLEVNDKLDASPELVNEDPLGEGWFFRFKPTDADAVAKLLDQDAYDRL
IKANAEA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory