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Comparing AO356_25585 FitnessBrowser__pseudo5_N2C3_1:AO356_25585 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
49% identity, 99% coverage: 4:485/486 of query aligns to 29:514/515 of 2d4eC
- active site: N173 (= N146), K196 (= K169), E271 (= E242), C305 (= C276), E409 (= E380), E486 (= E457)
- binding nicotinamide-adenine-dinucleotide: I169 (≠ V142), T170 (≠ S143), P171 (= P144), W172 (= W145), K196 (= K169), A198 (≠ S171), G229 (= G202), G233 (= G206), A234 (≠ D207), T248 (= T221), G249 (= G222), E250 (≠ G223), T253 (= T226), E271 (= E242), L272 (= L243), C305 (= C276), E409 (= E380), F411 (= F382), F475 (= F446)
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
41% identity, 98% coverage: 1:474/486 of query aligns to 9:485/487 of Q9H2A2
- R109 (= R101) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N146) mutation to A: Complete loss of activity.
- R451 (= R440) mutation to A: Complete loss of activity.
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
43% identity, 95% coverage: 13:476/486 of query aligns to 53:515/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
42% identity, 98% coverage: 3:479/486 of query aligns to 8:486/490 of Q9HTJ1
- GAWN 150:153 (≠ SPWN 143:146) binding
- K162 (= K155) active site, Charge relay system
- KPSE 176:179 (≠ KMSE 169:172) binding
- G209 (= G202) binding
- GTST 230:233 (≠ GTAT 223:226) binding
- E252 (= E242) active site, Proton acceptor
- C286 (= C276) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E380) binding
- E464 (= E457) active site, Charge relay system
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
42% identity, 98% coverage: 3:479/486 of query aligns to 7:485/489 of 4cazA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E380), E463 (= E457)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (≠ V142), G149 (≠ S143), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), T227 (= T221), G228 (= G222), G229 (= G223), T232 (= T226), V236 (≠ I230), E251 (= E242), L252 (= L243), C285 (= C276), E386 (= E380), F388 (= F382)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
42% identity, 98% coverage: 3:479/486 of query aligns to 7:485/489 of 2woxA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E380), E463 (= E457)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (≠ V142), G149 (≠ S143), W151 (= W145), N152 (= N146), K175 (= K169), S177 (= S171), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), T227 (= T221), G228 (= G222), G229 (= G223), T232 (= T226), V236 (≠ I230), E251 (= E242), L252 (= L243), C285 (= C276), E386 (= E380), F388 (= F382)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
42% identity, 98% coverage: 3:479/486 of query aligns to 7:485/489 of 2wmeA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E380), E463 (= E457)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ S143), W151 (= W145), K175 (= K169), S177 (= S171), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), G228 (= G222), G229 (= G223), T232 (= T226), V236 (≠ I230)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 29:491/496 of 4fr8C
- active site: N165 (= N146), K188 (= K169), Q264 (≠ E242), C298 (= C276), E395 (= E380), E472 (= E457)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V142), I162 (≠ S143), W164 (= W145), K188 (= K169), G221 (= G202), G225 (= G206), A226 (≠ D207), F239 (= F220), G241 (= G222), S242 (≠ G223), I245 (≠ T226), Q345 (≠ H323), E395 (= E380), F397 (= F382)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 26:488/493 of 4fr8A
- active site: N162 (= N146), K185 (= K169), Q261 (≠ E242), C295 (= C276), E392 (= E380), E469 (= E457)
- binding nicotinamide-adenine-dinucleotide: I158 (≠ V142), I159 (≠ S143), W161 (= W145), K185 (= K169), G218 (= G202), G222 (= G206), A223 (≠ D207), F236 (= F220), G238 (= G222), S239 (≠ G223), I242 (≠ T226), Q342 (≠ H323), K345 (= K326), E392 (= E380), F394 (= F382)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ V147), L166 (≠ M150), W170 (= W154), F289 (≠ S270), S294 (≠ R275), C295 (= C276), D450 (≠ N438), F452 (≠ R440)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 5l13A
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ V147), M168 (≠ T151), W171 (= W154), F290 (≠ S270), C295 (≠ R275), C296 (= C276), C297 (≠ T277), D451 (≠ N438), F453 (≠ R440)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 4kwgA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ V147), M168 (≠ T151), C295 (≠ R275), C296 (= C276), C297 (≠ T277), D451 (≠ N438), F453 (≠ R440)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 4kwfA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ V147), M168 (≠ T151), W171 (= W154), E262 (= E242), C295 (≠ R275), C296 (= C276), C297 (≠ T277), D451 (≠ N438), F453 (≠ R440), F459 (= F446)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 3sz9A
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ V147), C295 (≠ R275), C296 (= C276), D451 (≠ N438), F453 (≠ R440), F459 (= F446)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 3injA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ R101), F164 (≠ V147), L167 (≠ M150), F286 (= F266), F290 (≠ S270), D451 (≠ N438), F453 (≠ R440)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 2vleA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding daidzin: M118 (≠ R101), F164 (≠ V147), M168 (≠ T151), W171 (= W154), F286 (= F266), F290 (≠ S270), C295 (≠ R275), C296 (= C276), D451 (≠ N438), V452 (= V439), F453 (≠ R440)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 1o01B
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding (2e)-but-2-enal: C296 (= C276), C297 (≠ T277), F453 (≠ R440)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V142), I160 (≠ S143), P161 (= P144), W162 (= W145), K186 (= K169), E189 (= E172), G219 (= G202), G223 (= G206), A224 (≠ D207), F237 (= F220), G239 (= G222), S240 (≠ G223), I243 (≠ T226), L263 (= L243), G264 (= G244), C296 (= C276), Q343 (≠ H323), E393 (= E380), F395 (= F382)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
42% identity, 95% coverage: 13:476/486 of query aligns to 27:489/494 of 1cw3A
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E380), E470 (= E457)
- binding magnesium ion: V34 (≠ Y20), D103 (= D86), Q190 (≠ L173)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V142), I160 (≠ S143), P161 (= P144), W162 (= W145), K186 (= K169), G219 (= G202), G223 (= G206), A224 (≠ D207), F237 (= F220), G239 (= G222), S240 (≠ G223), I243 (≠ T226), L263 (= L243), G264 (= G244), C296 (= C276), Q343 (≠ H323), K346 (= K326), E393 (= E380), F395 (= F382)
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
40% identity, 97% coverage: 4:476/486 of query aligns to 5:483/483 of 4npiA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E380), E464 (= E457)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R101), L157 (≠ T151), W160 (= W154), E251 (= E242), C285 (= C276), Y445 (≠ N438), R447 (= R440), F453 (= F446)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ V142), S149 (= S143), P150 (= P144), W151 (= W145), K175 (= K169), E178 (= E172), G208 (= G202), G213 (= G206), E214 (≠ D207), F227 (= F220), G229 (= G222), E230 (≠ G223), T233 (= T226), G253 (= G244), C285 (= C276), K335 (= K326), E387 (= E380), F389 (= F382)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
40% identity, 97% coverage: 4:476/486 of query aligns to 5:483/483 of 4i2rA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E380), E464 (= E457)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R101), L157 (≠ T151), C285 (= C276), Y445 (≠ N438), R447 (= R440), F453 (= F446)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ V142), S149 (= S143), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ G223), T233 (= T226), E251 (= E242), L252 (= L243), G253 (= G244), C285 (= C276), E387 (= E380), F389 (= F382)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
40% identity, 97% coverage: 4:476/486 of query aligns to 5:483/483 of 4i25A
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E380), E464 (= E457)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R101), L157 (≠ T151), C285 (= C276), Y445 (≠ N438), R447 (= R440), F453 (= F446)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ V142), S149 (= S143), P150 (= P144), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), G213 (= G206), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ G223), T233 (= T226), E251 (= E242), L252 (= L243), C285 (= C276), E387 (= E380), F389 (= F382)
Query Sequence
>AO356_25585 FitnessBrowser__pseudo5_N2C3_1:AO356_25585
MIKHWIDGREVESKDVFVNYNPATGEAIGEVASGGAEEVAQAVAAAKEAFPKWANTPAKE
RARLMRKLGELIEQNVPKLAELETLDTGLPIHQTKNVLIPRASHNFDFFAEVCTRMDGHT
YPVDDQMLNYTLYQPVGVCALVSPWNVPFMTATWKTAPCLALGNTAVLKMSELSPLTANE
LGRLAVEAGIPNGVLNVIQGYGATAGDALVRHPDVRAISFTGGTATGKKIMQTAGLKKYS
MELGGKSPVLIFEDADLERALDAALFTIFSLNGERCTAGSRIFIQESVYPQFVAEFAARA
KRLIVGDPQDPKTQVGSMITQAHYDKVTGYIKIGLEEGATLLAGGLERPANLPAHLSHGQ
FIQPTVFADVNNKMRIAQEEIFGPVVCLIPFKDEAEALQLANDTEYGLASYIWTQDIGKA
HRLAHGIEAGMVFINSQNVRDLRQPFGGVKGSGTGREGGQYSFEVFAEIKNVCISMGSHH
IPRWGV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory