SitesBLAST
Comparing AO356_28710 FitnessBrowser__pseudo5_N2C3_1:AO356_28710 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
38% identity, 98% coverage: 5:467/473 of query aligns to 5:477/489 of 4o6rA
- active site: N150 (= N146), K173 (= K169), E248 (= E242), C282 (= C276), E383 (= E373), E460 (= E450)
- binding adenosine monophosphate: I146 (= I142), V147 (≠ T143), K173 (= K169), G206 (vs. gap), G210 (= G204), Q211 (≠ S205), F224 (= F218), G226 (= G220), S227 (= S221), T230 (= T224), R233 (≠ S227)
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/489 of 7a6qB
- active site: N163 (= N146), E262 (= E242), C296 (= C276), E470 (= E450)
- binding nicotinamide-adenine-dinucleotide: I159 (= I142), W162 (= W145), K186 (= K169), E189 (≠ S172), G219 (≠ E200), G223 (= G204), S240 (= S221), V243 (≠ T224), K342 (≠ E322)
- binding (3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium: A32 (≠ D21), T33 (≠ V22), C34 (≠ I23), P36 (= P25), D103 (≠ E89), E189 (≠ S172), Q190 (≠ L173), F218 (vs. gap), I339 (≠ Q319), D340 (≠ N320)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (= G103), D141 (≠ T124), N143 (≠ S126), N451 (≠ A431), L453 (≠ I433), A455 (≠ P435)
7a6qA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/489 of 7a6qA
- active site: N163 (= N146), E262 (= E242), C296 (= C276), E470 (= E450)
- binding nicotinamide-adenine-dinucleotide: I159 (= I142), T160 (= T143), W162 (= W145), K186 (= K169), A188 (≠ S171), E189 (≠ S172), G219 (≠ E200), G223 (= G204), S240 (= S221), V243 (≠ T224), K342 (≠ E322), K346 (≠ L326)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (= G103), D141 (≠ T124), N143 (≠ S126), N451 (≠ A431), L453 (≠ I433), Y454 (≠ Q434)
5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/489 of 5fhzA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E373), E470 (= E450)
- binding nicotinamide-adenine-dinucleotide: I159 (= I142), T160 (= T143), W162 (= W145), K186 (= K169), E189 (≠ S172), G219 (≠ E200), G223 (= G204), F237 (= F218), G239 (= G220), S240 (= S221), T241 (= T222), V243 (≠ T224), G264 (= G244), Q343 (= Q323), E393 (= E373)
- binding retinoic acid: G118 (= G103), R121 (≠ A106), F164 (≠ W147), M168 (≠ I151), W171 (= W154), C295 (≠ T275), C296 (= C276), L453 (≠ I433)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
35% identity, 98% coverage: 5:468/473 of query aligns to 33:506/512 of P47895
- R89 (= R57) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K169) binding
- E207 (≠ S172) binding
- GSTEVG 257:262 (≠ GSTATG 220:225) binding
- Q361 (= Q323) binding
- E411 (= E373) binding
- A493 (≠ G455) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 14:487/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I142), T159 (= T143), P160 (= P144), W161 (= W145), K185 (= K169), E188 (≠ S172), G218 (≠ E200), G222 (= G204), F236 (= F218), S239 (= S221), V242 (≠ T224)
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
37% identity, 98% coverage: 5:468/473 of query aligns to 13:486/492 of 6b5hA
- active site: N161 (= N146), E260 (= E242), C294 (= C276), E468 (= E450)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (vs. gap), G116 (= G103), F162 (≠ W147), W169 (= W154), Q284 (= Q266), F288 (≠ L270), T295 (≠ A277), N449 (≠ A431), L451 (≠ I433), N452 (≠ Q434), F457 (= F439)
- binding nicotinamide-adenine-dinucleotide: I157 (= I142), I158 (≠ T143), W160 (= W145), N161 (= N146), K184 (= K169), G217 (vs. gap), G221 (= G204), F235 (= F218), T236 (= T219), G237 (= G220), S238 (= S221), V241 (≠ T224), E260 (= E242), L261 (= L243), C294 (= C276), F393 (= F375)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118) (see paper)
37% identity, 98% coverage: 5:468/473 of query aligns to 13:486/492 of 6b5gA
- active site: N161 (= N146), E260 (= E242), C294 (= C276), E468 (= E450)
- binding (3-ethoxythiophen-2-yl){4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone: F162 (≠ W147), L165 (≠ M150), W169 (= W154), F288 (≠ L270), C293 (≠ T275), C294 (= C276), T295 (≠ A277), N449 (≠ A431), L451 (≠ I433)
- binding nicotinamide-adenine-dinucleotide: I157 (= I142), I158 (≠ T143), P159 (= P144), W160 (= W145), N161 (= N146), M166 (≠ I151), K184 (= K169), E187 (≠ S172), G217 (vs. gap), G221 (= G204), F235 (= F218), T236 (= T219), G237 (= G220), S238 (= S221), V241 (≠ T224), E260 (= E242), L261 (= L243), C294 (= C276), E391 (= E373), F393 (= F375)
6aljA Aldh1a2 liganded with NAD and compound win18,446 (see paper)
37% identity, 98% coverage: 5:468/473 of query aligns to 13:486/492 of 6aljA
- active site: N161 (= N146), E260 (= E242), C294 (= C276), E468 (= E450)
- binding N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide): G116 (= G103), F162 (≠ W147), L165 (≠ M150), M166 (≠ I151), W169 (= W154), E260 (= E242), C293 (≠ T275), C294 (= C276), L451 (≠ I433), N452 (≠ Q434), A453 (≠ P435)
- binding nicotinamide-adenine-dinucleotide: I157 (= I142), I158 (≠ T143), P159 (= P144), W160 (= W145), N161 (= N146), K184 (= K169), E187 (≠ S172), G217 (vs. gap), G221 (= G204), F235 (= F218), G237 (= G220), S238 (= S221), V241 (≠ T224), Q341 (= Q323), K344 (≠ L326), E391 (= E373), F393 (= F375)
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
37% identity, 98% coverage: 5:468/473 of query aligns to 39:512/518 of O94788
- E50 (= E16) to G: in dbSNP:rs34266719
- A110 (= A72) to V: in dbSNP:rs35365164
- Q182 (≠ S141) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (≠ TPW 143:145) binding
- KPAE 210:213 (≠ KPSS 169:172) binding
- STE 264:266 (≠ STA 221:223) binding
- C320 (= C276) active site, Nucleophile
- R347 (≠ Q303) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (= V304) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ EQLTL 322:326) binding
- A383 (= A339) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E373) binding
- E436 (≠ R392) to K: in dbSNP:rs34744827
- S461 (≠ A417) to Y: in DIH4; decreased retinoic acid biosynthetic process
Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
36% identity, 98% coverage: 5:468/473 of query aligns to 39:512/518 of Q63639
6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 7:477/478 of 6tgwA
- active site: N155 (= N146), E254 (= E242), C288 (= C276), E459 (= E450)
- binding methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate: I106 (≠ S99), G110 (= G103), F156 (≠ W147), Q278 (= Q266), F282 (≠ L270), L442 (≠ I433), A444 (≠ P435)
- binding nicotinamide-adenine-dinucleotide: I151 (= I142), T152 (= T143), P153 (= P144), W154 (= W145), K178 (= K169), G211 (≠ E200), G215 (= G204), F229 (= F218), G231 (= G220), S232 (= S221), V235 (≠ T224)
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
37% identity, 96% coverage: 5:459/473 of query aligns to 12:475/482 of P25526
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
37% identity, 96% coverage: 5:459/473 of query aligns to 11:474/481 of 3jz4A
- active site: N156 (= N146), K179 (= K169), E254 (= E242), C288 (= C276), E385 (= E373), E462 (= E450)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (= P144), W155 (= W145), K179 (= K169), A181 (≠ S171), S182 (= S172), A212 (≠ Q201), G216 (= G204), G232 (= G220), S233 (= S221), I236 (≠ T224), C288 (= C276), K338 (≠ L326), E385 (= E373), F387 (= F375)
7jwwA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/494 of 7jwwA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E373), E470 (= E450)
- binding 5-{4-[(Z)-2-hydroxyethenyl]phenyl}-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (= G103), T122 (≠ W107), F164 (≠ W147), M168 (≠ I151), Y290 (≠ L270), C295 (≠ T275), C296 (= C276), I297 (≠ A277), V453 (≠ I433), F459 (= F439)
7jwvA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/494 of 7jwvA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E373), E470 (= E450)
- binding 5-[4-(hydroxymethyl)phenyl]-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (= G103), T122 (≠ W107), F164 (≠ W147), M168 (≠ I151), Y290 (≠ L270), C295 (≠ T275), I297 (≠ A277), V453 (≠ I433), F459 (= F439)
7jwuA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/494 of 7jwuA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E373), E470 (= E450)
- binding nicotinamide-adenine-dinucleotide: I159 (= I142), I160 (≠ T143), P161 (= P144), W162 (= W145), N163 (= N146), K186 (= K169), E189 (≠ S172), G219 (vs. gap), G223 (= G204), A224 (≠ S205), F237 (= F218), T238 (= T219), G239 (= G220), S240 (= S221), V243 (≠ T224), L263 (= L243), C296 (= C276), Q343 (= Q323), K346 (≠ L326), E393 (= E373), F395 (= F375)
- binding 1-methyl-5-phenyl-6-{[(1R)-1-(pyridin-2-yl)ethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: T122 (≠ W107), F164 (≠ W147), W171 (= W154), Y290 (≠ L270), C295 (≠ T275), I297 (≠ A277), V453 (≠ I433), F459 (= F439)
7jwtA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/494 of 7jwtA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E373), E470 (= E450)
- binding 6-{[(1R)-1-(3-hydroxyphenyl)ethyl]sulfanyl}-1-methyl-5-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (= G103), T122 (≠ W107), F164 (≠ W147), M168 (≠ I151), W171 (= W154), Y290 (≠ L270), C295 (≠ T275), V453 (≠ I433), F459 (= F439)
7jwsA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/494 of 7jwsA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E373), E470 (= E450)
- binding 1-methyl-5-phenyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (= G103), T122 (≠ W107), F164 (≠ W147), M168 (≠ I151), W171 (= W154), Y290 (≠ L270), C295 (≠ T275), I297 (≠ A277), V453 (≠ I433), F459 (= F439)
6dumA Aldh1a1 n121s in complex with 6-{[(3-fluorophenyl)methyl]sulfanyl}-2- (oxetan-3-yl)-5-phenyl-2,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one (compound 13g) (see paper)
35% identity, 98% coverage: 5:468/473 of query aligns to 15:488/494 of 6dumA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E373), E470 (= E450)
- binding 6-{[(3-fluorophenyl)methyl]sulfanyl}-2-(oxetan-3-yl)-5-phenyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (= G103), T122 (≠ W107), F164 (≠ W147), M168 (≠ I151), W171 (= W154), H286 (≠ Q266), Y290 (≠ L270), C295 (≠ T275), C296 (= C276), I297 (≠ A277), G451 (≠ A431), V453 (≠ I433), F459 (= F439)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I142), I160 (≠ T143), P161 (= P144), W162 (= W145), N163 (= N146), K186 (= K169), E189 (≠ S172), G219 (vs. gap), P220 (≠ Q201), G223 (= G204), A224 (≠ S205), F237 (= F218), T238 (= T219), G239 (= G220), S240 (= S221), V243 (≠ T224), L263 (= L243), C296 (= C276), Q343 (= Q323), K346 (≠ L326), E393 (= E373), F395 (= F375)
Query Sequence
>AO356_28710 FitnessBrowser__pseudo5_N2C3_1:AO356_28710
MHDYQMLINGARVDGENGHFDVINPATGTVFARCAAGSLAQLDLAVEAAQSAFIEWRYSS
HEDRRQRLQSIAADIEQDAESLARLIVLEQGKPLELAFSEVMGAVAWTRYAAEQQIPVEL
VEQTPSQRIELHRKPLGVVASITPWNWPFMIAVWHIMPALRAGNCVISKPSSLTPLSTLR
LVEIIARHVPRGVINSVTGEQGFGSAITAHAGIQKIVFTGSTATGQSVMRGAAGNLKRLT
LELGGNDAAIVLPGTPVEAVAEDIFQAAFLNMGQTCAALKRLYIHQSQYEAFAEALTVIA
RRQVVGDGLAPGVTFGPVQNLEQLTLVEELVADARAQGARVLCGGARLDRPGFFYPPTLV
ADVTDGQRLVDEEQFGPVLPLIAYQDVEDVLRRANAGDMGLGGSVWGRDSEQAQALASRL
ECGMAWVNCHAQIQPNTPFGGSKMSGFGVEFGLEGLLEFTGQQLLYVRKRETE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory