Comparing AO356_28885 FitnessBrowser__pseudo5_N2C3_1:AO356_28885 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
27% identity, 92% coverage: 7:412/441 of query aligns to 12:424/425 of O59010
2nwwA Crystal structure of gltph in complex with tboa (see paper)
28% identity, 90% coverage: 7:404/441 of query aligns to 3:407/407 of 2nwwA
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
27% identity, 90% coverage: 7:404/441 of query aligns to 9:413/413 of 6x14A
Sites not aligning to the query:
6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
27% identity, 90% coverage: 7:404/441 of query aligns to 12:416/419 of 6x15A
Sites not aligning to the query:
6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
27% identity, 90% coverage: 7:404/441 of query aligns to 4:408/408 of 6bauA
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
27% identity, 90% coverage: 7:404/441 of query aligns to 4:408/409 of 6bavA
5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
29% identity, 92% coverage: 7:410/441 of query aligns to 10:422/427 of 5e9sA
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
29% identity, 92% coverage: 7:410/441 of query aligns to 10:422/426 of 6xwnB
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
29% identity, 92% coverage: 7:410/441 of query aligns to 7:419/424 of 6zl4A
Sites not aligning to the query:
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
29% identity, 92% coverage: 7:410/441 of query aligns to 8:420/425 of 6zgbA
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
29% identity, 92% coverage: 7:410/441 of query aligns to 3:411/416 of 6r7rA
6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
26% identity, 90% coverage: 7:404/441 of query aligns to 4:396/396 of 6bmiA
7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
25% identity, 84% coverage: 40:410/441 of query aligns to 57:409/412 of 7awmA
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
24% identity, 84% coverage: 40:410/441 of query aligns to 49:395/397 of 5mjuA
7xr4A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
26% identity, 84% coverage: 40:408/441 of query aligns to 46:420/425 of 7xr4A
P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat) (see paper)
25% identity, 91% coverage: 40:440/441 of query aligns to 82:530/573 of P31596
7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613 (see paper)
25% identity, 84% coverage: 40:408/441 of query aligns to 47:419/424 of 7xr6A
Sites not aligning to the query:
O35874 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Mus musculus (Mouse) (see 2 papers)
25% identity, 82% coverage: 40:401/441 of query aligns to 79:475/532 of O35874
P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse) (see paper)
25% identity, 84% coverage: 40:408/441 of query aligns to 82:501/572 of P43006
Sites not aligning to the query:
P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse) (see paper)
24% identity, 96% coverage: 8:431/441 of query aligns to 41:540/543 of P56564
>AO356_28885 FitnessBrowser__pseudo5_N2C3_1:AO356_28885
MGDAMKVVKSLYFQIICAVLLGVVVGHFWSQQAIALKPLGDAFIKLIKMMIAPVVFCTIV
TGIAGMSDKRSLGRLLSKTMLLFLALTVISLIIGLVSVYLFKPGAGMNIDPTQLSTQGLS
QYTESAAKLSVVDFFMHIIPDTFIGAFNKGEVLPVLFIAVLCGFALSSLGERGKPVLEVL
ESASHMVFKIFSYLMRFAPIGAFGALAFTVGQYGITSLGSLAKLIMTLYIACAFFVFVVL
GSLCRAHGFSLWKLLRYLREEFLVVLGTSSTEPVMPRMLEKLQALGCKKGVVGLVLPTGY
SFNLDGTAIYLSLAAIFIAQACNIDLTLTQVITMLAIMLLSSKGAAGVTGSGFVALASTL
TVIHDIPLAGLALLIGIDRFMSEARALTSLASNAVATVVISLSENACDREVLLQTLDGKP
ALTQTPATDSSWDGAKVAKHI
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory