SitesBLAST
Comparing AO356_30225 FitnessBrowser__pseudo5_N2C3_1:AO356_30225 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5nccA Structure of fatty acid photodecarboxylase in complex with fad and palmitic acid (see paper)
36% identity, 97% coverage: 2:532/546 of query aligns to 22:573/578 of 5nccA
- active site: R347 (≠ W319), L420 (≠ V383), I421 (≠ Y384), S507 (≠ A468), A509 (≠ H470), G552 (= G511), Q553 (≠ N512)
- binding flavin-adenine dinucleotide: G30 (= G10), G32 (= G12), T33 (≠ S13), A34 (≠ S14), L53 (≠ I33), E54 (= E34), A55 (= A35), F74 (= F55), W80 (= W61), A98 (≠ P79), G100 (= G81), G105 (= G86), S106 (= S87), N110 (= N91), A111 (≠ G92), T112 (≠ M93), L113 (≠ V94), V238 (≠ L218), A278 (= A252), H282 (≠ K256), L286 (≠ M260), N508 (≠ H469), Q553 (≠ N512), T554 (= T513), G555 (≠ N514), V558 (≠ S517)
8b7sA Crystal structure of the chloramphenicol-inactivating oxidoreductase from novosphingobium sp (see paper)
34% identity, 97% coverage: 4:532/546 of query aligns to 5:454/458 of 8b7sA
- binding flavin-adenine dinucleotide: G11 (= G10), G13 (= G12), S14 (= S13), A15 (≠ S14), E35 (= E34), A36 (= A35), W47 (= W61), P65 (= P79), G67 (= G81), V180 (≠ L218), A214 (= A252), G215 (= G253), A218 (≠ K256), T270 (≠ L334), Y391 (≠ H469), A424 (= A502), I435 (≠ T513), N436 (= N514)
6yrvAAA structure of fap after illumination at 100k (see paper)
35% identity, 99% coverage: 2:541/546 of query aligns to 6:573/573 of 6yrvAAA
- binding carbon dioxide: R375 (≠ S357), N499 (≠ H469)
- binding flavin-adenine dinucleotide: G14 (= G10), G16 (= G12), T17 (≠ S13), A18 (≠ S14), L37 (≠ I33), E38 (= E34), A39 (= A35), F58 (= F55), W64 (= W61), A82 (≠ P79), G89 (= G86), S90 (= S87), N94 (= N91), A95 (≠ G92), T96 (≠ M93), L97 (≠ V94), M191 (vs. gap), V222 (≠ L218), C264 (≠ S251), A265 (= A252), G266 (= G253), H269 (≠ K256), N499 (≠ H469), A534 (= A502), Q544 (≠ N512), T545 (= T513), G546 (≠ N514)
- binding heptadecane: V377 (≠ R359), G379 (≠ T362), M380 (≠ F363), G386 (= G369), T389 (≠ D372), Y390 (≠ V373), F393 (≠ H376), T408 (≠ G380), Q410 (≠ S382)
A0A248QE08 Fatty acid photodecarboxylase, chloroplastic; CvFAP; EC 4.1.1.106 from Chlorella variabilis (Green alga) (see paper)
35% identity, 97% coverage: 2:528/546 of query aligns to 82:636/654 of A0A248QE08
- TA 93:94 (≠ SS 13:14) binding
- E114 (= E34) binding
- L162 (= L83) binding
- S166 (= S87) binding
- NATL 170:173 (≠ NGMV 91:94) binding
- V298 (≠ L218) binding
- C432 (≠ S337) binding
- R451 (≠ S357) binding
- Y466 (≠ V373) binding
- Q486 (≠ S382) binding
- G622 (≠ N514) binding
8bxlB Patulin synthase from penicillium expansum
30% identity, 96% coverage: 2:525/546 of query aligns to 12:583/590 of 8bxlB
- binding flavin-adenine dinucleotide: G20 (= G10), G22 (= G12), T23 (≠ S13), A24 (≠ S14), E44 (= E34), A45 (= A35), W80 (= W61), G100 (= G81), G105 (= G86), S106 (= S87), R109 (≠ I90), N110 (= N91), Y111 (≠ G92), A113 (≠ V94), L253 (≠ E217), A254 (≠ L218), A288 (= A252), Q292 (≠ K256), F525 (≠ H469), D559 (= D501), A560 (= A502), H570 (≠ N512), P571 (≠ T513), Q572 (≠ N514), L575 (≠ S517)
6ze6A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment 4-nitrocatechol (see paper)
32% identity, 97% coverage: 4:531/546 of query aligns to 2:581/585 of 6ze6A
- binding 4-nitrocatechol: I75 (≠ P79), L92 (≠ I96), Q306 (vs. gap), V360 (≠ Y331), Y431 (= Y384), L433 (= L386), N514 (= N466), S516 (vs. gap), N517 (≠ S467), H519 (= H469), G561 (= G511), S562 (≠ N512)
- binding dihydroflavine-adenine dinucleotide: G8 (= G10), G10 (= G12), I11 (≠ S13), S12 (= S14), E32 (= E34), A33 (= A35), W56 (≠ N56), A77 (≠ G81), G82 (= G86), G83 (≠ S87), N87 (= N91), A88 (≠ G92), V90 (= V94), L227 (≠ E217), V228 (≠ L218), A265 (= A252), A518 (= A468), H519 (= H469), D551 (= D501), I552 (≠ A502), S562 (≠ N512), P563 (≠ T513), M564 (≠ N514)
6ze5A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment 2-(1h-indol-3-yl)-n-[(1-methyl-1h-pyrrol-2-yl) methyl]ethanamine (see paper)
32% identity, 97% coverage: 4:531/546 of query aligns to 2:581/585 of 6ze5A
- binding 2-(1H-indol-3-yl)-N-[(1-methyl-1H-pyrrol-2-yl)methyl]ethanamine: I75 (≠ P79), V90 (= V94), Y431 (= Y384), N517 (≠ S467), D576 (= D526), K580 (≠ E530)
- binding dihydroflavine-adenine dinucleotide: G8 (= G10), G10 (= G12), I11 (≠ S13), S12 (= S14), E32 (= E34), A33 (= A35), W56 (≠ N56), A77 (≠ G81), G82 (= G86), G83 (≠ S87), N87 (= N91), A88 (≠ G92), V90 (= V94), L227 (≠ E217), V228 (≠ L218), A265 (= A252), A518 (= A468), H519 (= H469), D551 (= D501), I552 (≠ A502), S562 (≠ N512), P563 (≠ T513), M564 (≠ N514)
Sites not aligning to the query:
6ze4A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment 4-oxo-n-[(1s)-1-(pyridin-3-yl)ethyl]-4-(thiophen-2-yl) butanamide (see paper)
32% identity, 97% coverage: 4:531/546 of query aligns to 2:581/585 of 6ze4A
- binding 4-oxo-N-[(1S)-1-(pyridin-3-yl)ethyl]-4-(thiophen-2-yl)butanamide: A88 (≠ G92), V90 (= V94), L354 (= L325), H421 (= H376), L429 (vs. gap), Y431 (= Y384), N517 (≠ S467)
- binding dihydroflavine-adenine dinucleotide: G8 (= G10), G10 (= G12), I11 (≠ S13), S12 (= S14), E32 (= E34), A33 (= A35), W56 (≠ N56), A77 (≠ G81), G82 (= G86), G83 (≠ S87), N87 (= N91), A88 (≠ G92), V90 (= V94), L227 (≠ E217), V228 (≠ L218), A265 (= A252), A518 (= A468), H519 (= H469), D551 (= D501), I552 (≠ A502), S562 (≠ N512), P563 (≠ T513), M564 (≠ N514)
6ze3A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment (4-methoxycarbonylphenyl)methylazanium (see paper)
32% identity, 97% coverage: 4:531/546 of query aligns to 2:581/585 of 6ze3A
- binding (4-methoxycarbonylphenyl)methylazanium: A88 (≠ G92), L354 (= L325), Y431 (= Y384), N517 (≠ S467)
- binding dihydroflavine-adenine dinucleotide: G10 (= G12), I11 (≠ S13), S12 (= S14), E32 (= E34), A33 (= A35), W56 (≠ N56), G82 (= G86), G83 (≠ S87), I86 (= I90), N87 (= N91), A88 (≠ G92), V90 (= V94), L227 (≠ E217), V228 (≠ L218), A265 (= A252), A518 (= A468), H519 (= H469), D551 (= D501), I552 (≠ A502), S562 (≠ N512), M564 (≠ N514)
6ze7B Chaetomium thermophilum fad-dependent oxidoreductase in complex with 4-nitrophenol (see paper)
32% identity, 97% coverage: 4:531/546 of query aligns to 3:582/586 of 6ze7B
- binding dihydroflavine-adenine dinucleotide: G9 (= G10), G11 (= G12), I12 (≠ S13), S13 (= S14), E33 (= E34), A34 (= A35), W57 (≠ N56), A78 (≠ G81), G83 (= G86), G84 (≠ S87), N88 (= N91), A89 (≠ G92), V91 (= V94), L228 (≠ E217), V229 (≠ L218), A266 (= A252), A519 (= A468), H520 (= H469), D552 (= D501), I553 (≠ A502), S563 (≠ N512), P564 (≠ T513), M565 (≠ N514)
- binding p-nitrophenol: L93 (≠ I96), V361 (≠ Y331), Y432 (= Y384), L434 (= L386), G562 (= G511), S563 (≠ N512)
7aa2A Chaetomium thermophilum fad-dependent oxidoreductase in complex with abts (see paper)
32% identity, 97% coverage: 4:531/546 of query aligns to 2:581/584 of 7aa2A
- binding 3-ethyl-2-[(2z)-2-(3-ethyl-6-sulfo-1,3-benzothiazol-2(3h)-ylidene)hydrazino]-6-sulfo-3h-1,3-benzothiazol-1-ium: W52 (vs. gap), A88 (≠ G92), V90 (= V94), L354 (= L325), Y431 (= Y384), N517 (≠ S467), H519 (= H469), S562 (≠ N512)
- binding dihydroflavine-adenine dinucleotide: G8 (= G10), G10 (= G12), I11 (≠ S13), S12 (= S14), E32 (= E34), A33 (= A35), W56 (≠ N56), A77 (≠ G81), G82 (= G86), G83 (≠ S87), I86 (= I90), N87 (= N91), A88 (≠ G92), V90 (= V94), L227 (≠ E217), V228 (≠ L218), A265 (= A252), A518 (= A468), H519 (= H469), D551 (= D501), I552 (≠ A502), S562 (≠ N512), P563 (≠ T513), M564 (≠ N514)
7vzsA Fad-dpendent glucose dehydrogenase complexed with an inhibitor at ph7.56
31% identity, 97% coverage: 4:532/546 of query aligns to 4:566/566 of 7vzsA
- binding D-glucal: Y6 (= Y6), L22 (= L22), N25 (≠ D25), Y51 (≠ G51), I349 (≠ Y324), Q356 (≠ Y331), E411 (vs. gap), E444 (≠ D415), W445 (≠ Y416), K448 (≠ N419), R499 (≠ N466), N501 (≠ A468), H546 (≠ N512), K563 (≠ R529), A566 (= A532)
- binding flavin-adenine dinucleotide: G10 (= G10), G12 (= G12), T13 (≠ S13), S14 (= S14), E34 (= E34), A35 (= A35), Y51 (≠ G51), F55 (= F55), W61 (= W61), R79 (≠ P79), G81 (= G81), G86 (= G86), T87 (≠ S87), N91 (= N91), G92 (= G92), M93 (= M93), A94 (≠ V94), T232 (≠ E217), A233 (≠ L218), A273 (= A252), G274 (= G253), R277 (≠ K256), F502 (≠ H469), A536 (= A502), H546 (≠ N512), L547 (≠ T513), V548 (≠ N514), L551 (≠ S517)
4yntA Crystal structure of aspergillus flavus fad glucose dehydrogenase (see paper)
31% identity, 97% coverage: 4:532/546 of query aligns to 5:567/570 of 4yntA
- active site: V342 (≠ L312), F413 (vs. gap), W414 (≠ Y384), N502 (≠ A468), H504 (= H470), G546 (= G511), H547 (≠ N512)
- binding dihydroflavine-adenine dinucleotide: G13 (= G12), T14 (≠ S13), S15 (= S14), E35 (= E34), A36 (= A35), F56 (= F55), W62 (= W61), R80 (≠ P79), G82 (= G81), G87 (= G86), T88 (≠ S87), N92 (= N91), G93 (= G92), M94 (= M93), A95 (≠ V94), A234 (≠ L218), A274 (= A252), R278 (≠ K256), F503 (≠ H469), A537 (= A502), H547 (≠ N512), L548 (≠ T513), V549 (≠ N514), L552 (≠ S517)
4ynuA Crystal structure of aspergillus flavus fadgdh in complex with d- glucono-1,5-lactone (see paper)
31% identity, 97% coverage: 4:532/546 of query aligns to 4:566/569 of 4ynuA
- active site: V341 (≠ L312), F412 (vs. gap), W413 (≠ Y384), N501 (≠ A468), H503 (= H470), G545 (= G511), H546 (≠ N512)
- binding flavin-adenine dinucleotide: G12 (= G12), T13 (≠ S13), S14 (= S14), E34 (= E34), A35 (= A35), Y51 (≠ G51), F55 (= F55), W61 (= W61), R79 (≠ P79), G81 (= G81), G86 (= G86), T87 (≠ S87), N91 (= N91), G92 (= G92), T232 (≠ E217), A233 (≠ L218), A273 (= A252), G274 (= G253), R277 (≠ K256), F502 (≠ H469), A536 (= A502), H546 (≠ N512), L547 (≠ T513), V548 (≠ N514), L551 (≠ S517)
- binding D-glucono-1,5-lactone: Y51 (≠ G51), E411 (vs. gap), A496 (≠ E463), N497 (≠ T464), R499 (≠ N466), R499 (≠ N466), N501 (≠ A468), H503 (= H470), H546 (≠ N512)
3ljpA Crystal structure of choline oxidase v464a mutant (see paper)
32% identity, 96% coverage: 4:529/546 of query aligns to 14:527/530 of 3ljpA
- active site: I333 (≠ V339), P377 (≠ V381), N378 (≠ S382), A464 (= A468), H466 (= H470), V509 (≠ G511), N510 (= N512)
- binding dihydroflavine-adenine dinucleotide: G22 (= G12), S23 (= S13), E44 (= E34), A45 (= A35), W71 (= W61), R89 (= R80), A90 (≠ G81), G95 (= G86), C96 (≠ S87), H99 (≠ I90), N100 (= N91), S101 (≠ G92), I103 (≠ V94), A232 (≠ L218), T269 (≠ A252), D273 (≠ K256), Y465 (≠ H469), H466 (= H470), D499 (= D501), A500 (= A502), N510 (= N512), P511 (≠ T513), N512 (= N514), V515 (≠ S517)
5oc1A Crystal structure of aryl-alcohol oxidase from pleurotus eryngii in complex with p-anisic acid (see paper)
28% identity, 97% coverage: 4:531/546 of query aligns to 2:564/565 of 5oc1A
- active site: V339 (≠ E320), N413 (≠ V383), A414 (≠ Y384), I499 (≠ A468), H501 (= H470), A544 (≠ G511), H545 (≠ N512)
- binding 4-methoxybenzoic acid: Y91 (≠ G92), I356 (≠ G335), I390 (vs. gap), F396 (vs. gap), T412 (≠ S382), I499 (≠ A468), H501 (= H470), H545 (≠ N512)
- binding flavin-adenine dinucleotide: G8 (= G10), G10 (= G12), N11 (≠ S13), A12 (≠ S14), E32 (= E34), A33 (= A35), W60 (= W61), P78 (= P79), G80 (= G81), G85 (= G86), S86 (= S87), H90 (≠ N91), Y91 (≠ G92), V93 (= V94), V230 (≠ L218), S270 (= S251), A271 (= A252), G272 (= G253), F500 (≠ H469), H545 (≠ N512), T546 (= T513), Q547 (≠ N514), I550 (≠ S517)
2jbvA Crystal structure of choline oxidase reveals insights into the catalytic mechanism (see paper)
32% identity, 96% coverage: 4:529/546 of query aligns to 14:527/527 of 2jbvA
- active site: I333 (≠ V339), P377 (≠ V381), N378 (≠ S382), V464 (≠ A468), H466 (= H470), V509 (≠ G511), N510 (= N512)
- binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(4aS,10aR)-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate: G22 (= G12), S23 (= S13), E44 (= E34), A45 (= A35), W71 (= W61), A90 (≠ G81), G95 (= G86), C96 (≠ S87), H99 (≠ I90), N100 (= N91), S101 (≠ G92), I103 (≠ V94), R231 (≠ E217), A232 (≠ L218), T269 (≠ A252), G270 (= G253), D273 (≠ K256), V464 (≠ A468), Y465 (≠ H469), H466 (= H470), D499 (= D501), A500 (= A502), N510 (= N512), P511 (≠ T513), N512 (= N514), V515 (≠ S517)
4mjwA Crystal structure of choline oxidase in complex with the reaction product glycine betaine (see paper)
32% identity, 96% coverage: 4:529/546 of query aligns to 14:527/532 of 4mjwA
- active site: I333 (≠ V339), P377 (≠ V381), N378 (≠ S382), V464 (≠ A468), H466 (= H470), V509 (≠ G511), N510 (= N512)
- binding flavin-adenine dinucleotide: G20 (= G10), G22 (= G12), S23 (= S13), E44 (= E34), A45 (= A35), W71 (= W61), R89 (= R80), A90 (≠ G81), G95 (= G86), C96 (≠ S87), H99 (≠ I90), N100 (= N91), S101 (≠ G92), I103 (≠ V94), R231 (≠ E217), A232 (≠ L218), T269 (≠ A252), G270 (= G253), D273 (≠ K256), Y465 (≠ H469), H466 (= H470), A500 (= A502), N510 (= N512), P511 (≠ T513), N512 (= N514), V515 (≠ S517)
3fimB Crystal structure of aryl-alcohol-oxidase from pleurotus eryingii (see paper)
28% identity, 97% coverage: 4:531/546 of query aligns to 2:564/565 of 3fimB
- active site: V339 (≠ E320), N413 (≠ V383), A414 (≠ Y384), I499 (≠ A468), H501 (= H470), A544 (≠ G511), H545 (≠ N512)
- binding flavin-adenine dinucleotide: G8 (= G10), N11 (≠ S13), A12 (≠ S14), E32 (= E34), A33 (= A35), W60 (= W61), P78 (= P79), G80 (= G81), G85 (= G86), S86 (= S87), H90 (≠ N91), Y91 (≠ G92), V93 (= V94), V230 (≠ L218), S270 (= S251), A271 (= A252), F500 (≠ H469), H501 (= H470), H545 (≠ N512), T546 (= T513), Q547 (≠ N514), I550 (≠ S517)
3t37A Crystal structure of pyridoxine 4-oxidase from mesorbium loti
31% identity, 95% coverage: 5:520/546 of query aligns to 3:496/509 of 3t37A
- active site: F360 (vs. gap), G361 (vs. gap), H444 (≠ A468), H446 (= H470), G487 (= G511), P488 (≠ N512)
- binding flavin-adenine dinucleotide: G8 (= G10), G10 (= G12), S11 (= S13), A12 (≠ S14), E32 (= E34), A33 (= A35), W58 (= W61), R77 (= R80), G78 (= G81), R79 (≠ K82), G83 (= G86), S84 (= S87), H88 (≠ N91), A89 (≠ G92), G91 (≠ V94), R217 (≠ E217), V218 (≠ L218), A251 (= A252), E255 (≠ K256), H445 (= H469), A478 (= A502), P488 (≠ N512), I489 (≠ T513), H490 (≠ N514)
Query Sequence
>AO356_30225 FitnessBrowser__pseudo5_N2C3_1:AO356_30225
MQIYDYIVVGAGSSGCPVARGLSDDPRNNVLLIEAGPASDRFWVNTPAGMGKLYFNKSLN
WNFRTSPMEKLQGRRMYWPRGKLLGGSSSINGMVFIRGHQKDFDGWRALGNPGWGYEDVL
PYFKKMEHFERGGDEYRGANGPLWISDPVVKEKSSYDFIEAANRIGIPVTEDMNGALHDG
VGFMQHNIQDGQRMSTYRAFIEPVIERPNLTVRTGCELQRVLFEGRTAVGIEVLKSGRLE
RIYAAREVILSAGSLKTPQMLMLSGIGPRAELEKHAIPEVLNSPGVGQNLQDHFYIHTAF
RCTPDSSYNANLVGLRKYWEGFRYLMTRKGYLALGSSQVAAFVKSSPDEDYADLQISFRP
MTFQYFPDGTVDVERHPGLGVSVYQLRPSTTGTVTLRSTNPSDPADYTPNFLSSDYDVNA
VISGVRWIRKIMNSEPIKSRVVSEELPGLHIRTDEDIYNYLVETGNSAHHQGGTCKMGND
AMAVVDERLRVRGIERLRVVDASIMPFITSGNTNAPSIMIGVKAADLIREDAMARRASSS
PVETVG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory