SitesBLAST
Comparing AO356_30355 FitnessBrowser__pseudo5_N2C3_1:AO356_30355 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6slbAAA Enoyl-CoA hydratase/carnithine racemase (see paper)
43% identity, 96% coverage: 12:264/264 of query aligns to 13:257/257 of 6slbAAA
- active site: Q64 (≠ G63), F69 (≠ E74), L80 (= L86), N84 (≠ H91), A108 (= A115), S111 (≠ D118), A130 (= A137), F131 (≠ Y138), L136 (= L143), P138 (= P145), D139 (≠ G146), A224 (≠ E231), G234 (≠ Q241)
- binding (~{E})-6-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-6-oxidanylidene-hex-3-enoic acid: R58 (≠ D57), A62 (≠ S61), Q64 (≠ G63), D65 (= D64), L66 (= L65), Y76 (≠ R82), A108 (= A115), F131 (≠ Y138), D139 (≠ G146)
6slaAAA Enoyl-CoA hydratase/carnithine racemase (see paper)
42% identity, 96% coverage: 12:264/264 of query aligns to 10:245/245 of 6slaAAA
- active site: Q61 (≠ G63), L68 (≠ I84), N72 (≠ H91), A96 (= A115), S99 (≠ D118), A118 (= A137), F119 (≠ Y138), L124 (= L143), P126 (= P145), N127 (≠ G146), A212 (≠ E231), G222 (≠ Q241)
- binding ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 2-(2,5-dihydrooxepin-7-yl)ethanethioate: L21 (≠ K23), A59 (≠ S61), Q61 (≠ G63), D62 (= D64), L63 (= L65), L68 (≠ I84), Y71 (≠ T90), A94 (≠ V113), G95 (= G114), A96 (= A115), F119 (≠ Y138), I122 (≠ V141), L124 (= L143), N127 (≠ G146), F234 (≠ Y253), K237 (= K256)
5zaiC Crystal structure of 3-hydroxypropionyl-coa dehydratase from metallosphaera sedula (see paper)
36% identity, 99% coverage: 4:264/264 of query aligns to 6:259/259 of 5zaiC
- active site: A65 (≠ G63), F70 (≠ E74), S82 (≠ Q87), R86 (≠ H91), G110 (≠ A115), E113 (≠ D118), P132 (≠ A137), E133 (≠ Y138), I138 (≠ L143), P140 (= P145), G141 (= G146), A226 (≠ E231), F236 (≠ Q241)
- binding coenzyme a: K24 (= K22), L25 (≠ K23), A63 (≠ S61), G64 (= G62), A65 (≠ G63), D66 (= D64), I67 (≠ L65), P132 (≠ A137), R166 (≠ F171), F248 (≠ Y253), K251 (= K256)
5jbxB Crystal structure of liuc in complex with coenzyme a and malonic acid (see paper)
31% identity, 100% coverage: 1:264/264 of query aligns to 4:261/261 of 5jbxB
- active site: A67 (≠ G63), R72 (= R68), L84 (≠ Q87), R88 (≠ H91), G112 (≠ A115), E115 (≠ D118), T134 (≠ A137), E135 (≠ Y138), I140 (≠ L143), P142 (= P145), G143 (= G146), A228 (≠ E231), L238 (≠ Q241)
- binding coenzyme a: S24 (≠ E21), R25 (≠ K22), R26 (≠ K23), A28 (= A25), A65 (≠ S61), D68 (= D64), L69 (= L65), K70 (≠ G66), L110 (≠ V113), G111 (= G114), T134 (≠ A137), E135 (≠ Y138), L138 (≠ V141), R168 (≠ F171)
2dubA Enoyl-coa hydratase complexed with octanoyl-coa (see paper)
31% identity, 97% coverage: 7:261/264 of query aligns to 14:251/254 of 2dubA
- active site: A67 (≠ G63), M72 (≠ R68), S82 (≠ T78), G105 (≠ A115), E108 (≠ D118), P127 (≠ A137), E128 (≠ Y138), T133 (≠ L143), P135 (= P145), G136 (= G146), K221 (≠ E231), F231 (≠ Q241)
- binding octanoyl-coenzyme a: K25 (≠ E21), A26 (≠ K22), L27 (≠ K23), A29 (= A25), A65 (≠ S61), A67 (≠ G63), D68 (= D64), I69 (≠ L65), K70 (≠ G66), G105 (≠ A115), E108 (≠ D118), P127 (≠ A137), E128 (≠ Y138), G136 (= G146), A137 (≠ N147)
1mj3A Crystal structure analysis of rat enoyl-coa hydratase in complex with hexadienoyl-coa (see paper)
31% identity, 97% coverage: 7:261/264 of query aligns to 15:255/258 of 1mj3A
- active site: A68 (≠ G63), M73 (≠ R68), S83 (≠ T78), L85 (= L80), G109 (≠ A115), E112 (≠ D118), P131 (≠ A137), E132 (≠ Y138), T137 (≠ L143), P139 (= P145), G140 (= G146), K225 (≠ E231), F235 (≠ Q241)
- binding hexanoyl-coenzyme a: K26 (≠ E21), A27 (≠ K22), L28 (≠ K23), A30 (= A25), A66 (≠ S61), G67 (= G62), A68 (≠ G63), D69 (= D64), I70 (≠ L65), G109 (≠ A115), P131 (≠ A137), E132 (≠ Y138), L135 (≠ V141), G140 (= G146)
2hw5C The crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1
33% identity, 97% coverage: 7:261/264 of query aligns to 15:257/260 of 2hw5C
- active site: A68 (≠ G63), M73 (≠ G75), S83 (≠ R85), L87 (≠ V89), G111 (≠ A115), E114 (≠ D118), P133 (≠ A137), E134 (≠ Y138), T139 (≠ L143), P141 (= P145), G142 (= G146), K227 (≠ E231), F237 (≠ Q241)
- binding crotonyl coenzyme a: K26 (≠ E21), A27 (≠ K22), L28 (≠ K23), A30 (= A25), K62 (≠ D57), I70 (≠ L65), F109 (≠ V113)
Q9P4U9 Enoyl-CoA hydratase AKT3-1; AF-toxin biosynthesis protein 3-1; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see paper)
33% identity, 95% coverage: 12:261/264 of query aligns to 25:268/296 of Q9P4U9
Sites not aligning to the query:
- 294:296 Peroxisomal targeting signal type 1
1ey3A Structure of enoyl-coa hydratase complexed with the substrate dac-coa (see paper)
32% identity, 97% coverage: 7:261/264 of query aligns to 13:255/258 of 1ey3A
- active site: A66 (≠ G63), M71 (vs. gap), S81 (≠ E74), L85 (= L86), G109 (≠ A115), E112 (≠ D118), P131 (≠ A137), E132 (≠ Y138), T137 (≠ L143), P139 (= P145), G140 (= G146), K225 (≠ E231), F235 (≠ Q241)
- binding 4-(n,n-dimethylamino)cinnamoyl-coa: K24 (≠ E21), L26 (≠ K23), A28 (= A25), A64 (≠ S61), G65 (= G62), A66 (≠ G63), D67 (= D64), I68 (≠ L65), L85 (= L86), W88 (≠ V89), G109 (≠ A115), P131 (≠ A137), L135 (≠ V141), G140 (= G146)
1dubA 2-enoyl-coa hydratase, data collected at 100 k, ph 6.5 (see paper)
32% identity, 97% coverage: 7:261/264 of query aligns to 15:257/260 of 1dubA
- active site: A68 (≠ G63), M73 (vs. gap), S83 (≠ E74), L87 (= L86), G111 (≠ A115), E114 (≠ D118), P133 (≠ A137), E134 (≠ Y138), T139 (≠ L143), P141 (= P145), G142 (= G146), K227 (≠ E231), F237 (≠ Q241)
- binding acetoacetyl-coenzyme a: K26 (≠ E21), A27 (≠ K22), L28 (≠ K23), A30 (= A25), A66 (≠ S61), A68 (≠ G63), D69 (= D64), I70 (≠ L65), Y107 (≠ A111), G110 (= G114), G111 (≠ A115), E114 (≠ D118), P133 (≠ A137), E134 (≠ Y138), L137 (≠ V141), G142 (= G146), F233 (≠ M237), F249 (≠ Y253)
P14604 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Rattus norvegicus (Rat) (see 3 papers)
32% identity, 97% coverage: 7:261/264 of query aligns to 45:287/290 of P14604
- E144 (≠ D118) mutation to D: Reduces activity 50-fold.; mutation to Q: Reduces activity 3300-fold.
- E164 (≠ Y138) mutation to D: Reduces activity 1250-fold.; mutation to Q: Reduces activity 330000-fold.
Sites not aligning to the query:
- 1:29 modified: transit peptide, Mitochondrion
3q0gD Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
31% identity, 95% coverage: 11:261/264 of query aligns to 12:249/250 of 3q0gD
- active site: A64 (≠ G63), M69 (≠ R68), T75 (≠ E74), F79 (≠ T78), G103 (≠ A115), E106 (≠ D118), P125 (≠ A137), E126 (≠ Y138), V131 (≠ L143), P133 (= P145), G134 (= G146), L219 (≠ E231), F229 (≠ Q241)
- binding Butyryl Coenzyme A: F225 (≠ M237), F241 (≠ Y253)
3q0jC Crystal structure of the mycobacterium tuberculosis crotonase in complex with the inhibitor acetoacetylcoa
31% identity, 95% coverage: 11:261/264 of query aligns to 13:254/255 of 3q0jC
- active site: A65 (≠ G63), M70 (≠ A69), T80 (≠ P79), F84 (≠ K83), G108 (≠ A115), E111 (≠ D118), P130 (≠ A137), E131 (≠ Y138), V136 (≠ L143), P138 (= P145), G139 (= G146), L224 (≠ E231), F234 (≠ Q241)
- binding acetoacetyl-coenzyme a: Q23 (≠ E21), A24 (≠ K22), L25 (≠ K23), A27 (= A25), A63 (≠ S61), G64 (= G62), A65 (≠ G63), D66 (= D64), I67 (≠ L65), K68 (≠ R67), M70 (≠ A69), F84 (≠ K83), G107 (= G114), G108 (≠ A115), E111 (≠ D118), P130 (≠ A137), E131 (≠ Y138), P138 (= P145), G139 (= G146), M140 (≠ N147)
3q0gC Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
31% identity, 95% coverage: 11:261/264 of query aligns to 13:254/255 of 3q0gC
- active site: A65 (≠ G63), M70 (≠ A69), T80 (≠ P79), F84 (≠ K83), G108 (≠ A115), E111 (≠ D118), P130 (≠ A137), E131 (≠ Y138), V136 (≠ L143), P138 (= P145), G139 (= G146), L224 (≠ E231), F234 (≠ Q241)
- binding coenzyme a: L25 (≠ K23), A63 (≠ S61), I67 (≠ L65), K68 (≠ R67), Y104 (≠ A111), P130 (≠ A137), E131 (≠ Y138), L134 (≠ V141)
3h81A Crystal structure of enoyl-coa hydratase from mycobacterium tuberculosis (see paper)
31% identity, 96% coverage: 11:264/264 of query aligns to 12:256/256 of 3h81A
- active site: A64 (≠ G63), M69 (≠ A69), T79 (≠ P79), F83 (≠ K83), G107 (≠ A115), E110 (≠ D118), P129 (≠ A137), E130 (≠ Y138), V135 (≠ L143), P137 (= P145), G138 (= G146), L223 (≠ E231), F233 (≠ Q241)
- binding calcium ion: F233 (≠ Q241), Q238 (≠ Y246)
3p85A Crystal structure enoyl-coa hydratase from mycobacterium avium (see paper)
35% identity, 81% coverage: 11:225/264 of query aligns to 10:199/224 of 3p85A
- active site: L62 (≠ G63), L67 (≠ T90), P68 (≠ H91), G92 (≠ A115), E95 (≠ D118), T114 (≠ A137), H115 (≠ Y138), L120 (= L143), P122 (= P145), T123 (≠ G146)
- binding calcium ion: D43 (≠ N44), D45 (= D46)
Sites not aligning to the query:
Q5HH38 1,4-dihydroxy-2-naphthoyl-CoA synthase; DHNA-CoA synthase; EC 4.1.3.36 from Staphylococcus aureus (strain COL) (see paper)
33% identity, 93% coverage: 17:261/264 of query aligns to 28:266/273 of Q5HH38