SitesBLAST

G89 (= G83) mutation to E: In sard4-3; compromises systemic acquired resistance (SAR).
G138 (= G132) mutation to D: In sard4-4; compromises systemic acquired resistance (SAR).
S205 (= S194) mutation to N: In sard4-1; compromises systemic acquired resistance (SAR).

6t3eB Structure of thermococcus litoralis delta(1)-pyrroline-2-carboxylate reductase in complex with nadh and l-proline (see paper)
34% identity, 99% coverage: 1:314/318 of query aligns to 1:317/325 of 6t3eB

query
sites
6t3eB

M

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binding 1,4-dihydronicotinamide adenine dinucleotide: L71 (≠ V69), S82 (≠ A80), V83 (= V81), T107 (= T105), R110 (= R108), T111 (= T109), G134 (= G132), A135 (≠ T133), G136 (= G134), V137 (≠ A135), Q138 (≠ L136), Y158 (≠ W156), D159 (≠ G157), I160 (≠ R158), N164 (≠ K162), A199 (= A196), T200 (= T197), T201 (≠ L198), A202 (= A199), V206 (≠ L203), V221 (= V218), G222 (= G219), W223 (≠ G220), S296 (= S293), V297 (= V294), G298 (= G295)
binding proline: R39 (= R35), L52 (= L51), M54 (= M53), K67 (= K65), V69 (= V67), V83 (= V81), R110 (= R108), W223 (≠ G220), V297 (= V294)

2i99A Crystal structure of human mu_crystallin at 2.6 angstrom (see paper)
36% identity, 87% coverage: 29:306/318 of query aligns to 40:304/312 of 2i99A

query
sites
2i99A

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active site: G59 (≠ L51), S228 (≠ F221)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: D81 (= D72), S90 (≠ A80), H91 (≠ V81), T115 (= T105), R118 (= R108), T119 (= T109), G142 (= G132), A143 (≠ T133), G144 (= G134), V145 (≠ A135), Q146 (≠ L136), N167 (≠ G157), R168 (= R158), T169 (≠ S159), N172 (≠ K162), V203 (≠ A196), T204 (= T197), L205 (= L198), A206 (= A199), V225 (= V218), G226 (= G219), S228 (≠ F221), S291 (= S293), L292 (≠ V294), G293 (= G295)

Q14894 Ketimine reductase mu-crystallin; NADP-regulated thyroid-hormone-binding protein; EC 1.5.1.25 from Homo sapiens (Human) (see paper)
36% identity, 87% coverage: 29:306/318 of query aligns to 41:305/314 of Q14894

query
sites
Q14894

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GAGVQA 143:148 (≠ GTGALA 132:137) binding
N168 (≠ G157) binding
R169 (= R158) binding

4bv9A Crystal structure of the NADPH form of mouse mu-crystallin. (see paper)
37% identity, 87% coverage: 29:306/318 of query aligns to 39:296/303 of 4bv9A

query
sites
4bv9A

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L

active site: G58 (≠ L51), S220 (≠ F221)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: S82 (≠ A80), H83 (≠ V81), T107 (= T105), R110 (= R108), T111 (= T109), G134 (= G132), A135 (≠ T133), G136 (= G134), V137 (≠ A135), Q138 (≠ L136), N159 (≠ G157), R160 (= R158), T161 (≠ S159), N164 (≠ K162), V195 (≠ A196), T196 (= T197), M197 (≠ L198), A198 (= A199), V217 (= V218), G218 (= G219), S220 (≠ F221), S283 (= S293), L284 (≠ V294), G285 (= G295)
binding pyruvic acid: R45 (= R35), M60 (= M53), K73 (= K65), V75 (= V67), T107 (= T105), R110 (= R108), L284 (≠ V294), G285 (= G295)

4bvaA Crystal structure of the NADPH-t3 form of mouse mu-crystallin. (see paper)
36% identity, 87% coverage: 29:306/318 of query aligns to 40:295/303 of 4bvaA

query
sites
4bvaA

G

G

V

V

E

M

V

Q

P

P

M

V

R
|
R

H

-

T

T

V
|
V

E

V

T

P

Y

V

G

A

Q

K

S

H

D

R

G

G

T
x
F

L

L

L
x
G

L

V

M

M

P

P

A

A

W

Y

Q

S

V

A

N

A

Q

E

-

D

S

A

I

L

G

T

V

T

K

K

V

L

V
|
V

T

T

V
x
F

F

Y

P

E

D

S

N
x
H

G

-

A

-

K

-

D

-

L

-

P

-

A

-

V

-

Q

Q

G

A

L

S

Y

V

L

L

M

F

D

D

G

P

K

S

T

N

G

G

M

S

P

L

Q

L

A

A

V

V

L

M

D

D

G

G

T

N

A

V

L

I

T
|
T

K

A

R

K

R
|
R

T
|
T

A

A

A

V

S

S

A

A

L

I

A

A

A

T

S

K

Y

L

L

L

A

K

R

P

P

P

D

G

S

S

E

D

R

V

L

L

L

C

M

I

V

L

G
|
G

T
x
A

G
|
G

A
x
V

L
x
Q

A

A

P

Y

E

S

L

H

I

Y

E

E

A

I

F

F

A

T

T

E

V

Q

L

F

P

S

I

F

K

K

H

E

V

V

L

R

V

M

W

W

G
x
N

R
|
R

S
x
T

L

R

E

E

K
x
N

A

A

K

E

K

K

V

F

A

A

S

S

R

T

F

V

H

Q

R

G

P

-

K

-

F

-

R

D

I

V

E

R

A

V

T

C

A

S

D

S

L

V

E

Q

G

E

A

A

V

V

R

T

G

G

A

A

Q

D

V

V

I

I

S

I

C

T

A
x
V

T
|
T

L
x
M

A
|
A

K

T

E

E

P

P

L

I

I

L

R

F

G

G

E

E

W

W

L

V

Q

K

P

P

G

G

A

A

H

H

L

I

D

N

L

A

V
|
V

G
|
G

G

A

F
x
S

T
x
R

P

P

E

D

M
x
W

R

R

E

E

A

L

D

D

D

E

C

L

I

M

R

R

R

Q

S

A

R

V

V

L

F

Y

V

V

D

D

T

S

R

R

E

E

G

A

A

A

C

L

K

K

E
|
E

A

S

G

G

D

D

I

V

V

-

Q

-

P

-

M

-

K

-

A

-

G

-

I

L

L

L

T

S

D

G

A

A

D

D

I

I

A

F

G

A

D

E

L

L

Y

G

D

E

L

V

T

I

R

S

G

G

Q

A

R

K

A

P

G

A

R

H

R

-

F

-

Y

C

D

E

Q

K

I

T

T

T

L

V

F

F

K

K

S
|
S

V
x
L

G
|
G

T

M

A

A

L

V

E

E

D

D

L

L

C

V

A

A

Q

K

L

L

active site: G59 (≠ L51), S219 (≠ F221)
binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: H82 (≠ N73), T106 (= T105), R109 (= R108), T110 (= T109), G133 (= G132), A134 (≠ T133), G135 (= G134), V136 (≠ A135), Q137 (≠ L136), N158 (≠ G157), R159 (= R158), T160 (≠ S159), N163 (≠ K162), V194 (≠ A196), T195 (= T197), M196 (≠ L198), A197 (= A199), V216 (= V218), G217 (= G219), S219 (≠ F221), S282 (= S293), L283 (≠ V294), G284 (= G295)
binding 3,5,3'triiodothyronine: R46 (= R35), V48 (= V40), F57 (≠ T49), G59 (≠ L51), V76 (= V67), F78 (≠ V69), H82 (≠ N73), S219 (≠ F221), R220 (≠ T222), W223 (≠ M225), E247 (= E249)

1omoA Alanine dehydrogenase dimer w/bound NAD (archaeal) (see paper)
28% identity, 98% coverage: 4:315/318 of query aligns to 6:312/320 of 1omoA

query
sites
1omoA

V

L

T

T

G

Q

A

E

E

E

L

V

K

E

S

S

V

L

L

I

H

S

F

M

R

D

M

E

L

A

I

M

E

N

R

A

M

V

R

E

Q

E

T

A

F

F

R

R

-

L

-

Y

-

A

-

L

A

G

G

K

V

A

E

Q

V

M

P

P

M

P

R

K

H

V

H

Y

H

L

T

E

V

F

E

E

T

K

Y

-

G

-

Q

-

S

-

D

-

G

G

T

D

L

L

L
x
R

L

A

M

M

P

P

A

A

W

H

Q

L

V

M

N

G

Q

Y

S

A

I

-

G

G

V

L

K

K

V

W

V

V

T

N

V

S

F

H

P

P

D

G

N

N

G

P

A

D

K

K

D

G

L

L

P

P

A

T

V

V

Q

M

G

A

L

L

Y

M

L

I

L

L

M

N

D

S

G

P

K

E

T

T

G

G

M

F

P

P

Q

L

A

A

V

V

L

M

D

D

G

A

T

T

A

Y

L

T

T

T

K

S

R

L

R
|
R

T
|
T

A

G

A

A

S

G

A

G

L

I

A

A

S

K

Y

Y

L

L

A

A

R

R

P

K

D

N

S

S

E

S

R

V

L

F

L

G

M

F

V

I

G
|
G

T
x
C

G
|
G

A
x
T

L
x
Q

A

A

P

Y

E

F

L

Q

I

L

E

E

A

A

F

L

A

R

T

R

V

V

L

F

P

D

I

I

K

G

H

E

V

V

L

K

V

A

W
x
Y

G
x
D

R
x
V

S
x
R

L

E

E

K

K

A

A

A

K

K

V

F

A

V

S

S

R

-

F

-

H

Y

R

C

P

E

K

D

F

R

R

G

I

I

E

S

A

A

T

S

A

V

D

Q

L

P

E

A

G

E

A

E

V

A

R

S

G

R

A

C

Q

D

V

V

I

L

S

V

C

T

A
x
T

T
|
T

L
x
P

A

S

K

R

E

K

P

P

L
x
V

I

V

R

K

G

A

E

E

W

W

L

V

Q

E

P

E

G

G

A

T

H

H

L

I

D

N

L

A

V
x
I

G
|
G

G

A

F
x
D

T

G

P

P

E

G

M
x
K

R

Q

E

E

A

L

D

D

D

V

D

E

C

I

I

L

R

K

S

A

R

K

V

I

F

V

V

V

D

D

T

D

R

L

E

E

G

Q

A

A

C

-

K

K

E

H

A

G

G

G

D

E

I

I

V

N

Q

V

P

A

M

V

K

S

A

K

G

G

I

V

L

I

T

G

D

V

A

E

D

D

I

V

A

H

G

A

D

T

L

I

Y

G

D

E

L

V

T

I

R

A

G

G

Q

L

R

K

A

D

G

G

R

R

R

E

F

S

Y

D

D

E

Q

E

I

I

T

T

L

I

F

F

K

D

S
|
S

V
x
T

G
|
G

T

L

A

A

L

I

E

Q

D

D

L

V

C

A

A

V

A

A

Q

K

L

V

A

V

V

Y

E

E

M

N

V

A

I

L

H

S

N

K

D

N

active site: R52 (≠ L51), D219 (≠ F221)
binding nicotinamide-adenine-dinucleotide: R108 (= R108), T109 (= T109), G132 (= G132), C133 (≠ T133), G134 (= G134), T135 (≠ A135), Q136 (≠ L136), Y156 (≠ W156), D157 (≠ G157), V158 (≠ R158), R159 (≠ S159), T194 (≠ A196), T195 (= T197), P196 (≠ L198), V201 (≠ L203), I216 (≠ V218), G217 (= G219), D219 (≠ F221), K223 (≠ M225), S290 (= S293), T291 (≠ V294), G292 (= G295)

O28608 Alanine dehydrogenase; AlaDH; EC 1.4.1.1 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
28% identity, 98% coverage: 4:315/318 of query aligns to 6:312/322 of O28608

query
sites
O28608

V

L

T

T

G

Q

A

E

E

E

L

V

K

E

S

S

V

L

L

I

H

S

F

M

R

D

M

E

L

A

I

M

E

N

R

A

M

V

R

E

Q

E

T

A

F

F

R

R

-

L

-

Y

-

A

-

L

A

G

G

K

V

A

E

Q

V

M

P

P

M

P

R

K

H

V

H

Y

H

L

T

E

V

F

E

E

T

K

Y

-

G

-

Q

-

S

-

D

-

G

G

T

D

L

L

L

R

L

A

M

M

P

P

A

A

W

H

Q

L

V

M

N

G

Q

Y

S

A

I

-

G

G

V

L

K

K

V

W

V

V

T

N

V

S

F

H

P

P

D

G

N

N

G

P

A

D

K

K

D

G

L

L

P

P

A

T

V

V

Q

M

G

A

L

L

Y

M

L

I

L

L

M

N

D

S

G

P

K

E

T

T

G

G

M

F

P

P

Q

L

A

A

V

V

L

M

D

D

G

A

T

T

A

Y

L

T

T

T

K

S

R

L

R
|
R

T

T

A

G

A

A

S

G

A

G

L

I

A

A

S

K

Y

Y

L

L

A

A

R

R

P

K

D

N

S

S

E

S

R

V

L

F

L

G

M

F

V

I

G

G

T

C

G

G

A
x
T

L
x
Q

A

A

P

Y

E

F

L

Q

I

L

E

E

A

A

F

L

A

R

T

R

V

V

L

F

P

D

I

I

K

G

H

E

V

V

L

K

V

A

W

Y

G
x
D

R
x
V

S
x
R

L

E

E

K

K

A

A

A

K

K

V

F

A

V

S

S

R

-

F

-

H

Y

R

C

P

E

K

D

F

R

R

G

I

I

E

S

A

A

T

S

A

V

D

Q

L

P

E

A

G

E

A

E

V

A

R

S

G

R

A

C

Q

D

V

V

I

L

S

V

C

T

A

T

T

T

L

P

A

S

K

R

E

K

P

P

L

V

I

V

R

K

G

A

E

E

W

W

L

V

Q

E

P

E

G

G

A

T

H

H

L

I

D

N

L

A

V

I

G
|
G

G
x
A

F
x
D

T

G

P

P

E

G

M
x
K

R

Q

E

E

A

L

D

D

D

V

D

E

C

I

I

L

R

K

S

A

R

K

V

I

F

V

V

V

D

D

T

D

R

L

E

E

G

Q

A

A

C

-

K

K

E

H

A

G

G

G

D

E

I

I

V

N

Q

V

P

A

M

V

K

S

A

K

G

G

I

V

L

I

T

G

D

V

A

E

D

D

I

V

A

H

G

A

D

T

L

I

Y

G

D

E

L

V

T

I

R

A

G

G

Q

L

R

K

A

D

G

G

R

R

R

E

F

S

Y

D

D

E

Q

E

I

I

T

T

L

I

F

F

K

D

S
|
S

V

T

G

G

T

L

A

A

L

I

E

Q

D

D

L

V

C

A

A

V

A

A

Q

K

L

V

A

V

V

Y

E

E

M

N

V

A

I

L

H

S

N

K

D

N

R108 (= R108) binding
TQ 135:136 (≠ AL 135:136) binding
DVR 157:159 (≠ GRS 157:159) binding
GAD 217:219 (≠ GGF 219:221) binding
K223 (≠ M225) binding
S290 (= S293) binding

1x7dA Crystal structure analysis of ornithine cyclodeaminase complexed with NAD and ornithine to 1.6 angstroms (see paper)
32% identity, 80% coverage: 48:302/318 of query aligns to 52:301/340 of 1x7dA

query
sites
1x7dA

G

G

T
x
V

L

I

L
x
E

L

L

M
|
M

P

P

A

V

W

A

Q

D

V

K

N

S

Q

R

S

-

I

Y

G

A

V

F

K
|
K

V

Y

V
|
V

T
x
N

V
x
G

F

H

P

P

D

A

N

N

G

T

A

A

K

R

D

N

L

L

P

H

A
x
T

V
|
V

Q

M

G

A

L

F

Y

G

L

V

L

L

M

A

D

D

G

V

K

D

T

S

G

G

M

Y

P

P

Q

V

A

L

V

L

L

S

D

E

G

L

T

T

A

I

L

A

T
|
T

K

A

R

L

R
|
R

T
|
T

A

A

A

T

S

S

A

L

L

M

A

A

S

Q

Y

A

L

L

A

A

R

R

P

P

D

N

S

A

E

R

R

K

L

M

L

A

M

L

V

I

G
|
G

T

N

G
|
G

A
|
A

L
x
Q

A

S

P

E

E

F

L

Q

I

A

E

L

A

A

F

F

A

H

T

K

V

H

L

L

P

G

I

I

K

E

H

E

V

I

L

V

V

A

W
x
Y

G
x
D

R
x
T

S
x
D

-

P

L

L

E

A

K

T

A

A

K

K

K

L

V

I

A

A

S

N

R

L

F

K

H

E

R

Y

P

S

K

G

F

L

R

T

I

I

E

R

A

R

T

A

A

S

D

S

L

V

E

A

G

E

A

A

V

V

R

K

G

G

A

V

Q

D

V

I

I

I

S

T

C

T

A
x
V

T
|
T

L
x
A

A

D

K

K

-

A

-

Y

E

A

P

T

L
x
I

I

I

R

T

G

P

E

D

W

M

L

L

Q

E

P

P

G

G

A

M

H

H

L

L

D

N

L

A

V
|
V

G
|
G

G

G

F
x
D

T

C

P

P

E

G

M
x
K

R

T

E

E

A

L

D

H

D

A

D

D

C

V

I

L

R

R

R

N

S

A

R

R

V

V

F

F

V

V

D

E

T

-

R

Y

E

E

G

P

A

Q

C

T

K

R

E

I

A

E

G

G

D

E

I

I

V

Q

Q

Q

-

L

P

P

M

A

K

D

A

F

G

P

I

V

L

V

T

-

D

-

A

-

D

-

I

-

A

-

G

-

D

D

L

L

Y

W

D

R

L

V

T

L

R

R

G

G

Q

E

R

T

A

E

G

G

R

R

R

Q

F

S

Y

D

D

S

Q

Q

I

V

T

T

L

V

F

F

K

D

S
|
S

V
|
V

G
|
G

T

F

A

A

L

L

E

E

D

D

L

Y

C

T

active site: E55 (≠ L51), D227 (≠ F221)
binding nicotinamide-adenine-dinucleotide: T83 (≠ A80), V84 (= V81), T108 (= T105), R111 (= R108), T112 (= T109), G135 (= G132), G137 (= G134), A138 (= A135), Q139 (≠ L136), Y159 (≠ W156), D160 (≠ G157), T161 (≠ R158), D162 (≠ S159), V200 (≠ A196), T201 (= T197), A202 (≠ L198), I209 (≠ L203), V224 (= V218), G225 (= G219), D227 (≠ F221), K231 (≠ M225), S292 (= S293), V293 (= V294), G294 (= G295)
binding L-ornithine: V53 (≠ T49), E55 (≠ L51), M57 (= M53), K68 (= K65), V70 (= V67), N71 (≠ T68), G72 (≠ V69), R111 (= R108), D227 (≠ F221), V293 (= V294), G294 (= G295)

Sites not aligning to the query:

binding L-ornithine: 44

1u7hA Structure and a proposed mechanism for ornithine cyclodeaminase from pseudomonas putida (see paper)
32% identity, 80% coverage: 48:302/318 of query aligns to 52:301/341 of 1u7hA

query
sites
1u7hA

G

G

T

V

L

I

L
x
E

L

L

M

M

P

P

A

V

W

A

Q

D

V

K

N

S

Q

R

S

-

I

Y

G

A

V

F

K

K

V

Y

V

V

T

N

V

G

F

H

P

P

D

A

N

N

G

T

A

A

K

R

D

N

L

L

P

H

A
x
T

V
|
V

Q

M

G

A

L

F

Y

G

L

V

L

L

M

A

D

D

G

V

K

D

T

S

G

G

M

Y

P

P

Q

V

A

L

V

L

L

S

D

E

G

L

T

T

A

I

L

A

T

T

K

A

R

L

R
|
R

T
|
T

A

A

A

T

S

S

A

L

L

M

A

A

S

Q

Y

A

L

L

A

A

R

R

P

P

D

N

S

A

E

R

R

K

L

M

L

A

M

L

V

I

G
|
G

T

N

G
|
G

A
|
A

L
x
Q

A

S

P

E

E

F

L

Q

I

A

E

L

A

A

F

F

A

H

T

K

V

H

L

L

P

G

I

I

K

E

H

E

V

I

L

V

V

A

W
x
Y

G
x
D

R
x
T

S
x
D

-

P

L

L

E

A

K

T

A

A

K

K

K

L

V

I

A

A

S

N

R

L

F

K

H

E

R

Y

P

S

K

G

F

L

R

T

I

I

E

R

A

R

T

A

A

S

D

S

L

V

E

A

G

E

A

A

V

V

R

K

G

G

A

V

Q

D

V

I

I

I

S

T

C

T

A
x
V

T
|
T

L
x
A

A

D

K

K

-

A

-

Y

E

A

P

T

L
x
I

I

I

R

T

G

P

E

D

W

M

L

L

Q

E

P

P

G

G

A

M

H

H

L

L

D

N

L

A

V
|
V

G
|
G

G

G

F
x
D

T

C

P

P

E

G

M
x
K

R

T

E

E

A

L

D

H

D

A

D

D

C

V

I

L

R

R

R

N

S

A

R

R

V

V

F

F

V

V

D

E

T

-

R

Y

E

E

G

P

A

Q

C

T

K

R

E

I

A

E

G

G

D

E

I

I

V

Q

Q

Q

-

L

P

P

M

A

K

D

A

F

G

P

I

V

L

V

T

-

D

-

A

-

D

-

I

-

A

-

G

-

D

D

L

L

Y

W

D

R

L

V

T

L

R

R

G

G

Q

E

R

T

A

E

G

G

R

R

R

Q

F

S

Y

D

D

S

Q

Q

I

V

T

T

L

V

F

F

K

D

S
|
S

V
|
V

G
|
G

T

F

A

A

L

L

E

E

D

D

L

Y

C

T

active site: E55 (≠ L51), D227 (≠ F221)
binding nicotinamide-adenine-dinucleotide: T83 (≠ A80), V84 (= V81), R111 (= R108), T112 (= T109), G135 (= G132), G137 (= G134), A138 (= A135), Q139 (≠ L136), Y159 (≠ W156), D160 (≠ G157), T161 (≠ R158), D162 (≠ S159), V200 (≠ A196), T201 (= T197), A202 (≠ L198), I209 (≠ L203), V224 (= V218), G225 (= G219), D227 (≠ F221), K231 (≠ M225), S292 (= S293), V293 (= V294), G294 (= G295)

Q88H32 Ornithine cyclodeaminase; OCD; EC 4.3.1.12 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
32% identity, 80% coverage: 48:302/318 of query aligns to 53:302/350 of Q88H32

query
sites
Q88H32

G

G

T

V

L

I

L

E

L

L

M

M

P

P

A

V

W

A

Q

D

V

K

N

S

Q

R

S

-

I

Y

G

A

V

F

K
|
K

V

Y

V

V

T

N

V

G

F

H

P

P

D

A

N

N

G

T

A

A

K

R

D

N

L

L

P

H

A
x
T

V

V

Q

M

G

A

L

F

Y

G

L

V

L

L

M

A

D

D

G

V

K

D

T

S

G

G

M

Y

P

P

Q

V

A

L

V

L

L

S

D

E

G

L

T

T

A

I

L

A

T

T

K

A

R

L

R
|
R

T

T

A

A

A

T

S

S

A

L

L

M

A

A

S

Q

Y

A

L

L

A

A

R

R

P

P

D

N

S

A

E

R

R

K

L

M

L

A

M

L

V

I

G

G

T

N

G

G

A
|
A

L
x
Q

A

S

P

E

E

F

L

Q

I

A

E

L

A

A

F

F

A

H

T

K

V

H

L

L

P

G

I

I

K

E

H

E

V

I

L

V

V

A

W

Y

G
x
D

R

T

S

D

-

P

L

L

E

A

K

T

A

A

K

K

K

L

V

I

A

A

S

N

R

L

F

K

H

E

R

Y

P

S

K

G

F

L

R

T

I

I

E

R

A

R

T

A

A

S

D

S

L

V

E

A

G

E

A

A

V

V

R

K

G

G

A

V

Q

D

V

I

I

I

S

T

C

T

A

V

T
|
T

L

A

A

D

K

K

-

A

-

Y

E

A

P

T

L

I

I

I

R

T

G

P

E

D

W

M

L

L

Q

E

P

P

G

G

A

M

H

H

L

L

D

N

L

A

V
|
V

G
|
G

F
x
D

T

C

P

P

E

G

M
x
K

R

T

E

E

A

L

D

H

D

A

D

D

C

V

I

L

R

R

R

N

S

A

R

R

V

V

F

F

V

V

D

E

T

Y

R

-

E

E

G

P

A

Q

C

T

K

R

E

I

A

E

G

G

D

E

I

I

V

Q

Q

Q

-

L

P

P

M

A

K

D

A

F

G

P

I

V

L

V

T

-

D

-

A

-

D

-

I

-

A

-

G

-

D

D

L

L

Y

W

D

R

L

V

T

L

R

R

G

G

Q

E

R

T

A

E

G

G

R

R

R

Q

F

S

Y

D

D

S

Q

Q

I

V

T

T

L

V

F

F

K

D

S
|
S

V
|
V

G

G

T

F

A

A

L

L

E

E

D

D

L

Y

C

T

K69 (= K65) binding
T84 (≠ A80) binding
R112 (= R108) binding ; binding
AQ 139:140 (≠ AL 135:136) binding
D161 (≠ G157) binding
T202 (= T197) binding
VGGD 225:228 (≠ VGGF 218:221) binding
D228 (≠ F221) binding
K232 (≠ M225) binding
S293 (= S293) binding
V294 (= V294) binding

Sites not aligning to the query:

45 binding
331 binding

4mp6A Staphyloferrin b precursor biosynthetic enzyme sbnb bound to citrate and NAD+ (see paper)
27% identity, 76% coverage: 63:304/318 of query aligns to 74:315/334 of 4mp6A

query
sites
4mp6A

G

G

V

I

K

K

V

W

V

I

T

G

V

S

F

K

P

H

D

D

N

N

G

P

A

S

K

K

-

R

D

N

L

M

P

E

A
x
R

V

A

Q

S

G

G

L

V

Y

I

L

I

L

L

M

N

D

D

G

P

K

E

T

T

G

N

M

Y

P

P

Q

I

A

A

V

V

L

M

D

E

G

A

T

S

A

L

L

I

T

S

K

S

R

M

R
|
R

T
|
T

A

A

A

V

S

S

A

V

L

I

A

A

S

K

Y

H

L

L

A

A

R

K

P

K

D

G

S

F

E

K

R

D

L

L

L

T

M

I

V

I

G
|
G

T
x
C

G
|
G

A
x
L

L
x
I

A

G

P

D

E

K

L

Q

I

L

E

Q

A

S

F

M

A

L

T

E

V

Q

L

F

P

D

-

H

I

I

K

E

H

R

V

V

L

F

V

V

W
x
Y

G
x
D

R
x
Q

S

F

L

S

E

E

K

A

A

C

K

A

K

R

V

F

A

V

S

D

R

R

F

W

H

Q

-

Q

R

R

P

P

K

E

F

I

R

N

I

F

E

I

A

A

T

T

A

E

D

N

L

A

E

K

G

E

A

A

V

V

R

S

G

N

A

G

Q

E

V

V

I

V

S

I

C

T

A
x
C

T
|
T

L
x
V

A
x
T

K

D

E

Q

P

P

L
x
Y

I

I

R

E

G

Y

E

D

W

W

L

L

Q

Q

P

K

G

G

A

A

H

F

L

I

D

S

L

N

V
x
I

G
x
S

G

I

F

-

T

-

P

-

E

-

M
|
M

R

D

E

V

A

H

D

K

D

E

D

V

C

F

I

I

R

K

R

A

S

D

R

K

V

V

F

V

V

V

D

D

T

D

R

W

E

S

G

Q

A

C

C

N

K

R

E

E

A

K

G

K

D

T

I

I

V

N

Q

Q

P

L

M

V

K

L

A

E

G

G

I

K

L

F

T

S

D

K

A

E

D

A

I

L

A

H

G

A

D

E

L

L

Y

G

D

Q

L

L

T

V

R

T

G

G

Q

D

R

I

A

P

G

G

R

R

R

E

F

D

Y

D

D

D

Q

E

I

I

T

I

L

L

F

L

K

N

S
x
P

V
x
M

G
|
G

T

M

A

A

L

I

E

E

D

D

L

I

C

S

A

S

A

A

active site: M236 (= M225)
binding nicotinamide-adenine-dinucleotide: R92 (≠ A80), R120 (= R108), T121 (= T109), G144 (= G132), C145 (≠ T133), G146 (= G134), L147 (≠ A135), I148 (≠ L136), Y169 (≠ W156), D170 (≠ G157), Q171 (≠ R158), C211 (≠ A196), T212 (= T197), V213 (≠ L198), T214 (≠ A199), Y218 (≠ L203), I233 (≠ V218), S234 (≠ G219), P304 (≠ S293), M305 (≠ V294), G306 (= G295)

Sites not aligning to the query:

active site: 60

5gziA Cyclodeaminase_pa
31% identity, 83% coverage: 53:315/318 of query aligns to 69:327/354 of 5gziA

query
sites
5gziA

M
|
M

P

P

A

H

W

R

Q

E

V

P

N

G

Q

D

S

H

I

I

G

T

V

L

K
|
K

V

T

V

V

T

G

V
x
Y

F

S

P

P

D

A

N

N

G

P

A

A

K

R

-

F

D

G

L

L

P

P

A
x
T

V
x
I

Q

L

G

G

L

T

Y

V

L

A

L

R

M

Y

D

D

G

D

K

T

T

T

G

G

M

A

P

L

Q

T

A

A

V

L

L

M

D

D

G

G

T

V

A

L

L

L

T
|
T

K

A

R

L

R
|
R

T
|
T

A

G

A

A

S

S

A

A

L

V

A

A

A

S

S

R

Y

L

L

L

A

A

R

R

P

P

D

D

S

S

E

H

R

T

L

L

L

G

M

L

V
x
I

G
|
G

T

T

G
|
G

A
|
A

L
x
Q

A

A

P

V

E

T

L

Q

I

L

E

H

A

A

F

L

A

S

T

L

V

V

L

L

P

P

I

L

K

Q

H

R

V

A

L

L

V

V

W

W

G
x
D

R
x
T

S
x
D

L

P

E

A

K
x
H

A

R

K

E

K

S

V

F

A

A

S

R

R

R

F

A

H

A

R

F

P

T

K

G

F

V

R

S

I

V

E

E

A

I

T

A

A

E

D

P

L

A

E

R

G

I

A

A

V

A

R

E

G

-

A

A

Q

D

V

V

I

I

S

S

C

T

A
|
A

T
|
T

-
x
S

-
x
V

-

A

L

V

A

G

K

Q

E

G

P

P

L
x
V

I

L

R

P

G

D

E

T

W

G

L

V

Q

R

P

E

G

H

A

L

H

H

L

I

D

N

L

A

V
|
V

G
|
G

G
x
A

F
x
D

T

L

P

V

E

G

M
x
K

R

T

E

E

A

L

D

P

D

L

D

G

C

L

I

L

R

E

R

R

S

A

R

F

V

V

F

T

V

A

D

D

-

H

-

P

-

E

-

Q

-

A

T

L

R

R

E

E

G

G

A

E

C

C

K

Q

E

Q

-

L

A

S

G

A

D

D

I

R

V

L

Q

G

P

P

M

Q

K

L

A

A

G

H

I

L

L

C

T

A

D

D

A

P

D

A

I

A

A

A

G

-

D

-

L

-

Y

-

D

-

L

-

T

-

R

-

G

-

Q

-

R

-

A

A

G

G

R

R

R

Q

F

-

Y

-

D

D

Q

T

I

L

T

S

L

V

F

F

K

D

S
|
S

V
x
T

G
|
G

T

F

A

A

L

F

E

E

D

D

L

A

C

L

A

A

A

M

Q

E

L

V

A

F

V

L

E

E

M

A

V

A

I

A

H

E

N

R

D

D

binding nicotinamide-adenine-dinucleotide: Y85 (≠ V69), T97 (≠ A80), I98 (≠ V81), T122 (= T105), R125 (= R108), T126 (= T109), I148 (≠ V131), G149 (= G132), G151 (= G134), A152 (= A135), Q153 (≠ L136), D174 (≠ G157), T175 (≠ R158), D176 (≠ S159), H179 (≠ K162), A212 (= A196), T213 (= T197), S214 (vs. gap), V215 (vs. gap), V222 (≠ L203), V237 (= V218), G238 (= G219), A239 (≠ G220), D240 (≠ F221), K244 (≠ M225), S305 (= S293), T306 (≠ V294), G307 (= G295)
binding (2S)-piperidine-2-carboxylic acid: M69 (= M53), K81 (= K65), R125 (= R108), A239 (≠ G220), T306 (≠ V294), G307 (= G295)

Sites not aligning to the query:

binding (2S)-piperidine-2-carboxylic acid: 53, 67

5yu4A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
31% identity, 83% coverage: 53:315/318 of query aligns to 65:323/344 of 5yu4A

query
sites
5yu4A

M
|
M

P

P

A

H

W

R

Q

E

V

P

N

G

Q

D

S

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binding 2,4-diaminobutyric acid: M65 (= M53), K77 (= K65), R121 (= R108), A235 (≠ G220), D236 (≠ F221), T302 (≠ V294), G303 (= G295)
binding nicotinamide-adenine-dinucleotide: Y81 (≠ V69), T93 (≠ A80), I94 (≠ V81), T118 (= T105), R121 (= R108), T122 (= T109), I144 (≠ V131), G145 (= G132), G147 (= G134), A148 (= A135), Q149 (≠ L136), D170 (≠ G157), T171 (≠ R158), D172 (≠ S159), H175 (≠ K162), A208 (= A196), T209 (= T197), S210 (vs. gap), V211 (vs. gap), V218 (≠ L203), V233 (= V218), G234 (= G219), A235 (≠ G220), D236 (≠ F221), K240 (≠ M225), S301 (= S293), T302 (≠ V294), G303 (= G295)

Sites not aligning to the query:

binding 2,4-diaminobutyric acid: 49, 63

5yu3A Structural basis for recognition of l-lysine, l-ornithine, and l-2,4- diamino butyric acid by lysine cyclodeaminase (see paper)
31% identity, 83% coverage: 53:315/318 of query aligns to 65:323/344 of 5yu3A

query
sites
5yu3A

M
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M

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x
Y

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S

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P

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A

N

N

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A

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-

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D

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L

L

P

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A
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