SitesBLAST
Comparing AZOBR_RS06730 FitnessBrowser__azobra:AZOBR_RS06730 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1ffvB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
35% identity, 99% coverage: 5:769/772 of query aligns to 11:796/797 of 1ffvB
- active site: Q231 (= Q224), V266 (≠ L259), P343 (≠ T336), I349 (≠ M342), R378 (= R370), C379 (≠ G371), E751 (= E724), S752 (≠ A725)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G260 (= G253), G261 (= G254), F262 (= F255), G263 (= G256), A376 (= A368), R378 (= R370), C379 (≠ G371), Q516 (≠ N493), G517 (= G494), Q518 (= Q495), H520 (= H497), T523 (≠ A500), Y556 (≠ G533), G557 (= G534), S558 (= S535), S560 (= S537), T561 (≠ V538), C674 (≠ F646), I678 (≠ V650), I683 (≠ V655), Q686 (= Q658), K747 (= K720), G748 (= G721), V749 (≠ A722), A750 (≠ G723), E751 (= E724)
1ffuB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
35% identity, 99% coverage: 5:769/772 of query aligns to 11:796/797 of 1ffuB
- active site: Q231 (= Q224), V266 (≠ L259), P343 (≠ T336), I349 (≠ M342), R378 (= R370), C379 (≠ G371), E751 (= E724), S752 (≠ A725)
- binding cytidine-5'-diphosphate: Q518 (= Q495), H520 (= H497), T523 (≠ A500), S558 (= S535), S560 (= S537), T561 (≠ V538), C674 (≠ F646), T676 (= T648), I678 (≠ V650), I683 (≠ V655), K747 (= K720), G748 (= G721), V749 (≠ A722), A750 (≠ G723)
P19913 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
35% identity, 98% coverage: 14:769/772 of query aligns to 26:802/803 of P19913
- R384 (= R370) modified: 4-hydroxyarginine
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
37% identity, 99% coverage: 1:766/772 of query aligns to 9:785/786 of 1t3qB
- active site: Q224 (= Q224), A259 (≠ L259), E336 (≠ P335), V343 (≠ M342), R371 (= R370), E743 (= E724), S744 (≠ A725)
- binding pterin cytosine dinucleotide: G254 (= G254), F255 (= F255), R371 (= R370), S506 (≠ N493), G507 (= G494), Q508 (= Q495), H510 (= H497), T513 (≠ A500), Y545 (≠ G533), S547 (= S535), G549 (≠ S537), A550 (≠ V538), C666 (≠ F646), I670 (≠ V650), I674 (≠ L654), V675 (= V655), Q678 (= Q658), K739 (= K720), G740 (= G721), M741 (≠ A722), G742 (= G723)
P19919 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
34% identity, 98% coverage: 5:760/772 of query aligns to 20:799/809 of P19919
- C388 (≠ G371) binding
- E763 (= E724) binding
1n62B Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state (see paper)
34% identity, 98% coverage: 5:760/772 of query aligns to 15:794/804 of 1n62B
- active site: Q235 (= Q224), V270 (≠ L259), P347 (≠ T336), I353 (≠ M342), R382 (= R370), C383 (≠ G371), E758 (= E724), S759 (≠ A725)
- binding cu(i)-s-mo(iv)(=o)o-nbic cluster: G267 (= G256), V379 (vs. gap), A380 (= A368), R382 (= R370), C383 (≠ G371), F385 (≠ G373), Y563 (≠ G533), G564 (= G534), E758 (= E724)
- binding pterin cytosine dinucleotide: G265 (= G254), F266 (= F255), R382 (= R370), Q523 (≠ N493), G524 (= G494), Q525 (= Q495), H527 (= H497), T530 (≠ A500), T562 (= T532), Y563 (≠ G533), G564 (= G534), S565 (= S535), S567 (= S537), T568 (≠ V538), C681 (≠ F646), I685 (≠ V650), I689 (≠ L654), I690 (≠ V655), Q693 (= Q658), K754 (= K720), G755 (= G721), V756 (≠ A722), G757 (= G723), E758 (= E724)
1n5wB Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
34% identity, 98% coverage: 5:760/772 of query aligns to 15:794/804 of 1n5wB
- active site: Q235 (= Q224), V270 (≠ L259), P347 (≠ T336), I353 (≠ M342), R382 (= R370), C383 (≠ G371), E758 (= E724), S759 (≠ A725)
- binding cu(i)-s-mo(vi)(=o)oh cluster: G267 (= G256), A380 (= A368), R382 (= R370), C383 (≠ G371), Y563 (≠ G533), G564 (= G534), E758 (= E724)
- binding pterin cytosine dinucleotide: G265 (= G254), F266 (= F255), R382 (= R370), Q523 (≠ N493), G524 (= G494), Q525 (= Q495), H527 (= H497), T530 (≠ A500), T562 (= T532), Y563 (≠ G533), S565 (= S535), S567 (= S537), T568 (≠ V538), C681 (≠ F646), I685 (≠ V650), I689 (≠ L654), I690 (≠ V655), Q693 (= Q658), K754 (= K720), G755 (= G721), V756 (≠ A722), E758 (= E724)
1zxiB Reconstituted co dehydrogenase from oligotropha carboxidovorans (see paper)
34% identity, 98% coverage: 5:760/772 of query aligns to 15:794/804 of 1zxiB
- active site: Q235 (= Q224), V270 (≠ L259), P347 (≠ T336), I353 (≠ M342), R382 (= R370), C383 (≠ G371), E758 (= E724), S759 (≠ A725)
- binding copper (ii) ion: C383 (≠ G371), S384 (≠ A372), E758 (= E724)
- binding cu(i)-s-mo(vi)(=o)oh cluster: F266 (= F255), G267 (= G256), A380 (= A368), Y381 (= Y369), R382 (= R370), C383 (≠ G371), Y563 (≠ G533), G564 (= G534), E758 (= E724)
- binding pterin cytosine dinucleotide: G265 (= G254), F266 (= F255), R382 (= R370), Q523 (≠ N493), G524 (= G494), Q525 (= Q495), H527 (= H497), T530 (≠ A500), T562 (= T532), Y563 (≠ G533), S565 (= S535), S567 (= S537), T568 (≠ V538), C681 (≠ F646), I685 (≠ V650), I689 (≠ L654), I690 (≠ V655), Q693 (= Q658), K754 (= K720), G755 (= G721), V756 (≠ A722), E758 (= E724)
1n60B Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide- inactivated form (see paper)
34% identity, 98% coverage: 5:760/772 of query aligns to 14:793/803 of 1n60B
- active site: Q234 (= Q224), V269 (≠ L259), P346 (≠ T336), I352 (≠ M342), R381 (= R370), C382 (≠ G371), E757 (= E724), S758 (≠ A725)
- binding pterin cytosine dinucleotide: G264 (= G254), F265 (= F255), R381 (= R370), Q522 (≠ N493), G523 (= G494), Q524 (= Q495), H526 (= H497), T529 (≠ A500), T561 (= T532), Y562 (≠ G533), G563 (= G534), S564 (= S535), S566 (= S537), T567 (≠ V538), C680 (≠ F646), I684 (≠ V650), I688 (≠ L654), I689 (≠ V655), Q692 (= Q658), K753 (= K720), G754 (= G721), V755 (≠ A722), E757 (= E724)
- binding mo(vi)(=o)(oh)2 cluster: F265 (= F255), G266 (= G256), Y562 (≠ G533), G563 (= G534), E757 (= E724)
1n63B Crystal structure of the cu,mo-co dehydrogenase (codh); carbon monoxide reduced state (see paper)
34% identity, 98% coverage: 5:760/772 of query aligns to 16:795/805 of 1n63B
- active site: Q236 (= Q224), V271 (≠ L259), P348 (≠ T336), I354 (≠ M342), R383 (= R370), C384 (≠ G371), E759 (= E724), S760 (≠ A725)
- binding cu(i)-s-mo(iv)(=o)oh cluster: G268 (= G256), A381 (= A368), R383 (= R370), C384 (≠ G371), Y564 (≠ G533), G565 (= G534), E759 (= E724)
- binding pterin cytosine dinucleotide: G266 (= G254), F267 (= F255), R383 (= R370), Q524 (≠ N493), G525 (= G494), Q526 (= Q495), H528 (= H497), T531 (≠ A500), T563 (= T532), Y564 (≠ G533), S566 (= S535), S568 (= S537), T569 (≠ V538), C682 (≠ F646), I686 (≠ V650), I690 (≠ L654), I691 (≠ V655), Q694 (= Q658), K755 (= K720), G756 (= G721), V757 (≠ A722), E759 (= E724)
4zohA Crystal structure of glyceraldehyde oxidoreductase (see paper)
36% identity, 95% coverage: 6:738/772 of query aligns to 3:682/701 of 4zohA
- active site: Q186 (= Q224), I219 (≠ L259), V298 (≠ A338), S300 (= S340), M304 (= M342), R332 (= R370), E668 (= E724), A669 (= A725)
- binding pterin cytosine dinucleotide: G213 (= G253), A214 (≠ G254), F215 (= F255), R332 (= R370), H442 (≠ N493), G443 (= G494), Q444 (= Q495), D446 (≠ H497), W482 (≠ G533), S484 (= S535), T486 (≠ S537), V487 (= V538), I594 (≠ V650), N595 (= N651), L598 (= L654), Q602 (= Q658), K664 (= K720), G665 (= G721), I666 (≠ A722), G667 (= G723), E668 (= E724)
7dqxD Crystal structure of xanthine dehydrogenase family protein
34% identity, 93% coverage: 6:724/772 of query aligns to 6:728/770 of 7dqxD
- binding pterin cytosine dinucleotide: G247 (= G253), S248 (≠ G254), F249 (= F255), R363 (= R370), V491 (≠ N493), G492 (= G494), Q493 (= Q495), G494 (= G496), V498 (≠ A500), S530 (≠ T532), W531 (≠ G533), S532 (≠ G534), S533 (= S535), R534 (= R536), S535 (= S537), T536 (≠ V538), T658 (≠ L654), T659 (≠ V655), Q662 (= Q658), G725 (= G721), L726 (≠ A722), G727 (= G723), E728 (= E724)
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
30% identity, 99% coverage: 6:770/772 of query aligns to 11:769/769 of O33819
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
30% identity, 99% coverage: 6:770/772 of query aligns to 3:761/761 of 1rm6A
- active site: Q206 (= Q224), T241 (≠ L259), Y318 (≠ D337), L322 (≠ M342), R350 (= R370), E718 (= E724), G719 (≠ A725)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G235 (= G253), G236 (= G254), F237 (= F255), G238 (= G256), R350 (= R370), I473 (≠ N493), G474 (= G494), Q475 (= Q495), G476 (= G496), Y513 (≠ G533), S514 (≠ G534), S515 (= S535), V517 (vs. gap), T518 (≠ S537), L646 (≠ V650), N647 (= N651), V651 (= V655), Q654 (= Q658), K714 (= K720), E715 (≠ G721), A716 (= A722), S717 (≠ G723), E718 (= E724)
2w54B Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde (see paper)
30% identity, 98% coverage: 6:764/772 of query aligns to 2:754/760 of 2w54B
- active site: Q196 (= Q224), E231 (≠ L259), R309 (≠ A338), H313 (≠ M342), R341 (= R370), G712 (= G729), E713 (≠ A730)
- binding 6-hydroxymethylpterin: E231 (≠ L259), P305 (= P332), R309 (≠ A338), F343 (≠ A372), F442 (vs. gap), T443 (= T461), L444 (≠ Y462), A512 (≠ G534), E713 (≠ A730)
- binding {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-kappaS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(hydroxy)oxo(thioxo)molybdenum: G226 (= G254), F227 (= F255), G228 (= G256), F340 (≠ Y369), R341 (= R370), M471 (≠ N493), G472 (= G494), Q473 (= Q495), A511 (≠ G533), S513 (= S535), G515 (≠ S537), Q646 (= Q658), E713 (≠ A730)
2w3sB Crystal structure of xanthine dehydrogenase (desulfo form) from rhodobacter capsulatus in complex with xanthine (see paper)
30% identity, 98% coverage: 6:764/772 of query aligns to 2:754/760 of 2w3sB
- active site: Q196 (= Q224), E231 (≠ L259), R309 (≠ A338), H313 (≠ M342), R341 (= R370), G712 (= G729), E713 (≠ A730)
- binding calcium ion: E171 (≠ R195), H172 (≠ V196), Y174 (≠ A198), T265 (≠ D292), G266 (≠ D293)
- binding hydroxy(dioxo)molybdenum: G228 (= G256), R341 (= R370), A511 (≠ G533), E713 (≠ A730)
- binding xanthine: E231 (≠ L259), F343 (≠ A372), F442 (vs. gap), T443 (= T461), L444 (≠ Y462), A511 (≠ G533), A512 (≠ G534)
2w3rB Crystal structure of xanthine dehydrogenase (desulfo form) from rhodobacter capsulatus in complex with hypoxanthine (see paper)
30% identity, 98% coverage: 6:764/772 of query aligns to 2:754/760 of 2w3rB
- active site: Q196 (= Q224), E231 (≠ L259), R309 (≠ A338), H313 (≠ M342), R341 (= R370), G712 (= G729), E713 (≠ A730)
- binding calcium ion: E171 (≠ R195), H172 (≠ V196), Y174 (≠ A198), T265 (≠ D292), G266 (≠ D293)
- binding hypoxanthine: E231 (≠ L259), R309 (≠ A338), F343 (≠ A372), F442 (vs. gap), T443 (= T461), L444 (≠ Y462), A512 (≠ G534)
- binding hydroxy(dioxo)molybdenum: G228 (= G256), R341 (= R370), A511 (≠ G533), E713 (≠ A730)
1jrpB Crystal structure of xanthine dehydrogenase inhibited by alloxanthine from rhodobacter capsulatus (see paper)
30% identity, 98% coverage: 6:764/772 of query aligns to 2:754/760 of 1jrpB
- active site: Q196 (= Q224), E231 (≠ L259), R309 (≠ A338), H313 (≠ M342), R341 (= R370), G712 (= G729), E713 (≠ A730)
- binding Oxypurinol: E231 (≠ L259), R309 (≠ A338), F343 (≠ A372), A511 (≠ G533), A512 (≠ G534), E713 (≠ A730)
- binding calcium ion: E171 (≠ R195), H172 (≠ V196), Y174 (≠ A198), T265 (≠ D292)
1jroB Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
30% identity, 98% coverage: 6:764/772 of query aligns to 2:754/760 of 1jroB
- active site: Q196 (= Q224), E231 (≠ L259), R309 (≠ A338), H313 (≠ M342), R341 (= R370), G712 (= G729), E713 (≠ A730)
- binding calcium ion: E171 (≠ R195), H172 (≠ V196), Y174 (≠ A198), T265 (≠ D292), G266 (≠ D293)
4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
27% identity, 98% coverage: 7:764/772 of query aligns to 177:906/907 of 4usaA
- active site: I390 (≠ Q224), F425 (≠ L259), R501 (≠ A338), F505 (≠ M342), R533 (= R370), E869 (= E724), L870 (≠ A725)
- binding bicarbonate ion: R460 (≠ G295), A531 (= A368), F532 (≠ Y369), Y535 (≠ A372), Q539 (≠ E376)
- binding hydrocinnamic acid: I255 (≠ A84), F425 (≠ L259), F494 (≠ Y330), L497 (≠ F333), Y535 (≠ A372), L626 (≠ C466)
- binding magnesium ion: E899 (≠ L757), E903 (≠ T761)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G254), F421 (= F255), G422 (= G256), R533 (= R370), W650 (≠ T490), H653 (≠ N493), G654 (= G494), Q655 (= Q495), G656 (= G496), S695 (≠ T532), G696 (= G533), G697 (= G534), Q700 (≠ S537), Q701 (≠ V538), C799 (≠ V650), N800 (= N651), T804 (≠ V655), Q807 (= Q658), S865 (≠ K720), G866 (= G721), V867 (≠ A722), G868 (= G723), E869 (= E724)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
Query Sequence
>AZOBR_RS06730 FitnessBrowser__azobra:AZOBR_RS06730
MMKFGIGQPVPRTEDARLLTGGGRYTDDVSLPGQTHAVFVRSPHAHADIRGIDAAEAAAQ
PGVLGVFTVADLEADGVQPIPCAAALTQRDGSPYVAPPRPALAKGRVRHVGDPVAVVVAE
TLDAARDAAELVMVDYDDRPAIAGTAEALEAGRPQVWDEAPGNLCFDWEQGEEAAVESAI
AKAARVVELEIVNNRVVANPMEGRACLAAVEAETGRLVIYVTSQGVHGLRKQFAQLFGLP
EEKFRVITTDVGGGFGMKLFNYPEYMVCLFAARRLNRPVKWAAERTEGFLSDDHGRDHVS
RARLALDGDGRFLGLRVDTVANLGAYLSNYGPFIPTDAGSAMLVGSYTTPAVYVRVKGVF
TNTQPVDAYRGAGRPEAAYLLERLIDHAGRVTGLGPAEIRRRNFIPPAAMPYATPMGQTY
DTGEFEQNLRDGLELSDHAGLPARKAAAKARGKLRGAGIATYIEACAGGGAEQATVQVNG
DGRIILMIGTQTNGQGHETAYKQIIADRLGVPPEDVEVIQGDTDRVSWGAGTGGSRSVPV
GGAALAEGAARVVTKATEVAADLLETAAVDVEFVEGRFSVVGTDRSVSFKEVAAKAAAQG
PIAFTEVARWTPPANTFPNGCHIAEVEVDPDTGVVEVVGYTVVDDFGTVVNPLLVMGQVH
GGVAQGIGQALQERVVFDPDSGQLLSGSFMDYQMPRAVDVPDIRIKLNCVPSTTNALGMK
GAGEAGAIGAPPAVINALVDALSDYGIEHIDMPATPLSVWTAIQTRSKAAAE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory