SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing AZOBR_RS08565 FitnessBrowser__azobra:AZOBR_RS08565 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
58% identity, 98% coverage: 5:165/165 of query aligns to 6:166/166 of P19921

query
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P19921

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C42 (= C41) binding
C47 (= C46) binding
C50 (= C49) binding
C62 (= C61) binding
C102 (= C101) binding
C105 (= C104) binding
C137 (= C136) binding
C139 (= C138) binding

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
59% identity, 93% coverage: 5:157/165 of query aligns to 4:156/161 of 1n5wA

query
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1n5wA

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binding flavin-adenine dinucleotide: T42 (= T43), S43 (= S44), H44 (≠ Q45)
binding fe2/s2 (inorganic) cluster: I38 (≠ V39), G39 (= G40), C40 (= C41), S43 (= S44), H44 (≠ Q45), C45 (= C46), G46 (= G47), C48 (= C49), K58 (= K59), C60 (= C61), L98 (= L99), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C135 (= C136), R136 (= R137), C137 (= C138)
binding pterin cytosine dinucleotide: Q99 (= Q100), C137 (= C138)

4zohC Crystal structure of glyceraldehyde oxidoreductase (see paper)
58% identity, 92% coverage: 5:155/165 of query aligns to 12:160/161 of 4zohC

query
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4zohC

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binding fe2/s2 (inorganic) cluster: I45 (≠ V39), G46 (= G40), C47 (= C41), S50 (= S44), N51 (≠ Q45), C52 (= C46), G53 (= G47), C55 (= C49), C67 (= C61), Q105 (= Q100), C106 (= C101), G107 (= G102), C109 (= C104), C141 (= C136), R142 (= R137), C143 (= C138)
binding pterin cytosine dinucleotide: Q105 (= Q100), C143 (= C138)

1ffuD Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
59% identity, 92% coverage: 5:156/165 of query aligns to 5:155/156 of 1ffuD

query
sites
1ffuD

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binding flavin-adenine dinucleotide: S44 (= S44), H45 (≠ Q45)
binding fe2/s2 (inorganic) cluster: I39 (≠ V39), G40 (= G40), C41 (= C41), S44 (= S44), H45 (≠ Q45), C46 (= C46), G47 (= G47), C49 (= C49), K59 (= K59), C61 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C135 (= C136), R136 (= R137), C137 (= C138)

1ffvA Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
59% identity, 92% coverage: 5:156/165 of query aligns to 4:154/155 of 1ffvA

query
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1ffvA

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binding flavin-adenine dinucleotide: T42 (= T43), S43 (= S44), H44 (≠ Q45)
binding fe2/s2 (inorganic) cluster: I38 (≠ V39), G39 (= G40), C40 (= C41), S43 (= S44), H44 (≠ Q45), C45 (= C46), G46 (= G47), C48 (= C49), K58 (= K59), C60 (= C61), L97 (= L99), Q98 (= Q100), C99 (= C101), G100 (= G102), C102 (= C104), C134 (= C136), R135 (= R137), C136 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q98 (= Q100), C136 (= C138)

5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
48% identity, 92% coverage: 4:155/165 of query aligns to 4:155/157 of 5y6qA

query
sites
5y6qA

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binding flavin-adenine dinucleotide: G44 (≠ S44), Q45 (= Q45)
binding fe2/s2 (inorganic) cluster: K39 (≠ V39), G40 (= G40), C41 (= C41), D42 (= D42), G44 (≠ S44), C46 (= C46), G47 (= G47), C49 (= C49), C61 (= C61), F99 (≠ L99), Q100 (= Q100), C101 (= C101), G102 (= G102), C104 (= C104), C136 (= C136), R137 (= R137), C138 (= C138)
binding pterin cytosine dinucleotide: Q100 (= Q100), C101 (= C101), C138 (= C138)

1sb3C Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
48% identity, 93% coverage: 1:154/165 of query aligns to 1:153/161 of 1sb3C

query
sites
1sb3C

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V

N

K

I

I

V

I

K

K

A

S

V

V

M

E

A

T

G

A

A

A

E

A

A

A

binding flavin-adenine dinucleotide: G44 (≠ S44), E45 (≠ Q45)
binding fe2/s2 (inorganic) cluster: Q39 (≠ V39), G40 (= G40), C41 (= C41), G44 (≠ S44), E45 (≠ Q45), C46 (= C46), G47 (= G47), C49 (= C49), L59 (≠ K59), C61 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C135 (= C136), R136 (= R137), C137 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C137 (= C138)

1t3qA Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
47% identity, 93% coverage: 5:158/165 of query aligns to 6:160/162 of 1t3qA

query
sites
1t3qA

V

I

S

S

M

A

T

T

V

I

N

N

G

G

K

K

A

P

V

R

S

V

R

F

E

Y

V

V

E

E

E

P

R

R

T

M

L

H

L

L

V

A

T

D

F

A

L

L

R

R

D

E

Q

V

L

V

G

G

L

L

T

T

G

G

T

T

H

K

V
x
I

G
|
G

C
|
C

D
x
E

T
x
Q

S
x
G

Q
x
V

C
|
C

G
|
G

A
x
S

C
|
C

V

T

V

I

H

L

I

I

D

D

G

G

R

A

S

P

V

M

K
x
R

S

S

C
|
C

T

L

M

T

L

L

A

A

A

V

Q

Q

A

A

D

E

G

G

A

C

A

S

V

I

T

E

T

T

I

V

E

E

G

G

L

L

A

S

A

Q

A

G

D

E

G

-

T

K

L

L

H

N

P

A

M

L

Q

Q

A

D

A

S

F

F

R

R

E

R

H

H

G

A

L
|
L

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

A

G

G

M

M

V

L

M

A

S

T

A

A

V

R

D

S

L

I

V

L

T

A

A

E

N

N

P

P

S

A

P

P

S

S

E

R

H

D

D

E

V

V

R

R

E

E

G

V

L

M

E

S

G

G

N

N

I

L

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

E

N

T

I

I

V

I

K

D

A

A

V

I

M

T

-

D

-

P

A

A

G

V

A

A

E

E

A

A

M

A

Q

R

G

R

G

G

binding flavin-adenine dinucleotide: Q44 (≠ T43), G45 (≠ S44), V46 (≠ Q45)
binding fe2/s2 (inorganic) cluster: I40 (≠ V39), G41 (= G40), C42 (= C41), E43 (≠ D42), G45 (≠ S44), C47 (= C46), G48 (= G47), S49 (≠ A48), C50 (= C49), R60 (≠ K59), C62 (= C61), L99 (= L99), Q100 (= Q100), C101 (= C101), G102 (= G102), C104 (= C104), C136 (= C136), R137 (= R137), C138 (= C138)
binding pterin cytosine dinucleotide: Q100 (= Q100), C138 (= C138)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of 4usaA

query
sites
4usaA

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
E

T

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), E41 (≠ D42), G43 (≠ S44), Q44 (= Q45), C45 (= C46), G46 (= G47), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), R138 (= R137), C139 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 501, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of 4us9A

query
sites
4us9A

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
E

T

Q

S
x
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), E41 (≠ D42), G43 (≠ S44), C45 (= C46), G46 (= G47), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), R138 (= R137), C139 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 256, 257, 258, 752, 753, 755
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539, 884, 888, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of 4us8A

query
sites
4us8A

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
E

T

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), E41 (≠ D42), G43 (≠ S44), Q44 (= Q45), C45 (= C46), G46 (= G47), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), R138 (= R137), C139 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding benzaldehyde: 255, 255, 394, 394, 425, 425, 425, 425, 494, 497, 497, 497, 501, 501, 531, 531, 535, 535, 626, 626, 626, 627, 694, 696, 697, 697, 869
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 697, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of 4c7yA

query
sites
4c7yA

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
E

T

Q

S
x
G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), E41 (≠ D42), G43 (≠ S44), C45 (= C46), G46 (= G47), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), C139 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 461, 498, 531, 532, 535, 536, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of 3fc4A

query
sites
3fc4A

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
E

T

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), E41 (≠ D42), G43 (≠ S44), Q44 (= Q45), C45 (= C46), G46 (= G47), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), R138 (= R137), C139 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 425, 531, 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of 3fahA

query
sites
3fahA

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
E

T

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), E41 (≠ D42), G43 (≠ S44), Q44 (= Q45), C45 (= C46), G46 (= G47), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), R138 (= R137), C139 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding glycerol: 416, 425, 531, 535, 622, 683, 696, 697, 869, 884, 888, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 425, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

1sijA Crystal structure of the aldehyde dehydrogenase (a.K.A. Aor or mop) of desulfovibrio gigas covalently bound to [aso3]- (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of 1sijA

query
sites
1sijA

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
E

T

Q

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), E41 (≠ D42), G43 (≠ S44), Q44 (= Q45), C45 (= C46), G46 (= G47), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), R138 (= R137), C139 (= C138)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding arsenite: 425, 531, 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 531, 532, 533, 650, 653, 654, 655, 656, 660, 695, 696, 698, 699, 700, 701, 795, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

Q46509 Aldehyde oxidoreductase; Molybdenum iron sulfur protein; EC 1.2.99.7 from Megalodesulfovibrio gigas (Desulfovibrio gigas) (see paper)
48% identity, 92% coverage: 7:157/165 of query aligns to 6:158/907 of Q46509

query
sites
Q46509

M

I

T

T

V

V

N

N

G

G

K

I

A

E

V

Q

S

N

R

L

E

F

V

V

E

D

E

A

R

E

T

A

L

L

V

S

T

D

F

V

L

L

R

R

D

Q

Q

Q

L

L

G

G

L

L

T

T

G

G

T

V

H

K

V

V

G

G

C
|
C

D

E

T

Q

S

G

Q

Q

C
|
C

G

G

A

A

C
|
C

V

S

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K

R

S

A

C
|
C

-

V

T

T

M

K

L

M

A

K

A

R

Q

V

A

A

D

D

G

G

A

A

A

Q

V

I

T

T

I

I

E

E

G

G

L

V

A

G

A

Q

A

P

D

E

G

-

T

N

L

L

H

H

P

P

M

L

Q

Q

A

K

A

A

F

W

R

V

E

L

H

H

H

G

G

G

L

A

Q

Q

C
|
C

G

G

F

F

C
|
C

T

S

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

G

L

L

V

L

T

D

A

T

N

N

P

A

S

D

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

-

R

N

N

I

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

V

M

I

Q

N

G

G

C40 (= C41) binding
C45 (= C46) binding
C48 (= C49) binding
C60 (= C61) binding
C100 (= C101) binding
C103 (= C104) binding
C137 (= C136) binding
C139 (= C138) binding

1dgjA Crystal structure of the aldehyde oxidoreductase from desulfovibrio desulfuricans atcc 27774 (see paper)
47% identity, 93% coverage: 4:157/165 of query aligns to 3:158/906 of 1dgjA

query
sites
1dgjA

T

T

V

K

S

T

M

L

T

I

V

V

N

N

G

G

K

M

A

A

V

R

S

R

R

L

E

L

V

V

E

S

E

P

R

N

T

D

L

L

V

V

T

D

F

V

L

L

R

R

D

S

Q

Q

L

L

G

Q

L

L

T

T

G

S

T

V

H

K

V
|
V

G
|
G

C
|
C

D
x
G

T

K

S
x
G

Q
|
Q

C
|
C

G
|
G

A
|
A

C
|
C

V

T

V

V

H

I

I

L

D

D

G

G

R

K

S

V

V

V

K
x
R

S

A

C
|
C

T

I

M

I

-

K

L

M

A

S

A

R

Q

V

A

A

D

E

G

N

A

A

A

S

V

V

T

T

I

L

E

E

G

G

L

I

A

G

A

A

A

P

D

D

G

-

T

C

L

L

H

H

P

P

M

L

Q

Q

A

H

A

A

F

W

R

I

E

Q

H

H

H

G

G

A

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

T

P

P

G

G

M

F

V

I

M

V

S

S

A

A

V

K

D

A

L

L

V

L

T

D

A

E

N

N

P

V

S

A

P

P

S

S

E

R

H

E

D

D

V

V

R

R

E

D

G

W

L

F

E

Q

G

K

-

H

N

N

I

I

C
|
C

R
|
R

C
|
C

T

T

G

G

Y

Y

H

K

N

P

I

L

V

V

K

D

A

A

V

V

M

M

A

D

G

A

A

A

E

A

A

I

M

L

Q

R

G

G

binding fe2/s2 (inorganic) cluster: V38 (= V39), G39 (= G40), C40 (= C41), G41 (≠ D42), G43 (≠ S44), Q44 (= Q45), C45 (= C46), G46 (= G47), A47 (= A48), C48 (= C49), R58 (≠ K59), C60 (= C61), Q99 (= Q100), C100 (= C101), G101 (= G102), C103 (= C104), C137 (= C136), R138 (= R137), C139 (= C138)
binding pterin cytosine dinucleotide: Q99 (= Q100), C139 (= C138)

Sites not aligning to the query:

active site: 391, 427, 503, 507, 535, 869, 870
binding molybdenum (iv)oxide: 424, 533, 534, 535, 655, 698, 869
binding pterin cytosine dinucleotide: 421, 422, 423, 424, 535, 652, 655, 656, 657, 658, 662, 697, 698, 700, 701, 702, 703, 797, 798, 799, 800, 803, 804, 807, 865, 866, 867, 868, 869

P77165 Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
46% identity, 92% coverage: 1:152/165 of query aligns to 61:224/229 of P77165

query
sites
P77165

M

M

P

P

C

L

T

T

V

-

S

-

M

L

T

K

V

V

N

N

G

G

K

K

A

T

V

E

S

Q

R

L

E

E

V

V

E

D

E

T

R

R

T

T

L

T

L

L

V

L

T

D

F

T

L

L

R

R

D

E

Q

N

L

L

G

H

L

L

T

I

G

G

T

T

H

K

V

K

G

G

C
|
C

D

D

T

H

S

G

Q

Q

C
|
C

G
|
G

A

A

C
|
C

V

T

V

V

H

L

I

V

D

N

G

G

R

R

S

R

V

L

K

N

S

A

C
|
C

T

L

M

T

L

L

A

A

A

V

Q

M

A

H

D

Q

G

G

A

A

A

E

V

I

T

T

I

I

E

E

G

G

L

L

A

G

A

S

A

P

D

D

G

N

T

-

L

L

H

H

P

P

M

M

Q

Q

A

A

F

F

R

I

E

K

H

H

H

D

G

G

L

F

Q

Q

C
|
C

G

G

F

Y

C
|
C

T

T

P

S

G

G

M

Q

V

I

M

C

S

S

A

S

-

V

-

A

-

V

-

L

-

K

-

E

-

I

-

Q

-

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

V

V

D

D

L

L

V

V

T

S

A

A

N

-

P

P

S

E

P

T

S

T

E

A

H

D

D

E

V

I

R

R

E

E

G

R

L

M

E

S

G

G

N

N

I

I

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

H

A

N

N

I

I

V

L

K

A

A

A

V

I

M

E

A

D

G

A

A

A

C99 (= C41) binding
C104 (= C46) binding
G105 (= G47) binding
C107 (= C49) binding
C119 (= C61) binding
C158 (= C101) binding
C161 (= C104) binding
C208 (= C136) binding
C210 (= C138) binding

5g5gA Escherichia coli periplasmic aldehyde oxidase (see paper)
46% identity, 90% coverage: 1:148/165 of query aligns to 10:169/175 of 5g5gA

query
sites
5g5gA

M

M

P

P

C

L

T

T

V

-

S

-

M

L

T

K

V

V

N

N

G

G

K

K

A

T

V

E

S

Q

R

L

E

E

V

V

E

D

E

T

R

R

T

T

L

T

L

L

V

L

T

D

F

T

L

L

R

R

D

E

Q

N

L

L

G

H

L

L

T

I

G

G

T

T

H

K

V
x
K

G
|
G

C
|
C

D
|
D

T

H

S
x
G

Q
|
Q

C
|
C

G
|
G

A

A

C
|
C

V

T

V

V

H

L

I

V

D

N

G

G

R

R

S

R

V

L

K
x
N

S

A

C
|
C

T

L

M

T

L

L

A

A

A

V

Q

M

A

H

D

Q

G

G

A

A

A

E

V

I

T

T

I

I

E

E

G

G

L

L

A

G

A

S

A

P

D

D

G

-

T

N

L

L

H

H

P

P

M

M

Q

Q

A

A

F

F

R

I

E

K

H

H

H

D

G

G

L

F

Q
|
Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

S

G

G

M

Q

V

I

M

C

S

S

A

S

-

V

-

A

-

V

-

L

-

K

-

E

-

I

-

Q

-

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

V

V

D

D

L

L

V

V

T

S

A

A

N

-

P

P

S

E

P

T

S

T

E

A

H

D

D

E

V

I

R

R

E

E

G

R

L

M

E

S

G

G

N

N

I

I

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

H

A

N

N

I

I

V

L

K

A

A

A

V

I

binding flavin-adenine dinucleotide: G51 (≠ S44), Q52 (= Q45)
binding fe2/s2 (inorganic) cluster: K46 (≠ V39), G47 (= G40), C48 (= C41), D49 (= D42), G51 (≠ S44), Q52 (= Q45), C53 (= C46), G54 (= G47), C56 (= C49), N66 (≠ K59), C68 (= C61), Q106 (= Q100), C107 (= C101), G108 (= G102), C110 (= C104), C157 (= C136), C159 (= C138)
binding pterin cytosine dinucleotide: Q106 (= Q100), C159 (= C138)

7dqxC Crystal structure of xanthine dehydrogenase family protein
46% identity, 88% coverage: 5:149/165 of query aligns to 6:150/160 of 7dqxC

query
sites
7dqxC

V

L

S

T

M

V

T

E

V

V

N

N

G

G

K

V

A

T

V

H

S

A

R

T

E

D

V

V

E

E

E

P

R

R

T

R

L

L

V

A

T

D

F

F

L

L

R

R

D

D

Q

D

L

L

G

H

L

L

T

R

G

G

T

T

H

R

V

V

G

G

C
|
C

D
x
E

T
x
H

S
x
G

Q
x
V

C
|
C

G

G

A

S

C
|
C

V

T

V

V

H

I

I

L

D

D

G

G

R

Q

S

P

V

V

K
x
R

S

S

C
|
C

T

T

M

V

L

L

A

A

A

V

Q

Q

A

A

D

N

G

N

A

S

A

R

V

I

T

E

T

T

I

V

E

E

G

S

L

L

A

-

A

Q

A

K

D

D

G

G

T

Q

L

L

H

H

P

P

M

L

Q

Q

A

R

A

S

F

F

R

S

E

K

H

C

H

H

G

A

L

L

Q
|
Q

C
|
C

G

G

F

F

C
|
C

T

T

P

S

G

G

M

F

V

L

M

M

S

-

A

-

V

-

D

-

L

-

V

-

T

T

A

L

N

K

P

P

S

L

P

Y

S

D

E

D

H

E

D

D

V

V

-

T

-

L

-

D

-

A

-

T

-

S

-

A

R

R

E

E

G

A

L

I

E

S

G

G

N

N

I

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

H

Q

N

Q

I

I

V

V

K

E

A

A

V

T

M

V

binding flavin-adenine dinucleotide: H44 (≠ T43), G45 (≠ S44)
binding fe2/s2 (inorganic) cluster: C42 (= C41), E43 (≠ D42), G45 (≠ S44), V46 (≠ Q45), C47 (= C46), C50 (= C49), R60 (≠ K59), C62 (= C61), Q100 (= Q100), C101 (= C101), C104 (= C104), C137 (= C136), C139 (= C138)
binding pterin cytosine dinucleotide: Q100 (= Q100), C101 (= C101), C139 (= C138)

Query Sequence

>AZOBR_RS08565 FitnessBrowser__azobra:AZOBR_RS08565
MPCTVSMTVNGKAVSREVEERTLLVTFLRDQLGLTGTHVGCDTSQCGACVVHIDGRSVKS
CTMLAAQADGAAVTTIEGLAAADGTLHPMQAAFREHHGLQCGFCTPGMVMSAVDLVTANP
SPSEHDVREGLEGNICRCTGYHNIVKAVMAGAEAMQGGTMKAAAE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory