Comparing AZOBR_RS10545 FitnessBrowser__azobra:AZOBR_RS10545 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 14 hits to proteins with known functional sites (download)
4f4fA X-ray crystal structure of plp bound threonine synthase from brucella melitensis
57% identity, 99% coverage: 1:465/470 of query aligns to 2:464/464 of 4f4fA
1kl7A Crystal structure of threonine synthase from yeast (see paper)
42% identity, 90% coverage: 3:424/470 of query aligns to 7:459/509 of 1kl7A
Q42598 Threonine synthase; TS; EC 4.2.3.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
42% identity, 90% coverage: 1:424/470 of query aligns to 5:462/514 of Q42598
8g1yA Crystal structure of the threonine synthase from streptococcus pneumoniae in complex with pyridoxal 5-phosphate.
39% identity, 91% coverage: 1:427/470 of query aligns to 5:443/496 of 8g1yA
1vb3A Crystal structure of threonine synthase from escherichia coli
32% identity, 98% coverage: 1:460/470 of query aligns to 1:425/428 of 1vb3A
A0R220 Threonine synthase; TS; EC 4.2.3.1 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
27% identity, 63% coverage: 107:403/470 of query aligns to 64:351/360 of A0R220
2c2bA Crystallographic structure of arabidopsis thaliana threonine synthase complexed with pyridoxal phosphate and s-adenosylmethionine (see paper)
24% identity, 68% coverage: 99:417/470 of query aligns to 115:403/444 of 2c2bA
Sites not aligning to the query:
Q9S7B5 Threonine synthase 1, chloroplastic; Protein METHIONINE OVER-ACCUMULATOR 2; EC 4.2.3.1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
24% identity, 68% coverage: 99:417/470 of query aligns to 190:478/526 of Q9S7B5
Sites not aligning to the query:
6cgqB Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala (see paper)
28% identity, 38% coverage: 85:264/470 of query aligns to 24:193/345 of 6cgqB
Sites not aligning to the query:
6nmxA Threonine synthase from bacillus subtilis atcc 6633 with plp and appa (see paper)
28% identity, 38% coverage: 85:264/470 of query aligns to 26:195/350 of 6nmxA
Sites not aligning to the query:
2c2gA Crystal structure of threonine synthase from arabidopsis thaliana in complex with its cofactor pyridoxal phosphate (see paper)
23% identity, 68% coverage: 99:417/470 of query aligns to 133:405/448 of 2c2gA
6cgqA Threonine synthase from bacillus subtilis atcc 6633 with plp and plp- ala (see paper)
27% identity, 38% coverage: 85:264/470 of query aligns to 22:185/339 of 6cgqA
Sites not aligning to the query:
P9WG59 Threonine synthase; TS; EC 4.2.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
30% identity, 34% coverage: 107:264/470 of query aligns to 64:205/360 of P9WG59
Sites not aligning to the query:
2d1fA Structure of mycobacterium tuberculosis threonine synthase (see paper)
30% identity, 34% coverage: 107:264/470 of query aligns to 55:196/349 of 2d1fA
Sites not aligning to the query:
>AZOBR_RS10545 FitnessBrowser__azobra:AZOBR_RS10545
LKYVSTRGQAPVLGFEEVLLAGLARDGGLYVPDSWPQFSADEIRAMRGLPYSEIAVRVML
PFLGGAIAEDDFRAIVKDAYASFDHAAVVPLVQLDQRTWVMELFHGPTLAFKDVALQLLG
RLFDHVLAKRGKRVTIVGATSGDTGSAAIEACRDRQNVDIFILHPKGRTSEVQRRQMTSV
LSDNVHNIALHGTFDDCQDLVKALFNDMAFRDKMGLSAVNSINWARIMAQIVYYFAAAVA
LGAPDRKVAFTVPTGNFGNVYAAYGARAMGLPVERLVVGSNANDILARFFASGTMSAAPV
VPTLSPSMDIQISSNFERLLFDLLGRDGAAVQAAMDGFRAEGKFAVTDAQLAEAHAIFAA
GRADDARTMDVIKEVWEKTGGYQVDPHTAVGIHSAATAPVDPSVPVVVMATAHPAKFPDA
VETATGRRPVLPPRLADLYEREERLSELPNDVAAVQEFVVARARAAKEAA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory