SitesBLAST – Find functional sites

 

SitesBLAST

Comparing AZOBR_RS15560 FitnessBrowser__azobra:AZOBR_RS15560 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
42% identity, 96% coverage: 4:194/198 of query aligns to 540:734/758 of O14289

query
sites
O14289
F
 
F
V
 
T
T
 
V
L
 
V
T
 
E
A
 
G
P
 
I
A
 
A
V
 
A
P
 
P
L
 
L
D
 
P
I
 
M
A
 
A
N
 
N
I
 
V
D
 
D
T
 
T
D
 
D
Q
 
K
L
 
I
L
 
I
P
 
P
A
 
K
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Q
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F
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L
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K
K
 
T
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I
R
 
K
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R
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T
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G
Y
 
L
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N
 
Q
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F
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A
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Y
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E
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I
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R
K
 
Y
-
 
D
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A
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D
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G
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K
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E
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D
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N
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E
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Y
 
Y
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H
A
 
A
R
 
T
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V
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L
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A
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H
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D
N
 
N
F
 
F
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G
C
 
C
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G
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S
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S
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R
E
 
E
G
 
H
A
 
A
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P
Y
 
W
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A
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L
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N
D
 
D
G
 
F
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G
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I
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R
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V
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I
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I
A
 
A
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P
S
 
S
F
 
F
G
 
A
D
 
D
I
 
I
F
 
F
A
 
F
A
 
N
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N
A
 
C
A
 
F
K
 
K
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N
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G
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M
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L
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P
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I
T
 
P
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P
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I
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E
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Q
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V
A
 
N
E
 
D
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M
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M
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K
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A
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A
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E
E
 
N
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Q
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-
G
 
-
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V
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K
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F
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S
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V
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D
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N
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Y
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D
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Q
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-
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E
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P
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F
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C
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D
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D
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A
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F
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A
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R
A
 
E
A
 
E
A
 
N
R
 
F
P
 
P
W
 
W
L
 
M

Sites not aligning to the query:

P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
42% identity, 99% coverage: 1:196/198 of query aligns to 1:196/198 of P9WK95

query
sites
P9WK95
M
 
M
D
 
E
P
 
A
F
 
F
V
 
H
T
 
T
L
 
H
T
 
S
A
 
G
P
 
I
A
 
G
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V
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P
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L
D
 
R
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R
A
 
S
N
 
N
I
 
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D
T
 
T
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D
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Q
L
 
I
L
 
I
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P
A
 
A
R
 
V
F
 
F
L
 
L
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K
K
 
R
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V
R
 
T
S
 
R
A
 
T
G
 
G
Y
 
F
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E
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D
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L
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F
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A
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G
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R
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S
-
 
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A
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S
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D
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E
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A
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D
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Y
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F
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I
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F
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G
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A
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A
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A
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Q
E
 
D
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D
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V
A
 
E
E
 
L
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E
E
 
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A
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-
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V
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P
F
 
F
A
x
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I
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D
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D
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A
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E
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D
D
 
D
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I
A
 
A
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L
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T
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L
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R
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K
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L
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I
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E
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A
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F
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E
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G
A
 
A
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C
A
 
A
A
 
Y
A
 
W
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K
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P
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R
L
 
T
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L
P
 
P

Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
37% identity, 48% coverage: 18:112/198 of query aligns to 13:103/170 of Q58667

query
sites
Q58667
N
 
D
I
 
V
D
 
D
T
 
T
D
 
D
Q
 
A
L
 
I
L
 
I
P
 
P
A
 
G
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P
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Y
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L
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x
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x
T
-
 
T
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D
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E
A
 
L
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A
Y
 
S
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H
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M
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A
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G
H
 
I
D
 
D
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E
R
 
-
K
 
-
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-
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N
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P
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-
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-
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-
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K
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K
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V
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K
G
 
E
A
 
G
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D
V
 
V
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I
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V
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A
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G
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E
N
 
N
F
 
F
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G
C
 
C
G
 
G
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S
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S
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R
E
 
E
G
 
Q
A
 
A
V
 
V
Y
 
I
A
 
A
L
 
I
V
 
K
D
 
Y
G
 
C
G
 
G
F
 
I
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K
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A
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V
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I
A
 
A
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K
S
 
S
F
 
F
G
 
A
D
 
R
I
 
I
F
 
F
A
 
Y
A
 
R
N
 
N
A
 
A
A
 
I
K
 
N
N
 
V
G
 
G
L
 
L
L
 
I
T
 
P
I
 
I

2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
37% identity, 48% coverage: 18:112/198 of query aligns to 13:103/167 of 2pkpA

query
sites
2pkpA
N
x
D
I
 
V
D
 
D
T
 
T
D
 
D
Q
 
A
L
 
I
L
 
I
P
 
P
A
 
G
R
 
P
F
 
Y
L
 
L
K
 
R
K
 
T
-
 
T
-
 
D
P
 
P
R
 
Y
S
 
E
A
 
L
G
 
A
Y
 
S
G
 
H
N
 
C
F
 
M
L
 
A
F
 
G
H
 
I
D
 
D
E
 
E
R
 
N
K
 
-
P
 
-
G
 
-
F
 
F
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P
L
 
-
D
 
-
D
 
-
P
 
K
A
 
K
Y
 
V
A
 
K
G
 
E
A
 
G
R
 
D
V
 
V
L
 
I
V
 
V
S
 
A
D
 
G
R
 
E
N
 
N
F
 
F
G
 
G
C
|
C
G
 
G
S
 
S
S
 
S
R
 
R
E
 
E
G
 
Q
A
 
A
V
 
V
Y
 
I
A
 
A
L
 
I
V
 
K
D
 
Y
G
 
C
G
 
G
F
 
I
R
 
K
C
 
A
V
 
V
V
 
I
A
 
A
P
 
K
S
 
S
F
 
F
G
 
A
D
 
R
I
 
I
F
 
F
A
 
Y
A
 
R
N
 
N
A
 
A
A
 
I
K
 
N
N
 
V
G
 
G
L
 
L
L
 
I
T
 
P
I
 
I

Query Sequence

>AZOBR_RS15560 FitnessBrowser__azobra:AZOBR_RS15560
MDPFVTLTAPAVPLDIANIDTDQLLPARFLKKPRSAGYGNFLFHDERKPGFPLDDPAYAG
ARVLVSDRNFGCGSSREGAVYALVDGGFRCVVAPSFGDIFAANAAKNGLLTITLPEETVA
ELRRQLQEAPGAAVTVDLPAQTLSGPDGQPLPFAIDPFKKECLIEGLDDVALTLRHQDAI
DAFDRADAAARPWLVPGG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory