SitesBLAST
Comparing AZOBR_RS16640 FitnessBrowser__azobra:AZOBR_RS16640 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
67% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 2ztlA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), L200 (≠ I201)
- binding (3s)-3-hydroxybutanoic acid: Q94 (= Q95), S142 (= S143), H144 (= H145), K152 (= K153), Y155 (= Y156), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), G15 (= G16), I16 (= I17), F36 (= F37), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), Y155 (= Y156), K159 (= K160), P185 (= P186), W187 (= W188), V188 (= V189), T190 (= T191), V193 (= V194)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
67% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 1wmbA
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 5b4tA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q95), S142 (= S143), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), G15 (= G16), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), G92 (= G93), L113 (= L114), I140 (= I141), Y155 (= Y156), K159 (= K160), P185 (= P186), G186 (= G187), W187 (= W188), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 3w8dA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding methylmalonic acid: Q94 (= Q95), S142 (= S143), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197), W257 (= W258)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), F36 (= F37), A62 (= A63), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), G186 (= G187), W187 (= W188), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 3vdrA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q95), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197), W257 (= W258)
- binding acetoacetic acid: Q94 (= Q95), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197), W257 (= W258)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), K159 (= K160), G186 (= G187), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G12), T13 (= T14), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), S142 (= S143), Y155 (= Y156), K159 (= K160), G186 (= G187), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 3vdqA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding acetate ion: Q94 (= Q95), H144 (= H145), K152 (= K153), W187 (= W188), L192 (= L193), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), S14 (= S15), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), I140 (= I141), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), G186 (= G187), W187 (= W188), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
63% identity, 100% coverage: 2:261/261 of query aligns to 1:255/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), G35 (= G36), F36 (= F37), L60 (= L65), N86 (= N91), G88 (= G93), I89 (= I94), A137 (= A142), Y151 (= Y156), K155 (= K160), P181 (= P186), G182 (= G187), V184 (= V189), T186 (= T191)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
66% identity, 100% coverage: 2:261/261 of query aligns to 1:255/255 of 2q2qD
- active site: G15 (= G16), S138 (= S143), Y151 (= Y156), K155 (= K160), R196 (≠ I201)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), F36 (= F37), D59 (= D64), L60 (= L65), N86 (= N91), G88 (= G93), L109 (= L114), I136 (= I141), S138 (= S143), Y151 (= Y156), K155 (= K160), P181 (= P186), G182 (= G187), W183 (= W188), V184 (= V189), T186 (= T191), L188 (= L193), V189 (= V194)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
63% identity, 99% coverage: 3:261/261 of query aligns to 2:236/236 of 1x1tA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160)
- binding cacodylate ion: S142 (= S143), H144 (= H145), Y155 (= Y156), W187 (= W188), W233 (= W258)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), G35 (= G36), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), G92 (= G93), L113 (= L114), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), W187 (= W188), V188 (= V189), T190 (= T191)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
42% identity, 99% coverage: 3:261/261 of query aligns to 4:260/260 of 6zzqA
- active site: G17 (= G16), S142 (= S143), Y155 (= Y156)
- binding acetoacetic acid: Q94 (= Q95), S142 (= S143), K152 (= K153), Y155 (= Y156), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G13 (= G12), S16 (= S15), G17 (= G16), I18 (= I17), D37 (≠ E45), M38 (≠ L46), D63 (≠ E70), V64 (≠ I71), N90 (= N91), A91 (= A92), G92 (= G93), M140 (≠ I141), A141 (= A142), S142 (= S143), Y155 (= Y156), K159 (= K160), Y187 (≠ W188), V188 (= V189), T190 (= T191)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
42% identity, 99% coverage: 3:261/261 of query aligns to 5:261/261 of 6zzsD
- active site: G18 (= G16), S143 (= S143), Y156 (= Y156)
- binding nicotinamide-adenine-dinucleotide: G14 (= G12), S17 (= S15), I19 (= I17), D38 (≠ E45), M39 (≠ L46), D64 (≠ E70), V65 (≠ I71), N91 (= N91), A92 (= A92), G93 (= G93), M141 (≠ I141), A142 (= A142), S143 (= S143), Y156 (= Y156), K160 (= K160), P186 (= P186), G187 (= G187), V189 (= V189), T191 (= T191), L193 (= L193)
- binding 3-oxidanylidenepentanoic acid: Q95 (= Q95), S143 (= S143), N145 (≠ H145), K153 (= K153), Y156 (= Y156), Q197 (= Q197)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
38% identity, 99% coverage: 3:260/261 of query aligns to 3:247/248 of 6ixmC
- active site: G16 (= G16), S142 (= S143), Y155 (= Y156), K159 (= K160)
- binding nicotinamide-adenine-dinucleotide: G12 (= G12), S15 (= S15), G16 (= G16), I17 (= I17), D36 (≠ G36), I37 (≠ F37), A61 (= A63), D62 (= D64), T63 (≠ L65), N89 (= N91), A90 (= A92), M140 (≠ I141), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), A186 (≠ G187), Y187 (≠ W188), I188 (≠ V189), L192 (= L193)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
39% identity, 99% coverage: 1:258/261 of query aligns to 1:245/247 of 4jroC
- active site: G16 (= G16), S142 (= S143), Q152 (≠ K153), Y155 (= Y156), K159 (= K160)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (≠ T14), R15 (≠ S15), G16 (= G16), I17 (= I17), N35 (= N35), Y36 (≠ G36), N37 (≠ F37), G38 (= G38), S39 (≠ E39), N63 (≠ D64), V64 (≠ L65), N90 (= N91), A91 (= A92), I93 (= I94), I113 (≠ L114), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), I188 (≠ V189), T190 (= T191)
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
38% identity, 98% coverage: 1:257/261 of query aligns to 4:244/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G12), R18 (≠ S15), G19 (= G16), I20 (= I17), D39 (vs. gap), R40 (vs. gap), C63 (≠ A63), I65 (≠ L65), N91 (= N91), G93 (= G93), I94 (= I94), V114 (≠ L114), Y155 (= Y156), K159 (= K160), I188 (≠ V189), T190 (= T191), T193 (= T204)
3sjuA Hedamycin polyketide ketoreductase bound to NADPH (see paper)
39% identity, 97% coverage: 6:257/261 of query aligns to 1:251/255 of 3sjuA
- active site: G11 (= G16), S138 (= S143), Y151 (= Y156), K155 (= K160), Y196 (≠ I201)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G7 (= G12), S10 (= S15), A31 (vs. gap), R32 (≠ L34), D33 (≠ N35), C56 (≠ A63), D57 (= D64), V58 (≠ L65), S84 (≠ N91), A85 (= A92), G86 (= G93), I136 (= I141), Y151 (= Y156), K155 (= K160), P181 (= P186), G182 (= G187), Y183 (≠ W188), V184 (= V189), T186 (= T191), M188 (≠ L193)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
36% identity, 98% coverage: 3:257/261 of query aligns to 5:241/244 of 4nbuB
- active site: G18 (= G16), N111 (= N115), S139 (= S143), Q149 (≠ K153), Y152 (= Y156), K156 (= K160)
- binding acetoacetyl-coenzyme a: D93 (≠ V97), K98 (≠ D102), S139 (= S143), N146 (≠ S150), V147 (= V151), Q149 (≠ K153), Y152 (= Y156), F184 (≠ W188), M189 (≠ L193), K200 (≠ L216)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G12), N17 (≠ S15), G18 (= G16), I19 (= I17), D38 (≠ G36), F39 (= F37), V59 (= V58), D60 (= D64), V61 (≠ L65), N87 (= N91), A88 (= A92), G89 (= G93), I90 (= I94), T137 (≠ I141), S139 (= S143), Y152 (= Y156), K156 (= K160), P182 (= P186), F184 (≠ W188), T185 (≠ V189), T187 (= T191), M189 (≠ L193)
2rh4B Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
39% identity, 98% coverage: 2:257/261 of query aligns to 10:264/268 of 2rh4B
- active site: G24 (= G16), N121 (= N115), S151 (= S143), Y164 (= Y156), K168 (= K160), Y209 (≠ I201)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G20 (= G12), T22 (= T14), S23 (= S15), I25 (= I17), A44 (≠ G36), R45 (≠ F37), G46 (= G38), C69 (≠ A63), D70 (= D64), V71 (≠ L65), N97 (= N91), S151 (= S143), Y164 (= Y156), K168 (= K160), G195 (= G187), V197 (= V189), T199 (= T191), M201 (≠ L193)
P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
39% identity, 98% coverage: 2:257/261 of query aligns to 3:257/261 of P16544
- 11:39 (vs. 10:38, 55% identical) binding
- D63 (= D64) binding
- K161 (= K160) binding
1w4zA Structure of actinorhodin polyketide (actiii) reductase (see paper)
39% identity, 98% coverage: 2:257/261 of query aligns to 1:255/259 of 1w4zA
- active site: G15 (= G16), N112 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), Y200 (≠ I201)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), R36 (≠ F37), G37 (= G38), D61 (= D64), V62 (≠ L65), N88 (= N91), G90 (= G93), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), G186 (= G187), V188 (= V189), T190 (= T191)
1xr3A Actinorhodin polyketide ketoreductase with NADP and the inhibitor isoniazid bound (see paper)
39% identity, 97% coverage: 6:257/261 of query aligns to 2:252/256 of 1xr3A
- active site: G12 (= G16), N109 (= N115), S139 (= S143), Y152 (= Y156), K156 (= K160), Y197 (≠ I201)
- binding 4-(diazenylcarbonyl)pyridine: T140 (≠ V144), G141 (≠ H145), V146 (≠ S150)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G12), T10 (= T14), S11 (= S15), G12 (= G16), I13 (= I17), A32 (≠ G36), R33 (≠ F37), G34 (= G38), C57 (≠ A63), D58 (= D64), V59 (≠ L65), N85 (= N91), A86 (= A92), G87 (= G93), S139 (= S143), Y152 (= Y156), K156 (= K160), G183 (= G187), V185 (= V189), T187 (= T191), P188 (= P192)
Query Sequence
>AZOBR_RS16640 FitnessBrowser__azobra:AZOBR_RS16640
MTLTQKVAVVTGSTSGIGLGIARALAGAGADVVLNGFGEAAAIEELRAGLAAEFGVRVGY
HGADLSKPAEIAALIGHAEETFGSVDVLVNNAGIQHVAPVEDFPAERWDAVIALNLSAVF
HGTHHALPGMKRRGWGRILNIASVHGHVASVNKSAYVAAKHGVVGLTKTVALETAGTGVT
CNAICPGWVLTPLVQKQIDAIASTKNIPEPQAKAELLGAKQPSGAFVTPDELGGLAVFLC
SDSAAQMTGASLLMDGGWTAQ
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory