SitesBLAST
Comparing AZOBR_RS16640 FitnessBrowser__azobra:AZOBR_RS16640 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
67% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 2ztlA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), L200 (≠ I201)
- binding (3s)-3-hydroxybutanoic acid: Q94 (= Q95), S142 (= S143), H144 (= H145), K152 (= K153), Y155 (= Y156), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), G15 (= G16), I16 (= I17), F36 (= F37), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), Y155 (= Y156), K159 (= K160), P185 (= P186), W187 (= W188), V188 (= V189), T190 (= T191), V193 (= V194)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
67% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 1wmbA
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 5b4tA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q95), S142 (= S143), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), G15 (= G16), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), G92 (= G93), L113 (= L114), I140 (= I141), Y155 (= Y156), K159 (= K160), P185 (= P186), G186 (= G187), W187 (= W188), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 3w8dA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding methylmalonic acid: Q94 (= Q95), S142 (= S143), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197), W257 (= W258)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), F36 (= F37), A62 (= A63), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), G186 (= G187), W187 (= W188), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 3vdrA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q95), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197), W257 (= W258)
- binding acetoacetic acid: Q94 (= Q95), H144 (= H145), K152 (= K153), Y155 (= Y156), W187 (= W188), Q196 (= Q197), W257 (= W258)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), K159 (= K160), G186 (= G187), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G12), T13 (= T14), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), S142 (= S143), Y155 (= Y156), K159 (= K160), G186 (= G187), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
64% identity, 99% coverage: 3:261/261 of query aligns to 2:260/260 of 3vdqA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160), I200 (= I201)
- binding acetate ion: Q94 (= Q95), H144 (= H145), K152 (= K153), W187 (= W188), L192 (= L193), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), S14 (= S15), I16 (= I17), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), A91 (= A92), G92 (= G93), L113 (= L114), I140 (= I141), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), G186 (= G187), W187 (= W188), V188 (= V189), T190 (= T191), L192 (= L193), V193 (= V194)
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
63% identity, 100% coverage: 2:261/261 of query aligns to 1:255/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), G35 (= G36), F36 (= F37), L60 (= L65), N86 (= N91), G88 (= G93), I89 (= I94), A137 (= A142), Y151 (= Y156), K155 (= K160), P181 (= P186), G182 (= G187), V184 (= V189), T186 (= T191)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
66% identity, 100% coverage: 2:261/261 of query aligns to 1:255/255 of 2q2qD
- active site: G15 (= G16), S138 (= S143), Y151 (= Y156), K155 (= K160), R196 (≠ I201)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), F36 (= F37), D59 (= D64), L60 (= L65), N86 (= N91), G88 (= G93), L109 (= L114), I136 (= I141), S138 (= S143), Y151 (= Y156), K155 (= K160), P181 (= P186), G182 (= G187), W183 (= W188), V184 (= V189), T186 (= T191), L188 (= L193), V189 (= V194)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
63% identity, 99% coverage: 3:261/261 of query aligns to 2:236/236 of 1x1tA
- active site: G15 (= G16), N114 (= N115), S142 (= S143), Y155 (= Y156), K159 (= K160)
- binding cacodylate ion: S142 (= S143), H144 (= H145), Y155 (= Y156), W187 (= W188), W233 (= W258)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), G35 (= G36), F36 (= F37), D63 (= D64), L64 (= L65), N90 (= N91), G92 (= G93), L113 (= L114), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), W187 (= W188), V188 (= V189), T190 (= T191)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
42% identity, 99% coverage: 3:261/261 of query aligns to 4:260/260 of 6zzqA
- active site: G17 (= G16), S142 (= S143), Y155 (= Y156)
- binding acetoacetic acid: Q94 (= Q95), S142 (= S143), K152 (= K153), Y155 (= Y156), Q196 (= Q197)
- binding nicotinamide-adenine-dinucleotide: G13 (= G12), S16 (= S15), G17 (= G16), I18 (= I17), D37 (≠ E45), M38 (≠ L46), D63 (≠ E70), V64 (≠ I71), N90 (= N91), A91 (= A92), G92 (= G93), M140 (≠ I141), A141 (= A142), S142 (= S143), Y155 (= Y156), K159 (= K160), Y187 (≠ W188), V188 (= V189), T190 (= T191)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
42% identity, 99% coverage: 3:261/261 of query aligns to 5:261/261 of 6zzsD
- active site: G18 (= G16), S143 (= S143), Y156 (= Y156)
- binding nicotinamide-adenine-dinucleotide: G14 (= G12), S17 (= S15), I19 (= I17), D38 (≠ E45), M39 (≠ L46), D64 (≠ E70), V65 (≠ I71), N91 (= N91), A92 (= A92), G93 (= G93), M141 (≠ I141), A142 (= A142), S143 (= S143), Y156 (= Y156), K160 (= K160), P186 (= P186), G187 (= G187), V189 (= V189), T191 (= T191), L193 (= L193)
- binding 3-oxidanylidenepentanoic acid: Q95 (= Q95), S143 (= S143), N145 (≠ H145), K153 (= K153), Y156 (= Y156), Q197 (= Q197)
8y83A Crystal structure of a ketoreductase from sphingobacterium siyangense sy1 with co-enzyme
40% identity, 99% coverage: 3:260/261 of query aligns to 4:248/249 of 8y83A
- binding nicotinamide-adenine-dinucleotide: G13 (= G12), S16 (= S15), G17 (= G16), I18 (= I17), D37 (≠ G36), I38 (≠ F37), A62 (= A63), D63 (= D64), S64 (≠ L65), N90 (= N91), M141 (≠ I141), Y156 (= Y156), K160 (= K160), P186 (= P186), G187 (= G187), Y188 (≠ W188), I189 (≠ V189), L193 (= L193)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
38% identity, 99% coverage: 3:260/261 of query aligns to 3:247/248 of 6ixmC
- active site: G16 (= G16), S142 (= S143), Y155 (= Y156), K159 (= K160)
- binding nicotinamide-adenine-dinucleotide: G12 (= G12), S15 (= S15), G16 (= G16), I17 (= I17), D36 (≠ G36), I37 (≠ F37), A61 (= A63), D62 (= D64), T63 (≠ L65), N89 (= N91), A90 (= A92), M140 (≠ I141), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), A186 (≠ G187), Y187 (≠ W188), I188 (≠ V189), L192 (= L193)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
39% identity, 99% coverage: 1:258/261 of query aligns to 1:245/247 of 4jroC
- active site: G16 (= G16), S142 (= S143), Q152 (≠ K153), Y155 (= Y156), K159 (= K160)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (≠ T14), R15 (≠ S15), G16 (= G16), I17 (= I17), N35 (= N35), Y36 (≠ G36), N37 (≠ F37), G38 (= G38), S39 (≠ E39), N63 (≠ D64), V64 (≠ L65), N90 (= N91), A91 (= A92), I93 (= I94), I113 (≠ L114), S142 (= S143), Y155 (= Y156), K159 (= K160), P185 (= P186), I188 (≠ V189), T190 (= T191)
9febA Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae in complex with NADP
39% identity, 98% coverage: 2:257/261 of query aligns to 5:256/261 of 9febA
9fe6B Short-chain dehydrogenase/reductase (sdr) from thermus caliditerrae
39% identity, 98% coverage: 2:257/261 of query aligns to 5:256/261 of 9fe6B