SitesBLAST

O95571 Persulfide dioxygenase ETHE1, mitochondrial; Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Homo sapiens (Human) (see 4 papers)
39% identity, 49% coverage: 108:209/210 of query aligns to 111:216/254 of O95571

query
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O95571

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H135 (= H132) binding
T152 (≠ V149) to I: in EE; reduces protein stability, iron content and enzyme activity; dbSNP:rs1317633085
D154 (= D151) binding
T164 (= T161) to K: in EE; reduces protein stability; dbSNP:rs1268640442
D196 (≠ G193) to N: in EE; reduces protein stability and affinity for substrate; dbSNP:rs763799125

Sites not aligning to the query:

1:7 modified: transit peptide, Mitochondrion
55 L → P: in EE; reduces protein stability; dbSNP:rs182983506
79 binding

4chlB Human ethylmalonic encephalopathy protein 1 (hethe1) (see paper)
39% identity, 49% coverage: 108:209/210 of query aligns to 95:200/237 of 4chlB

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4chlB

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active site: H119 (= H132), D138 (= D151), H179 (= H192)
binding fe (iii) ion: H119 (= H132), D138 (= D151)

Sites not aligning to the query:

active site: 63, 65, 67, 68
binding fe (iii) ion: 63

2gcuA X-ray structure of gene product from arabidopsis thaliana at1g53580 (see paper)
38% identity, 49% coverage: 108:209/210 of query aligns to 93:204/244 of 2gcuA

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2gcuA

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active site: H117 (= H132), D142 (= D151), H183 (= H192)
binding fe (ii) ion: H117 (= H132), D142 (= D151)

Sites not aligning to the query:

active site: 61, 63, 65, 66
binding fe (ii) ion: 61

Q9C8L4 Persulfide dioxygenase ETHE1 homolog, mitochondrial; Glyoxalase II; Glx II; Sulfur dioxygenase ETHE1; EC 1.13.11.18 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 49% coverage: 108:209/210 of query aligns to 142:253/294 of Q9C8L4

query
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Q9C8L4

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H166 (= H132) binding
D191 (= D151) binding

Sites not aligning to the query:

110 binding

3tp9A Crystal structure of alicyclobacillus acidocaldarius protein with beta-lactamase and rhodanese domains
29% identity, 90% coverage: 20:209/210 of query aligns to 22:227/473 of 3tp9A

query
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3tp9A

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active site: H58 (= H56), H60 (= H58), D62 (= D60), F63 (≠ H61), H122 (= H132), D148 (= D151)
binding zinc ion: H58 (= H56), H122 (= H132), D148 (= D151)

3r2uA 2.1 angstrom resolution crystal structure of metallo-beta-lactamase from staphylococcus aureus subsp. Aureus col
27% identity, 93% coverage: 11:205/210 of query aligns to 13:222/348 of 3r2uA

query
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3r2uA

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active site: H58 (= H56), H60 (= H58), D62 (= D60), F63 (≠ H61), H121 (= H132), D147 (= D151), H197 (= H192)
binding fe (iii) ion: H58 (= H56), H121 (= H132), D147 (= D151)

5ve5A Crystal structure of persulfide dioxygenase rhodanese fusion protein with rhodanese domain inactivating mutation (c314s) from burkholderia phytofirmans in complex with glutathione (see paper)
34% identity, 49% coverage: 107:208/210 of query aligns to 91:196/350 of 5ve5A

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5ve5A

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active site: H116 (= H132), D135 (= D151), H176 (= H192)
binding fe (iii) ion: H116 (= H132), D135 (= D151)
binding glutathione: H116 (= H132), D135 (= D151), G143 (= G159), R144 (= R160), Y178 (vs. gap)

Sites not aligning to the query:

4ysbA Crystal structure of ethe1 from myxococcus xanthus (see paper)
28% identity, 88% coverage: 23:206/210 of query aligns to 23:188/225 of 4ysbA

query
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4ysbA

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L

F

F

P

T

L

L

G

P

D

D

D

E

V

T

T

L

F

V

I

Y

P

P

G

G

H
|
H

-

D

-

Y

-

K

G

G

P

R

T

T

-

V

S

T

T

S

I

I

G

A

E

E

R

K

L

R

Y

H

N

N

P

P

active site: H57 (= H56), H59 (= H58), D61 (= D60), H62 (= H61), H112 (= H132), D129 (= D151), H170 (= H192)
binding fe (iii) ion: H57 (= H56), H112 (= H132), D129 (= D151)

6sg9FL uS3m (see paper)
41% identity, 38% coverage: 130:208/210 of query aligns to 220:297/320 of 6sg9FL

query
sites
6sg9FL

P

P

G

G

H
|
H

T

S

P

P

G

G

H

H

V

M

F

L

V

H

H

I

K

P

P

T

S

E

K

R

I

I

A

L

I

F

V

S

G

G

D
|
D

V

L

L

L

F

F

Q

F

G

N

S
x
K

I

V

G

G

R

R

T

V

D

D

F

L

P

P

K

W

G

A

N

T

H

G

G

V

D

R

L

L

I

A

E

E

S

S

I

L

R

R

S

-

K

L

L

L

F

E

P

A

L

L

G

P

D

D

D

N

V

T

T

V

F

V

I

V

P

P

G

G

H
|
H

G
|
G

P
x
R

T

M

S

T

T

T

I

L

G

G

E

R

E

E

R

R

L

R

Y

E

N

N

P

K

F

A

L

L

binding zinc ion: H222 (= H132), D241 (= D151), D241 (= D151), H281 (= H192)
binding : K247 (≠ S157), G282 (= G193), R283 (≠ P194)

Sites not aligning to the query:

binding zinc ion: 108, 110, 112, 320, 320
binding : 40, 43, 45, 57, 58, 63, 67, 319

6aufB Crystal structure of metalo beta lactamases mim-1 from novosphingobium pentaromativorans
32% identity, 61% coverage: 52:179/210 of query aligns to 80:213/273 of 6aufB

query
sites
6aufB

I

I

L

L

V

T

T

S

H
|
H

G

E

H
|
H

I

H

D
|
D

H
|
H

A

A

G

G

A

S

V

I

A

A

D

E

L

L

A

Q

D

K

E

A

L

T

K

G

L

A

P

Q

I

I

E

A

G

A

P

V

H

A

R

S

E

A

D

R

Q

Q

F

V

W

L

I

E

D

S

G

G

M

K

P

P

M

S

-

A

-

D

-

P

Q

Q

S

S

Q

G

M

L

F

I

-

E

G

G

F

F

P

P

V

V

R

H

S

V

F

A

T

-

P

-

D

-

R

R

W

V

L

L

E

V

E

D

G

G

D

D

T

S

V

V

T

T

V

L

G

G

N

R

L

L

T

A

L

L

D

T

V

V

H

R

H

E

C

T

P

P

G

A

H
|
H

T

S

P

P

G

G

H

S

V

A

V

S

F

W

V

T

H

W

K

Q

P

A

S

C

K

D

I

E

A

A

I

F

V

T

G

C

D

R

V

M

L

I

F

A

Q

Y

G

A

-

D

-

S

-

A

-

T

S

T

I

I

G

S

R

A

T

D

D

D

F
x
Y

P

R

K

F

G

S

N

D

H

H

G

P

D

D

L

R

I

I

E

A

S

R

I

I

R

R

S

T

K

G

L

L

active site: H84 (= H56), H86 (= H58), D88 (= D60), H89 (= H61), H162 (= H132), Y197 (≠ F163)
binding zinc ion: H84 (= H56), H86 (= H58), D88 (= D60), H89 (= H61), H162 (= H132)

Sites not aligning to the query:

active site: 228
binding zinc ion: 228

5nggA Crystal structure of the subclass b3 metallo-beta-lactamase bjp-1 in complex with acetate anion
36% identity, 40% coverage: 52:135/210 of query aligns to 77:160/274 of 5nggA

query
sites
5nggA

I

I

L

L

V

N

T

T

H
|
H

G

A

H
|
H

I

L

D
|
D

H
|
H

A

T

G

G

A

G

V

F

A

A

D

E

L

I

A

K

D

K

E

E

L

T

K

G

L

A

P

Q

I

L

E

V

G

A

P

G

H

E

R

R

E

D

D

K

Q

P

F

L

W

L

I

E

D

G

G

G

M

Y

-

Y

-

P

-

G

P

D

M

E

Q

K

S

N

Q

E

M

D

F

L

G

A

F

F

P

P

P

A

V

V

R

K

S

V

F

-

T

-

P

-

D

D

R

R

W

A

L

V

E

K

E
|
E

G

G

D

D

T

R

V

V

T

T

V

L

G

G

N

D

L

T

T

T

L

L

D

T

V

A

H
|
H

H

A

C

T

P

P

G

G

H
|
H

T

S

P

P

G

G

active site: H81 (= H56), H83 (= H58), D85 (= D60), H86 (= H61), H157 (= H132)
binding zinc ion: H81 (= H56), H83 (= H58), D85 (= D60), H86 (= H61), E138 (= E113), H152 (= H127), H157 (= H132)

Sites not aligning to the query:

active site: 188, 222
binding zinc ion: 209, 222

5wcmA Crystal structure of the complex between class b3 beta-lactamase bjp-1 and 4-nitrobenzene-sulfonamide - new refinement (see paper)
36% identity, 40% coverage: 52:135/210 of query aligns to 66:149/263 of 5wcmA

query
sites
5wcmA

I

I

L

L

V

N

T

T

H
|
H

G

A

H
|
H

I
x
L

D
|
D

H
|
H

A

T

G

G

A

G

V

F

A

A

D
x
E

L

I

A

K

D

K

E
|
E

L

T

K

G

L

A

P

Q

I

L

E

V

G

A

P

G

H

E

R

R

E

D

D

K

Q

P

F

L

W

L

I

E

D

G

G

G

M

Y

-

Y

-

P

-

G

P

D

M

E

Q

K

S

N

Q

E

M

D

F
x
L

G

A

F

F

P

P

P

A

V

V

R

K

S

V

F

-

T

-

P

-

D

D

R

R

W

A

L

V

E

K

E
|
E

G

G

D

D

T

R

V

V

T

T

V

L

G

G

N

D

L

T

T

T

L

L

D

T

V

A

H
|
H

H

A

C

T

P

P

G

G

H
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H

T

S

P

P

G

G

active site: H70 (= H56), H72 (= H58), D74 (= D60), H75 (= H61), H146 (= H132)
binding 4-nitrobenzenesulfonamide: L73 (≠ I59), D74 (= D60), L114 (≠ F97), H146 (= H132)
binding zinc ion: H70 (= H56), H72 (= H58), D74 (= D60), H75 (= H61), E81 (≠ D67), E85 (= E71), E127 (= E113), H141 (= H127), H146 (= H132)

Sites not aligning to the query:

active site: 177, 211
binding 4-nitrobenzenesulfonamide: 3, 176, 211
binding zinc ion: 8, 50, 55, 198, 211

2p18A Crystal structure of the leishmania infantum glyoxalase ii (see paper)
32% identity, 81% coverage: 27:196/210 of query aligns to 38:204/283 of 2p18A

query
sites
2p18A

A

A

V

V

D

D

P

V

G

N

G

A

D

D

L

Y

P

K

R

P

V

I

L

L

R

T

A

Y

A

I

Q

E

S

E

K

H

-

L

G

T

V

Y

T

T

L

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S

K

T

I

I

L

L

V

S

T

T

H
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H

G

K

H
|
H

I

W

D
|
D

H
|
H

A

S

G

G

A

G

V

N

A

A

D

K

L

L

A

K

D

A

E

E

L

L

K

E

L

-

P

A

I

M

E

N

G

V

P

P

H

V

R

V

E

V

D

V

Q

G

F

G

W

A

I

N

D

D

G

S

M

I

P

P

M

A

Q

V

S

T

Q

K

M

-

F

-

G

-

F

-

P

-

P

P

V

V

R

R

S

-

F

-

T

-

P

-

D

-

R

-

W

-

L

-

E

-

E

E

G

G

D

D

T

R

V

V

T

Q

V

V

G

G

N

D

L

L

T

S

L

V

D

E

V

V

H

I

H

D

C

A

P

P

G

C

H
|
H

T

T

P

R

G

G

H

H

V

V

V

L

F

Y

V

K

-

V

-

Q

-

H

-

P

-

Q

H

H

K

P

P

N

S

D

K

G

I

V

A

A

I

L

-

F

V

T

G

G

D
|
D

V

T

L

M

F

F

Q

I

G

A

S

G

I
|
I

G

G

R

A

T

-

D

-

F

F

P

F

K

E

G

G

N

D

H

E

G

K

D

D

L

M

I

C

E

R

S

A

I

M

R

E

S

-

K

K

L

V

F

Y

P

H

L

I

G

H

-

K

-

G

-

N

-

D

-

Y

-

A

-

L

D

D

D

K

V

V

T

T

F

F

I

I

-

F

P

P

G

G

H
|
H

G

E

P
x
Y

T

T

S

S

active site: H68 (= H56), H70 (= H58), D72 (= D60), H73 (= H61), H129 (= H132), D154 (= D151), H200 (= H192)
binding spermidine: I161 (= I158), Y202 (≠ P194)
binding zinc ion: H68 (= H56), H70 (= H58), D72 (= D60), H73 (= H61), H129 (= H132), D154 (= D151), D154 (= D151), H200 (= H192)

4efzA Crystal structure of a hypothetical metallo-beta-lactamase from burkholderia pseudomallei
31% identity, 64% coverage: 46:179/210 of query aligns to 62:204/295 of 4efzA

query
sites
4efzA

G

G

V

A

T

R

L

V

E

R

K

W

I

L

L

L

V

E

T

T

H
|
H

G

V

H
|
H

I

A

D
|
D

H
|
H

A

L

G

S

A

A

V

-

A

-

D

-

L

-

A

A

D

P

E

Y

L

L

K

K

L

T

P

R

I

V

E

G

G

G

P

E

H

I

R

A

E

I

D

G

Q

R

F

H

W

V

I

T

D

R

G

V

M

Q

P

D

M

V

Q

F

S

G

Q

K

M

L

F

F

G

N

F

A

P

G

P

P

V

A

R

F

S

A

F

H

T

D

P

G

-

S

-

Q

-

F

D

D

R

R

W

L

L

L

E

D

G

G

D

D

T

T

V

L

T

A

V

L

G

G

N

A

L

L

T

S

L

I

D

R

V

A

H

M

H

H

C

T

P

P

G

G

H
|
H

T

T

P

P

G

A

H

C

V

M

V

T

F

Y

V

V

-

V

-

T

-

E

-

A

-

H

-

A

-

H

H

D

K

A

P

R

S

D

K

A

I

A

A

A

I

F

V

V

G

G

D
|
D

V

T

L

L

F

F

Q

M

G

P

S

D

I

Y

G

G

-

T

-

A

R

R

T

C

D

D

F

F

P

P

K

G

G

G

N

D

H

A

G

R

D

S

L

L

I

Y

E

R

S

S

I

I

R

R

S

K

K

V

L

L

active site: H72 (= H56), H74 (= H58), D76 (= D60), H77 (= H61)
binding calcium ion: H72 (= H56), H147 (= H132), D174 (= D151)

Query Sequence

>AZOBR_RS19250 FitnessBrowser__azobra:AZOBR_RS19250
MQTIIVPVTPFQQNCTVLWCPETMKGAAVDPGGDLPRVLRAAQSKGVTLEKILVTHGHID
HAGAVADLADELKLPIEGPHREDQFWIDGMPMQSQMFGFPPVRSFTPDRWLEEGDTVTVG
NLTLDVHHCPGHTPGHVVFVHKPSKIAIVGDVLFQGSIGRTDFPKGNHGDLIESIRSKLF
PLGDDVTFIPGHGPTSTIGEERLYNPFLND

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory