SitesBLAST
Comparing AZOBR_RS19585 FitnessBrowser__azobra:AZOBR_RS19585 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5cevA Arginase from bacillus caldevelox, l-lysine complex (see paper)
41% identity, 96% coverage: 1:301/315 of query aligns to 3:298/298 of 5cevA
- active site: H98 (= H97), D121 (= D124), H123 (= H126), D125 (= D128), H138 (= H141), D225 (= D228), D227 (= D230), E270 (= E273)
- binding guanidine: H251 (= H254), E255 (= E258)
- binding lysine: S134 (= S137), H138 (= H141), E270 (= E273)
- binding manganese (ii) ion: H98 (= H97), D121 (= D124), D121 (= D124), H123 (= H126), D125 (= D128), D225 (= D228), D225 (= D228), D227 (= D230)
4cevA Arginase from bacillus caldevelox, l-ornithine complex (see paper)
41% identity, 96% coverage: 1:301/315 of query aligns to 3:298/298 of 4cevA
- active site: H98 (= H97), D121 (= D124), H123 (= H126), D125 (= D128), H138 (= H141), D225 (= D228), D227 (= D230), E270 (= E273)
- binding guanidine: H251 (= H254), E255 (= E258)
- binding manganese (ii) ion: H98 (= H97), D121 (= D124), D121 (= D124), H123 (= H126), D125 (= D128), D225 (= D228), D225 (= D228), D227 (= D230)
- binding L-ornithine: H123 (= H126), D125 (= D128), S134 (= S137), H138 (= H141), D177 (= D180)
3cevA Arginase from bacillus caldevelox, complexed with l-arginine (see paper)
41% identity, 96% coverage: 1:301/315 of query aligns to 3:298/298 of 3cevA
- active site: H98 (= H97), D121 (= D124), H123 (= H126), D125 (= D128), H138 (= H141), D225 (= D228), D227 (= D230), E270 (= E273)
- binding arginine: H123 (= H126), D125 (= D128), S134 (= S137), H138 (= H141), D225 (= D228), H251 (= H254), E255 (= E258), E270 (= E273), E295 (≠ R298), L297 (≠ I300)
- binding manganese (ii) ion: H98 (= H97), D121 (= D124), D125 (= D128), D225 (= D228)
2cevB Arginase from bacillus caldevelox, native structure at ph 8.5 (see paper)
41% identity, 96% coverage: 1:301/315 of query aligns to 3:298/298 of 2cevB
- active site: H98 (= H97), D121 (= D124), H123 (= H126), D125 (= D128), H138 (= H141), D225 (= D228), D227 (= D230), E270 (= E273)
- binding guanidine: H251 (= H254), E255 (= E258)
- binding manganese (ii) ion: H98 (= H97), D121 (= D124), D121 (= D124), H123 (= H126), D125 (= D128), D225 (= D228), D225 (= D228), D227 (= D230)
1cevA Arginase from bacillus caldovelox, native structure at ph 5.6 (see paper)
41% identity, 96% coverage: 1:301/315 of query aligns to 4:299/299 of 1cevA
- active site: H99 (= H97), D122 (= D124), H124 (= H126), D126 (= D128), H139 (= H141), D226 (= D228), D228 (= D230), E271 (= E273)
- binding manganese (ii) ion: H99 (= H97), D122 (= D124), D122 (= D124), H124 (= H126), D126 (= D128), D226 (= D228), D226 (= D228), D228 (= D230)
P53608 Arginase; EC 3.5.3.1 from Bacillus caldovelox (see paper)
41% identity, 96% coverage: 1:301/315 of query aligns to 4:299/299 of P53608
2ef5A Crystal structure of the arginase from thermus thermophilus
49% identity, 96% coverage: 1:301/315 of query aligns to 3:273/273 of 2ef5A
- active site: H80 (= H97), D102 (= D124), H104 (= H126), D106 (= D128), H118 (= H141), D200 (= D228), D202 (= D230), E245 (= E273)
- binding lysine: P9 (= P7), D15 (≠ G13), M16 (= M19), S19 (≠ A22)
- binding manganese (ii) ion: H80 (= H97), D102 (= D124), D102 (= D124), H104 (= H126), D106 (= D128), D200 (= D228), D200 (= D228), D202 (= D230)
6nfpA 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
40% identity, 96% coverage: 1:301/315 of query aligns to 3:292/292 of 6nfpA
6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
40% identity, 96% coverage: 1:301/315 of query aligns to 6:289/289 of 6nfpD
6dktA Crystal structure of arginase from bacillus subtilis
39% identity, 96% coverage: 1:301/315 of query aligns to 3:283/283 of 6dktA
6nbkA Crystal structure of arginase from bacillus cereus
39% identity, 95% coverage: 1:300/315 of query aligns to 3:288/289 of 6nbkA
P78540 Arginase-2, mitochondrial; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase; EC 3.5.3.1 from Homo sapiens (Human) (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 26:325/354 of P78540
6ss2AAA of arginase-2 in complex with the inhibitory human antigen-binding fragment fab c0021158' (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 5:304/320 of 6ss2AAA
6q39A Complex of arginase 2 with example 49 (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 3:302/306 of 6q39A
- active site: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), H137 (= H141), D228 (= D228), D230 (= D230), E273 (= E273)
- binding 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-1-[[(2~{S})-piperidin-2-yl]methyl]pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), N126 (= N130), S133 (= S137), H137 (= H141), D177 (≠ S178), D179 (= D180), D228 (= D228), T242 (= T242), E273 (= E273)
- binding manganese (ii) ion: H97 (= H97), D120 (= D124), D120 (= D124), H122 (= H126), D124 (= D128), D228 (= D228), D228 (= D228), D230 (= D230)
6q37A Complex of arginase 2 with example 23 (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 3:302/306 of 6q37A
- active site: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), H137 (= H141), D228 (= D228), D230 (= D230), E273 (= E273)
- binding 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), N126 (= N130), S133 (= S137), H137 (= H141), G138 (= G142), D179 (= D180), D228 (= D228)
- binding manganese (ii) ion: H97 (= H97), D120 (= D124), D120 (= D124), H122 (= H126), D124 (= D128), D228 (= D228), D228 (= D228), D230 (= D230)
4ixvA Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4- yl]pentyl}(trihydroxy)borate(1-) (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 3:302/306 of 4ixvA
- active site: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), H137 (= H141), D228 (= D228), D230 (= D230), E273 (= E273)
- binding manganese (ii) ion: H97 (= H97), D120 (= D124), D120 (= D124), H122 (= H126), D124 (= D128), D228 (= D228), D228 (= D228), D230 (= D230)
- binding {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-): D120 (= D124), H122 (= H126), D124 (= D128), S132 (≠ P136), S133 (= S137), H137 (= H141), G138 (= G142), D179 (= D180), D228 (= D228), E273 (= E273)
4ixuA Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8- azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-) (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 3:302/306 of 4ixuA
- active site: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), H137 (= H141), D228 (= D228), D230 (= D230), E273 (= E273)
- binding {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-): D120 (= D124), H122 (= H126), D124 (= D128), N126 (= N130), S133 (= S137), H137 (= H141), G138 (= G142), D179 (= D180), D228 (= D228)
- binding manganese (ii) ion: H97 (= H97), D120 (= D124), D120 (= D124), H122 (= H126), D124 (= D128), D228 (= D228), D228 (= D228), D230 (= D230)
4ie3A Crystal structure of human arginase-2 complexed with inhbitor 1o (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 3:302/306 of 4ie3A
- active site: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), H137 (= H141), D228 (= D228), D230 (= D230), E273 (= E273)
- binding [(5R)-5-amino-5-carboxy-7-(4-hydroxypiperidin-1-yl)heptyl](trihydroxy)borate(1-): D120 (= D124), H122 (= H126), D124 (= D128), N126 (= N130), S133 (= S137), H137 (= H141), D179 (= D180), D228 (= D228)
- binding manganese (ii) ion: H97 (= H97), D120 (= D124), D120 (= D124), H122 (= H126), D124 (= D128), D228 (= D228), D228 (= D228), D230 (= D230)
4ie2A Crystal structure of human arginase-2 complexed with inhibitor 1h (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 3:302/306 of 4ie2A
- active site: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), H137 (= H141), D228 (= D228), D230 (= D230), E273 (= E273)
- binding [(5R)-5-amino-5-carboxy-8-hydroxyoctyl](trihydroxy)borate(1-): H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), S133 (= S137), H137 (= H141), G138 (= G142), D179 (= D180), D228 (= D228)
- binding manganese (ii) ion: H97 (= H97), D120 (= D124), D120 (= D124), H122 (= H126), D124 (= D128), D228 (= D228), D228 (= D228), D230 (= D230)
4i06A Crystal structure of human arginase-2 complexed with inhibitor 14 (see paper)
38% identity, 95% coverage: 1:298/315 of query aligns to 3:302/306 of 4i06A
- active site: H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), H137 (= H141), D228 (= D228), D230 (= D230), E273 (= E273)
- binding manganese (ii) ion: H97 (= H97), D120 (= D124), D120 (= D124), H122 (= H126), D124 (= D128), D228 (= D228), D228 (= D228), D230 (= D230)
- binding [(5R)-5-carboxy-5-(methylamino)-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-): H97 (= H97), D120 (= D124), H122 (= H126), D124 (= D128), S133 (= S137), H137 (= H141), G138 (= G142), D179 (= D180), D228 (= D228)
Query Sequence
>AZOBR_RS19585 FitnessBrowser__azobra:AZOBR_RS19585
VEIIGVPIEAGAGHPGALMGPAALRTAGLVRALRELGHEVRDLGDLGRGDLTPAPWSEGD
AATARLAEITAWSRALADRSYAMMQAGGVPVFLGGDHSLSMGSVTGVARHCRETGKPLFV
LWLDAHGDFNTPHTSPSGNMHGMPVALLCGEDGFDNVFPPEQRATVNPAHVHLFGIRSLD
PGERRLLRARGVDVVDMRLIDEHGVGVHMRRIIERVRQAGGHLHVSLDVDFLDPAIAPAV
GTAVLGGATYREAHLIMEMLHDAGVVGSLDVVELNPFLDERGKSALLLVDLVASLFGRRI
IDPAVTQSQIGGQAV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory