SitesBLAST
Comparing AZOBR_RS19670 FitnessBrowser__azobra:AZOBR_RS19670 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2r0nA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
72% identity, 97% coverage: 15:400/400 of query aligns to 2:389/390 of 2r0nA
- active site: L133 (= L146), T134 (= T147), A247 (= A258), E368 (= E379), R380 (= R391)
- binding flavin-adenine dinucleotide: F131 (= F144), L133 (= L146), T134 (= T147), G139 (= G152), S140 (= S153), W166 (= W177), I167 (= I178), T168 (= T179), Y367 (= Y378), T370 (= T381), D372 (= D383)
- binding 3-thiaglutaryl-CoA: R92 (= R105), S93 (= S106), V97 (= V110), P142 (= P155), G238 (≠ V249), F241 (= F252), L244 (= L255), N245 (= N256), P318 (= P329), Y367 (= Y378), E368 (= E379), I377 (= I388)
1sirA The crystal structure and mechanism of human glutaryl-coa dehydrogenase (see paper)
72% identity, 97% coverage: 15:400/400 of query aligns to 2:389/390 of 1sirA
- active site: L133 (= L146), T134 (= T147), A247 (= A258), E368 (= E379), R380 (= R391)
- binding flavin-adenine dinucleotide: F131 (= F144), L133 (= L146), T134 (= T147), G139 (= G152), S140 (= S153), W166 (= W177), I167 (= I178), T168 (= T179), Y367 (= Y378), T370 (= T381)
- binding s-4-nitrobutyryl-coa: S93 (= S106), S140 (= S153), F241 (= F252), G242 (= G253), L244 (= L255), N245 (= N256), R248 (= R259), P318 (= P329), Y367 (= Y378), E368 (= E379), R380 (= R391)
2r0mA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
72% identity, 97% coverage: 15:400/400 of query aligns to 2:389/390 of 2r0mA
- active site: L133 (= L146), T134 (= T147), A247 (= A258), D368 (≠ E379), R380 (= R391)
- binding 4-nitrobutanoic acid: L101 (= L114), Y367 (= Y378), D368 (≠ E379)
- binding flavin-adenine dinucleotide: F131 (= F144), L133 (= L146), T134 (= T147), G139 (= G152), S140 (= S153), W166 (= W177), I167 (= I178), T168 (= T179), L210 (= L221), Y367 (= Y378), T370 (= T381)
3gqtC Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4- tetrahydroquinoxalin-6-yl)methylamine (see paper)
71% identity, 97% coverage: 13:399/400 of query aligns to 1:385/385 of 3gqtC
- active site: L135 (= L146), T136 (= T147), A250 (= A258), E365 (= E379), R377 (= R391)
- binding 1-(1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine: W166 (= W177), K210 (= K218), L213 (= L221), T218 (= T226), Y364 (= Y378)
3gncA Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment 6421 (see paper)
71% identity, 97% coverage: 13:398/400 of query aligns to 2:380/380 of 3gncA
3eonC 2.55a crystal structure of native glutaryl-coa dehydrogenase from burkholderia pseudomallei in complex with a small molecule (see paper)
71% identity, 97% coverage: 13:398/400 of query aligns to 1:382/382 of 3eonC
3d6bC 2.2 a crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei (see paper)
69% identity, 97% coverage: 13:398/400 of query aligns to 1:377/377 of 3d6bC
3sf6A Crystal structure of glutaryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
50% identity, 96% coverage: 18:399/400 of query aligns to 5:386/387 of 3sf6A
- active site: L134 (= L146), T135 (= T147), A245 (= A258), E366 (= E379), Q378 (≠ R391)
- binding dihydroflavine-adenine dinucleotide: F132 (= F144), L134 (= L146), T135 (= T147), G140 (= G152), S141 (= S153), W165 (= W177), I166 (= I178), T167 (= T179), S361 (≠ A374), T364 (= T377), Y365 (= Y378), T368 (= T381), E370 (≠ D383), M371 (≠ I384)
2ebaA Crystal structure of the putative glutaryl-coa dehydrogenase from thermus thermophilus
51% identity, 94% coverage: 23:399/400 of query aligns to 7:380/380 of 2ebaA
- active site: L131 (= L146), T132 (= T147), A239 (= A258), E360 (= E379), R372 (= R391)
- binding flavin-adenine dinucleotide: L131 (= L146), T132 (= T147), G136 (≠ A151), G137 (= G152), S138 (= S153), W161 (= W177), T163 (= T179), R265 (= R284), L272 (= L291), K275 (≠ N294), D333 (= D352), I334 (≠ M353), G337 (= G356), T355 (≠ A374), T358 (= T377), Y359 (= Y378), T362 (= T381)
3swoA Crystal structure of a glutaryl-coa dehydrogenase from mycobacterium smegmatis in complex with fadh2 (see paper)
48% identity, 94% coverage: 24:399/400 of query aligns to 13:387/388 of 3swoA
- active site: L135 (= L146), T136 (= T147), A246 (= A258), E367 (= E379), K379 (≠ R391)
- binding dihydroflavine-adenine dinucleotide: F133 (= F144), L135 (= L146), T136 (= T147), G141 (= G152), S142 (= S153), W166 (= W177), I167 (= I178), T168 (= T179), R272 (= R284), V274 (≠ Q286), F275 (= F287), L279 (= L291), Y282 (≠ N294), T340 (≠ D352), L341 (≠ M353), G344 (= G356), I347 (= I359), T365 (= T377), Y366 (= Y378), T369 (= T381), E371 (≠ D383), M372 (≠ I384)
2ix5A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 in complex with acetoacetyl-coa (see paper)
38% identity, 94% coverage: 23:399/400 of query aligns to 35:412/415 of 2ix5A
- active site: L158 (= L146), T159 (= T147), S271 (≠ A258), E392 (= E379), R404 (= R391)
- binding acetoacetyl-coenzyme a: S165 (= S153), A167 (≠ P155), S168 (≠ A156), F261 (≠ I248), L268 (= L255), R272 (= R259), E392 (= E379), G393 (= G380), R404 (= R391)
- binding flavin-adenine dinucleotide: L158 (= L146), T159 (= T147), G164 (= G152), S165 (= S153), W189 (= W177), N239 (≠ T226), R297 (= R284), F300 (= F287), L304 (= L291), F307 (≠ N294), L309 (≠ I296), N310 (≠ P297), E365 (≠ D352), L366 (≠ M353), G368 (= G355), G369 (= G356), Y391 (= Y378), T394 (= T381), D396 (= D383), I397 (= I384)
2ix6A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 (see paper)
38% identity, 94% coverage: 23:399/400 of query aligns to 35:412/416 of 2ix6A
- active site: L158 (= L146), T159 (= T147), S271 (≠ A258), E392 (= E379), R404 (= R391)
- binding flavin-adenine dinucleotide: T159 (= T147), G164 (= G152), S165 (= S153), W189 (= W177), N239 (≠ T226), R297 (= R284), F300 (= F287), L304 (= L291), F307 (≠ N294), N310 (≠ P297), E365 (≠ D352), L366 (≠ M353), G369 (= G356), I372 (= I359), Y391 (= Y378), T394 (= T381), D396 (= D383)
Q96329 Acyl-coenzyme A oxidase 4, peroxisomal; AOX 4; G6p; Short-chain acyl-CoA oxidase; AtCX4; AtG6; SAOX; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
38% identity, 94% coverage: 23:399/400 of query aligns to 51:428/436 of Q96329
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
35% identity, 93% coverage: 23:393/400 of query aligns to 1:377/380 of 4l1fA
- active site: L125 (= L146), T126 (= T147), G242 (≠ A258), E363 (= E379), R375 (= R391)
- binding coenzyme a persulfide: T132 (≠ S153), H179 (vs. gap), F232 (≠ I248), M236 (≠ F252), E237 (≠ G253), L239 (= L255), D240 (≠ N256), R243 (= R259), Y362 (= Y378), E363 (= E379), G364 (= G380), R375 (= R391)
- binding flavin-adenine dinucleotide: F123 (= F144), L125 (= L146), T126 (= T147), G131 (= G152), T132 (≠ S153), F156 (≠ W177), I157 (= I178), T158 (= T179), R268 (= R284), Q270 (= Q286), F271 (= F287), I275 (≠ L291), F278 (≠ N294), L281 (≠ P297), Q336 (≠ D352), I337 (≠ M353), G340 (= G356), I358 (≠ A374), Y362 (= Y378), T365 (= T381), Q367 (≠ D383)
- binding 1,3-propandiol: L5 (= L27), Q10 (≠ R32)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
35% identity, 92% coverage: 27:393/400 of query aligns to 1:368/370 of 2dvlA
- active site: L121 (= L146), T122 (= T147), G233 (≠ A258), E354 (= E379), R366 (= R391)
- binding flavin-adenine dinucleotide: L121 (= L146), T122 (= T147), G127 (= G152), S128 (= S153), W152 (= W177), I153 (= I178), T154 (= T179), T356 (= T381), E358 (≠ D383)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
33% identity, 93% coverage: 23:393/400 of query aligns to 1:381/383 of 1bucA
- active site: L128 (= L146), T129 (= T147), G246 (≠ A258), E367 (= E379), G379 (≠ R391)
- binding acetoacetyl-coenzyme a: L96 (= L114), F126 (= F144), G134 (= G152), T135 (≠ S153), T162 (= T179), N182 (vs. gap), H183 (vs. gap), F236 (≠ I248), M240 (≠ F252), M241 (≠ G253), L243 (= L255), D244 (≠ N256), T317 (≠ P329), Y366 (= Y378), E367 (= E379), G368 (= G380)
- binding flavin-adenine dinucleotide: F126 (= F144), L128 (= L146), T129 (= T147), G134 (= G152), T135 (≠ S153), F160 (≠ W177), T162 (= T179), Y366 (= Y378), T369 (= T381), E371 (≠ D383), M375 (≠ L387)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
33% identity, 93% coverage: 23:393/400 of query aligns to 1:381/383 of Q06319
- E367 (= E379) active site, Proton acceptor; mutation to Q: Loss of activity.
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
33% identity, 90% coverage: 32:389/400 of query aligns to 9:372/378 of 5ol2F
- active site: L124 (= L146), T125 (= T147), G241 (≠ A258)
- binding calcium ion: E29 (= E52), E33 (≠ H56), R35 (≠ I58)
- binding coenzyme a persulfide: L238 (= L255), R242 (= R259), E362 (= E379), G363 (= G380)
- binding flavin-adenine dinucleotide: F122 (= F144), L124 (= L146), T125 (= T147), P127 (= P149), T131 (≠ S153), F155 (≠ W177), I156 (= I178), T157 (= T179), E198 (= E216), R267 (= R284), F270 (= F287), L274 (= L291), F277 (≠ N294), Q335 (≠ D352), L336 (≠ M353), G338 (= G355), G339 (= G356), Y361 (= Y378), T364 (= T381), E366 (≠ D383)
Sites not aligning to the query:
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
33% identity, 93% coverage: 23:393/400 of query aligns to 2:378/378 of 4n5fA
- active site: L126 (= L146), T127 (= T147), G243 (≠ A258), E364 (= E379), R376 (= R391)
- binding dihydroflavine-adenine dinucleotide: L126 (= L146), T127 (= T147), G132 (= G152), S133 (= S153), F157 (≠ W177), T159 (= T179), T210 (= T226), Y363 (= Y378), T366 (= T381), E368 (≠ D383), M372 (≠ L387)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
32% identity, 92% coverage: 28:395/400 of query aligns to 3:374/374 of 5lnxD
- active site: L122 (= L146), T123 (= T147), G239 (≠ A258), E358 (= E379), K370 (≠ R391)
- binding flavin-adenine dinucleotide: L122 (= L146), T123 (= T147), G128 (= G152), S129 (= S153), F153 (≠ W177), T155 (= T179), R265 (= R284), Q267 (= Q286), F268 (= F287), I272 (≠ L291), N275 (= N294), I278 (≠ P297), Q331 (≠ D352), I332 (≠ M353), G335 (= G356), Y357 (= Y378), T360 (= T381), E362 (≠ D383)
Query Sequence
>AZOBR_RS19670 FitnessBrowser__azobra:AZOBR_RS19670
MAAKTGAASAKLASFAWEDPLLLDEQLTEDERMIRDAARSYCQDKLLPRVTEANRHEIFH
REIMNEMGELGFLGSTIDGYGCAGVNYVSYGLVAREVERVDSGYRSAMSVQSSLVMHPIY
AYGSDVQREKYLPKLATGEWIGCFGLTEPDAGSDPAGMKTRARKVADGYIVSGAKMWITN
SPVADVFVVWAKNDEGKINGFVLEKGMKGLSAPKIEGKFSLRASATGEIVMDEVFVPEEN
RLPNIEGIVGPFGCLNRARYGIAWGAMGAAEFCFHAARQYQIDRKQFGRPLAANQIPQLK
LANMQTEIALGLQAALQVGRLLDDGKAAPEMISLIKRNNCGKALEIARVARDMHGGNGIA
DEFHVIRHVMNLEAVNTYEGTHDIHALILGRAITGIQAFA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory