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Comparing AZOBR_RS22315 FitnessBrowser__azobra:AZOBR_RS22315 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
40% identity, 97% coverage: 17:496/497 of query aligns to 1:479/489 of 4o6rA
- active site: N150 (= N166), K173 (= K189), E248 (= E263), C282 (= C298), E383 (= E399), E460 (= E476)
- binding adenosine monophosphate: I146 (= I162), V147 (≠ I163), K173 (= K189), G206 (= G221), G210 (= G225), Q211 (≠ A226), F224 (= F239), G226 (= G241), S227 (= S242), T230 (= T245), R233 (≠ I248)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
42% identity, 95% coverage: 20:492/497 of query aligns to 11:485/494 of 4pz2B
- active site: N159 (= N166), K182 (= K189), E258 (= E263), C292 (= C298), E392 (= E399), D469 (≠ E476)
- binding nicotinamide-adenine-dinucleotide: I155 (= I162), I156 (= I163), P157 (= P164), W158 (= W165), N159 (= N166), M164 (≠ L171), K182 (= K189), A184 (= A191), E185 (= E192), G215 (= G221), G219 (= G225), F233 (= F239), T234 (= T240), G235 (= G241), S236 (= S242), V239 (≠ T245), E258 (= E263), L259 (= L264), C292 (= C298), E392 (= E399), F394 (= F401)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 99% coverage: 5:497/497 of query aligns to 1:491/491 of 5gtlA
- active site: N165 (= N166), K188 (= K189), E263 (= E263), C297 (= C298), E394 (= E399), E471 (= E476)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I162), P163 (= P164), K188 (= K189), A190 (= A191), E191 (= E192), Q192 (≠ E193), G221 (= G221), G225 (= G225), G241 (= G241), S242 (= S242), T245 (= T245), L264 (= L264), C297 (= C298), E394 (= E399), F396 (= F401)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 99% coverage: 5:497/497 of query aligns to 1:491/491 of 5gtkA
- active site: N165 (= N166), K188 (= K189), E263 (= E263), C297 (= C298), E394 (= E399), E471 (= E476)
- binding nicotinamide-adenine-dinucleotide: I161 (= I162), I162 (= I163), P163 (= P164), W164 (= W165), K188 (= K189), E191 (= E192), G221 (= G221), G225 (= G225), A226 (= A226), F239 (= F239), G241 (= G241), S242 (= S242), T245 (= T245), Y248 (≠ I248), L264 (= L264), C297 (= C298), Q344 (= Q345), R347 (= R348), E394 (= E399), F396 (= F401)
7radA Crystal structure analysis of aldh1b1
41% identity, 95% coverage: 23:496/497 of query aligns to 16:488/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), P160 (= P164), W161 (= W165), N162 (= N166), M167 (≠ L171), K185 (= K189), E188 (= E192), G218 (= G221), G222 (= G225), A223 (= A226), T237 (= T240), G238 (= G241), S239 (= S242), V242 (≠ T245), E261 (= E263), L262 (= L264), C295 (= C298), E392 (= E399), F394 (= F401)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ V117), E117 (≠ V121), F163 (≠ V167), E285 (≠ A287), F289 (≠ T292), N450 (≠ L457), V452 (= V459)
7mjdA Crystal structure analysis of aldh1b1
41% identity, 95% coverage: 23:496/497 of query aligns to 16:488/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), P160 (= P164), W161 (= W165), N162 (= N166), M167 (≠ L171), K185 (= K189), E188 (= E192), G218 (= G221), G222 (= G225), F236 (= F239), T237 (= T240), G238 (= G241), S239 (= S242), V242 (≠ T245), E261 (= E263), L262 (= L264), C295 (= C298), E392 (= E399), F394 (= F401)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ V121), E285 (≠ A287), F289 (≠ T292), N450 (≠ L457), V452 (= V459)
7mjcA Crystal structure analysis of aldh1b1
41% identity, 95% coverage: 23:496/497 of query aligns to 16:488/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), P160 (= P164), W161 (= W165), N162 (= N166), K185 (= K189), E188 (= E192), G218 (= G221), G222 (= G225), T237 (= T240), G238 (= G241), S239 (= S242), V242 (≠ T245), E261 (= E263), L262 (= L264), C295 (= C298), E392 (= E399), F394 (= F401)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
41% identity, 95% coverage: 20:493/497 of query aligns to 6:477/486 of 4pxlA
- active site: N154 (= N166), K177 (= K189), E253 (= E263), C287 (= C298), E384 (= E399), D461 (≠ E476)
- binding nicotinamide-adenine-dinucleotide: I150 (= I162), V151 (≠ I163), P152 (= P164), W153 (= W165), K177 (= K189), E180 (= E192), G210 (= G221), G214 (= G225), A215 (= A226), F228 (= F239), G230 (= G241), S231 (= S242), V234 (≠ T245), E253 (= E263), G255 (= G265), C287 (= C298), Q334 (= Q345), K337 (≠ R348), E384 (= E399), F386 (= F401)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
40% identity, 97% coverage: 16:497/497 of query aligns to 23:506/515 of 2d4eC
- active site: N173 (= N166), K196 (= K189), E271 (= E263), C305 (= C298), E409 (= E399), E486 (= E476)
- binding nicotinamide-adenine-dinucleotide: I169 (= I162), T170 (≠ I163), P171 (= P164), W172 (= W165), K196 (= K189), A198 (= A191), G229 (= G221), G233 (= G225), A234 (= A226), T248 (= T240), G249 (= G241), E250 (≠ S242), T253 (= T245), E271 (= E263), L272 (= L264), C305 (= C298), E409 (= E399), F411 (= F401), F475 (≠ Y465)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 14:491/496 of 4fr8C
- active site: N165 (= N166), K188 (= K189), Q264 (≠ E263), C298 (= C298), E395 (= E399), E472 (= E476)
- binding nicotinamide-adenine-dinucleotide: I161 (= I162), I162 (= I163), W164 (= W165), K188 (= K189), G221 (= G221), G225 (= G225), A226 (= A226), F239 (= F239), G241 (= G241), S242 (= S242), I245 (≠ T245), Q345 (= Q345), E395 (= E399), F397 (= F401)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 11:488/493 of 4fr8A
- active site: N162 (= N166), K185 (= K189), Q261 (≠ E263), C295 (= C298), E392 (= E399), E469 (= E476)
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), W161 (= W165), K185 (= K189), G218 (= G221), G222 (= G225), A223 (= A226), F236 (= F239), G238 (= G241), S239 (= S242), I242 (≠ T245), Q342 (= Q345), K345 (≠ R348), E392 (= E399), F394 (= F401)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ V167), L166 (= L170), W170 (≠ L174), F289 (≠ T292), S294 (= S297), C295 (= C298), D450 (≠ L457), F452 (≠ V459)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
39% identity, 97% coverage: 14:496/497 of query aligns to 1:483/490 of Q9HTJ1
- GAWN 150:153 (≠ IPWN 163:166) binding
- K162 (= K175) active site, Charge relay system
- KPSE 176:179 (≠ KSAE 189:192) binding
- G209 (= G221) binding
- GTST 230:233 (≠ SVET 242:245) binding
- E252 (= E263) active site, Proton acceptor
- C286 (= C298) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E399) binding
- E464 (= E476) active site, Charge relay system
5l13A Structure of aldh2 in complex with 2p3 (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 5l13A
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ V167), M168 (≠ L171), W171 (≠ L174), F290 (≠ T292), C295 (≠ S297), C296 (= C298), C297 (≠ T299), D451 (≠ L457), F453 (≠ V459)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 4kwgA
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ V167), M168 (≠ L171), C295 (≠ S297), C296 (= C298), C297 (≠ T299), D451 (≠ L457), F453 (≠ V459)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 4kwfA
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ V167), M168 (≠ L171), W171 (≠ L174), E262 (= E263), C295 (≠ S297), C296 (= C298), C297 (≠ T299), D451 (≠ L457), F453 (≠ V459), F459 (≠ Y465)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 3sz9A
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ V167), C295 (≠ S297), C296 (= C298), D451 (≠ L457), F453 (≠ V459), F459 (≠ Y465)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 3injA
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ V121), F164 (≠ V167), L167 (= L170), F286 (≠ A287), F290 (≠ T292), D451 (≠ L457), F453 (≠ V459)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 2vleA
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding daidzin: M118 (≠ V121), F164 (≠ V167), M168 (≠ L171), W171 (≠ L174), F286 (≠ A287), F290 (≠ T292), C295 (≠ S297), C296 (= C298), D451 (≠ L457), V452 (= V458), F453 (≠ V459)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 1o01B
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding (2e)-but-2-enal: C296 (= C298), C297 (≠ T299), F453 (≠ V459)
- binding nicotinamide-adenine-dinucleotide: I159 (= I162), I160 (= I163), P161 (= P164), W162 (= W165), K186 (= K189), E189 (= E192), G219 (= G221), G223 (= G225), A224 (= A226), F237 (= F239), G239 (= G241), S240 (= S242), I243 (≠ T245), L263 (= L264), G264 (= G265), C296 (= C298), Q343 (= Q345), E393 (= E399), F395 (= F401)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
39% identity, 96% coverage: 18:496/497 of query aligns to 12:489/494 of 1cw3A
- active site: N163 (= N166), K186 (= K189), E262 (= E263), C296 (= C298), E393 (= E399), E470 (= E476)
- binding magnesium ion: V34 (= V40), D103 (≠ E106), Q190 (≠ E193)
- binding nicotinamide-adenine-dinucleotide: I159 (= I162), I160 (= I163), P161 (= P164), W162 (= W165), K186 (= K189), G219 (= G221), G223 (= G225), A224 (= A226), F237 (= F239), G239 (= G241), S240 (= S242), I243 (≠ T245), L263 (= L264), G264 (= G265), C296 (= C298), Q343 (= Q345), K346 (≠ R348), E393 (= E399), F395 (= F401)
Query Sequence
>AZOBR_RS22315 FitnessBrowser__azobra:AZOBR_RS22315
MSVSTDLQLDPFALARELSSKHFFGGEFRPASSGKGFPVVNPATGETVAEAAFGEAADVD
AAVAAAVAAQKEWAKRPVRERGKLVAECGRVLDAHKEEIAKLIALETGKALRTESRVEAG
VLSDAFVFFGGLAPELKGETIPFNPSMLTMTVREPVGVVGAIIPWNVPLLLMALKIAPAM
VAGNAVVVKSAEEAPLAVLRVVQLINTVIPAGVVNILSGYGPECGAPLVAHKDVKKVTFT
GSVETGKIVYKTAAEKLIPVTLELGGKSPMIVCGDADLDQAIAGAIAGMRFTRQGQSCTA
SSRIFVHDSIHDAFVEKLKEKVNAMKMGDPLDESTDIGTIVSPQQLDRVQSYIAIGKEGG
ATPHVCSAMPSDPKLTKGLYVQPHIFTGVKNSDRIAQEEIFGPVCCVIRWTDYEEVIAQA
NDTEYGLAATIWTRDLKVAMDAVHRLEAGFVQVNQNLVVQPNLSYGGVKSSGLGKEASLE
AMLEHFTHKKTIIINMK
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory