SitesBLAST
Comparing AZOBR_RS22395 FitnessBrowser__azobra:AZOBR_RS22395 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2c20A Crystal structure of udp-glucose 4-epimerase
50% identity, 96% coverage: 5:330/339 of query aligns to 1:328/329 of 2c20A
- active site: T117 (= T121), A118 (= A122), A119 (≠ N123), Y141 (= Y145), K145 (= K149), H184 (= H188)
- binding nicotinamide-adenine-dinucleotide: G7 (= G11), G10 (= G14), Y11 (= Y15), I12 (≠ V16), D31 (= D35), N32 (= N36), Q34 (≠ R38), T35 (≠ Q39), G36 (= G40), D51 (= D55), L52 (= L56), F73 (= F77), A74 (= A78), A75 (= A79), N92 (≠ G96), Y141 (= Y145), K145 (= K149), Y168 (= Y172), F169 (= F173), V171 (≠ A175), H184 (= H188)
- binding zinc ion: E182 (= E186), H184 (= H188), E187 (= E191), H189 (= H193)
7k3pA The structure of the udp-glc/glcnac 4-epimerase from the human pathogen campylobacter jejuni
42% identity, 94% coverage: 7:324/339 of query aligns to 4:328/329 of 7k3pA
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), G11 (= G14), Y12 (= Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), S35 (≠ R38), G37 (= G40), D57 (= D55), L58 (= L56), F79 (= F77), A80 (= A78), I83 (≠ S81), N98 (≠ G96), Y147 (= Y145), K151 (= K149), Y175 (= Y172), N177 (= N174), V178 (≠ A175)
1gy8C Trypanosoma brucei udp-galactose 4' epimerase (see paper)
43% identity, 95% coverage: 7:329/339 of query aligns to 5:369/370 of 1gy8C
- active site: S144 (≠ T121), A145 (= A122), A146 (≠ N123), Y170 (= Y145), K174 (= K149)
- binding nicotinamide-adenine-dinucleotide: G9 (= G11), G12 (= G14), Y13 (= Y15), I14 (≠ V16), D34 (= D35), S35 (≠ N36), L36 (= L37), V37 (≠ R38), G38 (≠ Q39), D77 (= D55), V78 (≠ L56), M100 (≠ F77), C101 (≠ A78), A102 (= A79), L104 (≠ S81), N119 (≠ G96), S142 (= S119), S143 (= S120), S144 (≠ T121), Y170 (= Y145), K174 (= K149), Y197 (= Y172), A200 (= A175)
- binding uridine-5'-diphosphate: N199 (= N174), H218 (= H193), L219 (= L194), I222 (≠ L197), M241 (≠ I209), P242 (≠ E210), I243 (= I211), F244 (= F212), C255 (= C223), R257 (= R225), R324 (= R284), D327 (= D287)
2cnbA Trypanosoma brucei udp-galactose-4-epimerase in ternary complex with NAD and the substrate analogue udp-4-deoxy-4- fluoro-alpha-d-galactose (see paper)
43% identity, 95% coverage: 7:329/339 of query aligns to 5:365/366 of 2cnbA
- active site: S144 (≠ T121), A145 (= A122), A146 (≠ N123), Y169 (= Y145), K173 (= K149)
- binding nicotinamide-adenine-dinucleotide: G9 (= G11), G12 (= G14), Y13 (= Y15), I14 (≠ V16), D34 (= D35), S35 (≠ N36), V37 (≠ R38), G38 (≠ Q39), D77 (= D55), V78 (≠ L56), M100 (≠ F77), C101 (≠ A78), A102 (= A79), L104 (≠ S81), N119 (≠ G96), S143 (= S120), S144 (≠ T121), Y169 (= Y145), K173 (= K149), Y196 (= Y172), F197 (= F173), A199 (= A175)
- binding uridine-5'-diphosphate-4-deoxy-4-fluoro-alpha-d-galactose: L104 (≠ S81), S144 (≠ T121), Y169 (= Y145), F197 (= F173), N198 (= N174), H217 (= H193), L218 (= L194), P238 (≠ E210), I239 (= I211), F240 (= F212), C251 (= C223), R253 (= R225), V297 (= V261), R320 (= R284), D323 (= D287)
Q9SA77 UDP-arabinose 4-epimerase 1; UDP-D-xylose 4-epimerase 1; EC 5.1.3.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
40% identity, 95% coverage: 7:329/339 of query aligns to 73:409/419 of Q9SA77
- G275 (≠ P196) mutation to D: In mur4-1; 50% reduction in L-Ara in cell wall material.
- R304 (= R225) mutation to Q: In mur4-3; 50% reduction in L-Ara in cell wall material.
4twrA Structure of udp-glucose 4-epimerase from brucella abortus
44% identity, 93% coverage: 5:318/339 of query aligns to 2:316/325 of 4twrA
- active site: S117 (≠ T121), C118 (≠ A122), A119 (≠ N123), Y141 (= Y145), K145 (= K149), H184 (= H188), H189 (= H193)
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), G11 (= G14), F12 (≠ Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), L34 (= L37), S35 (≠ R38), T36 (≠ Q39), G37 (= G40), D51 (= D55), I52 (≠ L56), F73 (= F77), A74 (= A78), A75 (= A79), N92 (≠ G96), S115 (= S119), K145 (= K149), Y168 (= Y172), A171 (= A175), H184 (= H188)
- binding zinc ion: E182 (= E186), H184 (= H188), E187 (= E191), H189 (= H193)
7xpoA Crystal structure of udp-glc/glcnac 4-epimerase with NAD/udp-glc (see paper)
40% identity, 96% coverage: 5:331/339 of query aligns to 2:344/344 of 7xpoA
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), G11 (= G14), Y12 (= Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), N36 (≠ Q39), D62 (= D55), L63 (= L56), F84 (= F77), A85 (= A78), G86 (≠ A79), K88 (≠ S81), N103 (≠ G96), S126 (= S119), S128 (≠ T121), Y152 (= Y145), K156 (= K149), Y180 (= Y172), P183 (≠ A175)
- binding uridine-5'-diphosphate-glucose: S128 (≠ T121), A129 (= A122), F181 (= F173), N182 (= N174), N202 (≠ H193), L203 (= L194), T219 (≠ E210), V220 (≠ I211), Y221 (≠ F212), R234 (= R225), Y236 (= Y227), V275 (= V261), R298 (= R284), D301 (= D287)
1ek6A Structure of human udp-galactose 4-epimerase complexed with nadh and udp-glucose (see paper)
41% identity, 96% coverage: 5:329/339 of query aligns to 3:344/346 of 1ek6A
- active site: S132 (≠ T121), A133 (= A122), T134 (≠ N123), Y157 (= Y145), K161 (= K149)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G9 (= G11), G12 (= G14), Y13 (= Y15), I14 (≠ V16), D33 (= D35), N34 (= N36), H36 (≠ R38), N37 (≠ Q39), D66 (= D55), I67 (≠ L56), F88 (= F77), A89 (= A78), G90 (≠ A79), K92 (≠ S81), S130 (= S119), S131 (= S120), S132 (≠ T121), Y157 (= Y145), K161 (= K149), Y185 (= Y172), P188 (≠ A175)
- binding uridine-5'-diphosphate-glucose: S132 (≠ T121), Y157 (= Y145), F186 (= F173), N187 (= N174), N207 (≠ H193), L208 (= L194), N224 (≠ E210), V225 (≠ I211), F226 (= F212), R239 (= R225), Y241 (= Y227), V277 (= V261), R300 (= R284), D303 (= D287)
Q14376 UDP-glucose 4-epimerase; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-galactose 4-epimerase; EC 5.1.3.2; EC 5.1.3.7 from Homo sapiens (Human) (see 13 papers)
41% identity, 96% coverage: 5:329/339 of query aligns to 3:344/348 of Q14376
- GYI 12:14 (≠ GYV 14:16) binding
- DNFHN 33:37 (≠ DNLRQ 35:39) binding
- N34 (= N36) to S: in GALAC3; peripheral; nearly normal activity towards UDP-galactose; dbSNP:rs121908046
- DI 66:67 (≠ DL 55:56) binding
- F88 (= F77) binding
- G90 (≠ A79) to E: in GALAC3; 800-fold decrease in UDP-galactose epimerization activity; dbSNP:rs28940882
- K92 (≠ S81) binding
- V94 (= V83) to M: in GALAC3; generalized; 30-fold decrease in UDP-galactose epimerization activity; 2-fold decrease in affinity for UDP-galactose; 24% of normal activity with respect to UDP-N-acetylgalactosamine; dbSNP:rs121908047
- D103 (≠ L92) to G: in GALAC3; 7-fold decrease in UDP-galactose epimerization activity; very mild decrease in activity towards UDP-N-acetylgalactosamine; dbSNP:rs28940883
- S132 (≠ T121) mutation to A: Loss of activity.
- SAT 132:134 (≠ TAN 121:123) binding
- Y157 (= Y145) active site, Proton acceptor; mutation to F: Loss of activity.
- K161 (= K149) binding
- A180 (vs. gap) to V: in dbSNP:rs3204468
- L183 (= L170) to P: in GALAC3; peripheral; 3-fold decrease in UDP-galactose epimerization activity; dbSNP:rs121908045
- Y185 (= Y172) binding
- YFN 185:187 (= YFN 172:174) binding
- NNL 206:208 (≠ THL 192:194) binding
- NVF 224:226 (≠ EIF 210:212) binding
- R239 (= R225) binding
- K257 (≠ A243) to R: in GALAC3; 7-fold decrease in UDP-galactose epimerization activity; does not affect affinity for UDP-galactose; dbSNP:rs28940884
- REGD 300:303 (≠ RAGD 284:287) binding
- C307 (≠ L291) mutation to Y: No effect on activity towards UDP-galactose. Loss of activity towards UDP-N-acetylgalactosamine.
- L313 (≠ R297) to M: in GALAC3; 6-fold decrease in UDP-galactose epimerization activity; very mild decrease in activity towards UDP-N-acetylgalactosamine; dbSNP:rs3180383
- G319 (= G303) to E: in GALAC3; nearly normal activity towards UDP-galactose; mild impairment under conditions of substrate limitation; dbSNP:rs28940885
- R335 (≠ E320) to H: in GALAC3; 2-fold decrease in UDP-galactose epimerization activity; dbSNP:rs368637540
1hzjA Human udp-galactose 4-epimerase: accommodation of udp-n- acetylglucosamine within the active site (see paper)
41% identity, 96% coverage: 5:329/339 of query aligns to 2:343/345 of 1hzjA
- active site: S131 (≠ T121), A132 (= A122), T133 (≠ N123), Y156 (= Y145), K160 (= K149)
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), G11 (= G14), Y12 (= Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), H35 (≠ R38), N36 (≠ Q39), D65 (= D55), I66 (≠ L56), F87 (= F77), A88 (= A78), G89 (≠ A79), K91 (≠ S81), S129 (= S119), S131 (≠ T121), Y156 (= Y145), K160 (= K149), Y184 (= Y172), P187 (≠ A175)
- binding uridine-diphosphate-n-acetylglucosamine: N186 (= N174), N206 (≠ H193), L207 (= L194), N223 (≠ E210), V224 (≠ I211), F225 (= F212), R238 (= R225), Y240 (= Y227), V276 (= V261), R299 (= R284), D302 (= D287)
7xpqA Crystal structure of udp-glc/glcnac 4-epimerase with NAD/udp-glcnac (see paper)
40% identity, 96% coverage: 5:329/339 of query aligns to 2:342/343 of 7xpqA
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), G11 (= G14), Y12 (= Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), N36 (≠ Q39), D62 (= D55), L63 (= L56), F84 (= F77), A85 (= A78), G86 (≠ A79), K88 (≠ S81), N103 (≠ G96), S126 (= S119), S128 (≠ T121), Y152 (= Y145), K156 (= K149), Y180 (= Y172), P183 (≠ A175)
- binding uridine-diphosphate-n-acetylglucosamine: N182 (= N174), N202 (≠ H193), L203 (= L194), T219 (≠ E210), Y221 (≠ F212), R234 (= R225), Y236 (= Y227), V275 (= V261), R298 (= R284), D301 (= D287)
1i3lA Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m-substituted udp-galactose 4-epimerase (see paper)
41% identity, 96% coverage: 5:329/339 of query aligns to 2:343/347 of 1i3lA
- active site: S131 (≠ T121), A132 (= A122), T133 (≠ N123), Y156 (= Y145), K160 (= K149)
- binding galactose-uridine-5'-diphosphate: N186 (= N174), N206 (≠ H193), L207 (= L194), N223 (≠ E210), V224 (≠ I211), F225 (= F212), R238 (= R225), Y240 (= Y227), V276 (= V261), R299 (= R284), D302 (= D287)
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), G11 (= G14), Y12 (= Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), H35 (≠ R38), N36 (≠ Q39), D65 (= D55), I66 (≠ L56), F87 (= F77), A88 (= A78), G89 (≠ A79), K91 (≠ S81), S129 (= S119), S130 (= S120), S131 (≠ T121), Y156 (= Y145), K160 (= K149), Y184 (= Y172), P187 (≠ A175)
1i3kA Molecular basis for severe epimerase-deficiency galactosemia: x-ray structure of the human v94m-substituted udp-galactose 4-epimerase (see paper)
41% identity, 96% coverage: 5:329/339 of query aligns to 2:343/347 of 1i3kA
- active site: S131 (≠ T121), A132 (= A122), T133 (≠ N123), Y156 (= Y145), K160 (= K149)
- binding nicotinamide-adenine-dinucleotide: G8 (= G11), G11 (= G14), Y12 (= Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), H35 (≠ R38), N36 (≠ Q39), D65 (= D55), I66 (≠ L56), F87 (= F77), A88 (= A78), G89 (≠ A79), K91 (≠ S81), S129 (= S119), S131 (≠ T121), Y156 (= Y145), K160 (= K149), Y184 (= Y172), P187 (≠ A175)
- binding uridine-5'-diphosphate-glucose: F185 (= F173), N186 (= N174), N206 (≠ H193), L207 (= L194), N223 (≠ E210), V224 (≠ I211), F225 (= F212), R238 (= R225), Y240 (= Y227), V276 (= V261), R299 (= R284), D302 (= D287)
3enkA 1.9a crystal structure of udp-glucose 4-epimerase from burkholderia pseudomallei
43% identity, 97% coverage: 1:329/339 of query aligns to 1:339/340 of 3enkA
- active site: S127 (= S120), S128 (≠ T121), T130 (≠ N123), Y152 (= Y145), K156 (= K149)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), G14 (= G14), Y15 (= Y15), I16 (≠ V16), D35 (= D35), N36 (= N36), V38 (≠ R38), N39 (≠ Q39), S40 (≠ G40), D62 (= D55), V63 (≠ L56), F84 (= F77), A85 (= A78), A86 (= A79), K88 (≠ S81), N103 (≠ G96), S126 (= S119), S128 (≠ T121), Y152 (= Y145), K156 (= K149), Y180 (= Y172), P183 (≠ A175)
- binding uridine-5'-diphosphate-glucose: T130 (≠ N123), N182 (= N174), N201 (≠ T192), N202 (≠ H193), L203 (= L194), R219 (≠ E210), V220 (≠ I211), F221 (= F212), R234 (= R225), Y236 (= Y227), V272 (= V261), R295 (= R284), D298 (= D287)
7kn1A Crystal structure of udp-glucose-4-epimerase (gale) from stenotrophomonas maltophila with bound NAD and formylated udp- arabinopyranose
41% identity, 94% coverage: 7:323/339 of query aligns to 5:331/336 of 7kn1A
- active site: S126 (≠ T121), Y150 (= Y145), K154 (= K149)
- binding nicotinamide-adenine-dinucleotide: G9 (= G11), G12 (= G14), Y13 (= Y15), I14 (≠ V16), D33 (= D35), S34 (≠ N36), C36 (≠ R38), N37 (≠ Q39), D60 (= D55), I61 (≠ L56), F82 (= F77), A83 (= A78), A84 (= A79), K86 (≠ S81), S124 (= S119), S125 (= S120), S126 (≠ T121), Y150 (= Y145), K154 (= K149), Y178 (= Y172), P181 (≠ A175)
- binding UDP-4-deoxy-4-formamido-beta-L-arabinopyranose: V88 (= V83), S126 (≠ T121), Y150 (= Y145), N180 (= N174), S199 (≠ T192), N200 (≠ H193), L201 (= L194), Q217 (≠ E210), V218 (≠ I211), F219 (= F212), R232 (= R225), Y234 (= Y227), V270 (= V261), R293 (= R284), D296 (= D287)
Q564Q1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-galactose 4-epimerase; EC 5.1.3.2; EC 5.1.3.7 from Caenorhabditis elegans (see paper)
38% identity, 95% coverage: 7:329/339 of query aligns to 3:347/349 of Q564Q1
- P314 (≠ S295) mutation to L: In pv18; at the restrictive temperature of 25 degrees Celsius, embryos have cell-cell adhesion defects and die before hatching. The few surviving animals are arrested at the L1 larval stage. At the permissive temperature of 16-20 degrees Celsius, causes a developmental delay. Distal tip cell migration is impaired due to a reduced localization of metalloprotease mig-17 to the gonad basement membrane. Vulva lumen is smaller at the L4 larval stage. Accumulation of UDP-galactose (Gal) and reduction in UDP-N-acetylgalactosamine (GalNAc) levels. Hypersensitivity to a galactose-rich diet characterized by a slow development often resulting in an arrest at the L1 larval stage. Up-regulation of ER stress response protein hsp-4; expression is suppressed in an xbp-1 RNAi-mediated knockdown animals. Reduced survival upon E.faecalis or S.aureus-mediated infection.
4lisB Crystal structure of udp-galactose-4-epimerase from aspergillus nidulans (see paper)
40% identity, 96% coverage: 6:330/339 of query aligns to 3:356/363 of 4lisB
- active site: S126 (≠ T121), A127 (= A122), T128 (≠ N123), Y154 (= Y145), K158 (= K149)
- binding nicotinamide-adenine-dinucleotide: G11 (= G14), Y12 (= Y15), I13 (≠ V16), D32 (= D35), N33 (= N36), N36 (≠ Q39), S37 (≠ G40), D59 (= D55), V60 (≠ L56), F82 (= F77), A84 (= A79), K86 (≠ S81), S126 (≠ T121), Y154 (= Y145), K158 (= K149), Y195 (= Y172), P198 (≠ A175)
- binding uridine-5'-diphosphate: N197 (= N174), N217 (≠ H193), L218 (= L194), L234 (≠ E210), V235 (≠ I211), F236 (= F212), R249 (= R225), V288 (= V261), R311 (= R284), D314 (= D287)
4lisA Crystal structure of udp-galactose-4-epimerase from aspergillus nidulans (see paper)
40% identity, 96% coverage: 6:330/339 of query aligns to 4:357/364 of 4lisA
- active site: S127 (≠ T121), A128 (= A122), T129 (≠ N123), Y155 (= Y145), K159 (= K149)
- binding nicotinamide-adenine-dinucleotide: G12 (= G14), Y13 (= Y15), I14 (≠ V16), D33 (= D35), N34 (= N36), N37 (≠ Q39), S38 (≠ G40), D60 (= D55), V61 (≠ L56), F83 (= F77), A85 (= A79), K87 (≠ S81), S127 (≠ T121), Y155 (= Y145), K159 (= K149), Y196 (= Y172), P199 (≠ A175)
- binding uridine-5'-diphosphate-glucose: K87 (≠ S81), S127 (≠ T121), Y155 (= Y145), N218 (≠ H193), L235 (≠ E210), V236 (≠ I211), F237 (= F212), R250 (= R225), R312 (= R284), D315 (= D287)
2udpA Udp-galactose 4-epimerase complexed with udp-phenol (see paper)
40% identity, 95% coverage: 7:329/339 of query aligns to 3:336/338 of 2udpA
- active site: S124 (≠ T121), A125 (= A122), T126 (≠ N123), Y149 (= Y145), K153 (= K149), M189 (≠ I184)
- binding nicotinamide-adenine-dinucleotide: G7 (= G11), G10 (= G14), Y11 (= Y15), I12 (≠ V16), D31 (= D35), N32 (= N36), L33 (= L37), C34 (≠ R38), N35 (≠ Q39), S36 (≠ G40), D58 (= D55), I59 (≠ L56), F80 (= F77), A81 (= A78), G82 (≠ A79), K84 (≠ S81), S122 (= S119), S124 (≠ T121), Y149 (= Y145), K153 (= K149), Y177 (= Y172)
- binding phenyl-uridine-5'-diphosphate: N179 (= N174), N199 (≠ H193), L200 (= L194), A216 (≠ E210), I217 (= I211), F218 (= F212), R231 (= R225), Y233 (= Y227), V269 (= V261), R292 (= R284), D295 (= D287)
1udcA Structure of udp-galactose-4-epimerase complexed with udp-mannose (see paper)
40% identity, 95% coverage: 7:329/339 of query aligns to 3:336/338 of 1udcA
- active site: S124 (≠ T121), A125 (= A122), T126 (≠ N123), Y149 (= Y145), K153 (= K149), M189 (≠ I184)
- binding nicotinamide-adenine-dinucleotide: G7 (= G11), G10 (= G14), Y11 (= Y15), I12 (≠ V16), D31 (= D35), N32 (= N36), C34 (≠ R38), N35 (≠ Q39), S36 (≠ G40), D58 (= D55), I59 (≠ L56), F80 (= F77), A81 (= A78), G82 (≠ A79), K84 (≠ S81), S122 (= S119), Y149 (= Y145), K153 (= K149), Y177 (= Y172), P180 (≠ A175)
- binding uridine-5'-diphosphate-mannose: T126 (≠ N123), Y149 (= Y145), N179 (= N174), N199 (≠ H193), L200 (= L194), L215 (≠ I209), A216 (≠ E210), I217 (= I211), F218 (= F212), R231 (= R225), Y233 (= Y227), V269 (= V261), R292 (= R284)
Query Sequence
>AZOBR_RS22395 FitnessBrowser__azobra:AZOBR_RS22395
MNTPQTVLVTGGAGYVGSHCVAELLDRGFRVVVLDNLRQGHRAAVPSDAAFVEADLADMD
ALTRVFAEWRFDAVFHFAALSLVGESMRDPHLYLHGNTVNSLNLIRAATTAGVRKMVFSS
TANLFGTPERQPIDEETTIDPGSPYGESKFFIERALHWADRCHGLRSACLRYFNAAGAHP
NGIIGEDHDPETHLIPLVLDAASGRRSHIEIFGDDYPTPDGTCVRDYVHVCDLADAHLRV
LPALETRSVRFNLGNGTGYSVREVIDATERVTGLTVPVKVGPRRAGDPAMLIASSERIRG
ELGWSPRFPDLDSIIGSAWEWRRRHPGGYRGPALAQAAE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory