SitesBLAST
Comparing AZOBR_RS26030 FitnessBrowser__azobra:AZOBR_RS26030 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7wdsA Crystal structures of mebgld2 in complex with various saccharides
50% identity, 98% coverage: 6:439/444 of query aligns to 5:442/444 of 7wdsA
- binding beta-D-xylopyranose: Q19 (= Q20), H120 (= H120), E165 (= E165), L172 (≠ H172), Y294 (= Y291), W324 (= W321), E351 (= E348), W398 (= W395), E405 (= E402), W406 (= W403), R408 (≠ F405)
7wdnA Crystal structures of mebgld2 in complex with various saccharides (see paper)
50% identity, 98% coverage: 6:439/444 of query aligns to 5:442/444 of 7wdnA
- binding alpha-D-glucopyranose: Q19 (= Q20), E25 (≠ H26), D35 (= D36), H120 (= H120), E165 (= E165), E165 (= E165), K186 (≠ G186), N222 (= N222), F246 (≠ W246), W266 (vs. gap), Y267 (vs. gap), Y294 (= Y291), P306 (= P303), M307 (≠ F304), W324 (= W321), E351 (= E348), W398 (= W395), E405 (= E402), W406 (= W403), F414 (= F411)
7wdoA Crystal structures of mebgld2 in complex with various saccharides
50% identity, 98% coverage: 6:439/444 of query aligns to 5:442/445 of 7wdoA
- binding beta-D-glucopyranose: Q19 (= Q20), H120 (= H120), W121 (= W121), N164 (= N164), E165 (= E165), E165 (= E165), N222 (= N222), N224 (≠ Q224), Y294 (= Y291), E351 (= E348), W398 (= W395), E405 (= E402), W406 (= W403), F414 (= F411)
7wdrA Crystal structures of mebgld2 in complex with various saccharides
49% identity, 98% coverage: 6:439/444 of query aligns to 5:442/445 of 7wdrA
- binding 4-nitrophenyl beta-D-glucopyranoside: Q19 (= Q20), H120 (= H120), E165 (= E165), W167 (≠ N167), N222 (= N222), L223 (= L223), N224 (≠ Q224), F246 (≠ W246), Y294 (= Y291), A295 (≠ S292), R296 (= R293), T297 (≠ M294), F312 (≠ G309), W324 (= W321), W324 (= W321), E325 (≠ P322), W398 (= W395), E405 (= E402), W406 (= W403)
6z1mA Structure of an ancestral glycosidase (family 1) bound to heme (see paper)
46% identity, 98% coverage: 4:439/444 of query aligns to 1:421/423 of 6z1mA
- binding protoporphyrin ix containing fe: P164 (= P166), N165 (= N167), L194 (≠ Q197), L195 (≠ N198), L218 (≠ I221), L220 (= L223), N244 (= N247), F247 (≠ A250), K253 (≠ R256), Y256 (≠ I259), L288 (≠ I283), R318 (≠ E334), Y323 (= Y339)
- binding magnesium ion: H346 (= H364), K409 (≠ D427)
8ivyA Beta-glucosidase bgla mutant e166q in complex with glucose (see paper)
43% identity, 99% coverage: 1:441/444 of query aligns to 1:448/451 of 8ivyA
4ptwA Halothermothrix orenii beta-glucosidase a, 2-deoxy-2-fluoro-glucose complex (see paper)
45% identity, 98% coverage: 6:440/444 of query aligns to 3:444/445 of 4ptwA
- active site: R74 (= R76), H118 (= H120), E163 (= E165), V166 (= V168), N291 (= N289), Y293 (= Y291), E351 (= E348)
- binding 2-deoxy-2-fluoro-alpha-D-glucopyranose: Q17 (= Q20), H118 (= H120), E163 (= E165), Y293 (= Y291), E351 (= E348), W398 (= W395), E405 (= E402), W406 (= W403)
4ptvA Halothermothrix orenii beta-glucosidase a, thiocellobiose complex (see paper)
45% identity, 98% coverage: 6:440/444 of query aligns to 3:444/445 of 4ptvA
- active site: R74 (= R76), H118 (= H120), E163 (= E165), V166 (= V168), N291 (= N289), Y293 (= Y291), E351 (= E348)
- binding beta-D-glucopyranose: W324 (= W321), E405 (= E402), Y408 (≠ F405)
- binding 4-thio-beta-D-glucopyranose: Q17 (= Q20), H118 (= H120), E163 (= E165), Y293 (= Y291), E351 (= E348), W398 (= W395), E405 (= E402), W406 (= W403)
1gnxA B-glucosidase from streptomyces sp
48% identity, 98% coverage: 4:439/444 of query aligns to 2:444/447 of 1gnxA
- active site: R75 (= R76), H119 (= H120), E164 (= E165), C167 (≠ V168), N293 (= N289), Y295 (= Y291), E353 (= E348)
- binding beta-D-fructofuranose: Q285 (≠ F281), K286 (≠ P282)
- binding alpha-D-glucopyranose: Q204 (≠ R206), R281 (≠ E277), Q285 (≠ F281)
- binding sulfate ion: R190 (= R192), F274 (= F270), R276 (≠ L272)
4hz7A Crystal structure of bglb with glucose (see paper)
46% identity, 97% coverage: 6:435/444 of query aligns to 3:434/441 of 4hz7A
- active site: R74 (= R76), H118 (= H120), E163 (= E165), V166 (= V168), N290 (= N289), Y292 (= Y291), E347 (= E348)
- binding beta-D-glucopyranose: Q17 (= Q20), H118 (= H120), E163 (= E165), Y292 (= Y291), E347 (= E348), W394 (= W395), E401 (= E402), W402 (= W403), F410 (= F411)
1w3jA Family 1 b-glucosidase from thermotoga maritima in complex with tetrahydrooxazine (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 3:439/443 of 1w3jA
- active site: R74 (= R76), H118 (= H120), E163 (= E165), V166 (= V168), N290 (= N289), Y292 (= Y291), E348 (= E348)
- binding tetrahydrooxazine: Q17 (= Q20), H118 (= H120), E163 (= E165), Y292 (= Y291), E348 (= E348), W395 (= W395), E402 (= E402), W403 (= W403)
1oifA Family 1 b-glucosidase from thermotoga maritima (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 4:440/444 of 1oifA
- active site: R75 (= R76), H119 (= H120), E164 (= E165), V167 (= V168), N291 (= N289), Y293 (= Y291), E349 (= E348)
- binding 5-hydroxymethyl-3,4-dihydroxypiperidine: Q18 (= Q20), E164 (= E165), Y293 (= Y291), E349 (= E348), W396 (= W395), E403 (= E402), W404 (= W403), F412 (= F411)
5ossB Beta-glucosidase from thermotoga maritima in complex with gluco-1h- imidazole (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 4:440/443 of 5ossB
- active site: R75 (= R76), H119 (= H120), E164 (= E165), V167 (= V168), N291 (= N289), Y293 (= Y291), E349 (= E348)
- binding (4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol: Q18 (= Q20), H119 (= H120), E164 (= E165), Y293 (= Y291), E349 (= E348), W396 (= W395), E403 (= E402), W404 (= W403), F412 (= F411)
5n6tA Thermotoga maritima family 1 glycoside hydrolase complexed with a cyclophellitol analogue transition state mimic (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 4:440/443 of 5n6tA
- active site: R75 (= R76), H119 (= H120), E164 (= E165), V167 (= V168), N291 (= N289), Y293 (= Y291), E349 (= E348)
- binding [(1~{R},2~{R},3~{R},4~{S},5~{R},6~{S})-3,4,5-tris(oxidanyl)-7-oxabicyclo[4.1.0]heptan-2-yl]methanediazonium: Q18 (= Q20), H119 (= H120), N163 (= N164), E164 (= E165), Y293 (= Y291), E349 (= E348), W396 (= W395), E403 (= E402), W404 (= W403), F412 (= F411)
5n6sA Thermotoga maritima family 1 glycoside hydrolase complexed with carba- cyclophellitol transition state mimic (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 4:440/443 of 5n6sA
- active site: R75 (= R76), H119 (= H120), E164 (= E165), V167 (= V168), N291 (= N289), Y293 (= Y291), E349 (= E348)
- binding azanylidene-[4-[[(1~{S},2~{R},3~{R},4~{R},5~{S},6~{S},7~{S})-2-(hydroxymethyl)-3,4,5-tris(oxidanyl)-7-bicyclo[4.1.0]heptanyl]carbonylamino]butylimino]azanium: Q18 (= Q20), H119 (= H120), W120 (= W121), N163 (= N164), E164 (= E165), W166 (≠ N167), V167 (= V168), E349 (= E348), W396 (= W395), E403 (= E402), W404 (= W403), F412 (= F411)
2wc4A Structure of family 1 beta-glucosidase from thermotoga maritima in complex with 3-imino-2-thia-(+)-castanospermine (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 4:440/443 of 2wc4A
- active site: R75 (= R76), H119 (= H120), E164 (= E165), V167 (= V168), N291 (= N289), Y293 (= Y291), E349 (= E348)
- binding (3Z,5S,6R,7S,8R,8aS)-3-(octylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-5,6,7,8-tetrol: Q18 (= Q20), H119 (= H120), N163 (= N164), E164 (= E165), Y293 (= Y291), W322 (= W321), E349 (= E348), W396 (= W395), E403 (= E402), W404 (= W403), F412 (= F411)
2wbgA Structure of family 1 beta-glucosidase from thermotoga maritima in complex with 3-imino-2-oxa-(+)-castanospermine (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 4:440/443 of 2wbgA
- active site: R75 (= R76), H119 (= H120), E164 (= E165), V167 (= V168), N291 (= N289), Y293 (= Y291), E349 (= E348)
- binding (3Z,5S,6R,7S,8R,8aR)-3-(octylimino)hexahydro[1,3]oxazolo[3,4-a]pyridine-5,6,7,8-tetrol: Q18 (= Q20), H119 (= H120), N163 (= N164), E164 (= E165), Y293 (= Y291), H296 (≠ M294), W322 (= W321), E349 (= E348), W396 (= W395), E403 (= E402), W404 (= W403)
2jalB Beta-glucosidase from thermotoga maritima in complex with cyclophellitol (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 5:441/444 of 2jalB
- active site: R76 (= R76), H120 (= H120), E165 (= E165), V168 (= V168), N292 (= N289), Y294 (= Y291), E350 (= E348)
- binding calcium ion: D277 (≠ G274), E281 (≠ A278)
- binding (1r,2s,3s,4s,5r,6r)-6-(hydroxymethyl)cyclohexane-1,2,3,4,5-pentol: Q19 (= Q20), H120 (= H120), E165 (= E165), E350 (= E348), W397 (= W395), E404 (= E402), W405 (= W403), F413 (= F411)
2cesA Beta-glucosidase from thermotoga maritima in complex with glucoimidazole (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 4:437/440 of 2cesA
- active site: R75 (= R76), H119 (= H120), E164 (= E165), V167 (= V168), N291 (= N289), Y293 (= Y291), E346 (= E348)
- binding glucoimidazole: Q18 (= Q20), H119 (= H120), N163 (= N164), E164 (= E165), Y293 (= Y291), E346 (= E348), W393 (= W395), E400 (= E402), W401 (= W403), F409 (= F411)
1oinA Family 1 b-glucosidase from thermotoga maritima (see paper)
43% identity, 98% coverage: 6:439/444 of query aligns to 5:439/442 of 1oinA
- active site: R76 (= R76), H120 (= H120), E165 (= E165), V168 (= V168), N292 (= N289), Y294 (= Y291), E348 (= E348)
- binding 2-deoxy-2-fluoro-alpha-D-glucopyranose: Q19 (= Q20), H120 (= H120), N164 (= N164), E165 (= E165), Y294 (= Y291), E348 (= E348), W395 (= W395), E402 (= E402), W403 (= W403)
Query Sequence
>AZOBR_RS26030 FitnessBrowser__azobra:AZOBR_RS26030
MALFTFPKDFLWGASTAAYQIEGAIHEDGRGPCVWDTFTEAGRIQDGSSAAVACDHYHRW
AEDTALMKDAGFNAYRFSIAWPRILPSGTGAVNAAGLDFYDRLVDGLLADGIRPMACLYH
WDLPQPLEDRGGWQGREVVGPFADYARIVAARLADRVKDWMMLNEPNVVATHGYGTGEHA
PGHKLGETGILRALHHQNLAQGAALRALSAEHSGLTLGTVINLQPCRAESDRPQDVAAAA
RWDAVWNRVALDGVMRGKIPELMAERMKDFVLPGDEEAIRFPIDLLGINYYSRMTMKHET
GHPFDVWWGDAHCDRWTAMAWPVQPDGLYDLLMEFRRDYGNPAVFVAENGAAYDDVVTPD
GQVHDAERVAFLRDHVASVGRALADGCNVKGYLCWSLLDNFEWAFGLSKRFGIVRVDYDT
LVRTPKDSYRFLSEVAKSGQFDLA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory