Comparing AZOBR_RS26680 FitnessBrowser__azobra:AZOBR_RS26680 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5ktlA Dihydrodipicolinate synthase from the industrial and evolutionarily important cyanobacteria anabaena variabilis. (see paper)
31% identity, 93% coverage: 10:293/306 of query aligns to 8:292/295 of 5ktlA
Q9X1K9 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
31% identity, 88% coverage: 7:275/306 of query aligns to 2:273/294 of Q9X1K9
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
35% identity, 80% coverage: 7:251/306 of query aligns to 2:247/294 of Q8UGL3
1o5kA Crystal structure of dihydrodipicolinate synthase (tm1521) from thermotoga maritima at 1.80 a resolution
31% identity, 88% coverage: 7:275/306 of query aligns to 3:274/295 of 1o5kA
4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
35% identity, 80% coverage: 7:251/306 of query aligns to 2:247/294 of 4i7wA
2atsA Dihydrodipicolinate synthase co-crystallised with (s)-lysine
30% identity, 91% coverage: 9:287/306 of query aligns to 4:287/292 of 2atsA
P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Escherichia coli (strain K12) (see 7 papers)
30% identity, 91% coverage: 9:287/306 of query aligns to 4:287/292 of P0A6L2
5t25A Kinetic, spectral and structural characterization of the slow binding inhibitor acetopyruvate with dihydrodipicolinate synthase from escherichia coli.
30% identity, 91% coverage: 9:287/306 of query aligns to 5:288/293 of 5t25A
3i7sA Dihydrodipicolinate synthase mutant - k161a - with the substrate pyruvate bound in the active site. (see paper)
30% identity, 91% coverage: 9:287/306 of query aligns to 4:287/292 of 3i7sA
1xxxA Crystal structure of dihydrodipicolinate synthase (dapa, rv2753c) from mycobacterium tuberculosis (see paper)
35% identity, 79% coverage: 4:246/306 of query aligns to 5:245/296 of 1xxxA
5j5dA Crystal structure of dihydrodipicolinate synthase from mycobacterium tuberculosis in complex with alpha-ketopimelic acid (see paper)
35% identity, 79% coverage: 4:246/306 of query aligns to 6:246/297 of 5j5dA
Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
32% identity, 93% coverage: 7:290/306 of query aligns to 2:285/292 of Q07607
P9WP25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
35% identity, 79% coverage: 4:246/306 of query aligns to 9:249/300 of P9WP25
4dxvA Crystal structure of dihydrodipicolinate synthase from acinetobacter baumannii complexed with mg and cl ions at 1.80 a resolution
30% identity, 92% coverage: 7:287/306 of query aligns to 2:286/291 of 4dxvA
3u8gA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with oxalic acid at 1.80 a resolution
30% identity, 92% coverage: 7:287/306 of query aligns to 2:286/291 of 3u8gA
3tdfA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 2-ketobutanoic acid at 1.99 a resolution
30% identity, 92% coverage: 7:287/306 of query aligns to 2:286/291 of 3tdfA
3tceA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 5-hydroxylysine at 2.6 a resolution
30% identity, 92% coverage: 7:287/306 of query aligns to 2:286/291 of 3tceA
3rk8A Crystal structure of the chloride inhibited dihydrodipicolinate synthase from acinetobacter baumannii complexed with pyruvate at 1.8 a resolution
30% identity, 92% coverage: 7:287/306 of query aligns to 2:286/291 of 3rk8A
3pueB Crystal structure of the complex of dhydrodipicolinate synthase from acinetobacter baumannii with lysine at 2.6a resolution
30% identity, 92% coverage: 7:287/306 of query aligns to 2:286/291 of 3pueB
7kkdB Dihydrodipicolinate synthase (dhdps) from c.Jejuni, n84a mutant with pyruvate bound in the active site and r,r-bislysine bound at the allosteric site
31% identity, 92% coverage: 2:281/306 of query aligns to 9:289/306 of 7kkdB
>AZOBR_RS26680 FitnessBrowser__azobra:AZOBR_RS26680
MLDATKLRGILPATPTPVTADGTIDVAASKALFSWLNRQGIDGVVPLGGTGEYGALARAE
RNRFAALTVEAMDGKKPVIAGVLDTGYHDALAAGRDFAAAGVDGLLVLTPYYTNPTQAGI
RDYFLRYADESPVPILIYEIPYRTRIAVDPEVLHELSRHERIVGMKACNTDMYHFLRTMA
GLDPSFAMLSGEDTLFPLHVAAGAKGGIVVTANLLPRAWRLVFDLASSGKTAEALEVHRT
LIPMMNLAFAETNPGPMKSVMGLIGVNAPAMLPPLREPRPELREALKSELSRLLTTYEGL
PAAAVA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory