SitesBLAST
Comparing AZOBR_RS26825 AZOBR_RS26825 aldehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
38% identity, 96% coverage: 18:493/494 of query aligns to 19:490/491 of 5gtlA
- active site: N165 (= N162), K188 (= K185), E263 (= E259), C297 (= C294), E394 (= E396), E471 (= E473)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I158), P163 (= P160), K188 (= K185), A190 (= A187), E191 (= E188), Q192 (≠ E189), G221 (= G217), G225 (= G221), G241 (= G237), S242 (= S238), T245 (= T241), L264 (= L260), C297 (= C294), E394 (= E396), F396 (= F398)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
38% identity, 96% coverage: 18:493/494 of query aligns to 19:490/491 of 5gtkA
- active site: N165 (= N162), K188 (= K185), E263 (= E259), C297 (= C294), E394 (= E396), E471 (= E473)
- binding nicotinamide-adenine-dinucleotide: I161 (= I158), I162 (= I159), P163 (= P160), W164 (= W161), K188 (= K185), E191 (= E188), G221 (= G217), G225 (= G221), A226 (= A222), F239 (= F235), G241 (= G237), S242 (= S238), T245 (= T241), Y248 (≠ I244), L264 (= L260), C297 (= C294), Q344 (= Q341), R347 (= R344), E394 (= E396), F396 (= F398)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
40% identity, 97% coverage: 18:494/494 of query aligns to 6:480/489 of 4o6rA
- active site: N150 (= N162), K173 (= K185), E248 (= E259), C282 (= C294), E383 (= E396), E460 (= E473)
- binding adenosine monophosphate: I146 (= I158), V147 (≠ I159), K173 (= K185), G206 (= G217), G210 (= G221), Q211 (≠ A222), F224 (= F235), G226 (= G237), S227 (= S238), T230 (= T241), R233 (≠ I244)
7radA Crystal structure analysis of aldh1b1
40% identity, 96% coverage: 18:493/494 of query aligns to 15:488/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I158), I159 (= I159), P160 (= P160), W161 (= W161), N162 (= N162), M167 (≠ L167), K185 (= K185), E188 (= E188), G218 (= G217), G222 (= G221), A223 (= A222), T237 (= T236), G238 (= G237), S239 (= S238), V242 (≠ T241), E261 (= E259), L262 (= L260), C295 (= C294), E392 (= E396), F394 (= F398)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ V113), E117 (≠ L117), F163 (≠ V163), E285 (≠ A283), F289 (≠ T288), N450 (≠ L454), V452 (= V456)
7mjdA Crystal structure analysis of aldh1b1
40% identity, 96% coverage: 18:493/494 of query aligns to 15:488/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I158), I159 (= I159), P160 (= P160), W161 (= W161), N162 (= N162), M167 (≠ L167), K185 (= K185), E188 (= E188), G218 (= G217), G222 (= G221), F236 (= F235), T237 (= T236), G238 (= G237), S239 (= S238), V242 (≠ T241), E261 (= E259), L262 (= L260), C295 (= C294), E392 (= E396), F394 (= F398)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ L117), E285 (≠ A283), F289 (≠ T288), N450 (≠ L454), V452 (= V456)
7mjcA Crystal structure analysis of aldh1b1
40% identity, 96% coverage: 18:493/494 of query aligns to 15:488/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I158), I159 (= I159), P160 (= P160), W161 (= W161), N162 (= N162), K185 (= K185), E188 (= E188), G218 (= G217), G222 (= G221), T237 (= T236), G238 (= G237), S239 (= S238), V242 (≠ T241), E261 (= E259), L262 (= L260), C295 (= C294), E392 (= E396), F394 (= F398)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
41% identity, 96% coverage: 18:490/494 of query aligns to 13:485/494 of 4pz2B
- active site: N159 (= N162), K182 (= K185), E258 (= E259), C292 (= C294), E392 (= E396), D469 (≠ E473)
- binding nicotinamide-adenine-dinucleotide: I155 (= I158), I156 (= I159), P157 (= P160), W158 (= W161), N159 (= N162), M164 (≠ L167), K182 (= K185), A184 (= A187), E185 (= E188), G215 (= G217), G219 (= G221), F233 (= F235), T234 (= T236), G235 (= G237), S236 (= S238), V239 (≠ T241), E258 (= E259), L259 (= L260), C292 (= C294), E392 (= E396), F394 (= F398)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 7:491/496 of 4fr8C
- active site: N165 (= N162), K188 (= K185), Q264 (≠ E259), C298 (= C294), E395 (= E396), E472 (= E473)
- binding nicotinamide-adenine-dinucleotide: I161 (= I158), I162 (= I159), W164 (= W161), K188 (= K185), G221 (= G217), G225 (= G221), A226 (= A222), F239 (= F235), G241 (= G237), S242 (= S238), I245 (≠ T241), Q345 (= Q341), E395 (= E396), F397 (= F398)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 4:488/493 of 4fr8A
- active site: N162 (= N162), K185 (= K185), Q261 (≠ E259), C295 (= C294), E392 (= E396), E469 (= E473)
- binding nicotinamide-adenine-dinucleotide: I158 (= I158), I159 (= I159), W161 (= W161), K185 (= K185), G218 (= G217), G222 (= G221), A223 (= A222), F236 (= F235), G238 (= G237), S239 (= S238), I242 (≠ T241), Q342 (= Q341), K345 (≠ R344), E392 (= E396), F394 (= F398)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ V163), L166 (≠ Y166), W170 (≠ L170), F289 (≠ T288), S294 (= S293), C295 (= C294), D450 (≠ L454), F452 (≠ V456)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
39% identity, 98% coverage: 12:493/494 of query aligns to 23:505/515 of 2d4eC
- active site: N173 (= N162), K196 (= K185), E271 (= E259), C305 (= C294), E409 (= E396), E486 (= E473)
- binding nicotinamide-adenine-dinucleotide: I169 (= I158), T170 (≠ I159), P171 (= P160), W172 (= W161), K196 (= K185), A198 (= A187), G229 (= G217), G233 (= G221), A234 (= A222), T248 (= T236), G249 (= G237), E250 (≠ S238), T253 (= T241), E271 (= E259), L272 (= L260), C305 (= C294), E409 (= E396), F411 (= F398), F475 (≠ Y462)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 5l13A
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ V163), M168 (≠ L167), W171 (≠ L170), F290 (≠ T288), C295 (≠ S293), C296 (= C294), C297 (≠ T295), D451 (≠ L454), F453 (≠ V456)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 4kwgA
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ V163), M168 (≠ L167), C295 (≠ S293), C296 (= C294), C297 (≠ T295), D451 (≠ L454), F453 (≠ V456)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 4kwfA
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ V163), M168 (≠ L167), W171 (≠ L170), E262 (= E259), C295 (≠ S293), C296 (= C294), C297 (≠ T295), D451 (≠ L454), F453 (≠ V456), F459 (≠ Y462)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 3sz9A
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ V163), C295 (≠ S293), C296 (= C294), D451 (≠ L454), F453 (≠ V456), F459 (≠ Y462)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 3injA
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ L117), F164 (≠ V163), L167 (≠ Y166), F286 (≠ A283), F290 (≠ T288), D451 (≠ L454), F453 (≠ V456)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 2vleA
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding daidzin: M118 (≠ L117), F164 (≠ V163), M168 (≠ L167), W171 (≠ L170), F286 (≠ A283), F290 (≠ T288), C295 (≠ S293), C296 (= C294), D451 (≠ L454), V452 (= V455), F453 (≠ V456)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 1o01B
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding (2e)-but-2-enal: C296 (= C294), C297 (≠ T295), F453 (≠ V456)
- binding nicotinamide-adenine-dinucleotide: I159 (= I158), I160 (= I159), P161 (= P160), W162 (= W161), K186 (= K185), E189 (= E188), G219 (= G217), G223 (= G221), A224 (= A222), F237 (= F235), G239 (= G237), S240 (= S238), I243 (≠ T241), L263 (= L260), G264 (= G261), C296 (= C294), Q343 (= Q341), E393 (= E396), F395 (= F398)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
39% identity, 99% coverage: 7:493/494 of query aligns to 5:489/494 of 1cw3A
- active site: N163 (= N162), K186 (= K185), E262 (= E259), C296 (= C294), E393 (= E396), E470 (= E473)
- binding magnesium ion: V34 (= V36), D103 (≠ E102), Q190 (≠ E189)
- binding nicotinamide-adenine-dinucleotide: I159 (= I158), I160 (= I159), P161 (= P160), W162 (= W161), K186 (= K185), G219 (= G217), G223 (= G221), A224 (= A222), F237 (= F235), G239 (= G237), S240 (= S238), I243 (≠ T241), L263 (= L260), G264 (= G261), C296 (= C294), Q343 (= Q341), K346 (≠ R344), E393 (= E396), F395 (= F398)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
39% identity, 99% coverage: 6:493/494 of query aligns to 30:515/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
38% identity, 96% coverage: 18:493/494 of query aligns to 14:487/492 of 6b5hA
- active site: N161 (= N162), E260 (= E259), C294 (= C294), E468 (= E473)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (= V113), G116 (≠ L117), F162 (≠ V163), W169 (≠ L170), Q284 (≠ A283), F288 (≠ T288), T295 (= T295), N449 (≠ L454), L451 (≠ V456), N452 (≠ Q457), F457 (≠ Y462)
- binding nicotinamide-adenine-dinucleotide: I157 (= I158), I158 (= I159), W160 (= W161), N161 (= N162), K184 (= K185), G217 (= G217), G221 (= G221), F235 (= F235), T236 (= T236), G237 (= G237), S238 (= S238), V241 (≠ T241), E260 (= E259), L261 (= L260), C294 (= C294), F393 (= F398)
Query Sequence
>AZOBR_RS26825 AZOBR_RS26825 aldehyde dehydrogenase
LVLNTTPHALARELSGLLLIGGELRPAATGKTFDVVNPATGDVIATAADGGERDVDAAVR
AAVAAQGAWARLSARERGRLLVECGRRLVGHAEEIGRLLALETGKAIRTESRVEASLVAD
TLTFYGGLASELKGETVPFHPKMLTFTQREPIGVVGAIIPWNVPLYLMALKIAPALVAGN
AVIVKSAEEAPLAALRVIQVMNQLLPPGVLNILSGDGPGCGAPLVTHPGVGKVTFTGSVE
TGKIISHLAADKLIPVTLELGGKSPMIVMGDADLDKAIDGAVAGMRFTRQGQSCTASSRI
FVHESLHDAFIDKLKAKVDAMTMGDPLDEATDIGTIISPQQFERVQSYIALGETTAGAIA
HRCSALPTDERLARGLFVQPVLFTGLANDHRLAREEIFGPVTCVIAFRDYEDALAMANDS
DFGLAATIWTRDLRTALDATRRLQAGFVQVNQNLVVQPGLSYGGFKQSGLGKEASLEAML
DHFTHKKTVIINMD
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory