SitesBLAST
Comparing AZOBR_RS27005 FitnessBrowser__azobra:AZOBR_RS27005 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
50% identity, 99% coverage: 1:257/259 of query aligns to 2:258/260 of 2ztlA
- active site: G15 (= G14), N114 (= N113), S142 (= S141), Y155 (= Y154), K159 (= K158), L200 (≠ Q199)
- binding (3s)-3-hydroxybutanoic acid: Q94 (= Q93), S142 (= S141), H144 (≠ L143), K152 (= K151), Y155 (= Y154), Q196 (= Q195)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), G15 (= G14), I16 (= I15), F36 (= F35), L64 (= L63), N90 (= N89), A91 (= A90), G92 (= G91), L113 (≠ V112), Y155 (= Y154), K159 (= K158), P185 (= P184), W187 (≠ T186), V188 (= V187), T190 (= T189), V193 (≠ I192)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
50% identity, 99% coverage: 1:257/259 of query aligns to 2:258/260 of 1wmbA
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
49% identity, 99% coverage: 1:257/259 of query aligns to 2:258/260 of 5b4tA
- active site: G15 (= G14), N114 (= N113), S142 (= S141), Y155 (= Y154), K159 (= K158), I200 (≠ Q199)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q93), S142 (= S141), H144 (≠ L143), K152 (= K151), Y155 (= Y154), W187 (≠ T186), Q196 (= Q195)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (= T12), G15 (= G14), I16 (= I15), F36 (= F35), D63 (= D62), L64 (= L63), N90 (= N89), G92 (= G91), L113 (≠ V112), I140 (≠ T139), Y155 (= Y154), K159 (= K158), P185 (= P184), G186 (= G185), W187 (≠ T186), V188 (= V187), T190 (= T189), L192 (≠ I191), V193 (≠ I192)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
49% identity, 99% coverage: 1:257/259 of query aligns to 2:258/260 of 3w8dA
- active site: G15 (= G14), N114 (= N113), S142 (= S141), Y155 (= Y154), K159 (= K158), I200 (≠ Q199)
- binding methylmalonic acid: Q94 (= Q93), S142 (= S141), H144 (≠ L143), K152 (= K151), Y155 (= Y154), W187 (≠ T186), Q196 (= Q195), W257 (≠ Y256)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (= T12), S14 (≠ T13), G15 (= G14), I16 (= I15), F36 (= F35), A62 (= A61), D63 (= D62), L64 (= L63), N90 (= N89), A91 (= A90), G92 (= G91), L113 (≠ V112), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), G186 (= G185), W187 (≠ T186), V188 (= V187), T190 (= T189), L192 (≠ I191), V193 (≠ I192)
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
49% identity, 99% coverage: 1:257/259 of query aligns to 2:258/260 of 3vdrA
- active site: G15 (= G14), N114 (= N113), S142 (= S141), Y155 (= Y154), K159 (= K158), I200 (≠ Q199)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q93), H144 (≠ L143), K152 (= K151), Y155 (= Y154), W187 (≠ T186), Q196 (= Q195), W257 (≠ Y256)
- binding acetoacetic acid: Q94 (= Q93), H144 (≠ L143), K152 (= K151), Y155 (= Y154), W187 (≠ T186), Q196 (= Q195), W257 (≠ Y256)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (= T12), I16 (= I15), F36 (= F35), D63 (= D62), L64 (= L63), N90 (= N89), A91 (= A90), G92 (= G91), L113 (≠ V112), K159 (= K158), G186 (= G185), V188 (= V187), T190 (= T189), L192 (≠ I191), V193 (≠ I192)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G10), T13 (= T12), I16 (= I15), F36 (= F35), D63 (= D62), L64 (= L63), N90 (= N89), A91 (= A90), G92 (= G91), L113 (≠ V112), S142 (= S141), Y155 (= Y154), K159 (= K158), G186 (= G185), V188 (= V187), T190 (= T189), L192 (≠ I191), V193 (≠ I192)
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
49% identity, 99% coverage: 1:257/259 of query aligns to 2:258/260 of 3vdqA
- active site: G15 (= G14), N114 (= N113), S142 (= S141), Y155 (= Y154), K159 (= K158), I200 (≠ Q199)
- binding acetate ion: Q94 (= Q93), H144 (≠ L143), K152 (= K151), W187 (≠ T186), L192 (≠ I191), Q196 (= Q195)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), S14 (≠ T13), I16 (= I15), F36 (= F35), D63 (= D62), L64 (= L63), N90 (= N89), A91 (= A90), G92 (= G91), L113 (≠ V112), I140 (≠ T139), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), G186 (= G185), W187 (≠ T186), V188 (= V187), T190 (= T189), L192 (≠ I191), V193 (≠ I192)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
48% identity, 99% coverage: 1:257/259 of query aligns to 2:234/236 of 1x1tA
- active site: G15 (= G14), N114 (= N113), S142 (= S141), Y155 (= Y154), K159 (= K158)
- binding cacodylate ion: S142 (= S141), H144 (≠ L143), Y155 (= Y154), W187 (≠ T186), W233 (≠ Y256)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (= T12), S14 (≠ T13), G15 (= G14), I16 (= I15), G35 (= G34), F36 (= F35), D63 (= D62), L64 (= L63), N90 (= N89), G92 (= G91), L113 (≠ V112), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), W187 (≠ T186), V188 (= V187), T190 (= T189)
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
47% identity, 99% coverage: 1:256/259 of query aligns to 2:252/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (= T12), S14 (≠ T13), G15 (= G14), I16 (= I15), G35 (= G34), F36 (= F35), L60 (= L63), N86 (= N89), G88 (= G91), I89 (≠ V92), A137 (= A140), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185), V184 (= V187), T186 (= T189)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
48% identity, 99% coverage: 1:256/259 of query aligns to 2:252/255 of 2q2qD
- active site: G15 (= G14), S138 (= S141), Y151 (= Y154), K155 (= K158), R196 (≠ Q199)
- binding nicotinamide-adenine-dinucleotide: G11 (= G10), T13 (= T12), S14 (≠ T13), G15 (= G14), I16 (= I15), F36 (= F35), D59 (= D62), L60 (= L63), N86 (= N89), G88 (= G91), L109 (≠ V112), I136 (≠ T139), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185), W183 (≠ T186), V184 (= V187), T186 (= T189), L188 (≠ I191), V189 (≠ I192)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
38% identity, 100% coverage: 1:259/259 of query aligns to 5:261/261 of 6zzsD
- active site: G18 (= G14), S143 (= S141), Y156 (= Y154)
- binding nicotinamide-adenine-dinucleotide: G14 (= G10), S17 (≠ T13), I19 (= I15), D38 (≠ G34), M39 (≠ F35), D64 (= D62), V65 (≠ L63), N91 (= N89), A92 (= A90), G93 (= G91), M141 (≠ T139), A142 (= A140), S143 (= S141), Y156 (= Y154), K160 (= K158), P186 (= P184), G187 (= G185), V189 (= V187), T191 (= T189), L193 (≠ I191)
- binding 3-oxidanylidenepentanoic acid: Q95 (= Q93), S143 (= S141), N145 (≠ L143), K153 (= K151), Y156 (= Y154), Q197 (= Q195)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
38% identity, 100% coverage: 1:259/259 of query aligns to 4:260/260 of 6zzqA
- active site: G17 (= G14), S142 (= S141), Y155 (= Y154)
- binding acetoacetic acid: Q94 (= Q93), S142 (= S141), K152 (= K151), Y155 (= Y154), Q196 (= Q195)
- binding nicotinamide-adenine-dinucleotide: G13 (= G10), S16 (≠ T13), G17 (= G14), I18 (= I15), D37 (≠ G34), M38 (≠ F35), D63 (= D62), V64 (≠ L63), N90 (= N89), A91 (= A90), G92 (= G91), M140 (≠ T139), A141 (= A140), S142 (= S141), Y155 (= Y154), K159 (= K158), Y187 (≠ T186), V188 (= V187), T190 (= T189)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
37% identity, 97% coverage: 4:255/259 of query aligns to 5:243/246 of 3osuA
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
36% identity, 97% coverage: 4:255/259 of query aligns to 2:236/239 of 3sj7A
- active site: G12 (= G14), S138 (= S141), Q148 (≠ K151), Y151 (= Y154), K155 (= K158)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G10), S10 (≠ T12), R11 (≠ T13), I13 (= I15), N31 (= N33), Y32 (≠ G34), A33 (≠ F35), G34 (= G36), S35 (≠ D37), A58 (= A61), N59 (≠ D62), V60 (≠ L63), N86 (= N89), A87 (= A90), T109 (≠ V112), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185)
3sjuA Hedamycin polyketide ketoreductase bound to NADPH (see paper)
40% identity, 99% coverage: 4:259/259 of query aligns to 1:255/255 of 3sjuA
- active site: G11 (= G14), S138 (= S141), Y151 (= Y154), K155 (= K158), Y196 (≠ Q199)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G7 (= G10), S10 (≠ T13), A31 (≠ G36), R32 (≠ D37), D33 (≠ R38), C56 (≠ A61), D57 (= D62), V58 (≠ L63), S84 (≠ N89), A85 (= A90), G86 (= G91), I136 (≠ T139), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185), Y183 (≠ T186), V184 (= V187), T186 (= T189), M188 (≠ I191)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
36% identity, 99% coverage: 1:257/259 of query aligns to 3:246/248 of 6ixmC
- active site: G16 (= G14), S142 (= S141), Y155 (= Y154), K159 (= K158)
- binding nicotinamide-adenine-dinucleotide: G12 (= G10), S15 (≠ T13), G16 (= G14), I17 (= I15), D36 (≠ G34), I37 (≠ F35), A61 (= A61), D62 (= D62), T63 (≠ L63), N89 (= N89), A90 (= A90), M140 (≠ T139), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), A186 (≠ G185), Y187 (≠ T186), I188 (≠ V187), L192 (≠ I191)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
35% identity, 98% coverage: 1:255/259 of query aligns to 3:244/247 of 4jroC
- active site: G16 (= G14), S142 (= S141), Q152 (≠ K151), Y155 (= Y154), K159 (= K158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G10), S14 (≠ T12), R15 (≠ T13), G16 (= G14), I17 (= I15), N35 (= N33), Y36 (≠ F35), N37 (≠ G36), G38 (≠ D37), S39 (≠ R38), N63 (≠ D62), V64 (≠ L63), N90 (= N89), A91 (= A90), I93 (≠ V92), I113 (≠ V112), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), I188 (≠ V187), T190 (= T189)
4k6fB X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
36% identity, 99% coverage: 4:259/259 of query aligns to 2:245/245 of 4k6fB
- active site: G12 (= G14), N102 (≠ K105), S138 (= S141), Y151 (= Y154), K155 (= K158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G10), Y32 (≠ G34), S33 (≠ F35), N36 (≠ R38), V58 (≠ A61), D59 (= D62), V60 (≠ L63), A87 (= A90), G88 (= G91), I89 (≠ V92)
1edoA The x-ray structure of beta-keto acyl carrier protein reductase from brassica napus complexed with NADP+ (see paper)
36% identity, 96% coverage: 7:255/259 of query aligns to 5:241/244 of 1edoA
- active site: G12 (= G14), S138 (= S141), Y151 (= Y154), K155 (= K158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G10), S10 (≠ T12), R11 (≠ T13), I13 (= I15), N31 (= N33), Y32 (≠ G34), A33 (≠ F35), R34 (≠ G36), S35 (≠ D37), D59 (= D62), V60 (≠ L63), N86 (= N89), A87 (= A90), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185), I184 (≠ V187), S186 (≠ T189), M188 (≠ I191)
7do7A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NAD and l-rhamnose bound-form) (see paper)
37% identity, 98% coverage: 3:255/259 of query aligns to 5:250/256 of 7do7A
- active site: G16 (= G14), S146 (= S141), Y159 (= Y154)
- binding nicotinamide-adenine-dinucleotide: G12 (= G10), R15 (≠ T13), G16 (= G14), I17 (= I15), S37 (≠ F35), D66 (= D62), A67 (≠ L63), N93 (= N89), A94 (= A90), G95 (= G91), I96 (≠ V92), V144 (≠ T139), S145 (≠ A140), S146 (= S141), Y159 (= Y154), K163 (= K158), P189 (= P184), G190 (= G185), I192 (≠ V187), T194 (= T189), I196 (= I191)
- binding beta-L-rhamnopyranose: F99 (≠ V95), S146 (= S141), S148 (≠ L143), Q156 (≠ K151), Y159 (= Y154), N197 (≠ I192), D235 (= D240), M236 (≠ A241), R238 (≠ A243)
7b81A Crystal structure of azotobacter vinelandii l-rhamnose 1-dehydrogenase (NAD bound-form) (see paper)
37% identity, 98% coverage: 3:255/259 of query aligns to 5:250/256 of 7b81A
- active site: G16 (= G14), S146 (= S141), Y159 (= Y154)
- binding nicotinamide-adenine-dinucleotide: G12 (= G10), S14 (≠ T12), R15 (≠ T13), I17 (= I15), D66 (= D62), A67 (≠ L63), N93 (= N89), A94 (= A90), G95 (= G91), I96 (≠ V92), T116 (≠ V112), V144 (≠ T139), S146 (= S141), Y159 (= Y154), K163 (= K158), P189 (= P184), G190 (= G185), I192 (≠ V187), T194 (= T189), I196 (= I191)
Query Sequence
>AZOBR_RS27005 FitnessBrowser__azobra:AZOBR_RS27005
MRNRNAVVTGSTTGIGLATARELARQGCHVMLNGFGDRAEIDRLCTEIAAQSGTTIVYSG
ADLSRPEEARAMMADAAAALGPIDILVNNAGVQHVAAVHEFPDDKWDLLLAVNLSAAFHT
IKAALPAMRERRWGRIVNTASVLGMVGAPHKPAYVATKHGIIGLTKSVAIEVAEHGITCN
AVCPGTVLTPIIEKQIAQQAQVTGLPEERVLQAVFLDRMPTGRLIPPEEVAAAIAFLCSD
AAASITGTAIPVDGGYTTH
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory