Comparing AZOBR_RS28110 FitnessBrowser__azobra:AZOBR_RS28110 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
28% identity, 87% coverage: 26:423/457 of query aligns to 20:424/425 of O59010
2nwwA Crystal structure of gltph in complex with tboa (see paper)
28% identity, 86% coverage: 25:415/457 of query aligns to 6:407/407 of 2nwwA
6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
28% identity, 85% coverage: 26:415/457 of query aligns to 12:408/408 of 6bauA
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
28% identity, 85% coverage: 26:415/457 of query aligns to 12:408/409 of 6bavA
6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
28% identity, 86% coverage: 25:415/457 of query aligns to 15:416/419 of 6x15A
Sites not aligning to the query:
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
28% identity, 86% coverage: 25:415/457 of query aligns to 12:413/413 of 6x14A
Sites not aligning to the query:
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
28% identity, 87% coverage: 26:421/457 of query aligns to 15:419/424 of 6zl4A
Sites not aligning to the query:
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
28% identity, 87% coverage: 26:421/457 of query aligns to 18:422/426 of 6xwnB
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
28% identity, 87% coverage: 26:421/457 of query aligns to 16:420/425 of 6zgbA
5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
28% identity, 87% coverage: 26:421/457 of query aligns to 18:422/427 of 5e9sA
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
28% identity, 88% coverage: 18:421/457 of query aligns to 4:411/416 of 6r7rA
6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
29% identity, 71% coverage: 26:350/457 of query aligns to 12:343/396 of 6bmiA
Sites not aligning to the query:
7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
26% identity, 82% coverage: 51:426/457 of query aligns to 57:410/412 of 7awmA
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
25% identity, 82% coverage: 51:426/457 of query aligns to 49:396/397 of 5mjuA
Q10901 Excitatory amino acid transporter; Sodium-dependent glutamate/ aspartate transporter from Caenorhabditis elegans (see paper)
24% identity, 87% coverage: 51:446/457 of query aligns to 56:490/503 of Q10901
P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse) (see paper)
25% identity, 89% coverage: 51:455/457 of query aligns to 85:535/543 of P56564
O35874 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Mus musculus (Mouse) (see 2 papers)
24% identity, 99% coverage: 6:456/457 of query aligns to 21:516/532 of O35874
P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat) (see paper)
25% identity, 90% coverage: 24:435/457 of query aligns to 52:517/573 of P31596
7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613 (see paper)
26% identity, 84% coverage: 35:419/457 of query aligns to 31:419/424 of 7xr6A
Sites not aligning to the query:
P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse) (see paper)
25% identity, 90% coverage: 24:435/457 of query aligns to 52:517/572 of P43006
Sites not aligning to the query:
>AZOBR_RS28110 FitnessBrowser__azobra:AZOBR_RS28110
MRLQTGEQTPAPTKPKAFYKALYFQVVVGLTLGILAGHFWPDLGASLKPLGDGFVKLVKM
MIAPVVFCTIVSGITSLNDTREIGKTLVKSMALFYALTVAALLIGLAAVMIIEPGVGMHV
SAASLDPTVAARYAKQAAPVGFTDFVLHIIPHSFFGAFAEGEVLPVLLISVLVGFGLTRV
GKAGEPVVQGIESFSHVLFAAFGFIMKLAPIGAFGAMAFTVGKYGIDSIGSLGLLILTFY
VACGVFLMVVIGTLARLHGFSLWKVLRYFREELLIVLGTSSSEPVLPRVLQKLEALGCKK
GVSGLVLPMGYSFNLDGTAIYLTLASLFIAQACDIHLSGGQIFAMLGVMLLTSKGAAGVT
GSGFVALVATLTVMPDLPVAGVALLVGIDRFMSEARALTSIISNCVASIVVSIWENACDR
EVLQRELNQSYASTERCLEEKGDIAVLPLNAPAQPSH
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory