SitesBLAST
Comparing AZOBR_RS29185 AZOBR_RS29185 aldehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
36% identity, 99% coverage: 2:473/478 of query aligns to 16:494/505 of 4neaA
- active site: N166 (= N149), K189 (= K172), E264 (= E245), C298 (= C279), E399 (= E376), E476 (= E455)
- binding nicotinamide-adenine-dinucleotide: P164 (= P147), K189 (= K172), E192 (= E175), G222 (= G205), G226 (= G209), G242 (= G223), G243 (≠ S224), T246 (≠ V227), H249 (≠ A230), I250 (= I231), C298 (= C279), E399 (= E376), F401 (= F378)
7w5nA The crystal structure of the reduced form of gluconobacter oxydans wsh-004 sndh (see paper)
40% identity, 91% coverage: 40:475/478 of query aligns to 46:485/492 of 7w5nA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: W156 (= W148), K180 (= K172), A182 (≠ S174), T212 (≠ D204), G213 (= G205), G217 (= G209), F231 (= F221), G233 (= G223), S234 (= S224), V237 (= V227), Q337 (= Q326), E388 (= E376), F390 (= F378)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
37% identity, 99% coverage: 2:473/478 of query aligns to 2:478/489 of 4o6rA
- active site: N150 (= N149), K173 (= K172), E248 (= E245), C282 (= C279), E383 (= E376), E460 (= E455)
- binding adenosine monophosphate: I146 (= I145), V147 (≠ T146), K173 (= K172), G206 (= G205), G210 (= G209), Q211 (≠ P210), F224 (= F221), G226 (= G223), S227 (= S224), T230 (≠ V227), R233 (≠ A230)
7w5kA The c296a mutant of l-sorbosone dehydrogenase (sndh) from gluconobacter oxydans wsh-004 (see paper)
40% identity, 91% coverage: 40:475/478 of query aligns to 45:484/491 of 7w5kA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I152 (= I145), T153 (= T146), P154 (= P147), W155 (= W148), N156 (= N149), I161 (≠ V154), K179 (= K172), A181 (≠ S174), E182 (= E175), T211 (≠ D204), G212 (= G205), G216 (= G209), Q217 (≠ P210), F230 (= F221), T231 (= T222), G232 (= G223), S233 (= S224), V236 (= V227), E255 (= E245), L256 (= L246), G257 (= G247), A289 (≠ C279), E387 (= E376), F389 (= F378)
6j76A Structure of 3,6-anhydro-l-galactose dehydrogenase in complex with nap (see paper)
38% identity, 93% coverage: 29:474/478 of query aligns to 28:477/477 of 6j76A
- active site: N148 (= N149), E246 (= E245), C280 (= C279), E458 (= E455)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I144 (= I145), T145 (= T146), A146 (≠ P147), W147 (= W148), N148 (= N149), K171 (= K172), T173 (≠ S174), S174 (≠ E175), G204 (= G205), G208 (= G209), T223 (= T222), G224 (= G223), S225 (= S224), A228 (≠ V227), S231 (≠ A230), I232 (= I231), E246 (= E245), L247 (= L246), C280 (= C279), E381 (= E376), F383 (= F378), H447 (vs. gap)
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
37% identity, 99% coverage: 3:475/478 of query aligns to 5:483/489 of 4cazA
- active site: N152 (= N149), K175 (= K172), E251 (= E245), C285 (= C279), E386 (= E376), E463 (= E455)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I145), G149 (≠ T146), W151 (= W148), N152 (= N149), K175 (= K172), E178 (= E175), G208 (= G205), G212 (= G209), F226 (= F221), T227 (= T222), G228 (= G223), G229 (≠ S224), T232 (≠ V227), V236 (≠ I231), E251 (= E245), L252 (= L246), C285 (= C279), E386 (= E376), F388 (= F378)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
37% identity, 99% coverage: 3:475/478 of query aligns to 5:483/489 of 2woxA
- active site: N152 (= N149), K175 (= K172), E251 (= E245), C285 (= C279), E386 (= E376), E463 (= E455)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I145), G149 (≠ T146), W151 (= W148), N152 (= N149), K175 (= K172), S177 (= S174), E178 (= E175), G208 (= G205), G212 (= G209), F226 (= F221), T227 (= T222), G228 (= G223), G229 (≠ S224), T232 (≠ V227), V236 (≠ I231), E251 (= E245), L252 (= L246), C285 (= C279), E386 (= E376), F388 (= F378)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
37% identity, 99% coverage: 3:475/478 of query aligns to 5:483/489 of 2wmeA
- active site: N152 (= N149), K175 (= K172), E251 (= E245), C285 (= C279), E386 (= E376), E463 (= E455)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ T146), W151 (= W148), K175 (= K172), S177 (= S174), E178 (= E175), G208 (= G205), G212 (= G209), F226 (= F221), G228 (= G223), G229 (≠ S224), T232 (≠ V227), V236 (≠ I231)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
37% identity, 99% coverage: 3:475/478 of query aligns to 6:484/490 of Q9HTJ1
- GAWN 150:153 (≠ TPWN 146:149) binding
- K162 (= K158) active site, Charge relay system
- KPSE 176:179 (= KPSE 172:175) binding
- G209 (= G205) binding
- GTST 230:233 (≠ SPGV 224:227) binding
- E252 (= E245) active site, Proton acceptor
- C286 (= C279) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E376) binding
- E464 (= E455) active site, Charge relay system
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
36% identity, 99% coverage: 2:473/478 of query aligns to 1:476/487 of 4go4A
- active site: N149 (= N149), K172 (= K172), E247 (= E245), C281 (= C279), E381 (= E376), E458 (= E455)
- binding nicotinamide-adenine-dinucleotide: I145 (= I145), V146 (≠ T146), W148 (= W148), N149 (= N149), F154 (≠ V154), K172 (= K172), G205 (= G205), G209 (= G209), Q210 (≠ P210), F223 (= F221), T224 (= T222), G225 (= G223), S226 (= S224), T229 (≠ V227), E247 (= E245), G249 (= G247), C281 (= C279), E381 (= E376), F383 (= F378)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
35% identity, 99% coverage: 3:473/478 of query aligns to 16:489/491 of 5gtlA
- active site: N165 (= N149), K188 (= K172), E263 (= E245), C297 (= C279), E394 (= E376), E471 (= E455)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I145), P163 (= P147), K188 (= K172), A190 (≠ S174), E191 (= E175), Q192 (≠ V176), G221 (= G205), G225 (= G209), G241 (= G223), S242 (= S224), T245 (≠ V227), L264 (= L246), C297 (= C279), E394 (= E376), F396 (= F378)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
35% identity, 99% coverage: 3:473/478 of query aligns to 16:489/491 of 5gtkA
- active site: N165 (= N149), K188 (= K172), E263 (= E245), C297 (= C279), E394 (= E376), E471 (= E455)
- binding nicotinamide-adenine-dinucleotide: I161 (= I145), I162 (≠ T146), P163 (= P147), W164 (= W148), K188 (= K172), E191 (= E175), G221 (= G205), G225 (= G209), A226 (≠ P210), F239 (= F221), G241 (= G223), S242 (= S224), T245 (≠ V227), Y248 (≠ A230), L264 (= L246), C297 (= C279), Q344 (= Q326), R347 (≠ K329), E394 (= E376), F396 (= F378)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
40% identity, 97% coverage: 7:469/478 of query aligns to 14:483/494 of 4pz2B
- active site: N159 (= N149), K182 (= K172), E258 (= E245), C292 (= C279), E392 (= E376), D469 (≠ E455)
- binding nicotinamide-adenine-dinucleotide: I155 (= I145), I156 (≠ T146), P157 (= P147), W158 (= W148), N159 (= N149), M164 (≠ V154), K182 (= K172), A184 (≠ S174), E185 (= E175), G215 (= G205), G219 (= G209), F233 (= F221), T234 (= T222), G235 (= G223), S236 (= S224), V239 (= V227), E258 (= E245), L259 (= L246), C292 (= C279), E392 (= E376), F394 (= F378)
Q8VWZ1 Aminoaldehyde dehydrogenase 1, peroxisomal; PsAMADH1; Aminobutyraldehyde dehydrogenase AMADH1; Gamma-guanidinobutyraldehyde dehydrogenase AMADH1; EC 1.2.1.-; EC 1.2.1.19; EC 1.2.1.54 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
36% identity, 94% coverage: 21:468/478 of query aligns to 27:483/503 of Q8VWZ1
- N27 (= N21) binding
- I28 (≠ R22) binding
- D99 (≠ E89) binding
- L189 (≠ V176) binding
- 238:245 (vs. 223:230, 38% identical) binding
- C294 (= C279) binding
- E393 (= E376) binding
3iwkH Crystal structure of aminoaldehyde dehydrogenase 1 from pisum sativum (psamadh1) (see paper)
36% identity, 94% coverage: 21:468/478 of query aligns to 22:478/497 of 3iwkH
- active site: N157 (= N149), K180 (= K172), E255 (= E245), C289 (= C279), E388 (= E376), E465 (= E455)
- binding nicotinamide-adenine-dinucleotide: W156 (= W148), G213 (= G205), G217 (= G209), A218 (≠ P210), G233 (= G223), S234 (= S224), T237 (≠ V227), K240 (≠ A230), C289 (= C279), Q336 (= Q326), E388 (= E376), F390 (= F378)
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
37% identity, 91% coverage: 39:475/478 of query aligns to 52:489/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I145), T159 (= T146), P160 (= P147), W161 (= W148), K185 (= K172), E188 (= E175), G218 (= G205), G222 (= G209), F236 (= F221), S239 (= S224), V242 (= V227)
5ekcE Thermostable aldehyde dehydrogenase from pyrobaculum sp.1860 complexed with NADP+
37% identity, 87% coverage: 40:457/478 of query aligns to 45:461/490 of 5ekcE
- active site: N154 (= N149), K177 (= K172), E252 (= E245), C286 (= C279), E381 (= E376), E459 (= E455)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I150 (= I145), T151 (= T146), P152 (= P147), W153 (= W148), K177 (= K172), S180 (≠ E175), G210 (= G205), G214 (= G209), F228 (= F221), G230 (= G223), E231 (≠ S224), T234 (≠ V227), N331 (≠ S323), R333 (≠ A325), Q334 (= Q326)
5ek6A Thermostable aldehyde dehydrogenase from pyrobaculum sp. 1860 complexed with NADP and isobutyraldehyde (see paper)
37% identity, 87% coverage: 40:457/478 of query aligns to 38:454/482 of 5ek6A
- active site: N147 (= N149), K170 (= K172), E245 (= E245), C279 (= C279), E374 (= E376), E452 (= E455)
- binding 2-methylpropanal: I152 (≠ V154), K155 (≠ W157), T222 (= T222), E245 (= E245), F441 (= F443)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I143 (= I145), T144 (= T146), W146 (= W148), N147 (= N149), I152 (≠ V154), K170 (= K172), A172 (≠ S174), S173 (≠ E175), P202 (≠ D204), G203 (= G205), G207 (= G209), F221 (= F221), T222 (= T222), G223 (= G223), E224 (≠ S224), T227 (≠ V227), I231 (= I231), E245 (= E245), L246 (= L246), C279 (= C279), E374 (= E376)
4h73A Thermostable aldehyde dehydrogenase from pyrobaculum sp. Complexed with NADP+
37% identity, 87% coverage: 40:457/478 of query aligns to 38:454/482 of 4h73A
- active site: N147 (= N149), K170 (= K172), E245 (= E245), C279 (= C279), E374 (= E376), E452 (= E455)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I143 (= I145), T144 (= T146), P145 (= P147), W146 (= W148), K170 (= K172), A172 (≠ S174), S173 (≠ E175), G203 (= G205), G207 (= G209), F221 (= F221), G223 (= G223), E224 (≠ S224), T227 (≠ V227)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
37% identity, 91% coverage: 39:475/478 of query aligns to 71:508/512 of P47895
- R89 (≠ A57) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K172) binding
- E207 (= E175) binding
- GSTEVG 257:262 (≠ GSPGVG 223:228) binding
- Q361 (= Q326) binding
- E411 (= E376) binding
- A493 (= A460) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
Query Sequence
>AZOBR_RS29185 AZOBR_RS29185 aldehyde dehydrogenase
MMERRNWIAGRLVDGVRMEANRNPARPGEVIGHYAWASVEQAEEALGAAHAALPGWAASN
PQTRSDVLRRVGDELNARAEELGALLTREEGKTLREGIGEVRRSAQIFHYAAGEPLRQGG
EALPGLRDGTTAMVSREPVGVVVLITPWNFPMAVPAWKTAYALAFGNTVVLKPSEVTPAC
AWELADILHRAGLPAGAFNLVVGDGRTLGPALVDGADAVSFTGSPGVGRAILERSVARMT
RVQLELGGKNPLVVHDDADLELAVDIALQGAFHSTGQRCTATSRIIVDRRVHDAFVERLV
TRIAALRVGDPMDAATDMGPVVSEAQLAKDLHCIADARSEGAELAFGGGRMDGDGYFLEP
TLFVGTDNAMRINRDEVFGPVACVIPADGLDHAIAIANDSDHALSSGIVTRGLASAETFR
RRSRAGLVMVNAPTAGIDYHVPFGGRGPSGYGGREQGSAAVEFFTEGKTAYINHGIAG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory