SitesBLAST

P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
33% identity, 96% coverage: 6:265/270 of query aligns to 6:279/288 of P19920

query
sites
P19920

F

F

D

D

Y

Y

A

H

Q

R

P

P

A

K

T

S

L

I

D

A

A

D

A

A

L

V

E

A

L

L

S

T

R

K

E

L

D

G

V

E

M

D

V

A

R

R

P

P

V

L

A
|
A

G
|
G

S
x
G

Q
x
H

S
|
S

L

L

G

I

P

P

M

I

L

M

N

K

L

T

R

R

L

L

A

A

Q

T

P

P

E

E

L

H

L

L

V

V

D

D

I

L

T

R

R

D

I

I

A

G

E

D

L

L

R

V

T

G

I

I

R

R

R

E

E

E

G

G

D

T

R

D

L

V

V

V

I

I

G

G

A

A

C

M

V

T

T

T

H

Q

A

H

R

A

L

L

E

I

D

G

G

S

D

D

Y

F

P

L

D

A

V

A

T

K

R

L

G

P

V

I

L

I

P

R

S

E

V

T

A

S

A

L

V

L

I

I

A

A

Y

D

R

P

A

Q

V

I

R

R

N

Y

R

M

G

G

T
|
T

I
|
I

G
|
G

S
x
N

L

A

A

A

H

N

A

G

D

D

P

P

A

G

A

N

D

D

W

M

V

P

N

A

V

L

L

M

T

Q

A

C

L

L

G

G

A

A

D

A

V

Y

V

E

I

L

V

T

G

G

Q

P

G

E

G

G

R

A

R

R

S

I

V

V

P

A

M

A

T

R

D

D

F

Y

I

Y

L

Q

G

G

V

A

F

Y

E

F

T

T

A

A

L

I

Q

E

P

P

G

G

E

E

I

L

V

L

A

T

E

A

I

I

H

R

V

I

P

P

A

V

L

P

S

P

E

T

R

G

A

H

R

G

W

Y

G

A

Y

Y

Y

E

K

K

V

L

C

K

R

R

K

K

T

I

G

G

E

D

F

Y

S

A

H

T

A

A

T

A

G

A

A

A

V

V

L

V

I

L

D

T

P

M

A

S

R

G

G

G

V

-

Q

-

R

K

C

C

V

V

A

T

G

A

A

S

-

I

-

G

-

L

-

T

-

N

T

V

S

A

G

N

K

T

P

P

V

L

-

W

-

A

-

E

-

A

-

G

-

K

V

V

I

L

D

V

G

G

P

T

A

A

L

L

F

D

T

K

D

P

G

A

C

L

T

D

E

K

A

A

A

V

L

A

A

L

A

A

H

E

L

A

A

I

G

T

S

A

P

P

A

A

A

S

D

D

-

G

-

R

D

G

P

P

I

A

A

E

L

Y

R

R

T

T

H

K

T

M

-

A

-

G

V

V

A

M

L

L

K

R

R

R

A

A

I

V

AGGHS 32:36 (≠ AGSQS 32:36) binding
TIGGN 111:115 (≠ TIGGS 111:115) binding

1n5wC Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
33% identity, 96% coverage: 6:265/270 of query aligns to 6:279/287 of 1n5wC

query
sites
1n5wC

F

F

D

D

Y

Y

A

H

Q

R

P

P

A

K

T

S

L

I

D

A

A

D

A

A

L

V

E

A

L

L

S

T

R

K

E

L

D

G

V

E

M

D

V

A

R

R

P

P

V

L

A

A

G

G

S

G

Q
x
H

S

S

L

L

G

I

P

P

M

I

L

M

N

K

L

T

R

R

L

L

A

A

Q

T

P

P

E

E

L

H

L

L

V

V

D

D

I

L

T

R

R

D

I

I

A

G

E

D

L

L

R

V

T

G

I

I

R

R

R

E

E

E

G

G

D

T

R

D

L

V

V

V

I

I

G

G

A

A

C

M

V

T

T

T

H

Q

A

H

R

A

L

L

E

I

D

G

G

S

D

D

Y

F

P

L

D

A

V

A

T

K

R

L

G

P

V

I

L

I

P

R

S

E

V

T

A

S

A

L

V

L

I
|
I

A
|
A

Y

D

R

P

A

Q

V

I

R

R

N

Y

R

M

G

G

T

T

I

I

G

G

S
x
N

L

A

A

A

H

N

A

G

D

D

P

P

A

G

A
x
N

D
|
D

W

M

V

P

N

A

V

L

L

M

T

Q

A

C

L

L

G

G

A

A

D

A

V

Y

V

E

I

L

V

T

G

G

Q

P

G

E

G

G

R

A

R

R

S

I

V

V

P

A

M

A

T

R

D

D

F

Y

I

Y

L

Q

G

G

V

A

F

Y

E

F

T

T

A

A

L

I

Q

E

P

P

G

G

E

E

I

L

V

L

A

T

E

A

I

I

H

R

V

I

P

P

A

V

L

P

S

P

E

T

R

G

A

H

R

G

W

Y

G

A

Y

Y

Y

E

K

K

V

L

C

K

R

R

K

K

T

I

G

G

E

D

F
x
Y

S

A

H

T

A

A

T

A

G

A

A

A

V

V

L

V

I

L

D

T

P

M

A

S

R

G

G

G

V

-

Q

-

R

K

C

C

V

V

A

T

G

A

A

S

-

I

-

G

-

L

-

T

-

N

T

V

S

A

G

N

K

T

P

P

V

L

-

W

-

A

-

E

-

A

-

G

-

K

V

V

I

L

D

V

G

G

P

T

A

A

L

L

F

D

T

K

D

P

G

A

C

L

T

D

E

K

A

A

A

V

L

A

A

L

A

A

H

E

L

A

A

I

G

T

S

A

P

P

A

A

A

S

D

D

-

G

-

R

D

G

P

P

I

A

A

E

L

Y

R

R

T

T

H

K

T

M

-

A

-

G

V

V

A

M

L

L

K

R

R

R

A

A

I

V

binding flavin-adenine dinucleotide: H35 (≠ Q35), I101 (= I101), A102 (= A102), N115 (≠ S115), N123 (≠ A123), D124 (= D124), Y193 (≠ F193)

Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
32% identity, 69% coverage: 5:189/270 of query aligns to 3:191/296 of Q0QLF4

query
sites
Q0QLF4

D

D

F

F

D

E

Y

F

A

F

Q

A

P

P

A

K

T

T

L

L

D

E

A

E

A

A

L

K

E

G

L

L

S

H

R

Q

-

Y

E

K

D

D

V

V

M

P

V

P

R

A

P
x
I

V
x
I

A
|
A

G
|
G

S
x
G

Q
x
T

S
x
D

L
|
L

G

V

P

I

M

E

L

I

N

N

L

D

R

R

L

W

A

E

Q

K

P

P

E

D

L

V

V

I

D

D

I

I

T

K

R

K

I

L

A

K

E

E

L

L

R

E

T

Y

I

I

R

R

R

V

E

E

G

E

D

N

R

T

L

I

V

H

I

I

G

G

A

A

C

L

V

S

T

T

H

F

A

T

R

Q

L

I

E

E

D

N

G

H

D

P

Y

F

P

I

D

R

V

S

T

H

R

V

G

R

V

A

L

L

P

Y

S

K

V

A

A

A

A

S

V

Q

I

V

A
x
G

Y

S

R

P

A

Q

V

I

R

R

N

N

R

L

G

G

T
|
T

I
|
I

G
|
G

S
x
N

L

L

A

S

H

T

A

S

D

S

P

V

A

A

A

G

D
|
D

W

G

V

V

N

S

V

A

L

M

T

T

A

T

L

L

G

D

A

A

D

T

V

V

I

L

V

E

G

S

Q

V

G

R

G

G

R

T

R

R

S

Q

V

M

P

K

M

L

T

T

D

D

F

F

I

F

L

D

G

G

V

E

-

G

F

F

E

K

-

R

-
x
R

T

N

A

A

L

L

Q

E

P

A

G

D

E

E

I

I

V
x
M

A

T

E

E

I

V

H

I

V

I

P

D

A

R

L

P

S

D

E

A

R

H

A

S

R

A

W

S

G

A

Y

F

Y

Y

K
|
K

V

L

C

A

R

K

K

R

29:36 (vs. 30:37, 38% identical) binding
G101 (≠ A102) binding
TIGGN 110:114 (≠ TIGGS 111:115) binding
D123 (= D124) binding
R160 (vs. gap) binding
M169 (≠ V167) binding
K187 (= K185) binding

3hrdG Crystal structure of nicotinate dehydrogenase (see paper)
32% identity, 69% coverage: 5:189/270 of query aligns to 3:191/292 of 3hrdG

query
sites
3hrdG

D

D

F

F

D

E

Y

F

A

F

Q

A

P

P

A

K

T

T

L

L

D

E

A

E

A

A

L

K

E

G

L

L

S

H

R

Q

-

Y

E

K

D

D

V

V

M

P

V

P

R

A

P
x
I

V

I

A
|
A

G
|
G

S
x
G

Q
x
T

S
x
D

L

L

G

V

P

I

M

E

L

I

N

N

L

D

R

R

L

W

A

E

Q

K

P

P

E

D

L

V

V

I

D

D

I

I

T

K

R

K

I

L

A

K

E

E

L

L

R

E

T

Y

I

I

R

R

R

V

E

E

G

E

D

N

R

T

L

I

V

H

I

I

G

G

A

A

C

L

V

S

T

T

H
x
F

A

T

R

Q

L

I

E

E

D

N

G

H

D

P

Y

F

P

I

D

R

V

S

T

H

R

V

G

R

V

A

L

L

P

Y

S

K

V

A

A

A

A

S

V

Q

I
x
V

A
x
G

Y

S

R

P

A

Q

V
x
I

R

R

N

N

R

L

G

G

T
|
T

I

I

G

G

G
|
G

S
x
N

L

L

A
x
S

H
x
T

A

S

D

S

P

V

A

A

A
x
G

D
|
D

W

G

V

V

N

S

V

A

L

M

T

T

A

T

L

L

G

D

A

A

D

T

V

V

I

L

V

E

G

S

Q

V

G

R

G

G

R

T

R

R

S

Q

V

M

P

K

M

L

T

T

D

D

F

F

I

F

L

D

G

G

V

E

-

G

F

F

E

K

-

R

T

N

A

A

L

L

Q

E

P

A

G

D

E

E

I
|
I

V
x
M

A

T

E

E

I

V

H

I

V

I

P

D

A

R

L

P

S

D

E

A

R

H

A

S

R

A

W

S

G

A

Y

F

Y

Y

K

K

V

L

C

A

R

K

K

R

binding flavin-adenine dinucleotide: I29 (≠ P30), A31 (= A32), G32 (= G33), G33 (≠ S34), T34 (≠ Q35), D35 (≠ S36), F77 (≠ H78), V100 (≠ I101), G101 (≠ A102), I105 (≠ V106), T110 (= T111), G113 (= G114), N114 (≠ S115), S116 (≠ A117), T117 (≠ H118), G122 (≠ A123), D123 (= D124), I168 (= I166), M169 (≠ V167)

2e3tA Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l) (see paper)
26% identity, 73% coverage: 8:205/270 of query aligns to 208:417/1291 of 2e3tA

query
sites
2e3tA

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

M

D

E

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R
x
K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

L

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

V

R

H

E

G

G

P

D

E

R

G

L

I

V

S

I

F

G

G

A

A

C

S

V

C

T

P

H

L

A

S

R

L

L

V

E

E

D

S

-

V

-

L

-

A

-

E

-

I

G

A

D

K

Y

L

P

P

D

E

-

Q

-

K

-

T

-

E

V

V

T

F

R

R

G

G

V

V

L

M

P

E

S

Q

V

L

A

R

A

A

V

-

I
x
L

A

A

Y

G

R

K

A

Q

V

V

R

K

N

S

R

V

G
x
A

T
x
S

I

I

G

G

G
|
G

S
x
N

L

I

A
x
I

H
x
T

A

A

D

S

P

P

A

I

A
x
S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

A

D

K

V

L

V

T

I

L

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

R

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

G

V

Y

F

R

E

K

T

T

A

L

L

L

Q

R

P

P

G

E

E

E

I
|
I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

K

E

E

R

G

A

E

R

F

W

F

G

S

Y

A

Y

F

K

K

-

Q

V

A

C

S

R

R

K

R

T

E

G

D

E

D

F

I

S

A

H

K

A

V

T

T

G

S

A

G

-

M

-

R

V

V

L

L

I

F

D

K

P

P

A

G

binding flavin-adenine dinucleotide: K228 (≠ R29), L229 (≠ P30), V230 (= V31), V231 (≠ A32), G232 (= G33), N233 (≠ S34), T234 (≠ Q35), E235 (≠ S36), I236 (≠ L37), L309 (≠ I101), A318 (≠ G110), S319 (≠ T111), G322 (= G114), N323 (≠ S115), I325 (≠ A117), T326 (≠ H118), S331 (≠ A123), D332 (= D124), I375 (= I166), L376 (≠ V167)

Sites not aligning to the query:

active site: 740, 775, 853, 857, 885, 1233, 1234
binding bicarbonate ion: 812, 813, 850, 882, 883, 887, 888, 891
binding calcium ion: 713, 714, 716, 809, 810, 840, 843, 844, 847, 880, 881
binding flavin-adenine dinucleotide: 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 109, 110, 113, 145, 147, 717
binding uric acid: 775, 853, 887, 982, 983, 1051, 1052, 1234

1jroA Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
30% identity, 50% coverage: 54:189/270 of query aligns to 213:344/450 of 1jroA

query
sites
1jroA

I

L

T

S

R

H

I

C

A

K

E

D

L

L

R

A

T

Q

I

I

R

R

R

E

E

T

G

P

D

D

R

G

L

Y

V

G

I

I

G

G

A

A

C

G

V

V

T

T

H

I

A

A

R

A

L

L

E

R

D

A

G

-

D

-

Y

-

P

-

D

-

V

F

T

A

R

E

G

G

V

P

L

H

P

P

S

A

V

L

A

A

A

G

V

L

I

L

-

R

-
x
F

A
|
A

Y

S

R

E

A

Q

V

V

R

R

N

Q

R

V

G

A

T
|
T

I

I

G

G

G
|
G

S
x
N

L

I

A
|
A

H

N

A

G

D

S

P

P

A

I

A
x
G

D
|
D

W

G

V

P

N

P

V

A

L

L

T

I

A

A

L

M

G

G

A

A

D

S

V

L

V

T

I

L

V

R

G

R

Q

G

G

Q

G

E

R

R

S

R

V

M

P

P

M

L

T

E

D

D

F

F

I

F

L

L

G

E

V

Y

F

R

E

K

T

Q

A

D

L
x
R

Q

R

P

P

G

G

E

E

I

F

V
|
V

A

E

E

S

I

V

H

T

V

L

P

P

A

K

L

S

S

A

E

P

R

G

A

L

R

R

W

C

G

-

Y

-

Y

Y

K

K

V

L

C

S

R

K

K

R

binding flavin-adenine dinucleotide: F258 (vs. gap), A259 (= A102), T268 (= T111), G271 (= G114), N272 (≠ S115), A274 (= A117), G280 (≠ A123), D281 (= D124), R318 (≠ L161), V324 (= V167)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 42, 43, 189, 191, 192, 193, 194, 195, 196
binding fe2/s2 (inorganic) cluster: 37, 38, 39, 40, 42, 44, 45, 47, 63, 103, 106, 134, 136

2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde (see paper)
30% identity, 50% coverage: 54:189/270 of query aligns to 213:344/450 of 2w54A

query
sites
2w54A

I
x
L

T

S

R

H

I

C

A

K

E

D

L

L

R

A

T

Q

I

I

R

R

R

E

E

T

G

P

D

D

R

G

L

Y

V

G

I

I

G

G

A

A

C

G

V

V

T

T

H

I

A

A

R

A

L

L

E

R

D

A

G

-

D

-

Y

-

P

-

D

-

V

F

T

A

R

E

G

G

V

P

L

H

P

P

S

A

V

L

A

A

A

G

V

L

I

L

-

R

-
x
F

A
|
A

Y

S

R

E

A

Q

V

V

R

R

N

Q

R

V

G
x
A

T
|
T

I

I

G

G

G
|
G

S
x
N

L

I

A
|
A

H
x
N

A

G

D

S

P

P

A

I

A
x
G

D
|
D

W

G

V

P

N

P

V

A

L

L

T

I

A

A

L

M

G

G

A

A

D

S

V

L

V

T

I

L

V

R

G

R

Q

G

G

Q

G

E

R

R

S

R

V

M

P

P

M

L

T

E

D

D

F

F

I

F

L

L

G

E

V

Y

F

R

E

K

T

Q

A

D

L
x
R

Q

R

P

P

G

G

E

E

I

F

V
|
V

A

E

E

S

I

V

H

T

V

L

P

P

A

K

L

S

S

A

E

P

R

G

A

L

R

R

W

-

G

-

Y

C

Y

Y

K

K

V

L

C

S

R

K

K

R

binding flavin-adenine dinucleotide: L213 (≠ I54), F258 (vs. gap), A259 (= A102), A267 (≠ G110), T268 (= T111), G271 (= G114), N272 (≠ S115), A274 (= A117), N275 (≠ H118), G280 (≠ A123), D281 (= D124), R318 (≠ L161), V324 (= V167)

Sites not aligning to the query:

P47989 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Homo sapiens (Human) (see 4 papers)
25% identity, 73% coverage: 8:205/270 of query aligns to 236:445/1333 of P47989

query
sites
P47989

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

L

D

K

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R

K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

M

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

E

R

H

E

G

G

P

D

D

R

G

L

I

V

S

I

F

G

G

A

A

C

A

V

C

T

P

H

L

A

S

R

I

L

V

E

E

D

K

-

T

-

L

-

V

-

D

-

A

-

V

-

A

-

K

-

L

-

P

G

A

D

Q

Y

K

P

T

D

E

V

V

T

F

R

R

G

G

V

V

L

L

P

E

S

Q

V

L

A

R

A

W

V

-

I
x
F

A

A

Y

G

R

K

A

Q

V

V

R

K

N

S

R

V

G

A

T
x
S

I
x
V

G
|
G

S
x
N

L

I

A

I

H

T

A

A

D

S

P

P

A

I

A

S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

A

D

K

V

L

V

T

I

L

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

Q

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

G

V

Y

F

R

E
x
K

T

T

A

L

L

L

Q

S

P

P

G

E

E

E

I

I

V

L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

R

E

E

R

G

A

E

R

Y

W

F

G

S

Y

A

Y

F

K
|
K

-

Q

V

A

C

S

R

R

K

R

T

E

G

D

E

D

F

I

S

A

H

K

A

V

T

T

G

S

A

G

-

M

-

R

V

V

L

L

I

F

D

K

P

P

A

G

257:264 (vs. 30:37, 25% identical) binding
F337 (≠ I101) binding
SVGGN 347:351 (≠ TIGGS 111:115) binding
D360 (= D124) binding
K395 (≠ E158) to M: in dbSNP:rs34929837
K422 (= K185) binding

Sites not aligning to the query:

133 E → K: in dbSNP:rs45447191
172 G → R: in dbSNP:rs45523133
235 T → M: in dbSNP:rs45469499
509 modified: Disulfide link with 1318, In oxidase form
536 modified: Disulfide link with 993, In oxidase form
555 P → S: in dbSNP:rs45577338
584 D → A: in dbSNP:rs45491693
607 R → Q: in dbSNP:rs45442092
617 K → N: in dbSNP:rs45442398
623 T → I: in dbSNP:rs45448694
646 I → V: in dbSNP:rs17323225
703 I → V: in dbSNP:rs17011368
763 L → F: in a breast cancer sample; somatic mutation
791 R → G: in a breast cancer sample; somatic mutation; dbSNP:rs775646772
910 T → M: in dbSNP:rs669884
993 modified: Disulfide link with 536, In oxidase form
1091 V → L: in dbSNP:rs45619033
1109 N → T: in dbSNP:rs45547640
1150 P → R: in dbSNP:rs1042036
1176 R → C: in dbSNP:rs45624433
1296 R → W: in dbSNP:rs45564939
1318 modified: Disulfide link with 509, In oxidase form

2e1qA Crystal structure of human xanthine oxidoreductase mutant, glu803val (see paper)
25% identity, 73% coverage: 8:205/270 of query aligns to 210:419/1307 of 2e1qA

query
sites
2e1qA

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

L

D

K

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R
x
K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

M

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

E

R

H

E

G

G

P

D

D

R

G

L

I

V

S

I

F

G

G

A

A

C

A

V

C

T

P

H

L

A

S

R

I

L

V

E

E

D

K

-

T

-

L

-

V

-

D

-

A

-

V

-

A

-

K

-

L

-

P

G

A

D

Q

Y

K

P

T

D

E

V

V

T

F

R

R

G

G

V

V

L

L

P

E

S

Q

V

L

A

R

A

W

V

-

I
x
F

A
|
A

Y

G

R

K

A

Q

V
|
V

R

K

N

S

R

V

G
x
A

T
x
S

I

V

G

G

G
|
G

S
x
N

L

I

A
x
I

H
x
T

A

A

D

S

P

P

A

I

A
x
S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

A

D

K

V

L

V

T

I

L

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

Q

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

G

V

Y

F

R

E

K

T

T

A

L

L

L

Q

S

P

P

G

E

E

E

I
|
I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

R

E

E

R

G

A

E

R

Y

W

F

G

S

Y

A

Y

F

K

K

-

Q

V

A

C

S

R

R

K

R

T

E

G

D

E

D

F

I

S

A

H

K

A

V

T

T

G

S

A

G

-

M

-

R

V

V

L

L

I

F

D

K

P

P

A

G

binding flavin-adenine dinucleotide: K230 (≠ R29), L231 (≠ P30), V232 (= V31), V233 (≠ A32), G234 (= G33), N235 (≠ S34), T236 (≠ Q35), E237 (≠ S36), I238 (≠ L37), F311 (≠ I101), A312 (= A102), V316 (= V106), A320 (≠ G110), S321 (≠ T111), G324 (= G114), N325 (≠ S115), I327 (≠ A117), T328 (≠ H118), S333 (≠ A123), D334 (= D124), I377 (= I166), L378 (≠ V167)

Sites not aligning to the query:

active site: 742, 777, 855, 859, 887, 1235, 1236
binding bicarbonate ion: 814, 815, 852, 886, 889, 890, 893
binding calcium ion: 715, 716, 718, 741, 747, 780, 781, 784, 811, 812
binding flavin-adenine dinucleotide: 43, 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 71, 110, 111, 112, 114, 146, 148, 719
binding hydroxy(dioxo)molybdenum: 773, 774, 887, 1053, 1054, 1236

2ckjA Human milk xanthine oxidoreductase
25% identity, 73% coverage: 8:205/270 of query aligns to 207:412/1264 of 2ckjA

query
sites
2ckjA

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

L

D

K

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R

K

P
x
L

V

V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L

I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

M

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

E

R

H

E

G

G

P

D

D

R

G

L

I

V

S

I

F

G

G

A

A

C

A

V

C

T

P

H

L

A

S

R

I

L

V

E

E

D

K

-

T

-

L

-

V

-

D

-

A

-

V

-

A

-

K

-

L

-

P

G

A

D

Q

Y

K

P

T

D

E

V

V

T

F

R

R

G

G

V

V

L

L

P

E

S

Q

V

L

A

R

A

W

V

-

I
x
F

A
|
A

Y

G

R

K

A

Q

V

V

R

K

N

S

R

V

G
x
A

T
x
S

I

V

G

G

G
|
G

S
x
N

L

I

A
x
I

H
x
T

A

A

D

S

P

P

A

I

A

S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

A

D

K

V

L

V

T

I

L

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

Q

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

G

V

Y

F

R

E

K

T

T

A

L

L

L

Q

S

P

P

G

E

E

E

I

I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

R

E

E

R

G

A

E

R

-

W

-

G

-

Y

Y

Y

F

K

S

V

A

C

F

R

K

K

Q

T

A

G

S

E

D

F

I

S

A

H

K

A

V

T

T

G

S

A

G

-

M

-

R

V

V

L

L

I

F

D

K

P

P

A

G

binding flavin-adenine dinucleotide: L228 (≠ P30), V230 (≠ A32), G231 (= G33), N232 (≠ S34), T233 (≠ Q35), E234 (≠ S36), F308 (≠ I101), A309 (= A102), A317 (≠ G110), S318 (≠ T111), G321 (= G114), N322 (≠ S115), I324 (≠ A117), T325 (≠ H118), D331 (= D124), L375 (≠ V167)

Sites not aligning to the query:

active site: 711, 746, 824, 828, 856, 1204, 1205
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 71, 111, 112, 114, 146, 147, 148

6a7xA Rat xanthine oxidoreductase, d428a variant, NAD bound form
25% identity, 73% coverage: 8:205/270 of query aligns to 208:417/1295 of 6a7xA

query
sites
6a7xA

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

M

D

E

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R
x
K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

L

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

V

R

H

E

G

G

P

D

E

R

G

L

I

V

S

I

F

G

G

A

A

C

S

V

C

T

P

H

L

A

S

R

L

L

V

E

E

D

S

-

V

-

L

-

A

-

E

-

I

G

A

D

K

Y

L

P

P

D

E

-

Q

-

K

-

T

-

E

V

V

T

F

R

R

G

G

V

V

L

M

P

E

S

Q

V

L

A

R

A

W

V

-

I
x
F

A

A

Y

G

R

K

A

Q

V
|
V

R

K

N

S

R

V

G

A

T
x
S

I

I

G

G

G
|
G

S
x
N

L

I

A
x
I

H
x
T

A

A

D

S

P
|
P

A

I

A

S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

A

D

K

V

L

V

T

I

L

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

R

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

G

V
x
Y

F
x
R

E

K

T

T

A

L

L

L

Q

R

P

P

G

E

E

E

I

I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

K

E

E

R

G

A

E

R

F

W

F

G

S

Y

A

Y

F

K

K

-

Q

V

A

C

S

R

R

K

R

T

E

G

A

E

D

F

I

S

A

H

K

A

V

T

T

G

S

A

G

-

M

-

R

V

V

L

L

I

F

D

K

P

P

A

G

binding flavin-adenine dinucleotide: K228 (≠ R29), L229 (≠ P30), V230 (= V31), V231 (≠ A32), G232 (= G33), N233 (≠ S34), T234 (≠ Q35), E235 (≠ S36), I236 (≠ L37), F309 (≠ I101), V314 (= V106), S319 (≠ T111), G322 (= G114), N323 (≠ S115), I325 (≠ A117), T326 (≠ H118), D332 (= D124), L376 (≠ V167)
binding nicotinamide-adenine-dinucleotide: P329 (= P121), Y365 (≠ V156), R366 (≠ F157)

Sites not aligning to the query:

active site: 740, 775, 853, 857, 885, 1233, 1234
binding bicarbonate ion: 812, 813, 850, 883, 884, 887, 888, 891
binding flavin-adenine dinucleotide: 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 109, 110, 111, 113, 145, 147
binding nicotinamide-adenine-dinucleotide: 432, 433, 473, 480
binding uric acid: 775, 853, 887, 982, 983, 1052, 1234

6a7xB Rat xanthine oxidoreductase, d428a variant, NAD bound form
25% identity, 73% coverage: 8:205/270 of query aligns to 206:415/1291 of 6a7xB

query
sites
6a7xB

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

M

D

E

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R

K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

L

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

V

R

H

E

G

G

P

D

E

R

G

L

I

V

S

I

F

G

G

A

A

C

S

V

C

T

P

H

L

A

S

R

L

L

V

E

E

D

S

-

V

-

L

-

A

-

E

-

I

G

A

D

K

Y

L

P

P

D

E

-

Q

-

K

-

T

-

E

V

V

T

F

R

R

G

G

V

V

L

M

P

E

S

Q

V

L

A

R

A

W

V

-

I
x
F

A

A

Y

G

R

K

A

Q

V
|
V

R

K

N

S

R

V

G

A

T
x
S

I

I

G

G

G
|
G

S
x
N

L

I

A
x
I

H
x
T

A

A

D

S

P
|
P

A

I

A

S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

A

D

K

V

L

V

T

I

L

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

R

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

G

V
x
Y

F
x
R

E

K

T

T

A

L

L

L

Q

R

P

P

G

E

E

E

I
|
I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

K

E

E

R

G

A

E

R

F

W

F

G

S

Y

A

Y

F

K

K

-

Q

V

A

C

S

R

R

K

R

T

E

G

A

E

D

F

I

S

A

H

K

A

V

T

T

G

S

A

G

-

M

-

R

V

V

L

L

I

F

D

K

P

P

A

G

binding flavin-adenine dinucleotide: L227 (≠ P30), V228 (= V31), V229 (≠ A32), G230 (= G33), N231 (≠ S34), T232 (≠ Q35), E233 (≠ S36), I234 (≠ L37), F307 (≠ I101), V312 (= V106), S317 (≠ T111), G320 (= G114), N321 (≠ S115), I323 (≠ A117), T324 (≠ H118), D330 (= D124), I373 (= I166), L374 (≠ V167)
binding nicotinamide-adenine-dinucleotide: P327 (= P121), Y363 (≠ V156), R364 (≠ F157)

Sites not aligning to the query:

active site: 738, 773, 851, 855, 883, 1231, 1232
binding bicarbonate ion: 810, 811, 880, 881, 885, 886, 889
binding flavin-adenine dinucleotide: 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 109, 110, 111, 113, 145, 147, 715
binding nicotinamide-adenine-dinucleotide: 428, 430, 431, 471, 478
binding uric acid: 773, 851, 885, 980, 981, 1049, 1050, 1232

P22985 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 73% coverage: 8:205/270 of query aligns to 235:444/1331 of P22985

query
sites
P22985

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

M

D

E

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R

K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

L

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

V

R

H

E

G

G

P

D

E

R

G

L

I

V

S

I

F

G

G

A

A

C

S

V

C

T

P

H

L

A

S

R

L

L

V

E

E

D

S

-

V

-

L

-

A

-

E

-

I

G

A

D

K

Y

L

P

P

D

E

-

Q

-

K

-

T

-

E

V

V

T

F

R

R

G

G

V

V

L

M

P

E

S

Q

V

L

A

R

A
x
W

V

-

I
x
F

A

A

Y

G

R

K

A

Q

V

V

R

K

N

S

R

V

G

A

T
x
S

I
|
I

G
|
G

S
x
N

L

I

A

I

H

T

A

A

D

S

P

P

A

I

A

S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

A

D

K

V

L

V

T

I

L

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

R

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

G

V

Y

F

R

E

K

T

T

A

L

L

L

Q

R

P

P

G

E

E

E

I

I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

K

E

E

R

G

A

E

R

F

W

F

G

S

Y

A

Y

F

K

K

-

Q

V

A

C

S

R

R

K

R

T

E

G

D

E

D

F

I

S

A

H

K

A

V

T

T

G

S

A

G

-

M

-

R

V

V

L

L

I

F

D

K

P

P

A

G

256:263 (vs. 30:37, 25% identical) binding
W-F 335:336 (≠ AVI 99:101) mutation to AL: Converts the enzyme to the oxidase form that utilizes molecular oxygen as electron acceptor. Interferes with normal conversion to the dehydrogenase form by reducing agents.
SIGGN 346:350 (≠ TIGGS 111:115) binding
D359 (= D124) binding
L403 (≠ V167) binding

Sites not aligning to the query:

43 binding
48 binding
51 binding
73 binding
112 binding
115 binding
147 binding
149 binding
535 C→A: Slows the conversion from the dehydrogenase form to the oxidase form; when associated with R-992. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with R-992 and S-1316.
992 C→R: Slows the conversion from the dehydrogenase form to the oxidase form; when associated with A-535. Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and S-1316.
1316 C→S: Abolishes conversion from the dehydrogenase form to the oxidase form; when associated with A-535 and R-992.

P80457 Xanthine dehydrogenase/oxidase; EC 1.17.1.4; EC 1.17.3.2 from Bos taurus (Bovine) (see 5 papers)
25% identity, 66% coverage: 8:185/270 of query aligns to 236:422/1332 of P80457

query
sites
P80457

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

L

D

K

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

E

V

A

R

K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

Q

Q

L

P

F

E

P

L

M

L

I

V

I

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

A

I

V

R

E

R

H

E

G

G

P

D

E

R

G

L

I

V

S

I

F

G

G

A

A

C

A

V

C

T

A

H

L

A

S

R

S

L

V

E

E

D

K

-

T

-

L

-

E

-

A

-

V

G

A

D

K

Y

L

P

P

-

T

-

Q

-

K

-

T

D

E

V

V

T

F

R

R

G

G

V

V

L

L

P

E

S

Q

V

L

A
x
R

A
x
W

V

-

I
x
F

A

A

Y

G

R

K

A

Q

V

V

R

K

N

S

R

V

G

A

T
x
S

I
x
L

G
|
G

S
x
N

L

I

A

I

H

T

A

A

D

S

P

P

A

I

A

S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

T

D

K

V

L

V

T

I

I

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

P

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

S

V

Y

F

R

E

K

T

T

A

L

L

L

Q

G

P

P

G

E

E

E

I

I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

R

E

E

R

D

A

E

R

F

W

F

G

S

Y

A

Y

F

K
|
K

257:264 (vs. 30:37, 25% identical) binding
R335 (≠ A98) mutation to A: Promotes conversion to the oxidase form that utilizes molecular oxygen as electron acceptor. Interferes with normal conversion to the dehydrogenase form by reducing agents.
W336 (≠ A99) mutation to A: Promotes conversion to the oxidase form that utilizes molecular oxygen as electron acceptor. Interferes with normal conversion to the dehydrogenase form by reducing agents.
F337 (≠ I101) binding
SLGGN 347:351 (≠ TIGGS 111:115) binding
D360 (= D124) binding
L404 (≠ V167) binding
K422 (= K185) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
43 binding
48 binding
51 binding
73 binding
113 binding
116 binding
148 binding
150 binding
427 R→Q: Promotes conversion to the oxidase form that utilizes molecular oxygen as electron acceptor. Interferes with normal conversion to the dehydrogenase form by reducing agents.
767 binding
798 binding
912 binding
1079 binding
1261 active site, Proton acceptor

1n5xA Xanthine dehydrogenase from bovine milk with inhibitor tei-6720 bound (see paper)
25% identity, 66% coverage: 8:185/270 of query aligns to 208:394/1290 of 1n5xA

query
sites
1n5xA

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

L

D

K

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

E

V

A

R

K

P
x
L

V

V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

Q

Q

L

P

F

E

P

L

M

L

I

V

I

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

A

I

V

R

E

R

H

E

G

G

P

D

E

R

G

L

I

V

S

I

F

G

G

A

A

C

A

V

C

T

A

H

L

A

S

R

S

L

V

E

E

D

K

-

T

-

L

-

E

-

A

-

V

G

A

D

K

Y

L

P

P

-

T

-

Q

-

K

-

T

D

E

V

V

T

F

R

R

G

G

V

V

L

L

P

E

S

Q

V

L

A

R

A

W

V

-

I
x
F

A
|
A

Y

G

R

K

A

Q

V

V

R

K

N

S

R

V

G
x
A

T
x
S

I

L

G

G

G
|
G

S
x
N

L

I

A
x
I

H
x
T

A

A

D

S

P

P

A

I

A

S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

L

S

G

G

A

T

D

K

V

L

V

T

I

I

V

V

G

S

Q

R

G

G

G

T

R

R

S

T

V

V

P

P

M

M

T

D

-

H

D

T

F

F

I

F

L

P

G

S

V

Y

F

R

E

K

T

T

A

L

L

L

Q

G

P

P

G

E

E

E

I

I

V
x
L

A

L

E

S

I

I

H

E

V

I

P

P

A

Y

L

S

S

R

E

E

R

D

A

E

R

F

W

F

G

S

Y

A

Y

F

K

K

binding flavin-adenine dinucleotide: L229 (≠ P30), V231 (≠ A32), G232 (= G33), N233 (≠ S34), T234 (≠ Q35), E235 (≠ S36), I236 (≠ L37), F309 (≠ I101), A310 (= A102), A318 (≠ G110), S319 (≠ T111), G322 (= G114), N323 (≠ S115), I325 (≠ A117), T326 (≠ H118), D332 (= D124), L376 (≠ V167)

Sites not aligning to the query:

active site: 734, 769, 847, 851, 879, 1227, 1228
binding flavin-adenine dinucleotide: 43, 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 71, 110, 111, 112, 114, 146, 148, 711
binding 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-5-thiazole-carboxylic acid: 615, 738, 769, 840, 847, 881, 976, 977, 978, 981

4yswA Structure of rat xanthine oxidoreductase, c-terminal deletion protein variant, nadh bound form (see paper)
25% identity, 73% coverage: 8:205/270 of query aligns to 206:415/1286 of 4yswA

query
sites
4yswA

Y

W

A

I

Q

Q

P

A

A

S

T

T

L

M

D

E

A

E

A

L

L

L

E

D

L

L

L

K

S

A

R

Q

E

H

D

P

V

-

M

D

V

A

R
x
K

P
x
L

V
|
V

A
x
V

G
|
G

S
x
N

Q
x
T

S
x
E

L
x
I

G

G

P

I

M

E

L

M

N

K

L

F

R

K

L

N

A

M

Q

L

P

F

E

P

L

L

L

I

V

V

D

C

I

P

T

A

R

W

I

I

A

P

E

E

L

L

R

N

T

S

I

V

R

V

R

H

E

G

G

P

D

E

R

G

L

I

V

S

I

F

G

G

A

A

C

S

V

C

T

P

H

L

A

S

R

L

L

V

E

E

D

S

-

V

-

L

-

A

-

E

-

I

G

A

D

K

Y

L

P

P

D

E

-

Q

-

K

-

T

-

E

V

V

T

F

R

R

G

G

V

V

L

M

P

E

S

Q

V

L

A

R

A

W

V

-

I
x
F

A
|
A

Y

G

R

K

A

Q

V
|
V

R

K

N

S

R

V

G
x
A

T
x
S

I

I

G

G

G
|
G

S
x
N

L

I

A
x
I

H
x
T

A

A

D
x
S

P
|
P

A
x
I

A
x
S

D
|
D

W

L

V

N

N

P

V

V

L

F

T

M

A

A

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binding flavin-adenine dinucleotide: K226 (≠ R29), L227 (≠ P30), V228 (= V31), V229 (≠ A32), G230 (= G33), N231 (≠ S34), T232 (≠ Q35), E233 (≠ S36), I234 (≠ L37), F307 (≠ I101), A308 (= A102), V312 (= V106), A316 (≠ G110), S317 (≠ T111), G320 (= G114), N321 (≠ S115), I323 (≠ A117), T324 (≠ H118), S329 (≠ A123), D330 (= D124), I373 (= I166), L374 (≠ V167), D399 (≠ G191)
binding 1,4-dihydronicotinamide adenine dinucleotide: E233 (≠ S36), S326 (≠ D120), P327 (= P121), I328 (≠ A122), Y363 (≠ V156), R364 (≠ F157), D400 (≠ E192), I401 (≠ F193)

Sites not aligning to the query:

active site: 738, 773, 851, 855, 883, 1231, 1232
binding bicarbonate ion: 810, 811, 848, 880, 881, 882, 885, 886, 889
binding calcium ion: 838, 841, 842, 845, 878, 879
binding flavin-adenine dinucleotide: 44
binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 71, 110, 111, 113, 145, 147, 715
binding 1,4-dihydronicotinamide adenine dinucleotide: 428, 430, 431, 471, 478, 1196
binding uric acid: 773, 851, 885, 980, 981, 1050, 1232

Query Sequence

>AZOBR_RS29695 FitnessBrowser__azobra:AZOBR_RS29695
MKAVDFDYAQPATLDAALELLSREDVMVRPVAGSQSLGPMLNLRLAQPELLVDITRIAEL
RTIRREGDRLVIGACVTHARLEDGDYPDVTRGVLPSVAAVIAYRAVRNRGTIGGSLAHAD
PAADWVNVLTALGADVVIVGQGGRRSVPMTDFILGVFETALQPGEIVAEIHVPALSERAR
WGYYKVCRKTGEFSHATGAVLIDPARGVQRCVAGATSGKPVVIDGPALFTDGCTEAALAA
HLAGSPAADDPIALRTHTVALKRAIAQVMS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory