SitesBLAST

P19921 Carbon monoxide dehydrogenase small chain; CO dehydrogenase subunit S; CO-DH S; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
48% identity, 89% coverage: 8:151/162 of query aligns to 6:150/166 of P19921

query
sites
P19921

I

I

S

E

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L

T

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I

N

N

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G

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N

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A

H

H

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I

G

G

C
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C

E

D

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C

G

G

A

A

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C

T

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I

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D

D

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E

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C
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C

I

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M

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F

A

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A

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N

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G

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A

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M

-

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D

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H

H

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C

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A

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A

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A

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G

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C
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C

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C

T

T

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G

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Y

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G

N

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K

A

A

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I

R

Q

C42 (= C44) binding
C47 (= C49) binding
C50 (= C52) binding
C62 (= C64) binding
C102 (= C103) binding
C105 (= C106) binding
C137 (= C138) binding
C139 (= C140) binding

1n5wA Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
48% identity, 89% coverage: 8:151/162 of query aligns to 4:148/161 of 1n5wA

query
sites
1n5wA

I

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H

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x
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G

C
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C

E

D

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x
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x
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C

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A

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C

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T

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C

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A

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N

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-

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P

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M

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A

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C

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G

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Y

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A

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Q

binding flavin-adenine dinucleotide: S43 (≠ G47), H44 (≠ V48)
binding fe2/s2 (inorganic) cluster: I38 (≠ L42), G39 (= G43), C40 (= C44), S43 (≠ G47), C45 (= C49), G46 (= G50), C48 (= C52), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C135 (= C138), C137 (= C140)

1n5wD Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
48% identity, 89% coverage: 8:151/162 of query aligns to 4:148/158 of 1n5wD

query
sites
1n5wD

I

I

S

E

L

L

T

T

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N

N

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G

T

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E

A

A

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H

L

L

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G

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L

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E

Q

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L

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A

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H

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C

E

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x
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x
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A

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C

T

T

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D

I

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D

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G

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C

I

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F

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A

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A

D

N

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G

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A

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E

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-

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H

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Q

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T

T

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P

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G

M

M

L

I

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M

A

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A

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T

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G

Y

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I

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A

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binding flavin-adenine dinucleotide: S43 (≠ G47), H44 (≠ V48)
binding fe2/s2 (inorganic) cluster: C40 (= C44), S43 (≠ G47), C45 (= C49), G46 (= G50), C48 (= C52), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C135 (= C138), C137 (= C140)
binding pterin cytosine dinucleotide: Q99 (= Q102), C137 (= C140)

4zohC Crystal structure of glyceraldehyde oxidoreductase (see paper)
46% identity, 89% coverage: 8:151/162 of query aligns to 12:154/161 of 4zohC

query
sites
4zohC

I

I

S

T

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L

T

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N

N

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G

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Y

E

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E

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L

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H

H

L

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C

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x
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T

T

I

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L

I

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N

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I

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L

A

A

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A

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D

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E

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A

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F

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W

A

E

E

N

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H

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Q

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P

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A

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W

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G

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binding fe2/s2 (inorganic) cluster: C47 (= C44), S50 (≠ G47), C52 (= C49), G53 (= G50), C55 (= C52), C67 (= C64), C106 (= C103), G107 (= G104), C109 (= C106), C141 (= C138), C143 (= C140)
binding pterin cytosine dinucleotide: Q105 (= Q102), C143 (= C140)

7dqxC Crystal structure of xanthine dehydrogenase family protein
44% identity, 97% coverage: 4:160/162 of query aligns to 2:159/160 of 7dqxC

query
sites
7dqxC

H

N

A

A

K

F

T

R

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T

L

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T

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N

N

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G

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C

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C

A

D

N

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N

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K

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C

H

H

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A

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L

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Q

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C

G

G

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C

T

T

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S

G

G

M

F

L

L

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M

A

T

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L

R

K

-

P

-

L

-

Y

-

D

-

E

D

D

V

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T

L

L

R

-

P

-

D

-

A

-

D

D

N

A

P

T

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S

I

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E

A

A

M

I

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S

G

G

N

N

L

L

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T

T

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G

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Y

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Q

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N

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A

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C

R

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H

N

N

binding fe2/s2 (inorganic) cluster: C42 (= C44), G45 (= G47), V46 (= V48), C47 (= C49), C50 (= C52), R60 (= R62), C62 (= C64), Q100 (= Q102), C101 (= C103), C104 (= C106), C137 (= C138), C139 (= C140)
binding pterin cytosine dinucleotide: Q100 (= Q102), C139 (= C140)

1sb3C Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
44% identity, 93% coverage: 8:157/162 of query aligns to 5:154/161 of 1sb3C

query
sites
1sb3C

I

L

S

R

L

L

T

T

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L

N

N

G

G

T

R

R

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E

E

A

D

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L

V

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P

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N

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H

L

L

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L

D

D

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Y

L

L

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E

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L

L

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G

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T

H

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L
x
Q

G

G

C
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C

E

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H

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G
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G

V

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C

G
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G

A

A

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C

T

T

I

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L

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D

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A

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L

D

A

D

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P

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E

A

A

A

F

F

S

H

A

E

E

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H

L

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G

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T

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Q

C
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C

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G

F

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C
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C

T

T

P

P

G

G

M

M

L

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V

M

A

A

A

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V

L

L

R

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R

N

P

P

D

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A

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D

S

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D

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E

I

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T

A

A

A

M

L

S

A

G

G

N

N

L

L

C
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C

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R

C
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C

T

T

G

G

Y

Y

V

V

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K

I

I

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I

N

K

A

S

I

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E

R

T

V

A

I

A

D

A

A

A

R

R

binding fe2/s2 (inorganic) cluster: Q39 (≠ L42), C41 (= C44), G44 (= G47), C46 (= C49), G47 (= G50), C49 (= C52), C61 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C135 (= C138), C137 (= C140)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C137 (= C140)

3hrdD Crystal structure of nicotinate dehydrogenase (see paper)
40% identity, 92% coverage: 7:155/162 of query aligns to 5:153/160 of 3hrdD

query
sites
3hrdD

T

T

I

I

S

N

L

L

T

N

V

L

N

N

G

G

T

E

R

A

V

R

E

S

A

I

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V

T

P

E

P

P

R

N

Q

K

H

R

L

L

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L

D

D

F

L

L

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E

E

R

D

E

F

L

G

L

L

T

T

G

S

T

V

H

K

L
x
E

G

G

C
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C

E
x
S

H
x
E

G
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G

V
x
E

C
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C

G
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G

A

A

C
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C

T

T

I

V

L

I

I

F

D

N

G

G

E

D

P

P

A

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T

C
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C

I

C

T

M

F

L

A

A

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A

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C

A

D

D

G

E

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S

S

T

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I

T

I

T

T

V

L

E

E

G

G

L

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D

A

D

E

D

D

P

G

V

K

A

P

T

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E

L

L

L

R

Q

E

Q

A

C

F

F

S

L

A

E

E

A

H

G

G

A

L

V

Q
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Q

C
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C

G
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G

F

Y

C
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C

T

T

P

P

G

G

M

M

L

I

V

L

A

T

A

A

R

K

D

A

V

L

L

D

R

K

R

N

P

P

D

D

A

P

D

T

N

D

P

E

A

E

I

I

R

T

T

V

A

A

M

M

S

S

G

G

N

N

L

L

C
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C

R

R

C
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C

T

T

G

G

Y

Y

V

I

G

K

I

I

V

H

N

A

A

A

I

V

R

R

R

Y

V

A

I

V

D

E

binding flavin-adenine dinucleotide: E44 (≠ H46), G45 (= G47), E46 (≠ V48)
binding fe2/s2 (inorganic) cluster: E40 (≠ L42), C42 (= C44), S43 (≠ E45), G45 (= G47), C47 (= C49), G48 (= G50), C50 (= C52), C62 (= C64), Q100 (= Q102), C101 (= C103), G102 (= G104), C104 (= C106), C136 (= C138), C138 (= C140)
binding pterin cytosine dinucleotide: Q100 (= Q102), C138 (= C140)

Q0QLF3 Nicotinate dehydrogenase small FeS subunit; NDH; Nicotinic acid hydroxylase small FeS subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
40% identity, 92% coverage: 7:155/162 of query aligns to 5:153/157 of Q0QLF3

query
sites
Q0QLF3

T

T

I

I

S

N

L

L

T

N

V

L

N

N

G

G

T

E

R

A

V

R

E

S

A

I

S

V

V

T

P

E

P

P

R

N

Q

K

H

R

L

L

G

L

D

D

F

L

L

L

R

R

E

E

R

D

E

F

L

G

L

L

T

T

G

S

T

V

H

K

L

E

G

G

C
|
C

E

S

H

E

G

G

V

E

C
|
C

G

G

A

A

C
|
C

T

T

I

V

L

I

I

F

D

N

G

G

E

D

P

P

A

V

R

T

S

T

C
|
C

I

C

T

M

F

L

A

A

V

G

A

Q

C

A

D

D

G

E

R

S

S

T

V

I

T

I

T

T

V

L

E

E

G

G

L

V

D

A

D

E

D

D

P

G

V

K

A

P

T

S

E

L

L

L

R

Q

E

Q

A

C

F

F

S

L

A

E

E

A

H

G

G

A

L

V

Q

Q

C
|
C

G

G

F

Y

C
|
C

T

T

P

P

G

G

M

M

L

I

V

L

A

T

A

A

R

K

D

A

V

L

L

D

R

K

R

N

P

P

D

D

A

P

D

T

N

D

P

E

A

E

I

I

R

T

T

V

A

A

M

M

S

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

V

I

G

K

I

I

V

H

N

A

A

A

I

V

R

R

R

Y

V

A

I

V

D

E

C42 (= C44) binding
C47 (= C49) binding
C50 (= C52) binding
C62 (= C64) binding
C101 (= C103) binding
C104 (= C106) binding
C136 (= C138) binding
C138 (= C140) binding

5y6qA Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
40% identity, 90% coverage: 7:152/162 of query aligns to 4:150/157 of 5y6qA

query
sites
5y6qA

T

S

I

L

S

T

L

M

T

Q

V

V

N

N

G

G

T

Q

R

P

V

Y

E

P

A

M

S

E

V

I

P

D

P

P

R

R

Q

V

H

T

L

L

G

L

D

D

F

A

L

L

R

R

E

E

R

H

E

L

L

N

L

L

T

T

G

G

T

T

H

K

L

K

G
|
G

C
|
C

E
x
D

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

L

I

V

D

N

G

G

E

Q

P

R

A

V

R

L

S

S

C
|
C

I

L

T

T

F

L

A

A

V

A

A

Q

C

A

D

D

G

G

R

A

S

E

V

V

T

T

T

S

V

I

E

E

G

G

L

L

D

Q

D

S

D

-

P

-

V

A

A

S

T

G

E

E

L

L

-

H

-

P

-

V

R

Q

E

R

A

C

F

F

S

V

A

E

E

N

H

D

G

A

L

F

Q
|
Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

P

G

G

M

Q

L

I

V

M

A

S

A

A

R

V

D

A

V

C

V

I

L

K

R

E

R

G

P

H

D

A

A

G

D

S

N

D

P

D

A

E

I

I

R

R

T

E

A

Y

M

M

S

S

G

G

N

N

L

L

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

V

P

G

H

I

I

V

I

N

D

A

A

I

I

R

K

R

Q

binding fe2/s2 (inorganic) cluster: G40 (= G43), C41 (= C44), D42 (≠ E45), G44 (= G47), C46 (= C49), G47 (= G50), C49 (= C52), C61 (= C64), C101 (= C103), G102 (= G104), C104 (= C106), C136 (= C138), C138 (= C140)
binding pterin cytosine dinucleotide: Q100 (= Q102), C138 (= C140)

P77165 Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
37% identity, 89% coverage: 8:151/162 of query aligns to 63:221/229 of P77165

query
sites
P77165

I

L

S

T

L

L

T

K

V

V

N

N

G

G

T

K

R

T

V

E

E

Q

A

L

S

E

V

V

P

D

P

T

R

R

Q

T

H

T

L

L

G

L

D

D

F

T

L

L

R

R

E

E

R

N

E

L

L

H

L

L

T

I

G

G

T

T

H

K

L

K

G

G

C
|
C

E

D

H

H

G

G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

L

I

V

D

N

G

G

E

R

P

R

A

L

R

N

S

A

C
|
C

I

L

T

T

F

L

A

A

V

V

A

M

C

H

D

Q

G

G

R

A

S

E

V

I

T

T

V

I

E

E

G

G

L

L

D

G

D

S

D

P

P

D

V

N

A

L

T

H

E

P

L

M

R

Q

E

A

A

A

F

F

S

I

A

K

E

H

H

D

G

G

L

F

Q

Q

C
|
C

G

G

F

Y

C
|
C

T

T

P

S

G

G

M

Q

L

I

V

C

A

S

R

V

D

A

V

V

-

L

-

K

-

E

-

I

-

Q

-

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

-

V

-

D

V

L

L

V

R

S

R

A

P

P

D

E

A

T

D

T

N

A

P

D

A

E

I

I

R

R

T

E

A

R

M

M

S

S

G

G

N

N

L

I

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

V

A

G

N

I

I

V

L

N

A

A

A

I

I

R

E

C99 (= C44) binding
C104 (= C49) binding
G105 (= G50) binding
C107 (= C52) binding
C119 (= C64) binding
C158 (= C103) binding
C161 (= C106) binding
C208 (= C138) binding
C210 (= C140) binding

5g5gA Escherichia coli periplasmic aldehyde oxidase (see paper)
37% identity, 89% coverage: 8:151/162 of query aligns to 12:170/175 of 5g5gA

query
sites
5g5gA

I

L

S

T

L

L

T

K

V

V

N

N

G

G

T

K

R

T

V

E

E

Q

A

L

S

E

V

V

P

D

P

T

R

R

Q

T

H

T

L

L

G

L

D

D

F

T

L

L

R

R

E

E

R

N

E

L

L

H

L

L

T

I

G

G

T

T

H

K

L

K

G
|
G

C
|
C

E
x
D

H

H

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

T

I

V

L

L

I

V

D

N

G

G

E

R

P

R

A

L

R

N

S

A

C
|
C

I

L

T

T

F

L

A

A

V

V

A

M

C

H

D

Q

G

G

R

A

S

E

V

I

T

T

V

I

E

E

G

G

L

L

D

G

D

S

D

P

P

D

V

N

A

L

T

H

E

P

L

M

R

Q

E

A

A

A

F

F

S

I

A

K

E

H

H

D

G

G

L

F

Q

Q

C
|
C

G
|
G

F

Y

C
|
C

T

T

P

S

G

G

M

Q

L

I

V

C

A

S

R

V

D

A

V

V

-

L

-

K

-

E

-

I

-

Q

-

D

-

G

-

I

-

P

-

S

-

H

-

V

-

T

-

V

-

D

V

L

L

V

R

S

R

A

P

P

D

E

A

T

D

T

N

A

P

D

A

E

I

I

R

R

T

E

A

R

M

M

S

S

G

G

N

N

L

I

C
|
C

R

R

C
|
C

T

G

G

A

Y

Y

V

A

G

N

I

I

V

L

N

A

A

A

I

I

R

E

binding fe2/s2 (inorganic) cluster: G47 (= G43), C48 (= C44), D49 (≠ E45), G51 (= G47), C53 (= C49), G54 (= G50), C56 (= C52), C68 (= C64), C107 (= C103), G108 (= G104), C110 (= C106), C157 (= C138), C159 (= C140)

4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
38% identity, 87% coverage: 10:150/162 of query aligns to 6:149/907 of 4usaA

query
sites
4usaA

L

I

T

T

V

V

N

N

G

G

T

I

R

E

V

Q

E

N

A

L

S

F

V

V

P

D

P

A

R

E

Q

A

H

L

L

L

G

S

D

D

F

V

L

L

R

R

E

Q

R

Q

E

L

L

G

L

L

T

T

G

G

T

V

H

K

L
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

I

L

D

D

G

G

E

K

P

V

A

V

R
|
R

S

A

C
|
C

I

V

T

T

-

K

F

M

A

K

V

R

A

V

C

A

D

D

G

G

R

A

S

Q

V

I

T

T

V

I

E

E

G

G

L

V

D

G

D

Q

D

P

P

E

V

N

A

L

T

H

E

P

L

L

R

Q

E

K

A

A

F

W

S

V

A

L

E

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

A

S

A

A

R

K

D

G

V

L

L

D

R

T

R

N

P

A

D

D

A

P

D

S

N

R

P

E

A

D

I

V

R

R

T

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

V

K

G

P

I

L

V

V

N

D

A

A

I

V

binding fe2/s2 (inorganic) cluster: V38 (≠ L42), C40 (= C44), E41 (= E45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (= R62), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C138), C139 (= C140)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C140)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 531, 532, 535, 539
binding hydrocinnamic acid: 255, 425, 494, 497, 535, 626
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
38% identity, 87% coverage: 10:150/162 of query aligns to 6:149/907 of 4us9A

query
sites
4us9A

L

I

T

T

V

V

N

N

G

G

T

I

R

E

V

Q

E

N

A

L

S

F

V

V

P

D

P

A

R

E

Q

A

H

L

L

L

G

S

D

D

F

V

L

L

R

R

E

Q

R

Q

E

L

L

G

L

L

T

T

G

G

T

V

H

K

L
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

I

L

D

D

G

G

E

K

P

V

A

V

R
|
R

S

A

C
|
C

I

V

T

T

-

K

F

M

A

K

V

R

A

V

C

A

D

D

G

G

R

A

S

Q

V

I

T

T

V

I

E

E

G

G

L

V

D

G

D

Q

D

P

P

E

V

N

A

L

T

H

E

P

L

L

R

Q

E

K

A

A

F

W

S

V

A

L

E

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

A

S

A

A

R

K

D

G

V

L

L

D

R

T

R

N

P

A

D

D

A

P

D

S

N

R

P

E

A

D

I

V

R

R

T

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

V

K

G

P

I

L

V

V

N

D

A

A

I

V

binding fe2/s2 (inorganic) cluster: V38 (≠ L42), C40 (= C44), E41 (= E45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (= R62), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C138), C139 (= C140)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C140)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 3-phenylpropanal: 255, 257, 258, 752
binding bicarbonate ion: 460, 498, 531, 532, 535, 539, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
38% identity, 87% coverage: 10:150/162 of query aligns to 6:149/907 of 4us8A

query
sites
4us8A

L

I

T

T

V

V

N

N

G

G

T

I

R

E

V

Q

E

N

A

L

S

F

V

V

P

D

P

A

R

E

Q

A

H

L

L

L

G

S

D

D

F

V

L

L

R

R

E

Q

R

Q

E

L

L

G

L

L

T

T

G

G

T

V

H

K

L
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

I

L

D

D

G

G

E

K

P

V

A

V

R
|
R

S

A

C
|
C

I

V

T

T

-

K

F

M

A

K

V

R

A

V

C

A

D

D

G

G

R

A

S

Q

V

I

T

T

V

I

E

E

G

G

L

V

D

G

D

Q

D

P

P

E

V

N

A

L

T

H

E

P

L

L

R

Q

E

K

A

A

F

W

S

V

A

L

E

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

A

S

A

A

R

K

D

G

V

L

L

D

R

T

R

N

P

A

D

D

A

P

D

S

N

R

P

E

A

D

I

V

R

R

T

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

V

K

G

P

I

L

V

V

N

D

A

A

I

V

binding fe2/s2 (inorganic) cluster: V38 (≠ L42), C40 (= C44), E41 (= E45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (= R62), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C138), C139 (= C140)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C140)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 532, 535, 539
binding benzaldehyde: 255, 255, 394, 425, 425, 425, 425, 497, 497, 501, 531, 535, 535, 626, 626, 626, 694, 696, 697
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 653, 654, 655, 656, 695, 696, 697, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

4c7yA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with sodium dithionite and sodium sulfide (see paper)
38% identity, 87% coverage: 10:150/162 of query aligns to 6:149/907 of 4c7yA

query
sites
4c7yA

L

I

T

T

V

V

N

N

G

G

T

I

R

E

V

Q

E

N

A

L

S

F

V

V

P

D

P

A

R

E

Q

A

H

L

L

L

G

S

D

D

F

V

L

L

R

R

E

Q

R

Q

E

L

L

G

L

L

T

T

G

G

T

V

H

K

L

V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

I

L

D

D

G

G

E

K

P

V

A

V

R
|
R

S

A

C
|
C

I

V

T

T

-

K

F

M

A

K

V

R

A

V

C

A

D

D

G

G

R

A

S

Q

V

I

T

T

V

I

E

E

G

G

L

V

D

G

D

Q

D

P

P

E

V

N

A

L

T

H

E

P

L

L

R

Q

E

K

A

A

F

W

S

V

A

L

E

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

A

S

A

A

R

K

D

G

V

L

L

D

R

T

R

N

P

A

D

D

A

P

D

S

N

R

P

E

A

D

I

V

R

R

T

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

V

K

G

P

I

L

V

V

N

D

A

A

I

V

binding fe2/s2 (inorganic) cluster: C40 (= C44), E41 (= E45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (= R62), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C138), C139 (= C140)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C140)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding bicarbonate ion: 460, 498, 531, 535, 539
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869
binding hydrogen peroxide: 696, 697, 869

3fc4A Ethylene glycol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
38% identity, 87% coverage: 10:150/162 of query aligns to 6:149/907 of 3fc4A

query
sites
3fc4A

L

I

T

T

V

V

N

N

G

G

T

I

R

E

V

Q

E

N

A

L

S

F

V

V

P

D

P

A

R

E

Q

A

H

L

L

L

G

S

D

D

F

V

L

L

R

R

E

Q

R

Q

E

L

L

G

L

L

T

T

G

G

T

V

H

K

L
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

I

L

D

D

G

G

E

K

P

V

A

V

R
|
R

S

A

C
|
C

I

V

T

T

-

K

F

M

A

K

V

R

A

V

C

A

D

D

G

G

R

A

S

Q

V

I

T

T

V

I

E

E

G

G

L

V

D

G

D

Q

D

P

P

E

V

N

A

L

T

H

E

P

L

L

R

Q

E

K

A

A

F

W

S

V

A

L

E

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

A

S

A

A

R

K

D

G

V

L

L

D

R

T

R

N

P

A

D

D

A

P

D

S

N

R

P

E

A

D

I

V

R

R

T

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

V

K

G

P

I

L

V

V

N

D

A

A

I

V

binding fe2/s2 (inorganic) cluster: V38 (≠ L42), C40 (= C44), E41 (= E45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (= R62), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C138), C139 (= C140)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C140)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding 1,2-ethanediol: 535, 622, 696, 697, 869
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

3fahA Glycerol inhibited form of aldehyde oxidoreductase from desulfovibrio gigas (see paper)
38% identity, 87% coverage: 10:150/162 of query aligns to 6:149/907 of 3fahA

query
sites
3fahA

L

I

T

T

V

V

N

N

G

G

T

I

R

E

V

Q

E

N

A

L

S

F

V

V

P

D

P

A

R

E

Q

A

H

L

L

L

G

S

D

D

F

V

L

L

R

R

E

Q

R

Q

E

L

L

G

L

L

T

T

G

G

T

V

H

K

L
x
V

G

G

C
|
C

E
|
E

H

Q

G
|
G

V

Q

C
|
C

G
|
G

A

A

C
|
C

T

S

I

V

L

I

I

L

D

D

G

G

E

K

P

V

A

V

R
|
R

S

A

C
|
C

I

V

T

T

-

K

F

M

A

K

V

R

A

V

C

A

D

D

G

G

R

A

S

Q

V

I

T

T

V

I

E

E

G

G

L

V

D

G

D

Q

D

P

P

E

V

N

A

L

T

H

E

P

L

L

R

Q

E

K

A

A

F

W

S

V

A

L

E

H

H

G

G

G

L

A

Q
|
Q

C
|
C

G
|
G

F

F

C
|
C

T

S

P

P

G

G

M

F

L

I

V

V

A

S

A

A

R

K

D

G

V

L

L

D

R

T

R

N

P

A

D

D

A

P

D

S

N

R

P

E

A

D

I

V

R

R

T

D

A

W

M

F

S

Q

G

K

-

H

-

R

N

N

L

A

C
|
C

R

R

C
|
C

T

T

G

G

Y

Y

V

K

G

P

I

L

V

V

N

D

A

A

I

V

binding fe2/s2 (inorganic) cluster: V38 (≠ L42), C40 (= C44), E41 (= E45), G43 (= G47), C45 (= C49), G46 (= G50), C48 (= C52), R58 (= R62), C60 (= C64), C100 (= C103), G101 (= G104), C103 (= C106), C137 (= C138), C139 (= C140)
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): Q99 (= Q102), C139 (= C140)

Sites not aligning to the query:

active site: 390, 425, 501, 505, 533, 869, 870
binding glycerol: 416, 535, 622, 683, 696, 697, 869, 884, 889, 890, 892
binding magnesium ion: 899, 903
binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 419, 420, 421, 422, 533, 650, 653, 654, 655, 656, 695, 696, 700, 701, 799, 800, 804, 807, 865, 866, 867, 868, 869

Query Sequence

>AZOBR_RS29700 FitnessBrowser__azobra:AZOBR_RS29700
MSAHAKTISLTVNGTRVEASVPPRQHLGDFLRERELLTGTHLGCEHGVCGACTILIDGEP
ARSCITFAVACDGRSVTTVEGLDDDPVATELREAFSAEHGLQCGFCTPGMLVAARDVVLR
RPDADNPAIRTAMSGNLCRCTGYVGIVNAIRRVIDARNTNAG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory