SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing AZOBR_RS29760 AZOBR_RS29760 C4-dicarboxylate ABC transporter to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

8b01B Cryo-em structure of the tripartite atp-independent periplasmic (trap) transporter siaqm from photobacterium profundum in a nanodisc (see paper)
29% identity, 34% coverage: 5:205/596 of query aligns to 1:203/427 of 8b01B

query
sites
8b01B

M

M

F

F

A

T

T

S

L

I

V

V

G

G

-

W

-

L

-

G

M

L

L

L

L

F

L

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G

Y

M

P

P

V

V

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F

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L

L

A

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N

V

G

G

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F

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L

L

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L

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E

E

S

I

T

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G

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N

R

-

P

-

D

-

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-

F

F

Q

A

A

A

L

-

P

-

E

Q

R

Q

V

M

Y

I

G

G

T

G

M

L

N

D

N

N

D

F

V

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L

L

L

L

A

A

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V

P

P

F

F

F

F

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M

T

G

G

L

H

V

L

L

M

E

N

R

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S

A

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G

M

I

A

T

E

E

D

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D

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F

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K

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A

L

M

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G

G

S

H

I

I

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T

G

G

G

S

L

L

A

G

Y

H

A

V

V

N

I

I

F

L

V

A

G

S

A

L

L

L

L

F

A
x
S

A

G

T

M

T
x
S

G
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G

V

S

V

A

A

L

A

A

S

D

V

A

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G

M

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P

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P

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S

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L

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A

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P

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G

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L

L

L

L

C

A

C

G

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Y

L

A

C

L

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Y

M

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Y

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F

V

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S

A

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K

-

K

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R

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G

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Y

M

M

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W

L

P

P

K

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A

A

S

binding sodium ion: S103 (≠ A110), S106 (≠ T113), G107 (= G114), G145 (≠ A152), V148 (≠ I155), P149 (= P156), P150 (= P157)

Sites not aligning to the query:

binding sodium ion: 325, 326, 366, 367, 369, 372, 373

Query Sequence

>AZOBR_RS29760 AZOBR_RS29760 C4-dicarboxylate ABC transporter
MAPIMFATLVGMLLLGYPVAFALAANGLLFGLIGIEIGLFRPDLFQALPERVYGTMNNDV
LLAVPFFTFMGLVLERSGMAEDLLDTIGQLFGSIRGGLAYAVIFVGALLAATTGVVAASV
ISMGLISLPIMLRYGYDRRLASGVIAASGTLAQIIPPSLVLIVMADQLGRSVGDMYEAAF
IPGLLLAGLYALYVFVVSMIWPKAAPGLPPEAIAHREPNGARGVWQLGLLALFSGAVATW
VMGRTDVKSGADYVVLLLSVAVLVAFLAAAFNRGFGAQRLVLQTVATAALTAAAAWLTVN
EWTTLALIGDSIAAGALYALAVAVVERATGRRLISRMAEQATFVMVPPLALIFLVLGTIF
IGLATPTEGGAMGAVGALALAAMKKRLNFDMVRQATYSTAKLAAFVLFILIGARVFSLTF
YGVNGHIWVEELMVSLPGGQMGFLIAVSVMVFLLAFFLDFFELAFIVIPLLAPAADRLGI
DLVWFGVILAVNMQTSFMHPPFGFSLFFLRSVAPKLPYIDRITKKETAPVLTSQIYWGAV
PFVVIQLVMVALVIAFPQMVMHYKSTATKLDDKQIEEQFKGLGGDLNDDLPPLEFK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory