SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing AZOBR_RS31025 FitnessBrowser__azobra:AZOBR_RS31025 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
37% identity, 89% coverage: 38:335/335 of query aligns to 20:324/326 of Q8RDH4

query
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ASGKST 44:49 (≠ GCGKST 62:67) binding
N61 (≠ S79) binding
Q97 (= Q110) binding
C285 (= C296) binding
C291 (= C302) binding
C298 (= C309) binding
C316 (= C327) binding

4fwiB Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
37% identity, 88% coverage: 38:331/335 of query aligns to 19:309/310 of 4fwiB

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binding adenosine-5'-triphosphate: S42 (= S61), A43 (≠ G62), S44 (≠ C63), G45 (= G64), K46 (= K65), S47 (= S66), T48 (= T67), N60 (≠ S79), Q96 (= Q110)
binding magnesium ion: S47 (= S66), Q96 (= Q110)
binding iron/sulfur cluster: H247 (= H259), P248 (= P260), C274 (= C296), H277 (= H299), C280 (= C302), Y282 (≠ H304), C287 (= C309), C305 (= C327), H306 (= H328)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

P0AAH4 Putrescine export system ATP-binding protein SapD from Escherichia coli (strain K12) (see paper)
34% identity, 82% coverage: 36:309/335 of query aligns to 17:305/330 of P0AAH4

query
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P0AAH4

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K46 (= K65) mutation K->G,I,Q,R: 25% to 50% stimulation of K(+) uptake by TrkH.; mutation Missing: Almost no stimulation of K(+) uptake by TrkH.
G162 (= G169) mutation to A: 80% stimulation of K(+) uptake by TrkH.
Q165 (= Q172) mutation to L: 60% stimulation of K(+) uptake by TrkH.
D183 (= D190) mutation to E: About 60% stimulation of K(+) uptake by TrkH.; mutation D->K,N: 15% to 20% stimulation of K(+) uptake by TrkH.

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
34% identity, 71% coverage: 37:274/335 of query aligns to 16:249/343 of P30750

query
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P30750

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40:46 (vs. 61:67, 86% identical) binding
E166 (= E191) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
34% identity, 71% coverage: 37:274/335 of query aligns to 17:250/344 of 3tuzC

query
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3tuzC

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G

R

Q

D

E

L

L

R

T

E

T

L

L

S

S

P

E

A

S

D

E

R

L

H

T

H

K

A

A

N

R

L

R

K

Q

I

I

Q

G

M

M

V

I

F

F

Q

Q

D

H

P

-

M

F

A

N

S

L

L

L

N

S

P

S

R

R

L

T

R

V

V

F

A

G

D

N

I

V

V

A

G

-

E

-

A

L

P

P

V

L

V

E

H

L

G

D

L

N

V

T

P

P

R

K

R

D

E

E

A

V

E

K

D

R

Y

R

V

V

A

T

A

E

T

L

L

L

R

S

Q

L

V

V

G

G

L

L

D

G

P

D

A

K

Y

H

L

-

R

D

R

S

Y

Y

P

P

H

S

Q

N

F

L

S

S

G

G

Q

Q

R

K

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

S

K

N

P

P

D

K

V

V

L

L

V

L

C

C

D

D

E

Q

S

A

V

T

A

S

A

A

L

L

D

D

V

P

S

A

I

T

Q

T

A

R

Q

S

I

I

I

L

N

E

L

L

F

L

M

K

R

D

L

I

R

N

E

R

L

L

S

G

L

L

T

T

Y

I

L

L

F

L

I

I

S

T

H

H

D

E

L

M

G

D

V

V

E

K

H

R

I

I

S

C

D

D

R

C

T

V

A

A

I

V

M

I

Y

S

L

N

G

G

R

E

I

L

V

I

E

E

L

Q

A

D

P

T

T

V

P

S

E

E

L

V

F

F

D

S

K

H

P

P

N

K

H

T

P

P

Y

L

A

A

K

Q

A

K

L

F

L

I

D

Q

E

S

A

T

P

L

R

H

V

L

S

D

V

I

binding adenosine-5'-diphosphate: G42 (= G62), G44 (= G64), K45 (= K65), S46 (= S66), T47 (= T67)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12, 14
binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
34% identity, 71% coverage: 37:274/335 of query aligns to 17:250/344 of 3tuiC

query
sites
3tuiC

R

R

A

T

V

I

Q

Q

A

A

V

L

S

N

G

N

V

V

D

S

L

L

S

H

I

V

A

P

E

A

G

G

E

Q

V

I

V

Y

G

G

L

V

V

I

G

G

E

A

S

S

G
|
G

C
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

I

R

R

M

C

V

V

A

N

G

L

I

L

L

E

P

R

P

P

S

T

A

E

G

G

T

S

L

V

R

L

W

V

R

D

G

G

R

Q

D

E

L

L

R

T

E

T

L

L

S

S

P

E

A

S

D

E

R

L

H

T

H

K

A

A

N

R

L

R

K

Q

I

I

Q

G

M

M

V

I

F

F

Q

Q

D

H

P

-

M

F

A

N

S

L

L

L

N

S

P

S

R

R

L

T

R

V

V

F

A

G

D

N

I

V

V

A

G

-

E

-

A

L

P

P

V

L

V

E

H

L

G

D

L

N

V

T

P

P

R

K

R

D

E

E

A

V

E

K

D

R

Y

R

V

V

A

T

A

E

T

L

L

L

R

S

Q

L

V

V

G

G

L

L

D

G

P

D

A

K

Y

H

L

-

R

D

R

S

Y

Y

P

P

H

S

Q

N

F

L

S

S

G

G

Q

Q

R

K

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

S

K

N

P

P

D

K

V

V

L

L

V

L

C

C

D

D

E

Q

S

A

V

T

A

S

A

A

L

L

D

D

V

P

S

A

I

T

Q

T

A

R

Q

S

I

I

I

L

N

E

L

L

F

L

M

K

R

D

L

I

R

N

E

R

L

L

S

G

L

L

T

T

Y

I

L

L

F

L

I

I

S

T

H

H

D

E

L

M

G

D

V

V

E

K

H

R

I

I

S

C

D

D

R

C

T

V

A

A

I

V

M

I

Y

S

L

N

G

G

R

E

I

L

V

I

E

E

L

Q

A

D

P

T

T

V

P

S

E

E

L

V

F

F

D

S

K

H

P

P

N

K

H

T

P

P

Y

L

A

A

K

Q

A

K

L

F

L

I

D

Q

E

S

A

T

P

L

R

H

V

L

S

D

V

I

binding adenosine-5'-diphosphate: G42 (= G62), A43 (≠ C63), G44 (= G64), K45 (= K65), S46 (= S66), T47 (= T67)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
34% identity, 71% coverage: 37:274/335 of query aligns to 17:250/344 of 6cvlD

query
sites
6cvlD

R

R

A

T

V
x
I

Q

Q

A

A

V

L

S

N

G

N

V

V

D

S

L

L

S

H

I

V

A

P

E

A

G

G

E

Q

V

I

V

Y

G

G

L

V

V

I

G

G

E

A

S
|
S

G
|
G

C
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

I

R

R

M

C

V

V

A

N

G

L

I

L

L

E

P

R

P

P

S

T

A

E

G

G

T

S

L

V

R

L

W

V

R

D

G

G

R

Q

D

E

L

L

R

T

E

T

L

L

S

S

P

E

A

S

D

E

R

L

H

T

H

K

A

A

N

R

L

R

K

Q

I

I

Q

G

M

M

V

I

F

F

Q

Q

D

H

P

-

M

F

A

N

S

L

L

L

N

S

P

S

R

R

L

T

R

V

V

F

A

G

D

N

I

V

V

A

G

-

E

-

A

L

P

P

V

L

V

E

H

L

G

D

L

N

V

T

P

P

R

K

R

D

E

E

A

V

E

K

D

R

Y

R

V

V

A

T

A

E

T

L

L

L

R

S

Q

L

V

V

G

G

L

L

D

G

P

D

A

K

Y

H

L

-

R

D

R

S

Y

Y

P

P

H

S

Q
x
N

F

L

S
|
S

G

G

Q
|
Q

R

K

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

S

K

N

P

P

D

K

V

V

L

L

V

L

C

C

D

D

E

Q

S

A

V

T

A

S

A

A

L

L

D

D

V

P

S

A

I

T

Q

T

A

R

Q

S

I

I

I

L

N

E

L

L

F

L

M

K

R

D

L

I

R

N

E

R

L

L

S

G

L

L

T

T

Y

I

L

L

F

L

I

I

S

T

H
|
H

D

E

L

M

G

D

V

V

E

K

H

R

I

I

S

C

D

D

R

C

T

V

A

A

I

V

M

I

Y

S

L

N

G

G

R

E

I

L

V

I

E

E

L

Q

A

D

P

T

T

V

P

S

E

E

L

V

F

F

D

S

K

H

P

P

N

K

H

T

P

P

Y

L

A

A

K

Q

A

K

L

F

L

I

D

Q

E

S

A

T

P

L

R

H

V

L

S

D

V

I

binding phosphothiophosphoric acid-adenylate ester: I19 (≠ V39), S41 (= S61), G42 (= G62), A43 (≠ C63), G44 (= G64), K45 (= K65), S46 (= S66), T47 (= T67), N141 (≠ Q165), S143 (= S167), Q146 (= Q170), H200 (= H224)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 12, 14

7z15I E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
33% identity, 68% coverage: 40:266/335 of query aligns to 17:244/253 of 7z15I

query
sites
7z15I

Q
x
K

A
x
G

V

F

S

S

G

D

V

V

D

S

L

F

S

D

I

L

A

W

E

P

G

G

E

E

V

V

V

L

G

G

L

I

V

V

G

G

E

E

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
x
T

T
|
T

L

L

G

L

R

K

M

S

V

I

A

S

G

A

I

R

L

L

P

T

P

P

S

Q

A

Q

G

G

T

E

L

I

R

H

W

Y

R

E

G

N

R

R

D

S

L

L

R

Y

E

A

L

M

S

S

P

E

A

A

D

D

R

R

H

R

A

L

-

L

N

R

L

T

K

E

I

W

Q

G

M

V

V

V

F

H

Q
|
Q

D

H

P

P

M

L

A

D

S

G

L

L

N

R

P

R

R

Q

L

V

R

S

V

A

A

G

D

G

I

N

V

I

G

G

E

E

A

R

P

L

V

M

V

A

H

T

G

G

L

A

V

R

P

H

R

Y

R

G

E

D

A

I

E

R

D

A

Y

T

V

A

A

Q

A

K

T

W

L

L

R

E

Q

E

V

V

G

E

L

I

D

P

P

A

A

N

Y
x
R

L

I

R

D

Y

L

P

P

H

T

Q
x
T

F

F

S
|
S

G

G

Q
x
M

R

Q

Q

Q

R

R

I

L

G

Q

I

I

A

A

R

R

A

N

L

L

A

V

V

T

K

H

P

P

D

K

V

L

L

V

V

F

C

M

D

D

E

E

S

P

V

T

A

G

L

L

D

D

V

V

S

S

I

V

Q

Q

A

A

Q

R

I

L

N

D

L

L

F

L

M

R

R

G

L

L

R

V

E

V

E

E

L

L

S

N

L

L

T

A

Y

V

L

V

F

I

I

V

S

T

H

H

D

D

L

L

G

G

V

V

V

A

E

R

H

L

I

L

S

A

D

D

R

R

T

L

A

L

I

V

M

M

Y

K

L

Q

G

G

R

Q

I

V

V

V

E

E

L

S

A

G

P

L

T

T

P

D

E

R

L

V

F

L

D

D

K

D

P

P

N

H

H

H

P

P

Y

Y

A

T

K

Q

A

L

L

L

L

V

binding adenosine-5'-diphosphate: K17 (≠ Q40), G18 (≠ A41), S38 (= S61), G39 (= G62), G41 (= G64), K42 (= K65), T43 (≠ S66), T44 (= T67), R136 (≠ Y158), T143 (≠ Q165), S145 (= S167), M148 (≠ Q170)
binding magnesium ion: T43 (≠ S66), Q88 (= Q110)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 13

7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp (see paper)
33% identity, 68% coverage: 40:266/335 of query aligns to 17:244/250 of 7z18I

query
sites
7z18I

Q

K

A

G

V

F

S

S

G

D

V

V

D

S

L

F

S

D

I

L

A

W

E

P

G

G

E

E

V

V

V

L

G

G

L

I

V

V

G

G

E

E

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
x
T

T
|
T

L

L

G

L

R

K

M

S

V

I

A

S

G

A

I

R

L

L

P

T

P

P

S

Q

A

Q

G

G

T

E

L

I

R

H

W

Y

R

E

G

N

R

R

D

S

L

L

R

Y

E

A

L

M

S

S

P

E

A

A

D

D

R

R

H

R

A

L

-

L

N

R

L

T

K

E

I

W

Q

G

M

V

V

V

F

H

Q
|
Q

D

H

P

P

M

L

A

D

S

G

L

L

N

R

P

R

R

Q

L

V

R

S

V

A

A

G

D

G

I

N

V

I

G

G

E

E

A

R

P

L

V

M

V

A

H

T

G

G

L

A

V

R

P

H

R

Y

R

G

E

D

A

I

E

R

D

A

Y

T

V

A

A

Q

A

K

T

W

L

L

R

E

Q

E

V

V

G

E

L

I

D

P

P

A

A

N

Y
x
R

L

I

R

D

Y

L

P

P

H

T

Q
x
T

F

F

S
|
S

G

G

G
|
G

Q
x
M

R

Q

Q

Q

R

R

I

L

G

Q

I

I

A

A

R

R

A

N

L

L

A

V

V

T

K

H

P

P

D

K

V

L

L

V

V

F

C

M

D

D

E

E

S

P

V

T

A

G

L

L

D

D

V

V

S

S

I

V

Q

Q

A

A

Q

R

I

L

N

D

L

L

F

L

M

R

R

G

L

L

R

V

E

V

E

E

L

L

S

N

L

L

T

A

Y

V

L

V

F

I

I

V

S

T

H
|
H

D

D

L

L

G

G

V

V

V

A

E

R

H

L

I

L

S

A

D

D

R

R

T

L

A

L

I

V

M

M

Y

K

L

Q

G

G

R

Q

I

V

V

V

E

E

L

S

A

G

P

L

T

T

P

D

E

R

L

V

F

L

D

D

K

D

P

P

N

H

H

H

P

P

Y

Y

A

T

K

Q

A

L

L

L

L

V

binding adenosine-5'-triphosphate: S38 (= S61), G39 (= G62), S40 (≠ C63), G41 (= G64), K42 (= K65), T43 (≠ S66), T44 (= T67), Q88 (= Q110), R136 (≠ Y158), T143 (≠ Q165), S145 (= S167), G147 (= G169), M148 (≠ Q170), H202 (= H224)
binding magnesium ion: T43 (≠ S66), Q88 (= Q110)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

1vciA Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
32% identity, 75% coverage: 23:274/335 of query aligns to 9:236/353 of 1vciA

query
sites
1vciA

V

L

E

E

R

N

F

L

A

T

R

K

R

R

L
x
F

G

G

A

N

A

-

I

-

D

-

R

-

A

-

V
x
F

Q

T

A

A

V

V

S

N

G

K

V

L

D

N

L

L

S

T

I

I

A

K

E

D

G

G

E

E

V

F

V

L

G

V

L

L

V

L

G

G

E

P

S
|
S

G
|
G

C

C

G
|
G

K
|
K

S
x
T

T
|
T

L

T

G

L

R

R

M

M

V

I

A

A

G

G

I

L

L

E

P

E

P

P

S

T

A

E

G

G

T

R

L

I

R

Y

W

F

R

G

G

D

R

R

D

D

L

V

R

T

E

Y

L

L

S

P

P

P

A

K

D

D

R

R

H

N

H

-

A

-

N

-

L

-

K

-

I

I

Q

S

M

M

V

V

F

F

Q

Q

D

H

P

M

M

T

A

V

S

Y

L

E

N

N

P

I

R

A

L

F

R

P

V

L

A

K

D

K

I

F

V

-

G

-

E

-

A

-

P

-

V

-

H

-

G

-

L

-

V

-

P

P

R

K

R

D

E

E

A

I

E

D

D

K

Y

R

V

V

-

R

-

W

A

A

T

E

L

L

R

L

Q

Q

V

I

G

-

L

-

D

-

P

E

A

E

Y

L

L

L

R

N

R

R

Y

Y

P

P

H

A

Q

Q

F

L

S

S

G

G

Q

Q

R

R

Q

Q

R

R

I

V

G

A

I

V

A

A

R

R

A

A

L

I

A

V

V

V

K

E

P

P

D

D

V

V

L

L

V

L

C

M

D

D

E

E

S

P

V

L

A

S

A

N

L

L

D

D

V

A

S

K

I

L

Q

R

A

V

Q

A

I

M

I

R

N

A

L

E

F

I

M

K

R

K

L

L

R

Q

E

Q

E

K

L

L

S

K

L

V

T

T

Y

T

L

I

F

Y

I

V

S

T

H

H

D

D

L

Q

G

V

V

E

V

A

E

M

H

T

I

M

S

G

D

D

R

R

T

I

A

A

I

V

M

M

Y

N

L

R

G

G

R

Q

I

L

V

L

E

Q

L

I

A

G

P

S

T

P

P

T

E

E

L

V

F

Y

D

L

K

R

P

P

N

N

H

S

P

V

Y

F

A

V

K

A

A

T

L

F

L

I

D

G

E

-

A

A

P

P

R

E

V

M

S

N

V

I

binding adenosine-5'-triphosphate: F16 (≠ L30), F19 (≠ V39), S41 (= S61), G42 (= G62), G44 (= G64), K45 (= K65), T46 (≠ S66), T47 (= T67)

7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation (see paper)
33% identity, 68% coverage: 40:266/335 of query aligns to 17:244/250 of 7z16I

query
sites
7z16I

Q
x
K

A

G

V

F

S

S

G

D

V

V

D

S

L

F

S

D

I

L

A

W

E

P

G

G

E

E

V

V

V

L

G

G

L

I

V

V

G

G

E

E

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
x
T

T
|
T

L

L

G

L

R

K

M

S

V

I

A

S

G

A

I

R

L

L

P

T

P

P

S

Q

A

Q

G

G

T

E

L

I

R

H

W

Y

R

E

G

N

R

R

D

S

L

L

R

Y

E

A

L

M

S

S

P

E

A

A

D

D

R

R

H

R

A

L

-

L

N

R

L

T

K

E

I

W

Q

G

M

V

V

V

F

H

Q

Q

D

H

P

P

M

L

A

D

S

G

L

L

N

R

P

R

R

Q

L

V

R

S

V

A

A

G

D

G

I

N

V

I

G

G

E

E

A

R

P

L

V

M

V

A

H

T

G

G

L

A

V

R

P

H

R

Y

R

G

E

D

A

I

E

R

D

A

Y

T

V

A

A

Q

A

K

T

W

L

L

R

E

Q

E

V

V

G

E

L

I

D

P

P

A

A

N

Y
x
R

L

I

R

D

Y

L

P

P

H

T

Q
x
T

F

F

S
|
S

G

G

G
|
G

Q
x
M

R

Q

Q

Q

R

R

I

L

G

Q

I

I

A

A

R

R

A

N

L

L

A

V

V

T

K

H

P

P

D

K

V

L

L

V

V

F

C

M

D

D

E

Q

S

P

V

T

A

G

L

L

D

D

V

V

S

S

I

V

Q

Q

A

A

Q

R

I

L

N

D

L

L

F

L

M

R

R

G

L

L

R

V

E

V

E

E

L

L

S

N

L

L

T

A

Y

V

L

V

F

I

I

V

S

T

H
|
H

D

D

L

L

G

G

V

V

V

A

E

R

H

L

I

L

S

A

D

D

R

R

T

L

A

L

I

V

M

M

Y

K

L

Q

G

G

R

Q

I

V

V

V

E

E

L

S

A

G

P

L

T

T

P

D

E

R

L

V

F

L

D

D

K

D

P

P

N

H

H

H

P

P

Y

Y

A

T

K

Q

A

L

L

L

L

V

binding phosphoaminophosphonic acid-adenylate ester: K17 (≠ Q40), S38 (= S61), G39 (= G62), S40 (≠ C63), G41 (= G64), K42 (= K65), T43 (≠ S66), T44 (= T67), R136 (≠ Y158), T143 (≠ Q165), S145 (= S167), G147 (= G169), M148 (≠ Q170), H202 (= H224)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 13

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
31% identity, 79% coverage: 5:268/335 of query aligns to 16:250/378 of P69874

query
sites
P69874

P

P

I

L

I

V

E

Q

L

L

N

A

G

G

L

I

T

R

K

K

R
x
C

F
|
F

S

D

R

G

K

K

L

-

D

-

V

-

E

-

R

-

F

-

A

-

R

-

L

-

G

-

A

-

I

-

D

-

R

-

A

-

V

-

Q

E

A

V

V

I

S

P

G

Q

V

L

D

D

L

L

S

T

I

I

A

N

E

N

G

G

E

E

V
x
F

V

L

G

T

L

L

V

L

G

G

E

P

S

S

G

G

C
|
C

G

G

K

K

S

T

T

T

L

V

G
x
L

R

R

M

L

V

I

A

A

G

G

I

L

L

E

P

T

P

V

S

D

A

S

G

G

T

R

L

I

R

M

W
x
L

R

D

G

N

R

E

D

D

L

I

R

T

E

H

L

V

S

-

P

P

A

A

D

E

R

N

H

R

H

Y

A

V

N

N

L

-

K

-

I

-

Q

-

M

T

V

V

F

F

Q

Q

D

S

P

-

M

-

A

Y

S

A

L

L

N

F

P

P

R

H

L

M

R

T

V

V

A

F

D

E

I

-

V

-

G

-

E

-

A

-

P

N

V

V

V

A

H

F

G

G

L

L

-

R

-

M

-

Q

-

K

V

T

P

P

R

A

E

E

A

I

E

T

D

P

Y

R

V

V

A

M

A

E

T

A

L

L

R

R

Q

M

V
|
V

G

Q

L

L

D

E

P

-

A

T

Y

F

L

A

R

Q

R

R

Y

K

P

P

H

H

Q

Q

F

L

S

S

G

G

Q

Q

R

Q

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

V

A

V

V

N

K

K

P

P

D

R

V

L

L

L

V

L

C

L

D
|
D

E

E

S

S

V

L

A

S

A

A

L

L

D

D

V

Y

S

K

I

L

Q

R

A

K

Q

Q

I

M

I

Q

N

N

L

E

F

L

M

K

R

A

L

L

R

Q

E

R

E

K

L

L

S

G

L

I

T

T

Y

F

L

V

F

F

I

V

S

T

H

H

D

D

L

Q

G

E

V

E

V

A

E

L

H

T

I

M

S

S

D

D

R

R

T

I

A

V

I

V

M

M

Y

R

L

D

G

G

R

R

I

I

V

E

E

Q

L

D

A

G

P

T

T

P

P

R

E

E

L

I

F

Y

D

E

K

E

P

P

N

K

H

N

P

L

Y

F

A

V

K

A

A

G

L

F

L

I

D

G

E

E

C26 (≠ R15) mutation to A: Lower ATPase activity and transport efficiency.
F27 (= F16) mutation to L: Lower ATPase activity and transport efficiency.
F45 (≠ V54) mutation to L: Lower ATPase activity and transport efficiency.
C54 (= C63) mutation to T: Loss of ATPase activity and transport.
L60 (≠ G69) mutation to F: Lower ATPase activity and transport efficiency.
L76 (≠ W85) mutation to P: Lower ATPase activity and transport efficiency.
V135 (= V152) mutation to M: Loss of ATPase activity and transport.
D172 (= D190) mutation to N: Loss of ATPase activity and transport.

Sites not aligning to the query:

276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

7ahhC Opua inhibited inward-facing, sbd docked (see paper)
30% identity, 79% coverage: 7:269/335 of query aligns to 3:266/382 of 7ahhC

query
sites
7ahhC

I

I

E

K

L

I

N

E

G

H

L

L

T

T

K

K

R

I

F
|
F

S

G

R

K

K

R

-

I

-

K

-

T

-

A

L

L

D

T

V

M

V

V

E

E

R

K

-

G

-

E

-

P

-

K

-

N

-

E

F

I

A

L

R

K

L

T

G

G

A

A

A
x
T

I
x
V

D

-

R

-

A

-

V

-

Q

-

A
x
G

V

V

S

Y

G

D

V

T

D

N

L

F

S

E

I

I

A

N

E

E

G

G

E

E

V

I

V

F

G

V

L

I

V

M

G

G

E

L

S

S

G
|
G

C

S

G
|
G

K
|
K

S

S

T

T

L

L

G

L

R

R

M

L

V

L

A

N

G

R

I

L

L

I

P

E

P

P

S

T

A

S

G

G

T

K

L

I

R

F

W

I

R

D

G

N

R

Q

D

D

L

V

R

A

E

T

L

L

S

N

P

K

A

E

D

D

R

L

H

L

H

Q

A

V

N

R

L

R

K

K

-

T

I

M

Q

S

M

M

V

V

F

F

Q

Q

D

N

P

-

M

-

A

F

S

G

L

L

N

F

P

P

R

H

L

R

R

T

V

I

A

L

D

E

I

N

V

T

G

E

E

Y

A

G

P

L

V

E

V

V

H

Q

G

N

L

-

V

V

P

P

R

K

R

E

E

E

A

R

E

R

D

K

Y

R

V

A

A

E

A

K

T

A

L

L

R

D

Q

N

V

A

G

N

L

L

D

-

P

L

A

D

Y

F

L

K

R

D

R

Q

Y

Y

P

P

H

K

Q

Q

F

L

S

S

G

G

Q

M

R

Q

Q

Q

R

R

I

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

V

N

K

D

P

P

D

E

V

I

L

L

V

L

C

M

D
|
D

E
|
E

S

A

V

F

A

S

A

A

L

L

D

D

V

P

S

L

I

I

Q

R

A

R

Q

E

I

M

I

Q

N

D

L

E

F

L

M

L

R

E

L

L

R

Q

E

A

E

K

L

F

S

Q

L

K

T

T

Y

I

L

I

F

F

I

V

S

S

H

H

D

D

L

L

G

N

V

E

V

A

E

L

H

R

I

I

S

G

D

D

R

R

T

I

A

A

I

I

M

M

Y

K

L

D

G

G

R

K

I

I

V

M

E

Q

L

I

A

G

P

T

T

G

P

E

E

E

L

I

F

L

D

T

K

N

P

P

N

A

H

N

P

D

Y

Y

A

V

K

K

A

T

L

F

L

V

D

E

E

D

A

T

binding phosphoaminophosphonic acid-adenylate ester: F12 (= F16), T39 (≠ A33), V40 (≠ I34), G41 (≠ A41), G62 (= G62), G64 (= G64), K65 (= K65), D187 (= D190), E188 (= E191)

Sites not aligning to the query:

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: 275, 297, 298

7aheC Opua inhibited inward facing (see paper)
30% identity, 79% coverage: 7:269/335 of query aligns to 3:266/382 of 7aheC

query
sites
7aheC

I

I

E

K

L

I

N

E

G

H

L

L

T

T

K

K

R

I

F

F

S

G

R

K

K

R

-

I

-

K

-

T

-

A

L

L

D

T

V

M

V

V

E

E

R

K

-

G

-

E

-

P

-

K

-

N

-

E

F

I

A

L

R

K

L

T

G

G

A

A

A

T

I

V

D

-

R

-

A

-

V

-

Q

-

A

G

V

V

S

Y

G

D

V

T

D

N

L

F

S

E

I

I

A

N

E

E

G

G

E

E

V

I

V

F

G

V

L

I

V

M

G

G

E

L

S

S

G

G

C

S

G

G

K

K

S

S

T

T

L

L

G

L

R

R

M

L

V

L

A

N

G

R

I

L

L

I

P

E

P

P

S

T

A

S

G

G

T

K

L

I

R

F

W

I

R

D

G

N

R

Q

D

D

L

V

R

A

E

T

L

L

S

N

P

K

A

E

D

D

R

L

H

L

H

Q

A

V

N

R

L

R

K

K

-

T

I

M

Q

S

M

M

V

V

F

F

Q

Q

D

N

P

-

M

-

A

F

S

G

L

L

N

F

P

P

R

H

L

R

R

T

V

I

A

L

D

E

I

N

V

T

G

E

E

Y

A

G

P

L

V

E

V

V

H

Q

G

N

L

-

V

V

P

P

R

K

R

E

E

E

A

R

E

R

D

K

Y

R

V

A

A

E

A

K

T

A

L

L

R

D

Q

N

V

A

G

N

L

L

D

-

P

L

A

D

Y

F

L

K

R

D

R

Q

Y

Y

P

P

H

K

Q

Q

F

L

S

S

G

G

Q

M

R

Q

Q

Q

R

R

I

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

V

N

K

D

P

P

D

E

V

I

L

L

V

L

C

M

D

D

E

E

S

A

V

F

A

S

A

A

L

L

D

D

V

P

S

L

I

I

Q

R

A

R

Q

E

I

M

I

Q

N

D

L

E

F

L

M

L

R

E

L

L

R

Q

E

A

E

K

L

F

S

Q

L

K

T

T

Y

I

L

I

F

F

I

V

S

S

H

H

D

D

L

L

G

N

V

E

V

A

E

L

H

R

I

I

S

G

D

D

R

R

T

I

A

A

I

I

M

M

Y

K

L

D

G

G

R

K

I

I

V

M

E

Q

L

I

A

G

P

T

T

G

P

E

E

E

L

I

F

L

D

T

K

N

P

P

N

A

H

N

P

D

Y

Y

A

V

K

K

A

T

L

F

L

V

D

E

E

D

A

T

Sites not aligning to the query:

binding (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide: 275, 297, 298

7ahdC Opua (e190q) occluded (see paper)
31% identity, 77% coverage: 7:263/335 of query aligns to 3:260/260 of 7ahdC

query
sites
7ahdC

I

I

E

K

L

I

N

E

G

H

L

L

T

T

K

K

R

I

F
|
F

S

G

R

K

K

R

-

I

-

K

-

T

-

A

L

L

D

T

V

M

V

V

E

E

R

K

-

G

-

E

-

P

-

K

-

N

-

E

F

I

A

L

R

K

L

T

G

G

A

A

A
x
T

I

V

D

-

R

-

A

-

V

-

Q

-

A

G

V

V

S

Y

G

D

V

T

D

N

L

F

S

E

I

I

A

N

E

E

G

G

E

E

V

I

V

F

G

V

L

I

V

M

G

G

E

L

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

L

R

R

M

L

V

L

A

N

G

R

I

L

L

I

P

E

P

P

S

T

A

S

G

G

T

K

L

I

R

F

W

I

R

D

G

N

R

Q

D

D

L

V

R

A

E

T

L

L

S

N

P

K

A

E

D

D

R

L

H

L

H

Q

A

V

N

R

L

R

K

K

-

T

I

M

Q

S

M

M

V

V

F

F

Q
|
Q

D

N

P

-

M

-

A

F

S

G

L

L

N

F

P

P

R

H

L

R

R

T

V

I

A

L

D

E

I

N

V

T

G

E

E

Y

A

G

P

L

V

E

V

V

H

Q

G

N

L

-

V

V

P

P

R

K

R

E

E

E

A

R

E

R

D

K

Y

R

V

A

A

E

A

K

T

A

L

L

R

D

Q

N

V

A

G

N

L

L

D

-

P

L

A

D

Y

F

L

K

R

D

R

Q

Y

Y

P

P

H
x
K

Q
|
Q

F

L

S
|
S

G

G

G
|
G

Q
x
M

R

Q

Q

Q

R

R

I

V

G

G

I

L

A

A

R

R

A

A

L

L

A

A

V

N

K

D

P

P

D

E

V

I

L

L

V

L

C

M

D

D

E
x
Q

S

A

V

F

A

S

A

A

L

L

D

D

V

P

S

L

I

I

Q

R

A

R

Q

E

I

M

I

Q

N

D

L

E

F

L

M

L

R

E

L

L

R

Q

E

A

E

K

L

F

S

Q

L

K

T

T

Y

I

L

I

F

F

I

V

S

S

H
|
H

D

D

L

L

G

N

V

E

V

A

E

L

H

R

I

I

S

G

D

D

R

R

T

I

A

A

I

I

M

M

Y

K

L

D

G

G

R

K

I

I

V

M

E

Q

L

I

A

G

P

T

T

G

P

E

E

E

L

I

F

L

D

T

K

N

P

P

N

A

H

N

P

D

Y

Y

A

V

K

K

binding adenosine-5'-triphosphate: F12 (= F16), T39 (≠ A33), S61 (= S61), G62 (= G62), G64 (= G64), K65 (= K65), S66 (= S66), T67 (= T67), Q111 (= Q110), K161 (≠ H164), Q162 (= Q165), S164 (= S167), G166 (= G169), M167 (≠ Q170), Q188 (≠ E191), H221 (= H224)

3c4jA Abc protein artp in complex with atp-gamma-s
33% identity, 68% coverage: 38:266/335 of query aligns to 15:238/242 of 3c4jA

query
sites
3c4jA

A

S

V

L

Q

E

A
x
V

V

L

S

K

G

G

V

I

D

N

L

V

S

H

I

I

A

R

E

E

G

G

E

E

V

V

G

V

L

V

V

I

G

G

E

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R

R

M

C

V

L

A

N

G

L

I

L

L

E

P

D

P

F

S

D

A

E

G

G

T

E

L

I

R

I

W

I

R

D

G

G

R

I

D

N

L

L

R

K

E

A

L

-

S

K

P

D

A

T

D

N

R

L

H

N

H

K

A

V

N

R

L

E

K

E

I

V

Q

G

M

M

V

V

F

F

Q

Q

D

R

P

-

M

-

A

F

S

N

L

L

N

F

P

P

R

H

L

M

R

T

V

V

A

L

D

N

I

N

V

I

G

T

E

L

A

A

P

P

V

M

V

K

H

V

G

R

L

K

V

W

P

P

R

R

R

E

E

K

A

A

E

E

D

A

Y

K

V

A

A

M

A

E

T

L

L

L

R

D

Q

K

V

V

G

G

L

L

-

K

D

D

P

K

A

A

Y

H

L

-

R

-

R

A

Y

Y

P

P

H

D

Q

S

F

L

S

S

G

G

Q

Q

R

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

K

E

P

P

D

K

V

I

L

M

V

L

C

F

D

D

E

E

S

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

A

G

Q

E

I

V

I

L

N

S

L

V

F

M

M

K

R

Q

L

L

R

A

E

N

E

E

L

-

S

G

L

M

T

T

Y

M

L

V

F

V

I

V

S

T

H

H

D

E

L

M

G

G

V

F

V

A

E

R

H

E

I

V

S

G

D

D

R

R

T

V

A

L

I

F

M

M

Y

D

L

G

G

G

R

Y

I

I

V

I

E

E

L

E

A

G

P

K

T

P

P

E

E

D

L

L

F

F

D

D

K

R

P

P

N

Q

H

H

P

E

Y

R

A

T

K

K

A

A

L

F

L

L

binding phosphothiophosphoric acid-adenylate ester: V18 (≠ A41), S38 (= S61), G39 (= G62), S40 (≠ C63), G41 (= G64), K42 (= K65), S43 (= S66), T44 (= T67)

Sites not aligning to the query:

binding phosphothiophosphoric acid-adenylate ester: 13

3c41J Abc protein artp in complex with amp-pnp/mg2+
33% identity, 68% coverage: 38:266/335 of query aligns to 15:238/242 of 3c41J

query
sites
3c41J

A

S

V

L

Q

E

A
x
V

V

L

S

K

G

G

V

I

D

N

L

V

S

H

I

I

A

R

E

E

G

G

E

E

V

V

G

V

L

V

V

I

G

G

E

P

S
|
S

G
|
G

C

S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R

R

M

C

V

L

A

N

G

L

I

L

L

E

P

D

P

F

S

D

A

E

G

G

T

E

L

I

R

I

W

I

R

D

G

G

R

I

D

N

L

L

R

K

E

A

L

-

S

K

P

D

A

T

D

N

R

L

H

N

H

K

A

V

N

R

L

E

K

E

I

V

Q

G

M

M

V

V

F

F

Q

Q

D

R

P

-

M

-

A

F

S

N

L

L

N

F

P

P

R

H

L

M

R

T

V

V

A

L

D

N

I

N

V

I

G

T

E

L

A

A

P

P

V

M

V

K

H

V

G

R

L

K

V

W

P

P

R

R

R

E

E

K

A

A

E

E

D

A

Y

K

V

A

A

M

A

E

T

L

L

L

R

D

Q

K

V

V

G

G

L

L

-

K

D

D

P

K

A

A

Y

H

L

-

R

-

R

A

Y

Y

P

P

H

D

Q

S

F

L

S

S

G

G

Q

Q

R

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

K

E

P

P

D

K

V

I

L

M

V

L

C

F

D
|
D

E

E

S

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

A

G

Q

E

I

V

I

L

N

S

L

V

F

M

M

K

R

Q

L

L

R

A

E

N

E

E

L

-

S

G

L

M

T

T

Y

M

L

V

F

V

I

V

S

T

H

H

D

E

L

M

G

G

V

F

V

A

E

R

H

E

I

V

S

G

D

D

R

R

T

V

A

L

I

F

M

M

Y

D

L

G

G

G

R

Y

I

I

V

I

E

E

L

E

A

G

P

K

T

P

P

E

E

D

L

L

F

F

D

D

K

R

P

P

N

Q

H

H

P

E

Y

R

A

T

K

K

A

A

L

F

L

L

binding phosphoaminophosphonic acid-adenylate ester: V18 (≠ A41), S38 (= S61), G39 (= G62), G41 (= G64), K42 (= K65), S43 (= S66), T44 (= T67)
binding magnesium ion: S43 (= S66), D163 (= D190)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 13

2olkA Abc protein artp in complex with adp-beta-s
33% identity, 68% coverage: 38:266/335 of query aligns to 15:238/242 of 2olkA

query
sites
2olkA

A

S

V

L

Q

E

A
x
V

V

L

S

K

G

G

V

I

D

N

L

V

S

H

I

I

A

R

E

E

G

G

E

E

V

V

G

V

L

V

V

I

G

G

E

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R

R

M

C

V

L

A

N

G

L

I

L

L

E

P

D

P

F

S

D

A

E

G

G

T

E

L

I

R

I

W

I

R

D

G

G

R

I

D

N

L

L

R

K

E

A

L

-

S

K

P

D

A

T

D

N

R

L

H

N

H

K

A

V

N

R

L

E

K

E

I

V

Q

G

M

M

V

V

F

F

Q

Q

D

R

P

-

M

-

A

F

S

N

L

L

N

F

P

P

R

H

L

M

R

T

V

V

A

L

D

N

I

N

V

I

G

T

E

L

A

A

P

P

V

M

V

K

H

V

G

R

L

K

V

W

P

P

R

R

R

E

E

K

A

A

E

E

D

A

Y

K

V

A

A

M

A

E

T

L

L

L

R

D

Q

K

V

V

G

G

L

L

-

K

D

D

P

K

A

A

Y

H

L

-

R

-

R

A

Y

Y

P

P

H

D

Q

S

F

L

S

S

G

G

Q

Q

R

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

K

E

P

P

D

K

V

I

L

M

V

L

C

F

D

D

E

E

S

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

A

G

Q

E

I

V

I

L

N

S

L

V

F

M

M

K

R

Q

L

L

R

A

E

N

E

E

L

-

S

G

L

M

T

T

Y

M

L

V

F

V

I

V

S

T

H

H

D

E

L

M

G

G

V

F

V

A

E

R

H

E

I

V

S

G

D

D

R

R

T

V

A

L

I

F

M

M

Y

D

L

G

G

G

R

Y

I

I

V

I

E

E

L

E

A

G

P

K

T

P

P

E

E

D

L

L

F

F

D

D

K

R

P

P

N

Q

H

H

P

E

Y

R

A

T

K

K

A

A

L

F

L

L

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: V18 (≠ A41), S38 (= S61), G39 (= G62), S40 (≠ C63), G41 (= G64), K42 (= K65), S43 (= S66), T44 (= T67)

Sites not aligning to the query:

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: 13

2oljA Abc protein artp in complex with adp/mg2+
33% identity, 68% coverage: 38:266/335 of query aligns to 15:238/242 of 2oljA

query
sites
2oljA

A

S

V

L

Q

E

A
x
V

V

L

S

K

G

G

V

I

D

N

L

V

S

H

I

I

A

R

E

E

G

G

E

E

V

V

G

V

L

V

V

I

G

G

E

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

G

L

R

R

M

C

V

L

A

N

G

L

I

L

L

E

P

D

P

F

S

D

A

E

G

G

T

E

L

I

R

I

W

I

R

D

G

G

R

I

D

N

L

L

R

K

E

A

L

-

S

K

P

D

A

T

D

N

R

L

H

N

H

K

A

V

N

R

L

E

K

E

I

V

Q

G

M

M

V

V

F

F

Q

Q

D

R

P

-

M

-

A

F

S

N

L

L

N

F

P

P

R

H

L

M

R

T

V

V

A

L

D

N

I

N

V

I

G

T

E

L

A

A

P

P

V

M

V

K

H

V

G

R

L

K

V

W

P

P

R

R

R

E

E

K

A

A

E

E

D

A

Y

K

V

A

A

M

A

E

T

L

L

L

R

D

Q

K

V

V

G

G

L

L

-

K

D

D

P

K

A

A

Y

H

L

-

R

-

R

A

Y

Y

P

P

H

D

Q

S

F

L

S

S

G

G

Q

Q

R

A

Q

Q

R

R

I

V

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

K

E

P

P

D

K

V

I

L

M

V

L

C

F

D

D

E

E

S

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

A

G

Q

E

I

V

I

L

N

S

L

V

F

M

M

K

R

Q

L

L

R

A

E

N

E

E

L

-

S

G

L

M

T

T

Y

M

L

V

F

V

I

V

S

T

H

H

D

E

L

M

G

G

V

F

V

A

E

R

H

E

I

V

S

G

D

D

R

R

T

V

A

L

I

F

M

M

Y

D

L

G

G

G

R

Y

I

I

V

I

E

E

L

E

A

G

P

K

T

P

P

E

E

D

L

L

F

F

D

D

K

R

P

P

N

Q

H

H

P

E

Y

R

A

T

K

K

A

A

L

F

L

L

binding adenosine-5'-diphosphate: V18 (≠ A41), S38 (= S61), G39 (= G62), S40 (≠ C63), G41 (= G64), K42 (= K65), S43 (= S66), T44 (= T67)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 13

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 69% coverage: 38:268/335 of query aligns to 13:238/240 of 4ymuJ

query
sites
4ymuJ

A

S

V

L

Q

E

A
x
V

V

L

S

K

G

G

V

V

D

T

L

L

S

K

I

V

A

N

E

K

G

G

E

E

V

V

G

V

L

I

V

I

G

G

E

P

S
|
S

G
|
G

C
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

G

L

R

R

M

C

V

I

A

N

G

L

I

L

L

E

P

E

P

P

S

T

A

K

G

G

T

E

L

V

R

F

W

I

R

D

G

G

R

V

D

K

L

I

R

N

E

N

L

-

S

G

P

K

A

V

D

N

R

I

H

N

H

K

A

V

N

R

L

Q

K

K

I

V

Q

G

M

M

V

V

F

F

Q

Q

D

H

P

-

M

-

A

F

S

N

L

L

N

F

P

P

R

H

L

L

R

T

V

A

A

I

D

E

I

N

V

I

G

T

E

L

A

A

P

P

V

V

V

K

H

V

G

K

L

K

V

M

P

N

R

K

E

E

A

A

E

E

D

E

Y

L

V

A

A

V

A

D

T

L

L

L

R

A

Q

K

V

V

G

G

L

L

D

L

P

D

A

K

Y

K

L

-

R

D

R

Q

Y

Y

P

P

H

I

Q

K

F

L

S

S

G

G

Q

Q

R

K

Q

Q

R

R

I

L

G

A

I

I

A

A

R

R

A

A

L

L

A

A

V

M

K

Q

P

P

D

E

V

V

L

M

V

L

C

F

D

D

E
|
E

S

P

V

T

A

S

A

A

L

L

D

D

V

P

S

E

I

M

Q

V

A

K

Q

E

I

V

I

L

N

N

L

V

F

M

M

K

R

Q

L

L

R

A

E

N

E

E

L

-

S

G

L

M

T

T

Y

M

L

V

F

V

I

V

S

T

H
|
H

D

E

L

M

G

G

V

F

V

A

E

R

H

E

I

V

S

G

D

D

R

R

T

V

A

I

I

F

M

M

Y

D

L

D

G

G

R

V

I

I

V

V

E

E

L

E

A

G

P

T

T

P

P

E

E

E

L

I

F

F

D

Y

K

R

P

A

N

K

H

N

P

E

Y

R

A

T

K

R

A

E

L

F

L

L

D

S

E

K

binding adenosine-5'-triphosphate: V16 (≠ A41), S36 (= S61), G37 (= G62), S38 (≠ C63), G39 (= G64), K40 (= K65), S41 (= S66), T42 (= T67), E162 (= E191), H194 (= H224)
binding magnesium ion: S41 (= S66), E162 (= E191)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11

Query Sequence

>AZOBR_RS31025 FitnessBrowser__azobra:AZOBR_RS31025
MTTPPIIELNGLTKRFSRKLDVVERFARRLGAAIDDRAVQAVSGVDLSIAEGEVVGLVGE
SGCGKSTLGRMVAGILPPSAGTLRWRGRDLRELSPADRHHANLKIQMVFQDPMASLNPRL
RVADIVGEAPVVHGLVPRREAEDYVAATLRQVGLDPAYLRRYPHQFSGGQRQRIGIARAL
AVKPDVLVCDESVAALDVSIQAQIINLFMRLREELSLTYLFISHDLGVVEHISDRTAIMY
LGRIVELAPTPELFDKPNHPYAKALLDEAPRVSVEKRRFAPIRGEIPSPLDPPSGCAFHP
RCPHAMPRCSAERPALREIAPRRWSACHLNETTGP

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory