SitesBLAST
Comparing AZOBR_RS31550 FitnessBrowser__azobra:AZOBR_RS31550 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
56% identity, 95% coverage: 16:387/392 of query aligns to 5:376/383 of 4iv6B
- active site: L121 (= L132), T122 (= T133), G240 (= G251), E361 (= E372), K373 (= K384)
- binding dihydroflavine-adenine dinucleotide: L121 (= L132), T122 (= T133), G126 (≠ C137), G127 (= G138), S128 (≠ T139), W152 (= W163), I153 (= I164), S154 (≠ T165), R266 (= R277), S268 (≠ T279), F269 (= F280), I273 (= I284), H276 (= H287), V279 (= V290), R334 (= R345), V335 (≠ I346), G338 (= G349), L356 (= L367), G360 (= G371), T363 (= T374), E365 (= E376), I366 (= I377)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
42% identity, 92% coverage: 27:388/392 of query aligns to 18:378/378 of 5ol2F
- active site: L124 (= L132), T125 (= T133), G241 (= G251), G374 (≠ K384)
- binding calcium ion: E29 (≠ K38), E33 (≠ D42), R35 (≠ T44)
- binding coenzyme a persulfide: L238 (= L248), R242 (= R252), E362 (= E372), G363 (= G373)
- binding flavin-adenine dinucleotide: F122 (≠ L130), L124 (= L132), T125 (= T133), P127 (= P135), T131 (= T139), F155 (≠ W163), I156 (= I164), T157 (= T165), E198 (≠ L207), R267 (= R277), F270 (= F280), L274 (≠ I284), F277 (≠ H287), Q335 (≠ R345), L336 (≠ I346), G338 (= G348), G339 (= G349), Y361 (≠ G371), T364 (= T374), E366 (= E376)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
42% identity, 95% coverage: 16:387/392 of query aligns to 4:373/374 of 5lnxD
- active site: L122 (= L132), T123 (= T133), G239 (= G251), E358 (= E372), K370 (= K384)
- binding flavin-adenine dinucleotide: L122 (= L132), T123 (= T133), G128 (= G138), S129 (≠ T139), F153 (≠ W163), T155 (= T165), R265 (= R277), Q267 (≠ T279), F268 (= F280), I272 (= I284), N275 (≠ H287), I278 (≠ V290), Q331 (≠ R345), I332 (= I346), G335 (= G349), Y357 (≠ G371), T360 (= T374), E362 (= E376)
6es9A Methylsuccinyl-coa dehydrogenase of paracoccus denitrificans with bound flavin adenine dinucleotide (see paper)
40% identity, 96% coverage: 14:388/392 of query aligns to 162:545/545 of 6es9A
- active site: F281 (≠ L132), T282 (= T133), A408 (≠ G251), R541 (≠ K384)
- binding coenzyme a: F467 (≠ Q310), W470 (≠ K313)
- binding flavin-adenine dinucleotide: A279 (≠ L130), F281 (≠ L132), T282 (= T133), G287 (= G138), S288 (≠ T139), W312 (= W163), I313 (= I164), T314 (= T165), E374 (≠ S217), R434 (= R277), Q436 (≠ T279), F437 (= F280), L441 (≠ I284), F444 (≠ H287), Q502 (≠ R345), I503 (= I346), G505 (= G348), G506 (= G349), F528 (≠ G371), A531 (≠ T374), E533 (= E376), I534 (= I377)
Sites not aligning to the query:
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
41% identity, 95% coverage: 15:386/392 of query aligns to 8:378/378 of 4n5fA
- active site: L126 (= L132), T127 (= T133), G243 (= G251), E364 (= E372), R376 (≠ K384)
- binding dihydroflavine-adenine dinucleotide: L126 (= L132), T127 (= T133), G132 (= G138), S133 (≠ T139), F157 (≠ W163), T159 (= T165), T210 (≠ S217), Y363 (≠ G371), T366 (= T374), E368 (= E376), M372 (≠ I380)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
40% identity, 96% coverage: 12:387/392 of query aligns to 33:407/412 of P16219
- G90 (= G69) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (≠ R83) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 130:139, 50% identical) binding in other chain
- R171 (≠ K149) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (= WIT 163:165) binding in other chain
- A192 (≠ G170) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G189) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R277) binding
- Q308 (= Q288) binding in other chain
- R325 (= R305) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (= S333) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ RIHGG 345:349) binding
- R380 (= R360) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ TNE 374:376) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
40% identity, 96% coverage: 12:387/392 of query aligns to 6:380/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ Y350), T347 (≠ K354), E348 (= E355)
- binding flavin-adenine dinucleotide: F125 (≠ L130), L127 (= L132), S128 (≠ T133), G133 (= G138), S134 (≠ T139), W158 (= W163), T160 (= T165), R270 (= R277), F273 (= F280), L280 (≠ H287), V282 (≠ A289), Q338 (≠ R345), I339 (= I346), G342 (= G349), I360 (≠ L367), Y364 (≠ G371), T367 (= T374), E369 (= E376), I370 (= I377), L373 (≠ I380)
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
40% identity, 96% coverage: 12:387/392 of query aligns to 3:377/381 of 8sgsA
- binding coenzyme a: S131 (≠ T139), A133 (≠ L141), N177 (≠ H187), F231 (≠ M241), M235 (≠ I245), L238 (= L248), I312 (≠ D322), E362 (= E372), G363 (= G373)
- binding flavin-adenine dinucleotide: F122 (≠ L130), L124 (= L132), S125 (≠ T133), G130 (= G138), S131 (≠ T139), W155 (= W163), T157 (= T165), R267 (= R277), F270 (= F280), L274 (≠ I284), L277 (≠ H287), Q335 (≠ R345), I336 (= I346), G338 (= G348), G339 (= G349), I357 (≠ L367), I360 (= I370), Y361 (≠ G371), T364 (= T374), E366 (= E376)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
40% identity, 96% coverage: 12:387/392 of query aligns to 9:383/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ L130), L130 (= L132), S131 (≠ T133), G136 (= G138), S137 (≠ T139), W161 (= W163), T163 (= T165), T214 (≠ S217), R273 (= R277), F276 (= F280), L280 (≠ I284), L283 (≠ H287), V285 (≠ A289), Q341 (≠ R345), I342 (= I346), G345 (= G349), I363 (≠ L367), Y367 (≠ G371), T370 (= T374), E372 (= E376), L376 (≠ I380)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
41% identity, 95% coverage: 15:386/392 of query aligns to 3:368/370 of 2dvlA
- active site: L121 (= L132), T122 (= T133), G233 (= G251), E354 (= E372), R366 (≠ K384)
- binding flavin-adenine dinucleotide: L121 (= L132), T122 (= T133), G127 (= G138), S128 (≠ T139), W152 (= W163), I153 (= I164), T154 (= T165), T356 (= T374), E358 (= E376)
7szvA Crystal structure of acyl-coa dehydrogenase from mycobacterium marinum in complex with fda
38% identity, 95% coverage: 13:386/392 of query aligns to 4:370/372 of 7szvA
- binding dihydroflavine-adenine dinucleotide: L122 (= L132), T123 (= T133), F153 (≠ W163), I154 (= I164), T155 (= T165), K194 (= K209), R261 (= R277), S263 (≠ T279), Y271 (≠ H287), I274 (≠ V290), Q329 (≠ R345), V330 (≠ I346), G332 (= G348), G333 (= G349), T358 (= T374), E360 (= E376)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
39% identity, 96% coverage: 10:387/392 of query aligns to 2:377/379 of 1ukwB
- active site: L124 (= L132), S125 (≠ T133), T241 (≠ G251), E362 (= E372), R374 (≠ K384)
- binding cobalt (ii) ion: D145 (= D153), H146 (≠ D154)
- binding flavin-adenine dinucleotide: F122 (≠ L130), L124 (= L132), S125 (≠ T133), G130 (= G138), S131 (≠ T139), W155 (= W163), S157 (≠ T165), K200 (= K209), L357 (= L367), Y361 (≠ G371), E362 (= E372), T364 (= T374), E366 (= E376), L370 (≠ I380)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
39% identity, 96% coverage: 10:387/392 of query aligns to 2:377/379 of 1ukwA
- active site: L124 (= L132), S125 (≠ T133), T241 (≠ G251), E362 (= E372), R374 (≠ K384)
- binding flavin-adenine dinucleotide: F122 (≠ L130), L124 (= L132), S125 (≠ T133), G130 (= G138), S131 (≠ T139), W155 (= W163), S157 (≠ T165), L357 (= L367), Y361 (≠ G371), E362 (= E372), T364 (= T374), E366 (= E376), L370 (≠ I380)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
38% identity, 97% coverage: 6:387/392 of query aligns to 27:407/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
39% identity, 96% coverage: 12:387/392 of query aligns to 6:380/384 of 1jqiA
- active site: G377 (≠ K384)
- binding acetoacetyl-coenzyme a: L95 (= L99), F125 (≠ L130), S134 (≠ T139), F234 (≠ M241), M238 (≠ I245), Q239 (≠ S246), L241 (= L248), D242 (≠ E249), R245 (= R252), Y364 (≠ G371), E365 (= E372), G366 (= G373)
- binding flavin-adenine dinucleotide: F125 (≠ L130), L127 (= L132), S128 (≠ T133), G133 (= G138), S134 (≠ T139), W158 (= W163), T160 (= T165), R270 (= R277), F273 (= F280), L280 (≠ H287), Q338 (≠ R345), I339 (= I346), G342 (= G349), I360 (≠ L367), T367 (= T374), E369 (= E376), I370 (= I377)
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
38% identity, 93% coverage: 22:387/392 of query aligns to 6:368/369 of 3pfdC
- active site: L116 (= L132), S117 (≠ T133), T233 (≠ G251), E353 (= E372), R365 (≠ K384)
- binding dihydroflavine-adenine dinucleotide: Y114 (≠ L130), L116 (= L132), S117 (≠ T133), G122 (= G138), S123 (≠ T139), W147 (= W163), I148 (= I164), T149 (= T165), R259 (= R277), F262 (= F280), V266 (≠ I284), N269 (≠ H287), Q326 (≠ R345), L327 (≠ I346), G330 (= G349), I348 (≠ L367), Y352 (≠ G371), T355 (= T374), Q357 (≠ E376)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
38% identity, 96% coverage: 10:387/392 of query aligns to 2:378/380 of 4l1fA
- active site: L125 (= L132), T126 (= T133), G242 (= G251), E363 (= E372), R375 (≠ K384)
- binding coenzyme a persulfide: T132 (= T139), H179 (= H187), F232 (≠ M241), M236 (≠ I245), E237 (≠ S246), L239 (= L248), D240 (≠ E249), R243 (= R252), Y362 (≠ G371), E363 (= E372), G364 (= G373), R375 (≠ K384)
- binding flavin-adenine dinucleotide: F123 (≠ L130), L125 (= L132), T126 (= T133), G131 (= G138), T132 (= T139), F156 (≠ W163), I157 (= I164), T158 (= T165), R268 (= R277), Q270 (≠ T279), F271 (= F280), I275 (= I284), F278 (≠ H287), L281 (≠ V290), Q336 (≠ R345), I337 (= I346), G340 (= G349), I358 (≠ L367), Y362 (≠ G371), T365 (= T374), Q367 (≠ E376)
- binding 1,3-propandiol: L5 (≠ R13), Q10 (≠ R18)
2d29A Structural study on project id tt0172 from thermus thermophilus hb8
41% identity, 96% coverage: 12:388/392 of query aligns to 5:384/386 of 2d29A
- active site: L126 (= L132), T127 (= T133), G247 (= G251), E368 (= E372), R380 (≠ K384)
- binding flavin-adenine dinucleotide: L126 (= L132), T127 (= T133), G132 (= G138), S133 (≠ T139), F157 (≠ W163), I158 (= I164), T159 (= T165), L363 (= L367), T370 (= T374), E372 (= E376)
1ivhA Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity (see paper)
37% identity, 94% coverage: 15:384/392 of query aligns to 10:382/387 of 1ivhA
- active site: M130 (≠ L132), S131 (≠ T133), E249 (≠ G251), A370 (≠ E372), R382 (≠ K384)
- binding coenzyme a persulfide: S137 (≠ T139), S185 (≠ H187), R186 (≠ K188), V239 (≠ M241), Y240 (≠ A242), M243 (≠ I245), E249 (≠ G251), R250 (= R252), G369 (= G371), A370 (≠ E372), G371 (= G373), V375 (≠ I377)
- binding flavin-adenine dinucleotide: L128 (= L130), M130 (≠ L132), S131 (≠ T133), G136 (= G138), S137 (≠ T139), W161 (= W163), T163 (= T165), R275 (= R277), F278 (= F280), F285 (≠ H287), M288 (≠ V290), Q343 (≠ R345), C344 (≠ I346), G347 (= G349), T372 (= T374), E374 (= E376)
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
39% identity, 95% coverage: 15:387/392 of query aligns to 3:367/371 of 2vigB
- active site: L121 (= L132), S122 (≠ T133), G231 (= G251), E352 (= E372), G364 (≠ K384)
- binding coenzyme a persulfide: S128 (≠ T139), F221 (≠ M241), M225 (≠ I245), Q226 (≠ S246), L228 (= L248), D229 (≠ E249), R232 (= R252), E352 (= E372), G353 (= G373), I357 (= I377)
- binding flavin-adenine dinucleotide: L121 (= L132), S122 (≠ T133), G127 (= G138), S128 (≠ T139), W152 (= W163), T154 (= T165), R257 (= R277), F260 (= F280), L264 (≠ I284), L267 (≠ H287), Q325 (≠ R345), I326 (= I346), G329 (= G349), I347 (≠ L367), Y351 (≠ G371), T354 (= T374), E356 (= E376)
Query Sequence
>AZOBR_RS31550 FitnessBrowser__azobra:AZOBR_RS31550
MSETTTSMTDAERDEQDRLILDSVDRFLDRHVRPVALKLEHDDTYPDEIVERMKELGLFG
ATIPEEYGGLGLRPSTYAKMIERISSVWMSLSGIINSHLIMAFIVTKTGTEEQKAAFLPR
FATGELRGGLALTEPDCGTDLQAIRTVAKRDGDDYVINGSKTWITNGIQGSCFALLVKTD
PTAQPRHKGMTMFLAEKGPGFKVSRKLEKLGYKGIDSAELVFEDYRVPADRLIGGVEGRG
MACAISGLELGRVNVASRGVGVAQAALDESVKYSQQRKTFGKPIHEHQAVAMKLADMATR
VSAARLLVQQAAKALDRGERCDYEAGMAKLFASEAAVENSLDAMRIHGGYGYSKEFVVER
LYRDAPLLCIGEGTNEIQRIIIAKRLIEQNPV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory