SitesBLAST
Comparing Ac3H11_1086 FitnessBrowser__acidovorax_3H11:Ac3H11_1086 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
8i01A Crystal structure of escherichia coli glyoxylate carboligase
74% identity, 99% coverage: 1:590/596 of query aligns to 2:586/594 of 8i01A
- binding flavin-adenine dinucleotide: R155 (= R154), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (≠ C255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), A283 (= A282), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), G417 (= G418)
- binding magnesium ion: D447 (= D448), F452 (= F453), E455 (= E456), N474 (= N475), Y476 (= Y477)
- binding thiamine diphosphate: G395 (= G396), L396 (= L397), S397 (= S398), L422 (= L423), G446 (= G447), D447 (= D448), F448 (≠ Y449), D449 (= D450), N474 (= N475), Y476 (= Y477), L477 (= L478), G478 (= G479), L479 (= L480), I480 (= I481)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q354 (= Q353), C492 (= C493), Q494 (= Q495)
Sites not aligning to the query:
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
74% identity, 99% coverage: 2:590/596 of query aligns to 1:584/592 of 8beoB
- binding methyl hydrogen (s)-acetylphosphonate: C490 (= C493), Q492 (= Q495)
- binding flavin-adenine dinucleotide: R153 (= R154), P154 (= P155), G210 (= G211), G211 (= G212), G212 (= G213), N215 (= N216), T236 (= T237), L237 (= L238), M238 (= M239), V254 (≠ C255), G255 (= G256), Q257 (= Q258), T258 (= T259), G277 (= G278), N278 (= N279), R279 (= R280), A281 (= A282), R283 (= R284), H284 (= H285), D301 (= D302), I302 (= I303), Q306 (= Q307), D320 (= D321), A321 (= A322), G415 (= G418)
- binding magnesium ion: D445 (= D448), F450 (= F453), L451 (≠ M454), E453 (= E456), N472 (= N475), Y474 (= Y477)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R284), G393 (= G396), L394 (= L397), S395 (= S398), L420 (= L423), G444 (= G447), D445 (= D448), F446 (≠ Y449), D447 (= D450), N472 (= N475), Y474 (= Y477), L475 (= L478), G476 (= G479), L477 (= L480), I478 (= I481)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q352 (= Q353), R356 (≠ H357)
Sites not aligning to the query:
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
74% identity, 99% coverage: 2:590/596 of query aligns to 1:584/592 of 8beoA
- binding flavin-adenine dinucleotide: R153 (= R154), P154 (= P155), G210 (= G211), G211 (= G212), G212 (= G213), N215 (= N216), T236 (= T237), L237 (= L238), M238 (= M239), V254 (≠ C255), G255 (= G256), Q257 (= Q258), T258 (= T259), G277 (= G278), N278 (= N279), R279 (= R280), A281 (= A282), R283 (= R284), H284 (= H285), D301 (= D302), I302 (= I303), Q306 (= Q307), D320 (= D321), A321 (= A322), I397 (= I400), G415 (= G418)
- binding magnesium ion: R384 (≠ K387), V405 (= V408), F406 (≠ Y409), H410 (= H413), D445 (= D448), F450 (= F453), L451 (≠ M454), E453 (= E456), N472 (= N475), Y474 (= Y477)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R284), G393 (= G396), L394 (= L397), S395 (= S398), L420 (= L423), G444 (= G447), D445 (= D448), F446 (≠ Y449), D447 (= D450), N472 (= N475), Y474 (= Y477), L475 (= L478), G476 (= G479), L477 (= L480), I478 (= I481)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: E248 (≠ P249), Q352 (= Q353)
Sites not aligning to the query:
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
74% identity, 99% coverage: 1:590/596 of query aligns to 2:586/594 of 8i07D
- binding 2-oxidanylethanal: R285 (= R284), I480 (= I481)
- binding flavin-adenine dinucleotide: R155 (= R154), P156 (= P155), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (≠ C255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), I399 (= I400), G417 (= G418)
- binding magnesium ion: D447 (= D448), F452 (= F453), L453 (≠ M454), E455 (= E456), N474 (= N475), Y476 (= Y477)
- binding thiamine diphosphate: V52 (= V51), T76 (= T75), G395 (= G396), L396 (= L397), S397 (= S398), L422 (= L423), G446 (= G447), D447 (= D448), F448 (≠ Y449), D449 (= D450), N474 (= N475), Y476 (= Y477), L477 (= L478), G478 (= G479), L479 (= L480), I480 (= I481)
- binding ubiquinone-1: Q354 (= Q353), R358 (≠ H357), C492 (= C493), Q494 (= Q495)
Sites not aligning to the query:
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
74% identity, 99% coverage: 1:590/596 of query aligns to 2:586/594 of 8i07A
- binding flavin-adenine dinucleotide: R155 (= R154), P156 (= P155), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (≠ C255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), I394 (= I395), I399 (= I400), G417 (= G418)
- binding magnesium ion: D447 (= D448), F452 (= F453), L453 (≠ M454), E455 (= E456), N474 (= N475), Y476 (= Y477)
- binding thiamine diphosphate: I394 (= I395), G395 (= G396), L396 (= L397), S397 (= S398), L422 (= L423), G446 (= G447), D447 (= D448), F448 (≠ Y449), D449 (= D450), N474 (= N475), Y476 (= Y477), L477 (= L478), G478 (= G479), L479 (= L480), I480 (= I481)
- binding ubiquinone-1: Q354 (= Q353), C492 (= C493), Q494 (= Q495)
Sites not aligning to the query:
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
32% identity, 93% coverage: 5:560/596 of query aligns to 95:638/667 of P09342
- C161 (= C72) modified: Disulfide link with 307
- P194 (= P105) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ I214) modified: Disulfide link with 161
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ I395), G401 (= G396), Q402 (≠ L397), H403 (≠ S398), G426 (= G421), M428 (≠ L423), G452 (= G447), D453 (= D448), G454 (≠ Y449), S455 (≠ D450), M458 (≠ F453), N480 (= N475), H482 (≠ Y477), L483 (= L478), G484 (= G479), M485 (≠ L480), V486 (≠ I481)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I400), G423 (= G418)
- binding magnesium ion: F370 (≠ R363), D453 (= D448), M458 (≠ F453), Q461 (≠ E456), N480 (= N475), H482 (≠ Y477)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ L257), R292 (= R284), M485 (≠ L480), W489 (≠ A484)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 5wj1A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), M263 (= M254), L264 (≠ C255), G286 (= G278), R288 (= R280), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I400), G423 (= G418), G424 (≠ Q419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ L257), D291 (≠ N283), R292 (= R284), M485 (≠ L480), W489 (≠ A484)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I395), G401 (= G396), Q402 (≠ L397), H403 (≠ S398), M428 (≠ L423), D453 (= D448), G454 (≠ Y449), S455 (≠ D450), M458 (≠ F453), N480 (= N475), H482 (≠ Y477), L483 (= L478), G484 (= G479), M485 (≠ L480), V486 (≠ I481)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 5k6tA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ Q258), R292 (= R284), M485 (≠ L480), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), G286 (= G278), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q399), M405 (≠ I400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I395), G401 (= G396), Q402 (≠ L397), H403 (≠ S398), G426 (= G421), M428 (≠ L423), G452 (= G447), G454 (≠ Y449), S455 (≠ D450), N480 (= N475), H482 (≠ Y477), L483 (= L478), G484 (= G479)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 5k6rA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R284), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), M266 (≠ L257), G286 (= G278), R288 (= R280), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), G328 (≠ S320), D329 (= D321), V330 (≠ A322), M405 (≠ I400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I395), G401 (= G396), Q402 (≠ L397), H403 (≠ S398), G426 (= G421), M428 (≠ L423), D453 (= D448), G454 (≠ Y449), S455 (≠ D450), M458 (≠ F453), N480 (= N475), H482 (≠ Y477), L483 (= L478), G484 (= G479), M485 (≠ L480), V486 (≠ I481)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 1z8nA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K128), R161 (= R154), Y191 (= Y178), R194 (≠ L181), D291 (≠ N283), R292 (= R284), D312 (≠ E304), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I400), G423 (= G418), G424 (≠ Q419)
- binding magnesium ion: D453 (= D448), N480 (= N475)
- binding thiamine diphosphate: V400 (≠ I395), G401 (= G396), Q402 (≠ L397), H403 (≠ S398), G426 (= G421), M428 (≠ L423), G452 (= G447), G454 (≠ Y449), S455 (≠ D450), N480 (= N475), H482 (≠ Y477), L483 (= L478), G484 (= G479), M485 (≠ L480), V486 (≠ I481)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 1yi1A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (≠ N283), R292 (= R284), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), M263 (= M254), L264 (≠ C255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I400), G423 (= G418), G424 (≠ Q419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 1yi0A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N283), R292 (= R284), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), G328 (≠ S320), D329 (= D321), V330 (≠ A322), M405 (≠ I400), G423 (= G418), G424 (≠ Q419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 1yhzA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (≠ N283), R292 (= R284), M485 (≠ L480), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q399), M405 (≠ I400), G423 (= G418), G424 (≠ Q419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 1yhyA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N283), R292 (= R284), V486 (≠ I481), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q399), M405 (≠ I400), G423 (= G418), G424 (≠ Q419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
Sites not aligning to the query:
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/582 of 1ybhA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ L257), D291 (≠ N283), R292 (= R284), M485 (≠ L480), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q399), M405 (≠ I400), G423 (= G418), G424 (≠ Q419)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
Sites not aligning to the query:
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/585 of 5k2oA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ L257), R292 (= R284), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), G286 (= G278), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q399), M405 (≠ I400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I395), G401 (= G396), Q402 (≠ L397), H403 (≠ S398), M428 (≠ L423), D453 (= D448), G454 (≠ Y449), S455 (≠ D450), N480 (= N475), H482 (≠ Y477), L483 (= L478), G484 (= G479), M485 (≠ L480), V486 (≠ I481)
Sites not aligning to the query:
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
33% identity, 81% coverage: 5:488/596 of query aligns to 98:578/670 of P17597
- A122 (= A29) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ N31) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (≠ V51) binding
- S186 (= S94) binding
- P197 (= P105) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ A107) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q115) binding
- K220 (= K128) binding
- R246 (= R154) binding ; binding
- K256 (≠ I164) binding
- G308 (= G212) binding
- TL 331:332 (= TL 237:238) binding
- C340 (≠ D246) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ CGLQ 255:258) binding
- GVRFD 371:375 (≠ GNRWA 278:282) binding
- DR 376:377 (≠ NR 283:284) binding
- DI 395:396 (= DI 302:303) binding
- DV 414:415 (≠ DA 321:322) binding
- QH 487:488 (≠ LS 397:398) binding
- GG 508:509 (≠ GQ 418:419) binding
- GAM 511:513 (≠ GPL 421:423) binding
- D538 (= D448) binding
- DGS 538:540 (≠ DYD 448:450) binding
- N565 (= N475) binding
- NQHLGM 565:570 (≠ NSYLGL 475:480) binding
- H567 (≠ Y477) binding
- W574 (≠ A484) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
Sites not aligning to the query:
- 653 binding ; S→A: No effect on catalytic activity or sensitivity to herbicides.; S→F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; S→N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; S→T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 13:493/583 of 5k3sA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ I164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I395), G426 (= G421), M428 (≠ L423), D453 (= D448), N480 (= N475), H482 (≠ Y477), L483 (= L478), M485 (≠ L480), V486 (≠ I481), W489 (≠ A484)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R284), M485 (≠ L480), W489 (≠ A484)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ C255), M266 (≠ L257), G286 (= G278), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I400), G423 (= G418)
- binding magnesium ion: D453 (= D448), N480 (= N475), H482 (≠ Y477)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I395), G401 (= G396), Q402 (≠ L397), H403 (≠ S398), G426 (= G421), M428 (≠ L423), D453 (= D448), G454 (≠ Y449), S455 (≠ D450), N480 (= N475), H482 (≠ Y477), L483 (= L478), G484 (= G479), M485 (≠ L480), V486 (≠ I481)
Sites not aligning to the query:
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
33% identity, 81% coverage: 5:488/596 of query aligns to 12:492/582 of 3ea4A
- active site: Y32 (≠ V25), G34 (= G27), G35 (≠ A28), A36 (= A29), S37 (≠ I30), E58 (≠ V51), T81 (= T75), F120 (= F114), Q121 (= Q115), E122 (≠ A116), K170 (≠ I164), M265 (≠ L257), V292 (≠ H285), V399 (≠ I395), G425 (= G421), M427 (≠ L423), D452 (= D448), N479 (= N475), H481 (≠ Y477), L482 (= L478), M484 (≠ L480), V485 (≠ I481), W488 (≠ A484)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (≠ N283), R291 (= R284), W488 (≠ A484)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G211), G222 (= G212), G223 (= G213), T245 (= T237), L246 (= L238), M247 (= M239), L263 (≠ C255), G264 (= G256), M265 (≠ L257), H266 (≠ Q258), G285 (= G278), R287 (= R280), D289 (≠ A282), R291 (= R284), D309 (= D302), I310 (= I303), G327 (≠ S320), D328 (= D321), V329 (≠ A322), M404 (≠ I400), G422 (= G418)
- binding magnesium ion: D452 (= D448), N479 (= N475), H481 (≠ Y477)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ I395), G400 (= G396), Q401 (≠ L397), H402 (≠ S398), M427 (≠ L423), G451 (= G447), D452 (= D448), G453 (≠ Y449), S454 (≠ D450), N479 (= N475), H481 (≠ Y477), L482 (= L478), G483 (= G479), M484 (≠ L480), V485 (≠ I481)
Sites not aligning to the query:
Query Sequence
>Ac3H11_1086 FitnessBrowser__acidovorax_3H11:Ac3H11_1086
MARMKAIEAAVKVMEKEGVSVAFGVPGAAINPLYAALKAHGGIGHILARHVEGASHMAEG
YTRAVAGNIGVCIGTSGPAGTDMITGLYSASADSIPILCITGQAPRARLHKEDFQAVDIA
SIAKSVTKWATTVLEPAQVPGAFQQAFHLMRSGRPGPVLIDLPIDVQLAEIEFDPDTYEP
LVPYKPAATRAQIEKALSMLNAAERPLIVAGGGIINADASDLLVQFAEVLGVPVIPTLMG
WGSIPDDHPLMVGMCGLQTSQRYGNATLLASDFVLGIGNRWANRHTGSVDVYTKGRKFVH
VDIEPTQIGRVFAPDFGIVSDAGAALKLFVEVAREWKAVGQLRDRSTWAAECQGRKHSVD
YLRKTHFDSVPMKPQRVYQCMNRALGKDVCYVSTIGLSQIAGAQFLHVYQPRHWINCGQA
GPLGWTVPAALGVRVADPARKIVALSGDYDFQFMIEELAVGAQFKLPYLHVLVNNSYLGL
IRQAQRTFSIDYCVQLAFDNVNMAEGEVARGYGVDHVKVVEGLGCKAIRVHRPEEFAPAL
AQAEAWMAEHRTPVVIEVILERVTNIAMGTEIDNIVEFEELAMQAADVPSALAVLD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory