SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ac3H11_1332 Acetylornithine aminotransferase (EC 2.6.1.11) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

2eh6A Crystal structure of acetylornithine aminotransferase from aquifex aeolicus vf5
45% identity, 96% coverage: 11:392/398 of query aligns to 2:375/375 of 2eh6A

query
sites
2eh6A

H

Y

V

L

M

M

N

N

T

N

Y

Y

G

A

R

R

V

L

P

P

I

V

A

K

L

F

E

V

R

R

G

G

Q

K

G

G

C

V

R

Y

V

L

W

Y

D

D

V

E

N

E

G

G

K

K

E

E

Y

Y

I

L

D

D

G

F

L

V

G

S

G

G

I

I

A

G

V

V

N

N

T

S

L

L

G

G

H

H

N

A

H

Y

G

P

K

K

L

L

V

T

P

E

A

A

L

L

Q

K

D

E

Q

Q

I

V

A

E

K

K

L

L

I

L

H

H

T

V

S

S

N

N

Y

L

Y

Y

H

E

V

N

P

P

L

W

Q

Q

E

E

K

E

L

L

A

A

T

H

K

K

L

L

V

V

E

K

L

H

S

F

G

W

M

T

Q

E

-

G

N

K

V

V

F

F

F

F

C

A

N

N

S
|
S

G
|
G

L
x
T

E

E

A

S

N

V

E

E

A

A

A

A

L

I

K

K

I

L

A

A

R

R

K

K

F

Y

G

W

V

R

D

D

K

K

G

G

I

K

A

N

K

K

P

W

E

K

I

F

V

I

V

S

Y

F

E

E

K

N

A

S

F
|
F

H
|
H

G
|
G

R

R

S

T

I

Y

A

G

T

S

M

L

S

S

A

A

T

T

G

G

N

Q

P

P

K

K

I

F

H

H

N

K

G

G

F

F

G

E

P

P

L

L

V

V

E

P

G

G

F

F

V

S

R

Y

V

A

P

K

M

L

N

N

D

D

I

I

E

D

A

S

I

V

K

Y

Q

K

A

L

T

L

E

-

G

-

N

D

P

E

N

E

V

T

V

A

A

G

V

I

F

I

F

I

E
|
E

T

V

I

I

Q

Q

G

G

E

E

G

G

G

G

I

V

N

N

G

E

M

A

R

S

I

E

E

D

Y

F

L

L

Q

S

Q

K

L

L

R

Q

K

E

L

I

C

C

D

K

E

E

R

K

G

D

W

V

L

L

M

L

M

I

I

I

D
|
D

E

E

V
|
V

Q
|
Q

C

T

G

G

M

I

G

G

R

R

T

T

G

G

K

E

W

F

F

Y

A

A

H

Y

Q

Q

W

H

A

F

G

N

I

L

V

K

P

P

D

D

V

V

M

I

P

A

L

L

A

A

K
|
K

G

G

L

L

G

G

S

G

G

G

V

V

P

P

I

I

G

G

A

A

V

I

V

L

A

A

G

R

P

E

K

E

A

V

A

A

N

Q

V

S

L

F

Q

T

P

P

G

G

N

S

H

H

G

G

T
x
S

T
|
T

F
|
F

G

G

G

G

N

N

P

P

L

L

A

A

M

C

R

R

A

A

G

G

V

-

E

-

T

T

I

V

R

V

I

V

M

D

E

E

E

V

D

E

G

K

L

L

L

L

H

P

N

H

A

V

A

R

Q

E

V

V

G

G

D

N

H

Y

L

F

R

K

A

E

A

K

L

L

Q

-

R

K

E

E

L

L

G

G

S

K

L

-

P

-

G

-

V

-

K

G

E

K

I

V

R

K

G

G

Q

R

G

G

L

L

M

M

L

L

G

G

I

L

E

E

L

L

N

E

K

R

P

E

C

C

G

K

A

D

L

Y

I

V

G

L

R

K

A

A

A

L

E

E

A

K

G

G

L

L

L

L

L

I

S

N

V

C

T

T

A

A

D

G

S

K

V

V

I

L

R
|
R

L

F

V

L

P

P

P

P

L

L

I

I

L

I

T

Q

T

K

A

E

E

H

A

I

D

D

A

R

I

A

V

I

A

S

I

V

L

L

T

R

P

E

L

I

V

L

active site: F127 (= F135), E179 (= E189), D212 (= D222), Q215 (= Q225), K241 (= K251), T270 (= T280), R352 (= R369)
binding pyridoxal-5'-phosphate: S94 (= S102), G95 (= G103), T96 (≠ L104), F127 (= F135), H128 (= H136), G129 (= G137), E179 (= E189), D212 (= D222), V214 (= V224), Q215 (= Q225), K241 (= K251), S269 (≠ T279), T270 (= T280), F271 (= F281)

O66442 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Aquifex aeolicus (strain VF5)
45% identity, 96% coverage: 11:392/398 of query aligns to 3:376/376 of O66442

query
sites
O66442

H

Y

V

L

M

M

N

N

T

N

Y

Y

G

A

R

R

V

L

P

P

I

V

A

K

L

F

E

V

R

R

G

G

Q

K

G

G

C

V

R

Y

V

L

W

Y

D

D

V

E

N

E

G

G

K

K

E

E

Y

Y

I

L

D

D

G

F

L

V

G

S

G

G

I

I

A

G

V

V

N

N

T

S

L

L

G

G

H

H

N

A

H

Y

G

P

K

K

L

L

V

T

P

E

A

A

L

L

Q

K

D

E

Q

Q

I

V

A

E

K

K

L

L

I

L

H

H

T

V

S

S

N

N

Y

L

Y

Y

H

E

V

N

P

P

L

W

Q

Q

E

E

K

E

L

L

A

A

T

H

K

K

L

L

V

V

E

K

L

H

S

F

G

W

M

T

Q

E

-

G

N

K

V

V

F

F

F

F

C

A

N

N

S

S

G
|
G

L
x
T

E

E

A

S

N

V

E

E

A

A

A

A

L

I

K

K

I

L

A

A

R

R

K

K

F

Y

G

W

V

R

D

D

K

K

G

G

I

K

A

N

K

K

P

W

E

K

I

F

V

I

V

S

Y

F

E

E

K

N

A

S

F

F

H

H

G

G

R

R

S

T

I

Y

A

G

T

S

M

L

S

S

A

A

T

T

G

G

N

Q

P

P

K

K

I

F

H

H

N

K

G

G

F

F

G

E

P

P

L

L

V

V

E

P

G

G

F

F

V

S

R

Y

V

A

P

K

M

L

N

N

D

D

I

I

E

D

A

S

I

V

K

Y

Q

K

A

L

T

L

E

-

G

-

N

D

P

E

N

E

V

T

V

A

A

G

V

I

F

I

F

I

E

E

T

V

I

I

Q

Q

G

G

E

E

G

G

G

G

I

V

N

N

G

E

M

A

R

S

I

E

E

D

Y

F

L

L

Q

S

Q

K

L

L

R

Q

K

E

L

I

C

C

D

K

E

E

R

K

G

D

W

V

L

L

M

L

M

I

I

I

D

D

E

E

V

V

Q

Q

C

T

G

G

M

I

G

G

R

R

T

T

G

G

K

E

W

F

F

Y

A

A

H

Y

Q

Q

W

H

A

F

G

N

I

L

V

K

P

P

D

D

V

V

M

I

P

A

L

L

A

A

K
|
K

G

G

L

L

G

G

S

G

G

G

V

V

P

P

I

I

G

G

A

A

V

I

V

L

A

A

G

R

P

E

K

E

A

V

A

A

N

Q

V

S

L

F

Q

T

P

P

G

G

N

S

H

H

G

G

T

S

T
|
T

F

F

G

G

G

G

N

N

P

P

L

L

A

A

M

C

R

R

A

A

G

G

V

-

E

-

T

T

I

V

R

V

I

V

M

D

E

E

E

V

D

E

G

K

L

L

L

L

H

P

N

H

A

V

A

R

Q

E

V

V

G

G

D

N

H

Y

L

F

R

K

A

E

A

K

L

L

Q

-

R

K

E

E

L

L

G

G

S

K

L

-

P

-

G

-

V

-

K

G

E

K

I

V

R

K

G

G

Q

R

G

G

L

L

M

M

L

L

G

G

I

L

E

E

L

L

N

E

K

R

P

E

C

C

G

K

A

D

L

Y

I

V

G

L

R

K

A

A

A

L

E

E

A

K

G

G

L

L

L

L

L

I

S

N

V

C

T

T

A

A

D

G

S

K

V

V

I

L

R

R

L

F

V

L

P

P

P

P

L

L

I

I

L

I

T

Q

T

K

A

E

E

H

A

I

D

D

A

R

I

A

V

I

A

S

I

V

L

L

T

R

P

E

L

I

V

L

GT 96:97 (≠ GL 103:104) binding
K242 (= K251) modified: N6-(pyridoxal phosphate)lysine
T271 (= T280) binding

2ordA Crystal structure of acetylornithine aminotransferase (ec 2.6.1.11) (acoat) (tm1785) from thermotoga maritima at 1.40 a resolution
45% identity, 97% coverage: 11:395/398 of query aligns to 10:393/393 of 2ordA

query
sites
2ordA

H

Y

V

L

M

M

N

N

T

T

Y

Y

G

S

R

R

V

F

P

P

I

A

A

T

L

F

E

V

R

Y

G

G

Q

K

G

G

C

S

R

W

V

I

W

Y

D

D

V

E

N

K

G

G

K

N

E

A

Y

Y

I

L

D

D

G

F

L

T

G

S

G

G

I

I

A

A

V

V

N

N

T

V

L

L

G

G

H

H

N

S

H

H

G

P

K

R

L

L

V

V

P

E

A

A

L

I

Q

K

D

D

Q

Q

I

A

A

E

K

K

L

L

I

I

H

H

T

C

S

S

N

N

Y

L

Y

F

H

W

V

N

P

R

L

P

Q

Q

E

M

K

E

L

L

A

A

T

E

K

L

L

L

V

S

E

K

L

N

S

T

G

F

M

G

Q

G

N

K

V

V

F

F

F

F

C

A

N

N

S
x
T

G
|
G

L
x
T

E

E

A

A

N
|
N

E

E

A

A

A

A

L

I

K

K

I

I

A

A

R

R

K

K

F

Y

G

G

V

K

D

K

K

K

G

S

I

E

A

K

K

K

P

Y

E

R

I

I

V

L

V

S

Y

A

E

H

K

N

A

S

F
|
F

H
|
H

G
|
G

R

R

S

T

I

L

A

G

T

S

M

L

S

T

A

A

T

T

G

G

N

Q

P

P

K

K

I

Y

H

Q

N

K

G

P

F

F

G

E

P

P

L

L

V

V

E

P

G

G

F

F

V

E

R

Y

V

F

P

E

M

F

N

N

D

N

I

V

E

E

A

D

I

L

K

R

Q

R

A

K

T

M

E

-

G

-

N

S

P

E

N

D

V

V

V

C

A

A

V

V

F

F

F

L

E
|
E

T

P

I

I

Q

Q

G

G

E
|
E

G

S

G

G

I

I

N

V

G

P

M

A

R

T

I

K

E

E

Y

F

L

L

Q

E

Q

E

L

A

R

R

K

K

L

L

C

C

D

D

E

E

R

Y

G

D

W

A

L

L

M

L

M

V

I

F

D
|
D

E

E

V
|
V

Q
|
Q

C

C

G

G

M

M

G

G

R

R

T

T

G

G

K

K

W

L

F

F

A

A

H

Y

Q

Q

W

K

A

Y

G

G

I

V

V

V

P

P

D

D

V

V

M

L

P

T

L

T

A

A

K
|
K

G

G

L

L

G

G

S

G

G

G

V

V

P

P

I

I

G

G

A

A

V

V

V

I

A

V

G

N

P

E

K

R

A

-

A

A

N

N

V

V

L

L

Q

E

P

P

G

G

N

D

H

H

G

G

T
|
T

T
|
T

F

F

G

G

G

G

N

N

P

P

L

L

A

A

M

C

R

R

A

A

G

G

V

V

E

T

T

V

I

I

R

K

I

E

M

L

E

T

E

K

D

E

G

G

L

F

L

L

H

E

N

E

A

V

A

E

Q

E

V

K

G

G

D

N

H

Y

L

L

R

M

A

K

A

K

L

L

Q

Q

R

E

E

M

L

K

G

E

S

E

L

Y

P

D

G

V

V

V

K

A

E

D

I

V

R

R

G

G

Q

M

G

G

L

L

M

M

L

I

G

G

I

I

E

Q

L

F

N

R

K

E

P

E

C

V

G

S

-

N

-

R

A

E

L

V

I

A

G

T

R

K

A

C

A

F

E

E

A

N

G

K

L

L

L

L

L

V

S

V

V

P

T

A

A

G

D

N

S

N

V

T

I

I

R
|
R

L

F

V

L

P

P

P

P

L

L

I

T

L

V

T

E

T

Y

A

G

E

E

A

I

D

D

A

L

I

A

V

V

A

E

I

T

L

L

T

K

P

K

L

V

V

L

K

Q

A

G

I

I

active site: F134 (= F135), E186 (= E189), D219 (= D222), Q222 (= Q225), K248 (= K251), T276 (= T280), R367 (= R369)
binding pyridoxal-5'-phosphate: T101 (≠ S102), G102 (= G103), T103 (≠ L104), N106 (= N107), F134 (= F135), H135 (= H136), G136 (= G137), E186 (= E189), E191 (= E194), D219 (= D222), V221 (= V224), Q222 (= Q225), K248 (= K251), T275 (= T279), T276 (= T280)

Q9X2A5 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
45% identity, 97% coverage: 11:395/398 of query aligns to 2:385/385 of Q9X2A5

query
sites
Q9X2A5

H

Y

V

L

M

M

N

N

T

T

Y

Y

G

S

R

R

V

F

P

P

I

A

A

T

L

F

E

V

R

Y

G

G

Q

K

G

G

C

S

R

W

V

I

W

Y

D

D

V

E

N

K

G

G

K

N

E

A

Y

Y

I

L

D

D

G

F

L

T

G

S

G

G

I

I

A

A

V

V

N

N

T

V

L

L

G

G

H

H

N

S

H

H

G

P

K

R

L

L

V

V

P

E

A

A

L

I

Q

K

D

D

Q

Q

I

A

A

E

K

K

L

L

I

I

H

H

T

C

S

S

N

N

Y

L

Y

F

H

W

V

N

P

R

L

P

Q

Q

E

M

K

E

L

L

A

A

T

E

K

L

L

L

V

S

E

K

L

N

S

T

G

F

M

G

Q

G

N

K

V

V

F

F

F

F

C

A

N

N

S

T

G
|
G

L
x
T

E

E

A

A

N

N

E

E

A

A

A

A

L

I

K

K

I

I

A

A

R

R

K

K

F

Y

G

G

V

K

D

K

K

K

G

S

I

E

A

K

K

K

P

Y

E

R

I

I

V

L

V

S

Y

A

E

H

K

N

A

S

F

F

H

H

G

G

R

R

S

T

I

L

A

G

T

S

M

L

S

T

A

A

T

T

G

G

N

Q

P

P

K

K

I

Y

H

Q

N

K

G

P

F

F

G

E

P

P

L

L

V

V

E

P

G

G

F

F

V

E

R

Y

V

F

P

E

M

F

N

N

D

N

I

V

E

E

A

D

I

L

K

R

Q

R

A

K

T

M

E

-

G

-

N

S

P

E

N

D

V

V

V

C

A

A

V

V

F

F

F

L

E

E

T

P

I

I

Q

Q

G

G

E

E

G

S

G

G

I

I

N

V

G

P

M

A

R

T

I

K

E

E

Y

F

L

L

Q

E

Q

E

L

A

R

R

K

K

L

L

C

C

D

D

E

E

R

Y

G

D

W

A

L

L

M

L

M

V

I

F

D

D

E

E

V

V

Q

Q

C

C

G

G

M

M

G

G

R

R

T

T

G

G

K

K

W

L

F

F

A

A

H

Y

Q

Q

W

K

A

Y

G

G

I

V

V

V

P

P

D

D

V

V

M

L

P

T

L

T

A

A

K

K

G

G

L

L

G

G

S

G

G

G

V

V

P

P

I

I

G

G

A

A

V

V

V

I

A

V

G

N

P

E

K

R

A

-

A

A

N

N

V

V

L

L

Q

E

P

P

G

G

N

D

H

H

G

G

T

T

T
|
T

F

F

G

G

G

G

N

N

P

P

L

L

A

A

M

C

R

R

A

A

G

G

V

V

E

T

T

V

I

I

R

K

I

E

M

L

E

T

E

K

D

E

G

G

L

F

L

L

H

E

N

E

A

V

A

E

Q

E

V

K

G

G

D

N

H

Y

L

L

R

M

A

K

A

K

L

L

Q

Q

R

E

E

M

L

K

G

E

S

E

L

Y

P

D

G

V

V

V

K

A

E

D

I

V

R

R

G

G

Q

M

G

G

L

L

M

M

L

I

G

G

I

I

E

Q

L

F

N

R

K

E

P

E

C

V

G

S

-

N

-

R

A

E

L

V

I

A

G

T

R

K

A

C

A

F

E

E

A

N

G

K

L

L

L

L

L

V

S

V

V

P

T

A

A

G

D

N

S

N

V

T

I

I

R

R

L

F

V

L

P

P

P

P

L

L

I

T

L

V

T

E

T

Y

A

G

E

E

A

I

D

D

A

L

I

A

V

V

A

E

I

T

L

L

T

K

P

K

L

V

V

L

K

Q

A

G

I

I

GT 94:95 (≠ GL 103:104) binding
T268 (= T280) binding

Q9M8M7 Acetylornithine aminotransferase, chloroplastic/mitochondrial; ACOAT; Acetylornithine transaminase; AOTA; Protein HOPW1-1-INTERACTING 1; EC 2.6.1.11 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
39% identity, 98% coverage: 5:395/398 of query aligns to 62:456/457 of Q9M8M7

query
sites
Q9M8M7

I

I

E

E

A

E

A

E

S

A

P

K

H

V

V

I

M

V

N

G

T

T

Y

Y

G

A

R

R

V

A

P

P

I

V

A

V

L

L

E

S

R

S

G

G

Q

K

G

G

C

C

R

K

V

L

W

F

D

D

V

P

N

E

G

G

K

K

E

E

Y

Y

I

L

D

D

G

C

L

A

G

S

G

G

I

I

A

A

V

V

N

N

T

A

L

L

G

G

H

H

N

G

H

D

G

P

K

D

L

W

V

L

P

R

A

A

L

V

Q

T

D

E

Q

Q

I

A

A

G

K

V

L

L

I

A

H

H

T

V

S

S

N

N

Y

V

Y

Y

H

Y

V

T

P

I

L

P

Q

Q

E

I

K

E

L

L

A

A

T

K

K

R

L

L

V

V

E

A

L

S

S

S

G

F

M

A

Q

D

N

R

V

V

F

F

F

F

C

C

N

N

S

S

G

G

L

T

E

E

A

A

N

N

E

E

A

A

A

A

L

I

K

K

I

F

A

S

R

R

K

K

F

F

G

Q

V

R

-

F

-

T

-

H

-

P

-

E

D

D

K

K

G

E

I

V

A

A

K

T

P

G

E

-

I

F

V

I

V

A

Y

F

E

T

K

N

A

S

F

F

H

H

G

G

R

R

S

T

I

L

A

G

T

A

M

L

S

A

A

L

T

T

G

S

N

K

P

E

K

Q

I

Y

H

R

N

T

G

P

F

F

G

E

P

P

L

I

V

M

E

P

G

G

F

V

V

T

R

F

V

L

P

E

M

Y

N

G

D

N

I

I

E

Q

A

A

I

A

K

T

Q

D

A

L

T

I

E

R

G

S

N

G

P

-

N

K

V

I

V

A

A

A

V

V

F

F

F

V

E

E

T

P

I

I

Q

Q

G

G

E

E

G

G

G

G

I

I

N

Y

G

S

M

A

R

T

I

K

E

E

Y

F

L

L

Q

Q

Q

S

L

L

R

R

K

S

L

A

C

C

D

D

E

A

R

A

G

G

W

S

L

L

M

L

M

V

I

F

D

D

E

E

V

V

Q

Q

C

C

G

G

M

L

G

G

R

R

T

T

G

G

K

L

W

M

F

W

A

A

H

Y

Q

E

W

A

A

F

G

G

I

V

V

T

P

P

D

D

V

I

M

M

P

T

L

V

A

A

K

K

G

P

L

L

G

A

S

G

G

G

V

L

P

P

I

I

G

G

A

A

V

V

V

L

A

V

G

T

P

E

K

K

A

V

A

A

N

E

V

T

L

I

Q

N

P

Y

G

G

N

D

H

H

G

G

T

S

T

T

F

F

G

A

G

G

N

S

P

P

L

L

A

V

M

C

R

S

A

A

G

A

V

I

E

A

T

V

I

M

R

D

I

K

M

V

E

S

E

K

D

P

G

S

L

F

L

L

H

S

N

S

A

V

A

S

Q

N

V

K

G

G

D

R

H

Y

L

F

R

R

A

D

A

L

L

L

Q

V

R

K

E

K

L

L

G

G

S

G

L

N

P

S

G

H

V

V

K

K

E

E

I

V

R

R

G

G

Q

E

G

G

L

L

M

I

L

I

G

G

I

V

E

E

L

L

N

D

K

V

P

P

C

A

G

S

A

S

L

L

I

V

G

D

R

A

A

C

A

R

E

D

A

S

G

G

L

L

L

L

-

I

L

L

S

T

V

A

T

G

A

K

D

G

S

N

V

V

I

V

R

R

L

I

V

V

P

P

P

P

L

L

I

V

L

I

T

S

T

E

A

E

E

E

A

I

D

E

A

R

I

A

V

V

A

E

I

I

L

M

T

S

P

Q

L

N

V

L

K

T

A

A

I

L

Sites not aligning to the query:

1:41 modified: transit peptide, Chloroplast and mitochondrion
42 modified: N-acetylvaline; in Acetylornithine aminotransferase, chloroplastic

3nx3A Crystal structure of acetylornithine aminotransferase (argd) from campylobacter jejuni
38% identity, 97% coverage: 10:395/398 of query aligns to 2:388/388 of 3nx3A

query
sites
3nx3A

P

S

H

H

V

I

M

I

N

P

T

T

Y

Y

G

K

R

R

V

F

P

D

I

I

A

V

L

L

E

E

R

K

G

G

Q

Q

G

G

C

V

R

Y

V

L

W

F

D

D

V

D

N

K

G

A

K

K

E

K

Y

Y

I

L

D

D

G

F

L

S

G

S

G

G

I

I

A

G

V

V

N

C

T

A

L

L

G

G

H

Y

N

N

H

H

G

A

K

K

L

F

V

N

P

A

A

K

L

I

Q

K

D

A

Q

Q

I

V

A

D

K

K

L

L

I

L

H

H

T

T

S

S

N

N

Y

L

Y

Y

H

Y

V

N

P

E

L

N

Q

I

E

A

K

A

L

A

A

A

T

K

K

N

L

L

V

A

E

K

L

A

S

S

G

A

M

L

Q

E

N

R

V

V

F

F

F

F

C

T

N

N

S

S

G

G

L

T

E

E

A

S

N

I

E

E

A

G

A

A

L

M

K

K

I

T

A

A

R

R

K

K

F

Y

G

A

V

F

D

N

K

K

G

G

I

V

A

K

K

G

P

G

E

Q

I

F

V

I

V

A

Y

F

E

K

K

H

A

S

F
|
F

H

H

G

G

R

R

S

T

I

L

A

G

T

A

M

L

S

S

A

L

T

T

G

A

N

N

P

E

K

K

I

Y

H

Q

N

K

G

P

F

F

G

K

P

P

L

L

V

I

E

S

G

G

F

V

V

K

R

F

V

A

P

K

M

Y

N

N

D

D

I

I

E

S

A

S

I

V

K

E

Q

K

A

L

T

V

E

-

G

-

N

N

P

E

N

K

V

T

V

C

A

A

V

I

F

I

F

L

E
|
E

T

S

I

V

Q

Q

G

G

E

E

G

G

G

G

I

I

N

N

G

P

M

A

R
x
N

I

K

E

D

Y
x
F

L

Y

Q

K

Q

A

L

L

R

R

K

K

L

L

C

C

D

D

E

E

R

K

G

D

W

I

L

L

M

L

M

I

I

A

D
|
D

E

E

V

I

Q
|
Q

C

C

G

G

M

M

G

G

R

R

T

S

G

G

K

K

W

F

F

F

A

A

H

Y

Q

E

W

H

A

A

G

Q

I

I

V

L

P

P

D

D

V

I

M

M

P

T

L

S

A

A

K
|
K

G

A

L

L

G

G

S

C

G

G

V

L

P

S

I

V

G

G

A

A

V

F

V

V

A

I

G

N

P

Q

K

K

-

V

A

A

A

S

N

N

V

S

L

L

Q

E

P

A

G

G

N

D

H

H

G

G

T

S

T
|
T

F

Y

G

G

G

G

N

N

P

P

L

L

A

V

M

C

R

-

A

A

G

G

V

V

E

N

T

A

I

V

-

F

R

E

I

I

M

F

E

K

E

E

D

E

G

K

L

I

L

L

H

E

N

N

A

V

A

N

Q

K

V

L

G

T

D

P

H

Y

L

L

R

E

A

Q

A

S

L

L

Q

D

R

E

E

L

L
x
I

G

N

S

E

L
x
F

P
x
D

G

F

V
x
C

K

K

E

K

I

R

R

K

G

G

Q

L

G

G

L

F

M

M

L

Q

G

G

I

L

E

S

L

L

N

D

K

K

P

S

-

V

-

K

C

V

G

A

A

K

L

V

I

I

G

Q

R

K

A

C

A

Q

E

E

A

N

G

A

L

L

L

L

L

L

S

I

V

S

T

C

A

G

D

E

S

N

V

D

I

L

R
|
R

L

F

V

L

P

P

P

P

L

L

I

I

L

L

T
x
Q

T
x
K

A

E

E

H

A

I

D

D

A

E

I

M

V

S

A

E

I

K

L

L

T

R

P

K

L

A

V

L

K

K

A

S

I

F

active site: F127 (= F135), E179 (= E189), D212 (= D222), Q215 (= Q225), K241 (= K251), T271 (= T280), R362 (= R369)
binding magnesium ion: N191 (≠ R201), F194 (≠ Y204), I313 (≠ L322), F316 (≠ L325), D317 (≠ P326), C319 (≠ V328), Q370 (≠ T377), K371 (≠ T378)

A0QYS9 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
44% identity, 95% coverage: 12:388/398 of query aligns to 11:379/390 of A0QYS9

query
sites
A0QYS9

V

M

M

M

N

N

T

N

Y

Y

G

G

R

T

V

P

P

P

I

L

A

S

L

L

E

V

R

S

G

G

Q

E

G

G

C

A

R

V

V

V

W

T

D

D

V

A

N

D

G

G

K

R

E

E

Y

Y

I

L

D

D

G

L

L

L

G

G

G

G

I

I

A

A

V

V

N

N

T

L

L

L

G

G

H

H

N

R

H

H

G

P

K

A

L

V

V

I

P

E

A

A

L

V

Q

T

D

T

Q

Q

I

L

A

D

K

T

L

L

I

G

H

H

T

T

S

S

N

N

Y

L

Y

Y

H

A

V

T

P

E

L

P

Q

G

E

I

K

A

L

L

A

A

T

E

K

A

L

L

V

V

E

G

L

Q

S

L

G

G

M

T

Q

Q

-

A

N

R

V

V

F

F

F

F

C

C

N

N

S

S

G

G

L

T

E

E

A

A

N

N

E

E

A

V

A

A

L

F

K

K

I

I

A

T

R

R

K

L

F

T

G

G

V

-

D

-

K

-

G

-

I

-

A

-

K

K

P

T

E

K

I

I

V

V

V

A

Y

A

E

E

K

G

A

A

F

F

H

H

G

G

R

R

S

T

I

M

A

G

T

S

M

L

S

A

A

L

T

T

G

G

N

Q

P

P

K

S

I

K

H

Q

N

A

G

P

F

F

G

E

P

P

L

L

V

P

E

G

G

N

F

V

V

M

R

H

V

V

P

P

M

Y

N

G

D

D

I

V

E

A

A

A

I

L

K

E

Q

A

A

A

T

V

E

-

G

-

N

D

P

D

N

Q

V

T

V

A

A

A

V

V

F

F

F

L

E

E

T

P

I

I

Q

M

G

G

E

E

G

G

G

G

I

V

N

V

G

V

M

P

R

P

I

A

E

G

Y

Y

L

L

Q

V

Q

A

L

A

R

R

K

E

L

I

C

T

D

S

E

K

R

H

G

G

W

A

L

L

M

L

M

V

I

L

D

D

E

E

V

V

Q

Q

C

T

G

G

M

V

G

G

R

R

T

T

G

G

K

A

W

F

F

F

A

A

H

H

Q

Q

W

H

A

D

G

G

I

I

V

V

P

P

D

D

V

V

M

V

P

T

L

M

A

A

K

K

G

G

L

L

G

G

S

G

G

G

V

L

P

P

I

I

G

G

A

A

V

C

V

L

A

A

G

V

P

G

K

A

A

T

A

G

N

D

V

L

L

L

Q

T

P

P

G

G

N

L

H

H

G

G

T

S

T

T

F

F

G

G

G

G

N

N

P

P

L

V

A

C

M

T

R

A

A

A

G

G

V

L

E

A

T

V

I

L

R

K

I

T

M

L

E

A

E

A

D

E

G

D

L

L

L

V

H

A

N

R

A

A

A

G

Q

V

V

L

G

G

D
x
K

H

T

L

L

R

S

A

H

A

G

L

I

Q

E

R

-

E

E

L

L

G

G

S

H

L

-

P

P

G

L

V

V

K

D

E

K

I

V

R

R

G

G

Q

K

G

G

L

L

M

L

L

Q

G

G

I

I

E

V

L

L

N

T

K

V

P

P

C

S

G

A

A

K

L

A

I

V

G

E

R

T

A

A

A

A

-

R

E

D

A

A

G

G

L

F

L

L

L

V

S

N

V

A

T

A

A

A

D

P

S

E

V

V

I

V

R

R

L

L

V

A

P

P

P

P

L

L

I

I

L

I

T

T

T

E

A

G

E

Q

A

I

D

E

A

A

I

F

V

I

A

T

I

A

L

L

K304 (≠ D312) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

7nncC Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal-5'-phosphate and 6-methoxyquinoline-3-carboxylic acid
45% identity, 95% coverage: 12:388/398 of query aligns to 13:383/391 of 7nncC

query
sites
7nncC

V

M

M

M

N

N

T

N

Y

Y

G

G

R

T

V

P

P

P

I

I

A

A

L

L

E

A

R

S

G

G

Q

D

G

G

C

A

R

V

V

V

W

T

D

D

V

V

N

D

G

G

K

R

E

T

Y

Y

I

I

D

D

G

L

L

L

G

G

G

G

I

I

A

A

V

V

N

N

T

V

L

L

G

G

H

H

N

R

H

H

G

P

K

A

L

V

V

I

P

E

A

A

L

V

Q

T

D

R

Q

Q

I

M

A

S

K

T

L

L

I

G

H

H

T

T

S

S

N
|
N

Y
x
L

Y

Y

H

A

V

T

P

E

L

P

Q

G

E

I

K

A

L

L

A

A

T

E

K

E

L

L

V

V

E

A

L

L

S

L

G

G

M

A

Q

D

N

Q

-

R

-

T

-

R

V

V

F

F

F

F

C

C

N

N

S

S

G

G

L

A

E

E

A

A

N

N

E

E

A

A

A

A

L

F

K

K

I

L

A

S

R

R

K

L

F

T

G

G

V

-

D

-

K

-

G

-

I

-

A

-

K

R

P

T

E

K

I

L

V

V

V

A

Y

A

E

H

K

D

A

A

F
|
F

H

H

G

G

R

R

S

T

I

M

A

G

T

S

M

L

S

A

A

L

T

T

G

G

N

Q

P

P

K

A

I

K

H

Q

N

T

G

P

F

F

G

A

P

P

L

L

V

P

E

G

G

D

F

V

V

T

R

H

V

V

P

G

M

Y

N

G

D

D

I

V

E

D

A

A

I

L

K

A

Q

A

A

A

T

V

E

D

G

D

N

H

P

-

N

-

V

T

V

A

A

A

V

V

F

F

F

L

E

E

T

P

I

I

Q

M

G

G

E

E

G

S

G

G

I

V

N

V

G

V

M

P

R

P

I

A

E

G

Y

Y

L

L

Q

A

Q

A

L

A

R

R

K

D

L

I

C

T

D

A

E

R

R

R

G

G

W

A

L

L

M

L

M

V

I

L

D
|
D

E

E

V

V

Q

Q

C

T

G

G

M

M

G

G

R

R

T

T

G

G

K

A

W

F

F

F

A

A

H

H

Q

Q

W

H

A

D

G

G

I

I

V

T

P

P

D

D

V

V

M

V

P

T

L

L

A

A

K
|
K

G

G

L

L

G

G

S

G

G

G

V

L

P

P

I

I

G

G

A

A

V

C

V

L

A

A

G

V

P

G

K

P

A

A

A

A

N

E

V

L

L

L

Q

T

P
|
P

G
|
G

N

L

H

H

G

G

T
x
S

T
|
T

F

F

G

G

G

G

N

N

P

P

L

V

A

C

M

A

R

A

A

A

G

A

V

L

E

A

T

V

I

L

R

R

I

V

M

L

E

A

E

S

D

D

G

G

L

L

L

V

H

R

N

R

A

A

A

E

Q

V

V

L

G

G

D

K

H

S

L

L

R

R

A

H

A

G

L

I

Q

E

R

-

E

A

L

L

G

G

S

H

L

-

P

P

G

L

V

I

K

D

E

H

I

V

R

R

G

G

Q

R

G

G

L

L

M

L

L

L

G

G

I

I

E

A

L

L

N

T

K

A

P

P

C

H

G

A

A

K

L

D

I

A

-

E

G

A

R

T

A

A

A

R

E

D

A

A

G

G

L

Y

L

L

L

V

S

N

V

A

T

A

A

A

D

P

S

D

V

V

I

I

R

R

L

L

V

A

P

P

P

P

L

L

I

I

L

I

T

A

T

E

A

A

E

Q

A

L

D

D

A

G

I

F

V

V

A

A

I

A

L

L

active site: F133 (= F135), D218 (= D222), K247 (= K251)
binding 6-methoxyquinoline-3-carboxylic acid: N75 (= N74), L76 (≠ Y75), P270 (= P274), G271 (= G275), S275 (≠ T279), T276 (= T280)

7nn4A Crystal structure of mycobacterium tuberculosis argd with prosthetic group pyridoxal 5'-phosphate and 3-hydroxy-2-naphthoic acid.
45% identity, 95% coverage: 12:388/398 of query aligns to 13:383/391 of 7nn4A

query
sites
7nn4A

V

M

M

M

N

N

T

N

Y
|
Y

G

G

R

T

V

P

P

P

I

I

A

A

L

L

E

A

R

S

G

G

Q

D

G

G

C

A

R

V

V

V

W

T

D

D

V

V

N

D

G

G

K

R

E

T

Y

Y

I

I

D

D

G

L

L

L

G

G

G

G

I

I

A

A

V

V

N

N

T

V

L

L

G

G

H

H

N

R

H

H

G

P

K

A

L

V

V

I

P

E

A

A

L

V

Q

T

D

R

Q

Q

I

M

A

S

K

T

L

L

I

G

H

H

T

T

S

S

N
|
N

Y
x
L

Y

Y

H

A

V

T

P

E

L

P

Q

G

E

I

K

A

L

L

A

A

T

E

K

E

L

L

V

V

E

A

L

L

S

L

G

G

M

A

Q

D

N

Q

-

R

-

T

-

R

V

V

F

F

F

F

C

C

N

N

S

S

G

G

L

A

E

E

A

A

N

N

E

E

A

A

A

A

L

F

K

K

I

L

A

S

R

R

K

L

F

T

G

G

V

-

D

-

K

-

G

-

I

-

A

-

K

R

P

T

E

K

I

L

V

V

V

A

Y

A

E

H

K

D

A

A

F
|
F

H

H

G

G

R
|
R

S

T

I

M

A

G

T

S

M

L

S

A

A

L

T

T

G

G

N

Q

P

P

K

A

I

K

H

Q

N

T

G

P

F

F

G

A

P

P

L

L

V

P

E

G

G

D

F

V

V

T

R

H

V

V

P

G

M

Y

N

G

D

D

I

V

E

D

A

A

I

L

K

A

Q

A

A

A

T

V

E

D

G

D

N

H

P

-

N

-

V

T

V

A

A

A

V

V

F

F

F

L

E

E

T

P

I

I

Q

M

G

G

E

E

G

S

G

G

I

V

N

V

G

V

M

P

R

P

I

A

E

G

Y

Y

L

L

Q

A

Q

A

L

A

R

R

K

D

L

I

C

T

D

A

E

R

R

R

G

G

W

A

L

L

M

L

M

V

I

L

D
|
D

E

E

V

V

Q

Q

C

T

G

G

M

M

G

G

R

R

T

T

G

G

K

A

W

F

F

F

A

A

H

H

Q

Q

W

H

A

D

G

G

I

I

V

T

P

P

D

D

V

V

M

V

P

T

L

L

A

A

K
|
K

G

G

L

L

G

G

S

G

G

G

V

L

P

P

I

I

G

G

A

A

V

C

V

L

A

A

G

V

P

G

K

P

A

A

A

A

N

E

V

L

L

L

Q

T

P

P

G

G

N

L

H

H

G
|
G

T
x
S

T
|
T

F

F

G

G

G

G

N

N

P

P

L

V

A

C

M

A

R

A

A

A

G

A

V

L

E

A

T

V

I

L

R

R

I

V

M

L

E

A

E

S

D

D

G

G

L

L

L

V

H

R

N

R

A

A

A

E

Q

V

V

L

G

G

D

K

H

S

L

L

R

R

A

H

A

G

L

I

Q

E

R

-

E

A

L

L

G

G

S

H

L

-

P

P

G

L

V

I

K

D

E

H

I

V

R

R

G

G

Q

R

G

G

L

L

M

L

L

L

G

G

I

I

E

A

L

L

N

T

K

A

P

P

C

H

G

A

A

K

L

D

I

A

-

E

G

A

R

T

A

A

A

R

E

D

A

A

G

G

L

Y

L

L

L

V

S

N

V

A

T

A

A

A

D

P

S

D

V

V

I

I

R

R

L

L

V

A

P

P

P

P

L

L

I

I

L

I

T

A

T

E

A

A

E

Q

A

L

D

D

A

G

I

F

V

V

A

A

I

A

L

L

active site: F133 (= F135), D218 (= D222), K247 (= K251)
binding 3-hydroxynaphthalene-2-carboxylic acid: Y17 (= Y16), N75 (= N74), L76 (≠ Y75), R136 (= R138), G274 (= G278), S275 (≠ T279), T276 (= T280)

P9WPZ7 Acetylornithine aminotransferase; ACOAT; EC 2.6.1.11 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
45% identity, 95% coverage: 12:388/398 of query aligns to 19:389/400 of P9WPZ7

query
sites
P9WPZ7

V

M

M

M

N

N

T

N

Y

Y

G

G

R

T

V

P

P

P

I

I

A

A

L

L

E

A

R

S

G

G

Q

D

G

G

C

A

R

V

V

V

W

T

D

D

V

V

N

D

G

G

K

R

E

T

Y

Y

I

I

D

D

G

L

L

L

G

G

G

G

I

I

A

A

V

V

N

N

T

V

L

L

G

G

H

H

N

R

H

H

G

P

K

A

L

V

V

I

P

E

A

A

L

V

Q

T

D

R

Q

Q

I

M

A

S

K

T

L

L

I

G

H

H

T

T

S

S

N

N

Y

L

Y

Y

H

A

V

T

P

E

L

P

Q

G

E

I

K

A

L

L

A

A

T

E

K

E

L

L

V

V

E

A

L

L

S

L

G

G

M

A

Q

D

N

Q

-

R

-

T

-

R

V

V

F

F

F

F

C

C

N

N

S

S

G

G

L

A

E

E

A

A

N

N

E

E

A

A

A

A

L

F

K

K

I

L

A

S

R

R

K

L

F

T

G

G

V

-

D

-

K

-

G

-

I

-

A

-

K

R

P

T

E

K

I

L

V

V

V

A

Y

A

E

H

K

D

A

A

F

F

H

H

G

G

R

R

S

T

I

M

A

G

T

S

M

L

S

A

A

L

T

T

G

G

N

Q

P

P

K

A

I

K

H

Q

N

T

G

P

F

F

G

A

P

P

L

L

V

P

E

G

G

D

F

V

V

T

R

H

V

V

P

G

M

Y

N

G

D

D

I

V

E

D

A

A

I

L

K

A

Q

A

A

A

T

V

E

D

G

D

N

H

P

-

N

-

V

T

V

A

A

A

V

V

F

F

F

L

E

E

T

P

I

I

Q

M

G

G

E

E

G

S

G

G

I

V

N

V

G

V

M

P

R

P

I

A

E

G

Y

Y

L

L

Q

A

Q

A

L

A

R

R

K

D

L

I

C

T

D

A

E

R

R

R

G

G

W

A

L

L

M

L

M

V

I

L

D

D

E

E

V

V

Q

Q

C

T

G

G

M

M

G

G

R

R

T

T

G

G

K

A

W

F

F

F

A

A

H

H

Q

Q

W

H

A

D

G

G

I

I

V

T

P

P

D

D

V

V

M

V

P

T

L

L

A

A

K

K

G

G

L

L

G

G

S

G

G

G

V

L

P

P

I

I

G

G

A

A

V

C

V

L

A

A

G

V

P

G

K

P

A

A

A

A

N

E

V

L

L

L

Q

T

P

P

G

G

N

L

H

H

G

G

T

S

T

T

F

F

G

G

G

G

N

N

P

P

L

V

A

C

M

A

R

A

A

A

G

A

V

L

E

A

T

V

I

L

R

R

I

V

M

L

E

A

E

S

D

D

G

G

L

L

L

V

H

R

N

R

A

A

A

E

Q

V

V

L

G

G

D
x
K

H

S

L

L

R

R

A

H

A

G

L

I

Q

E

R

-

E

A

L

L

G

G

S

H

L

-

P

P

G

L

V

I

K

D

E

H

I

V

R

R

G

G

Q

R

G

G

L

L

M

L

L

L

G

G

I

I

E

A

L

L

N

T

K

A

P

P

C

H

G

A

A

K

L

D

I

A

-

E

G

A

R

T

A

A

A

R

E

D

A

A

G

G

L

Y

L

L

L

V

S

N

V

A

T

A

A

A

D

P

S

D

V

V

I

I

R

R

L

L

V

A

P

P

P

P

L

L

I

I

L

I

T

A

T

E

A

A

E

Q

A

L

D

D

A

G

I

F

V

V

A

A

I

A

L

L

K314 (≠ D312) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylthreonine; partial

Q5SHH5 [LysW]-aminoadipate semialdehyde transaminase; EC 2.6.1.118 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
40% identity, 99% coverage: 3:397/398 of query aligns to 11:395/395 of Q5SHH5

query
sites
Q5SHH5

A

A

F

L

I

L

E

E

A

A

A

E

S

K

P

T

H

L

V

D

M

S

N

G

T

V

Y

Y

G

N

R

K

V

H

P

D

I

L

A

L

L

I

E

V

R

R

G

G

Q

Q

G

G

C

A

R

R

V

V

W

W

D

D

V

A

N

E

G

G

K

N

E

E

Y

Y

I

I

D

D

G

C

L

V

G

G

G

G

I

Y

A

G

V

V

N

A

T

N

L

L

G

G

H

H

N

G

H

N

G

P

K

E

L

V

V

V

P

E

A

A

L

V

Q

K

D

R

Q

Q

I

A

A

E

K

T

L

L

I

M

H

A

T

M

S

P

N

Q

Y

T

Y

L

H

P

V

T

P

P

L

M

Q

R

E

G

K

E

L

F

A

Y

T

R

K

T

L

L

V

T

E

A

L

I

-

L

-

P

S

P

G

E

M

L

Q

N

N

R

V

V

F

F

F

P

C

V

N

N

S

S

G
|
G

L
x
T

E

E

A

A

N

N

E

E

A

A

A

A

L

L

K

K

I

F

A

A

R

R

K

A

F

H

G

-

V

-

D

-

K

-

G

-

I

T

A

G

K

R

P

K

E

K

I

F

V

V

V

A

Y

A

E

M

K

R

A

G

F

F

H

S

G

G

R

R

S

T

I

M

A

G

T

S

M

L

S

S

A

V

T

T

G

W

N

E

P

P

K

K

I

Y

H

R

N

E

G

P

F

F

G

L

P

P

L

L

V

V

E

E

G

P

F

V

V

E

R

F

V

I

P

P

M

Y

N

N

D

D

I

V

E

E

A

A

I

L

K

K

Q

R

A

A

T

V

E

-

G

-

N

D

P

E

N

E

V

T

V

A

A

A

V

V

F

I

F

L

E

E

T

P

I

V

Q

Q

G

G

E

E

G

G

G

G

I

V

N

R

G

P

M

A

R

T

I

P

E

E

Y

F

L

L

Q

R

Q

A

L

A

R

R

K

E

L

I

C

T

D

Q

E

E

R

K

G

G

W

A

L

L

M

L

M

I

I

L

D

D

E

E

V

I

Q

Q

C

T

G

G

M

M

G

G

R

R

T

T

G

G

K

K

W

R

F

F

A

A

H

F

Q

E

W

H

A

F

G

G

I

I

V

V

P

P

D

D

V

I

M

L

P

T

L

L

A

A

K
|
K

G

A

L

L

G

G

S

G

G

G

V

V

P

P

I

L

G

G

A

A

V

A

V

V

A

M

G

R

P

E

K

E

A

V

A

A

N

R

V

S

L

M

Q

P

P

K

G

G

N

G

H

H

G

G

T

T

T
|
T

F

F

G

G

G

G

N

N

P

P

L

L

A

A

M

M

R

A

A

A

G

G

V

V

E

A

T

A

I

I

R

R

I

Y

M

L

E

E

E

R

D

T

G

R

L

L

L

W

H

E

N

R

A

A

A

A

Q

E

V

L

G

G

D

P

H

W

L

F

R

M

A

E

A

K

L

L

Q

-

R

R

E

A

L

I

G

P

S

S

L

-

P

P

G

K

V

I

K

R

E

E

I

V

R

R

G

G

Q

M

G

G

L

L

M

M

L

V

G

G

I

L

E

E

L

L

N

K

K

E

P

K

C

A

G

A

A

P

L

Y

I

I

G

A

R

R

A

L

A

E

E

K

A

E

G

H

L

R

L

V

L

L

S

A

V

L

T

Q

A

A

-

G

D

P

S

T

V

V

I

I

R

R

L

F

V

L

P

P

P

P

L

L

I

V

L

I

T

E

T

K

A

E

E

D

A

L

D

E

A

R

I

V

V

V

A

E

I

A

L

-

T

-

P

-

L

-

V

V

K

R

A

A

I

V

L

L

A

A

GT 113:114 (≠ GL 103:104) binding
K254 (= K251) modified: N6-(pyridoxal phosphate)lysine
T283 (= T280) binding

1wkhA Acetylornithine aminotransferase from thermus thermophilus hb8
39% identity, 99% coverage: 3:397/398 of query aligns to 3:387/387 of 1wkhA

query
sites
1wkhA

A

A

F

L

I

L

E

E

A

A

A

E

S

K

P

T

H

L

V

D

M
x
S

N

G

T

V

Y

Y

G

N

R

K

V

H

P

D

I

L

A

L

L

I

E

V

R

R

G

G

Q

Q

G

G

C

A

R

R

V

V

W

W

D

D

V

A

N

E

G

G

K

N

E

E

Y

Y

I

I

D

D

G

C

L

V

G

G

G

G

I
x
Y

A

G

V

V

N

A

T

N

L

L

G

G

H

H

N

G

H

N

G

P

K

E

L

V

V

V

P

E

A

A

L

V

Q

K

D

R

Q

Q

I

A

A

E

K

T

L

L

I

M

H

A

T

M

S

P

N

Q

Y

T

Y

L

H

P

V

T

P

P

L

M

Q

R

E

G

K

E

L

F

A

Y

T

R

K

T

L

L

V

T

E

A

L

I

-

L

-

P

S

P

G

E

M

L

Q

N

N

R

V

V

F

F

F

P

C

V

N

N

S
|
S

G
|
G

L
x
T

E

E

A

A

N
|
N

E

E

A

A

A

A

L

L

K

K

I

F

A

A

R

R

K

A

F

H

G

-

V

-

D

-

K

-

G

-

I

T

A

G

K

R

P

K

E

K

I

F

V

V

V

A

Y

A

E

M

K

R

A

G

F
|
F

H
x
S

G
|
G

R

R

S

T

I

M

A

G

T

S

M

L

S

S

A

V

T

T

G

W

N

E

P

P

K

K

I

Y

H

R

N

E

G

P

F

F

G

L

P

P

L

L

V

V

E

E

G

P

F

V

V

E

R

F

V

I

P

P

M

Y

N

N

D

D

I

V

E

E

A

A

I

L

K

K

Q

R

A

A

T

V

E

-

G

-

N

D

P

E

N

E

V

T

V

A

A

A

V

V

F

I

F

L

E
|
E

T

P

I

V

Q

Q

G

G

E
|
E

G

G

G

G

I

V

N

R

G

P

M

A

R

T

I

P

E

E

Y

F

L

L

Q

R

Q

A

L

A

R

R

K

E

L

I

C

T

D

Q

E

E

R

K

G

G

W

A

L

L

M

L

M

I

I

L

D
|
D

E

E

V
x
I

Q
|
Q

C

T

G

G

M

M

G

G

R

R

T

T

G

G

K

K

W

R

F

F

A

A

H

F

Q

E

W

H

A

F

G

G

I

I

V

V

P

P

D

D

V

I

M

L

P

T

L

L

A

A

K
|
K

G

A

L

L

G

G

S

G

G

G

V

V

P

P

I

L

G

G

A

V

V

A

V

V

A

M

G

R

P

E

K

E

A

V

A

A

N

R

V

S

L

M

Q

P

P

K

G

G

N

G

H

H

G

G

T
|
T

T
|
T

F

F

G

G

G

G

N

N

P

P

L

L

A

A

M

M

R

A

A

A

G

G

V

V

E

A

T

A

I

I

R

R

I

Y

M

L

E

E

E

R

D

T

G

R

L

L

L

W

H

E

N

R

A

A

A

A

Q

E

V

L

G

G

D

P

H

W

L

F

R

M

A

E

A

K

L

L

Q

-

R

R

E

A

L

I

G

P

S

S

L

-

P

P

G

K

V

I

K

R

E

E

I

V

R

R

G

G

Q

M

G

G

L

L

M

M

L

V

G

G

I

L

E

E

L

L

N

K

K

E

P

K

C

A

G

A

A

P

L

Y

I

I

G

A

R

R

A

L

A

E

E

K

A

E

G

H