SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ac3H11_1341 FitnessBrowser__acidovorax_3H11:Ac3H11_1341 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7kb1C Complex of o-acety-l-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima and a key reaction intermediate (see paper)
54% identity, 97% coverage: 11:438/442 of query aligns to 3:426/428 of 7kb1C

query
sites
7kb1C

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binding pyridoxal-5'-phosphate: Y57 (= Y64), R59 (= R66)
binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: G87 (= G94), Q88 (≠ M95), Y112 (= Y119), N160 (= N166), D185 (= D191), S206 (= S213), T208 (= T215), K209 (= K216), N369 (= N381), I370 (= I382), R404 (= R416)

7kb1A Complex of o-acety-l-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima and a key reaction intermediate (see paper)
54% identity, 97% coverage: 11:438/442 of query aligns to 3:426/428 of 7kb1A

query
sites
7kb1A

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binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: Y57 (= Y64), R59 (= R66), G87 (= G94), Q88 (≠ M95), Y112 (= Y119), N160 (= N166), D185 (= D191), S206 (= S213), T208 (= T215), K209 (= K216), N369 (= N381), I370 (= I382), R404 (= R416)

8wkoA Crystal structure of o-acetylhomoserine sulfhydrylase from lactobacillus plantarum in the closed form (see paper)
50% identity, 99% coverage: 2:437/442 of query aligns to 1:424/425 of 8wkoA

query
sites
8wkoA

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A

N

N

I
x
V

G
x
A

D

D

A

A

K

K

T

S

L

L

V

I

I

I

H

H

P

P

A

A

S

S

T

T

T

T

H

H

R

A

Q

Q

L

L

N

N

E

E

E

Q

E

E

L

L

A

L

R

A

A

A

G

G

V

V

S

T

A

P

D

D

M

L

V

I

R

R

L

I

S

S

V

V

G

G

I

V

E

E

D

N

L

A

D

D

D

D

I

L

L

I

W

A

D

D

I

L

D

D

Q

Q

A

A

L

L

G

A

R

Q

binding (2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid: G87 (= G94), S88 (≠ M95), Y112 (= Y119), E155 (= E162), D184 (= D191), T186 (= T193), S206 (= S213), A207 (= A214), T208 (= T215), F209 (≠ Y217), G212 (= G220), M217 (= M225), V369 (≠ I382), A370 (≠ G383)
binding proline: H213 (= H221), Q284 (= Q292), S288 (≠ T296)

2ctzA Crystal structure of o-acetyl homoserine sulfhydrylase from thermus thermophilus hb8
51% identity, 95% coverage: 15:435/442 of query aligns to 3:420/421 of 2ctzA

query
sites
2ctzA

F

F

G

E

T

T

R

L

A

Q

I

L

H

H

A

A

G

G

A

Y

Q

E

P

P

D

E

P

P

V

T

T

T

G

L

A

S

R

R

A

Q

T

V

P

P

I

I

H

Y

Q

P

T

T

T

T

S

S

F

Y

V

V

F

F

D

K

N

S

A

P

E

E

H

H

A

A

S

A

S

N

L

L

F

F

N

A

L

L

Q

K

T

E

F

F

G

G

N

N

V

I

Y

Y

S

S

R
|
R

I

I

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

L

E

E

E

K

R

R

I

L

A

A

S

A

L

L

E

E

N

G

G

G

R

K

A

A

A

A

L

L

A

A

C

T

A

A

S
|
S

G
|
G

M
x
H

A

A

A

A

Q
|
Q

M

F

A

L

A

A

L

L

L

T

A

T

I

L

L

A

K

Q

T

A

G

G

D

D

H

N

I

I

V

V

A

S

A

T

S

P

T

N

L

L

Y
|
Y

G

G

G

G

T

T

V

F

G

N

Q

Q

L

F

G

K

V

V

G

T

F

L

A

K

R

R

L

L

G

G

I

I

E

E

T

V

T

R

F

F

V

T

D

S

P

R

A

E

D

E

-

R

P

P

E

E

N

E

F

F

A

L

R

A

A

L

M

T

R

D

P

E

N

K

T

T

R

R

A

A

V

W

Y

W

G

V

E

E

T

S

I

I

G

G

N

N

P

P

L

A

V

L

N

N

V

I

L

P

D

D

I

L

A

E

A

A

V

L

A

A

E

Q

V

A

A

A

H

R

A

E

H

K

G

G

V

V

P

A

L

L

I

I

I

V

D
|
D

N

N

T
|
T

V

F

A

G

-

M

S

G

P

G

Y

Y

L

L

C

L

N

R

P

P

L

L

A

A

L

W

G

G

A

A

D

A

I

L

V

V

V

T

H

H

S
|
S

A

L

T
|
T

K
|
K

Y

W

I

V

G

G

G

G

H

H

G

G

T

A

T

V

M

I

G

A

G

G

V

A

V

I

V

V

E

D

G

G

G

G

Q

N

F

F

P

P

W

W

D

E

N

G

G

G

K

R

F

Y

P

P

E

L

M

L

V

T

E

E

P

P

S

Q

R

P

A

G

Y

Y

H

H

G

G

V

L

K

R

F

L

Y

T

E

E

T

A

F

F

G

G

D

E

F

L

G

A

Y

F

T

I

M

V

K

K

A

A

R

R

M

V

E

D

V

G

N

L

R

R

T

D

F

Q

G

G

G

Q

V

A

L

L

S

G

P

P

M

F

N

E

A

A

W

W

Q

V

L

V

L

L

Q

L

G

G

A

M

E

E

T

T

L

L

H

S

L

L

R

R

M

A

R

E

E

R

H

H

C

V

R

E

N

N

A

T

L

L

A

H

V

L

A

A

K

H

F

W

L

L

Q

L

S

E

H

Q

P

P

Q

Q

V

V

A

A

W

W

V

V

N

N

Y

Y

P

P

G

G

L

L

S

P

D

H

S

H

P

P

Y

H

F

H

D

D

L

R

A

A

Q

Q

K

K

Q

Y

F

F

R

K

A

-

V

-

D

-

G

G

A

K

P

P

G

G

A

A

S

-

G

-

I

V

L

L

T

T

F

F

G

G

V

L

K

K

G

G

G

G

A

Y

T

E

A

A

G

A

E

K

K

R

F

F

I

I

D

S

A

R

C

L

E

K

F

L

L

I

S

S

H

H

L

L

A

A

N

N

I

V

G

G

D

D

A

T

K

R

T

T

L

L

V

A

I

I

H

H

P

P

A

A

S

S

T

T

T

T

H

H

R

S

Q

Q

L

L

N

S

E

P

E

E

E

E

L

Q

A

A

R

Q

A

A

G

G

V

V

S

S

A

P

D

E

M

M

V

V

R

R

L

L

S

S

V

V

G

G

I

L

E

E

D

H

L

V

D

E

D

D

I

L

L

K

W

A

D

E

I

L

D

K

Q

E

A

A

L

L

active site: R54 (= R66), Y107 (= Y119), D180 (= D191), K206 (= K216)
binding pyridoxal-5'-phosphate: S81 (= S93), G82 (= G94), H83 (≠ M95), Q86 (= Q98), Y107 (= Y119), D180 (= D191), T182 (= T193), S203 (= S213), T205 (= T215), K206 (= K216)

Q5SK88 O-acetyl-L-homoserine sulfhydrylase 1; OAH-sulfhydrylase 1; EC 2.5.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
51% identity, 95% coverage: 15:435/442 of query aligns to 3:420/421 of Q5SK88

query
sites
Q5SK88

F

F

G

E

T

T

R

L

A

Q

I

L

H

H

A

A

G

G

A

Y

Q

E

P

P

D

E

P

P

V

T

T

T

G

L

A

S

R

R

A

Q

T

V

P

P

I

I

H

Y

Q

P

T

T

T

T

S

S

F

Y

V

V

F

F

D

K

N

S

A

P

E

E

H

H

A

A

S

A

S

N

L

L

F

F

N

A

L

L

Q

K

T

E

F

F

G

G

N

N

V

I

Y

Y

S

S

R

R

I

I

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

L

E

E

E

K

R

R

I

L

A

A

S

A

L

L

E

E

N

G

G

G

R

K

A

A

A

A

L

L

A

A

C

T

A

A

S

S

G

G

M

H

A

A

A

A

Q

Q

M

F

A

L

A

A

L

L

L

T

A

T

I

L

L

A

K

Q

T

A

G

G

D

D

H

N

I

I

V

V

A

S

A

T

S

P

T

N

L

L

Y

Y

G

G

G

G

T

T

V

F

G

N

Q

Q

L

F

G

K

V

V

G

T

F

L

A

K

R

R

L

L

G

G

I

I

E

E

T

V

T

R

F

F

V

T

D

S

P

R

A

E

D

E

-

R

P

P

E

E

N

E

F

F

A

L

R

A

A

L

M

T

R

D

P

E

N

K

T

T

R

R

A

A

V

W

Y

W

G

V

E

E

T

S

I

I

G

G

N

N

P

P

L

A

V

L

N

N

V

I

L

P

D

D

I

L

A

E

A

A

V

L

A

A

E

Q

V

A

A

A

H

R

A

E

H

K

G

G

V

V

P

A

L

L

I

I

I

V

D

D

N

N

T

T

V

F

A

G

-

M

S

G

P

G

Y

Y

L

L

C

L

N

R

P

P

L

L

A

A

L

W

G

G

A

A

D

A

I

L

V

V

V

T

H

H

S

S

A

L

T

T

K
|
K

Y

W

I

V

G

G

G

G

H

H

G

G

T

A

T

V

M

I

G

A

G

G

V

A

V

I

V

V

E

D

G

G

G

G

Q

N

F

F

P

P

W

W

D

E

N

G

G

G

K

R

F

Y

P

P

E

L

M

L

V

T

E

E

P

P

S

Q

R

P

A

G

Y

Y

H

H

G

G

V

L

K

R

F

L

Y

T

E

E

T

A

F

F

G

G

D

E

F

L

G

A

Y

F

T

I

M

V

K

K

A

A

R

R

M

V

E

D

V

G

N

L

R

R

T

D

F

Q

G

G

G

Q

V

A

L

L

S

G

P

P

M

F

N

E

A

A

W

W

Q

V

L

V

L

L

Q

L

G

G

A

M

E

E

T

T

L

L

H

S

L

L

R

R

M

A

R

E

E

R

H

H

C

V

R

E

N

N

A

T

L

L

A

H

V

L

A

A

K

H

F

W

L

L

Q

L

S

E

H

Q

P

P

Q

Q

V

V

A

A

W

W

V

V

N

N

Y

Y

P

P

G

G

L

L

S

P

D

H

S

H

P

P

Y

H

F

H

D

D

L

R

A

A

Q

Q

K

K

Q

Y

F

F

R

K

A

-

V

-

D

-

G

G

A

K

P

P

G

G

A

A

S

-

G

-

I

V

L

L

T

T

F

F

G

G

V

L

K

K

G

G

G

G

A

Y

T

E

A

A

G

A

E

K

K

R

F

F

I

I

D

S

A

R

C

L

E

K

F

L

L

I

S

S

H

H

L

L

A

A

N

N

I

V

G

G

D

D

A

T

K

R

T

T

L

L

V

A

I

I

H

H

P

P

A

A

S

S

T

T

T

T

H

H

R

S

Q

Q

L

L

N

S

E

P

E

E

E

E

L

Q

A

A

R

Q

A

A

G

G

V

V

S

S

A

P

D

E

M

M

V

V

R

R

L

L

S

S

V

V

G

G

I

L

E

E

D

H

L

V

D

E

D

D

I

L

L

K

W

A

D

E

I

L

D

K

Q

E

A

A

L

L

K206 (= K216) modified: N6-(pyridoxal phosphate)lysine

O13326 Homocysteine synthase; O-acetylhomoserine sulfhydrylase; OAH SHL; OAH sulfhydrylase; EC 2.5.1.49 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
51% identity, 95% coverage: 15:435/442 of query aligns to 8:426/429 of O13326

query
sites
O13326

F

F

G

E

T

T

R

L

A

Q

I

L

H

H

A

A

G

G

A

Q

Q

E

P

P

D

D

P

A

V

A

T

T

G

S

A

S

R

R

A

A

T

V

P

P

I

I

H

Y

Q

A

T

T

T

T

S

S

F

Y

V

V

F

F

D

R

N

D

A

C

E

D

H

H

A

G

S

G

S

R

L

L

F

F

N

G

L

L

Q

Q

T

E

F

P

G

G

N

Y

V

I

Y

Y

S

S

R

R

I

M

S

M

N

N

P

P

T

T

V

A

A

D

V

V

F

F

E

E

E

K

R

R

I

I

A

A

S

A

L

L

E

E

N

H

G

G

R

A

A

A

A

A

L

I

A

A

C

T

A

S

S

S

G

G

M

T

A

S

A

A

Q

L

M

F

A

M

A

A

L

L

L

T

A

T

I

L

L

A

K

K

T

A

G

G

D

D

H

N

I

I

V

V

A

S

A

T

S

S

T

Y

L

L

Y

Y

G

G

G

G

T

T

V

Y

G

N

Q

L

L

F

G

K

V

V

G

T

F

L

A

P

R

R

L

L

G

G

I

I

E

T

T

T

T

K

F

F

V

V

D

N

P

G

A

D

D

D

P

P

E

N

N

D

F

L

A

A

R

A

A

Q

M

I

R

D

P

E

N

N

T

T

R

K

A

A

V

V

Y

Y

G

V

E

E

T

S

I

I

G

G

N

N

P

P

L

M

V

Y

N

N

V

V

L

P

D

D

I

F

A

E

A

R

V

I

A

A

E

E

V

V

A

A

H

H

A

A

H

A

G

G

V

V

P

P

L

L

I

M

I

V

D

D

N

N

T

T

V

F

-

G

A

G

S

G

P

G

Y

Y

L

L

C

V

N

R

P

P

L

I

A

D

L

H

G

G

A

A

D

D

I

I

V

V

V

T

H

H

S

S

A

A

T

T

K

K

Y

W

I

I

G

G

G

G

H

H

G

G

T

T

T

T

M

I

G

G

G

G

V

V

V

I

V

V

E

D

G

S

G

G

Q

K

F

F

P

D

W

W

-

K

-

K

D

N

N

S

G

K

K

R

F

F

P

P

E

E

M

F

V

N

E

E

P

P

S

H

R

P

A

G

Y

Y

H

H

G

G

V

M

K

V

F

F

Y

T

E

E

T

T

F

F

G

G

D

N

F

L

G

A

Y

Y

T

A

M

F

K

A

A

C

R

R

M

T

E

Q

V

T

N

L

R

R

T

D

F

V

G

G

G

G

V

N

L

A

S

N

P

P

M

F

N

G

A

V

W

F

Q

L

L

L

L

L

Q

Q

G

G

A

L

E

E

T

T

L

L

H

S

L

L

R

R

M

M

R

E

E

R

H

H

C

V

R

Q

N

N

A

A

L

F

A

A

V

L

A

A

K

K

F

Y

L

L

Q

E

S

K

H

H

P

P

Q

K

V

V

A

N

W

W

V

V

N

S

Y

Y

P

P

G

G

L

L

S

E

D

S

S

H

P

V

Y

S

F

H

D

K

L

L

A

A

Q

K

K

K

Q

Y

F

L

R

K

A

N

V

-

D

-

G

-

A

-

P

-

G

G

A

Y

S

G

G

A

I

V

L

L

T

S

F

F

G

G

V

A

K

K

G

G

G

G

A

P

T

D

A

Q

G

S

E

R

K

K

F

V

I

V

D

N

A

A

C

L

E

K

F

L

L

A

S

S

H

Q

L

L

A

A

N

N

I

V

G

G

D

D

A

A

K

K

T

T

L

L

V

V

I

I

H

A

P

P

A

A

S

Y

T

T

T

T

H

H

R

L

Q

Q

L

L

N

T

E

D

E

E

E

E

L

Q

A

I

R

S

A

A

G

G

V

V

S

T

A

K

D

D

M

L

V

I

R

R

L

V

S

A

V

V

G
|
G

I

I

E

E

D

H

L

I

D

D

D

D

I

I

L

I

W

A

D

D

I

F

D

A

Q

Q

A

A

L

L

G411 (= G420) mutation to D: Impairs homocysteine synthase activity.

8erbK Crystal structure of fub7 in complex with vinylglycine ketimine (see paper)
48% identity, 96% coverage: 15:440/442 of query aligns to 6:429/429 of 8erbK

query
sites
8erbK

F

F

G

E

T

T

R

L

A

Q

I

L

H

H

A

A

G

G

A

Y

Q

T

P

P

D

D

P

P

V

H

T

T

G

R

A

S

R

T

A

A

T

V

P

P

I

I

H

Y

Q

A

T

T

T

S

S

S

F

Y

V

T

F

F

D

N

N

D

A

S

E

A

H

H

A

G

S

A

S

R

L

L

F

F

N

G

L

L

Q

K

T

E

F

L

G

G

N

N

V

I

Y
|
Y

S

S

R
|
R

I

L

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

F

E

E

E

K

R

R

I

I

A

A

S

A

L

L

E

E

N

G

G

G

R

I

A

A

A

A

L

A

A

A

C

T

A

S

S

S

G
|
G

M
x
Q

A

A

A

A

Q
|
Q

M

F

A

L

A

T

L

I

L

A

A

T

I

L

L

A

K

K

T

A

G

G

D

D

H

N

I

I

V

V

A

A

A

S

S

S

T

H

L

L

Y
|
Y

G

G

G

G

T

T

V

Y

G

N

Q

Q

L

L

G

N

V

V

G

L

F

L

A

P

R

R

L

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

D

R

P

S

A

G

D

K

P

L

E

E

N

D

F

Y

A

A

R

A

A

A

M

I

R

D

P

D

N

Q

T

T

R

R

A

A

V

I

Y

Y

G

V

E

E

T

S

I

M

G

S

N
|
N

P

P

L

D

V

Y

N

V

V

V

L

P

D

D

I

F

A

E

A

G

V

I

A

A

E

K

V

I

A

A

H

H

A

E

H

H

G

G

V

I

P

P

L

L

I

V

I

V

D
|
D

N

N

T

T

V

L

-

G

A

A

S

G

P

G

Y

Y

L

Y

C

I

N

R

P

P

L

I

A

E

L

H

G

G

A

A

D

D

I

I

V

V

V

V

H

H

S
|
S

A

A

T
|
T

K
|
K

Y

W

I

I

G

G

G

G

H

H

G

G

T

T

T

T

M

I

G

G

G

G

V

V

V

I

V

V

E

D

G

S

G

G

Q

R

F

F

P

N

W

W

D

N

-

K

-

H

N

S

G

D

K

R

F

F

P

P

E

E

M

M

V

V

E

E

P

P

S

S

R

P

A

S

Y

Y

H

H

G

G

V

L

K

K

F

Y

Y

W

E

E

T

A

F

F

G

G

D

P

F

A

G

T

Y

F

T

I

M

T

K

R

A

I

R

R

M

V

E

E

V

M

N

L

R

R

T

D

F

I

G

G

G

A

V

C

L

L

S

S

P

P

M

F

N

S

A

A

W

Q

Q

Q

L

L

L

L

Q

L

G

G

A

I

E

E

T

T

L

L

H

G

L

L

R

R

M

A

R

E

E

R

H

H

C

A

R

Q

N

N

A

T

L

E

A

K

V

L

A

S

K

K

F

Y

L

F

Q

E

S

S

H

S

P

P

Q

N

V

V

A

S

W

W

V

V

N

L

Y

W

P

P

G

G

L

S

S

E

D

S

S

H

P

P

Y

T

F

Y

D

S

L

Q

A

A

Q

K

K

K

Q

Y

F

L

R

-

A

-

V

-

D

-

G

-

A

T

P

R

G

G

A

F

S

G

G

A

I

M

L

L

T

S

F

I

G

G

V

V

K

K

G

G

G

D

A

A

T

S

A

A

G

G

E

S

K

K

F

V

I

V

D

D

A

G

C

L

E

K

F

L

L

V

S

S

H

N

L

L

A

A

N

N

I

V

G

G

D

D

A

A

K

K

T

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T
|
T

H

H

R

E

Q

Q

L

L

N

S

E

E

E

D

E

E

L

R

A

L

R

A

A

S

G

G

V

V

S

T

A

E

D

D

M

M

V

I

R
|
R

L

I

S

S

V

V

G

G

I

I

E

E

D

H

L

V

D

D

D

D

I

I

L

I

W

A

D

D

I

F

D

E

Q

Q

A

S

L

F

G

Q

R

K

T

A

G

Y

G

G

binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: Y55 (= Y64), R57 (= R66), G85 (= G94), Q86 (≠ M95), Q89 (= Q98), Y110 (= Y119), N157 (= N166), D182 (= D191), S205 (= S213), T207 (= T215), K208 (= K216), T385 (= T396), R405 (= R416)

8erjB Crystal structure of fub7 in complex with e-2-aminocrotonate (see paper)
48% identity, 96% coverage: 15:440/442 of query aligns to 5:428/428 of 8erjB

query
sites
8erjB

F

F

G

E

T

T

R

L

A

Q

I

L

H

H

A

A

G

G

A

Y

Q

T

P

P

D

D

P

P

V

H

T

T

G

R

A

S

R

T

A

A

T

V

P

P

I

I

H

Y

Q

A

T

T

T

S

S

S

F

Y

V

T

F

F

D

N

N

D

A

S

E

A

H

H

A

G

S

A

S

R

L

L

F

F

N

G

L

L

Q

K

T

E

F

L

G

G

N

N

V

I

Y

Y

S

S

R

R

I

L

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

F

E

E

E

K

R

R

I

I

A

A

S

A

L

L

E

E

N

G

G

G

R

I

A

A

A

A

L

A

A

A

C

T

A

S

S

S

G
|
G

M
x
Q

A

A

A

A

Q
|
Q

M

F

A

L

A

T

L

I

L

A

A

T

I

L

L

A

K

K

T

A

G

G

D

D

H

N

I

I

V

V

A

A

A

S

S

S

T

H

L

L

Y
|
Y

G

G

G

G

T

T

V

Y

G

N

Q

Q

L

L

G

N

V

V

G

L

F

L

A

P

R

R

L

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

D

R

P

S

A

G

D

K

P

L

E

E

N

D

F

Y

A

A

R

A

A

A

M

I

R

D

P

D

N

Q

T

T

R

R

A

A

V

I

Y

Y

G

V

E

E

T

S

I

M

G

S

N

N

P

P

L

D

V

Y

N

V

V

V

L

P

D

D

I

F

A

E

A

G

V

I

A

A

E

K

V

I

A

A

H

H

A

E

H

H

G

G

V

I

P

P

L

L

I

V

I

V

D
|
D

N

N

T

T

V

L

-

G

A

A

S

G

P

G

Y

Y

L

Y

C

I

N

R

P

P

L

I

A

E

L

H

G

G

A

A

D

D

I

I

V

V

V

V

H

H

S
|
S

A

A

T

T

K
|
K

Y

W

I

I

G

G

G

G

H

H

G

G

T

T

T

T

M

I

G

G

G

G

V

V

V

I

V

V

E

D

G

S

G

G

Q

R

F

F

P

N

W

W

D

N

-

K

-

H

N

S

G

D

K

R

F

F

P

P

E

E

M

M

V

V

E

E

P

P

S

S

R

P

A

S

Y

Y

H

H

G

G

V

L

K

K

F

Y

Y

W

E

E

T

A

F

F

G

G

D

P

F

A

G

T

Y

F

T

I

M

T

K

R

A

I

R

R

M

V

E

E

V

M

N

L

R

R

T

D

F

I

G

G

G

A

V

C

L

L

S

S

P

P

M

F

N

S

A

A

W

Q

Q

Q

L

L

L

L

Q

L

G

G

A

I

E

E

T

T

L

L

H

G

L

L

R

R

M

A

R

E

E

R

H

H

C

A

R

Q

N

N

A

T

L

E

A

K

V

L

A

S

K

K

F

Y

L

F

Q

E

S

S

H

S

P

P

Q

N

V

V

A

S

W

W

V

V

N

L

Y

W

P

P

G

G

L

S

S

E

D

S

S

H

P

P

Y

T

F

Y

D

S

L

Q

A

A

Q

K

K

K

Q

Y

F

L

R

-

A

-

V

-

D

-

G

-

A

T

P

R

G

G

A

F

S

G

G

A

I

M

L

L

T

S

F

I

G

G

V

V

K

K

G

G

G

D

A

A

T

S

A

A

G

G

E

S

K

K

F

V

I

V

D

D

A

G

C

L

E

K

F

L

L

V

S

S

H

N

L

L

A
|
A

N
|
N

I

V

G

G

D

D

A

A

K

K

T

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T
|
T

H

H

R

E

Q

Q

L

L

N

S

E

E

E

D

E

E

L

R

A

L

R

A

A

S

G

G

V

V

S

T

A

E

D

D

M

M

V

I

R
|
R

L

I

S

S

V

V

G

G

I

I

E

E

D

H

L

V

D

D

D

D

I

I

L

I

W

A

D

D

I

F

D

E

Q

Q

A

S

L

F

G

Q

R

K

T

A

G

Y

G

G

binding (2S)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]but-3-enoic acid: G84 (= G94), Q85 (≠ M95), Q88 (= Q98), Y109 (= Y119), D181 (= D191), S204 (= S213), K207 (= K216), A368 (= A380), N369 (= N381), T384 (= T396), R404 (= R416)

8erjA Crystal structure of fub7 in complex with e-2-aminocrotonate (see paper)
48% identity, 96% coverage: 15:440/442 of query aligns to 5:428/428 of 8erjA

query
sites
8erjA

F

F

G

E

T

T

R

L

A

Q

I

L

H

H

A

A

G

G

A

Y

Q

T

P

P

D

D

P

P

V

H

T

T

G

R

A

S

R

T

A

A

T

V

P

P

I

I

H

Y

Q

A

T

T

T

S

S

S

F

Y

V

T

F

F

D

N

N

D

A

S

E

A

H

H

A

G

S

A

S

R

L

L

F

F

N

G

L

L

Q

K

T

E

F

L

G

G

N

N

V

I

Y

Y

S

S

R

R

I

L

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

F

E

E

E

K

R

R

I

I

A

A

S

A

L

L

E

E

N

G

G

G

R

I

A

A

A

A

L

A

A

A

C

T

A

S

S
|
S

G
|
G

M
x
Q

A

A

A

A

Q
|
Q

M

F

A

L

A

T

L

I

L

A

A

T

I

L

L

A

K

K

T

A

G

G

D

D

H

N

I

I

V

V

A

A

A

S

S

S

T

H

L

L

Y
|
Y

G

G

G

G

T

T

V

Y

G

N

Q

Q

L

L

G

N

V

V

G

L

F

L

A

P

R

R

L

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

D

R

P

S

A

G

D

K

P

L

E

E

N

D

F

Y

A

A

R

A

A

A

M

I

R

D

P

D

N

Q

T

T

R

R

A

A

V

I

Y

Y

G

V

E

E

T

S

I

M

G

S

N
|
N

P

P

L

D

V

Y

N

V

V

V

L

P

D

D

I

F

A

E

A

G

V

I

A

A

E

K

V

I

A

A

H

H

A

E

H

H

G

G

V

I

P

P

L

L

I

V

I

V

D
|
D

N

N

T

T

V

L

-

G

A

A

S

G

P

G

Y

Y

L

Y

C

I

N

R

P

P

L

I

A

E

L

H

G

G

A

A

D

D

I

I

V

V

V

V

H

H

S
|
S

A

A

T
|
T

K
|
K

Y

W

I

I

G

G

G

G

H

H

G

G

T

T

T

T

M

I

G

G

G

G

V

V

V

I

V

V

E

D

G

S

G

G

Q

R

F

F

P

N

W

W

D

N

-

K

-

H

N

S

G

D

K

R

F

F

P

P

E

E

M

M

V

V

E

E

P

P

S

S

R

P

A

S

Y

Y

H

H

G

G

V

L

K

K

F

Y

Y

W

E

E

T

A

F

F

G

G

D

P

F

A

G

T

Y

F

T

I

M

T

K

R

A

I

R

R

M

V

E

E

V

M

N

L

R

R

T

D

F

I

G

G

G

A

V

C

L

L

S

S

P

P

M

F

N

S

A

A

W

Q

Q

Q

L

L

L

L

Q

L

G

G

A

I

E

E

T

T

L

L

H

G

L

L

R

R

M

A

R

E

E

R

H

H

C

A

R

Q

N

N

A

T

L

E

A

K

V

L

A

S

K

K

F

Y

L

F

Q

E

S

S

H

S

P

P

Q

N

V

V

A

S

W

W

V

V

N

L

Y

W

P

P

G

G

L

S

S

E

D

S

S

H

P

P

Y

T

F

Y

D

S

L

Q

A

A

Q

K

K

K

Q

Y

F

L

R

-

A

-

V

-

D

-

G

-

A

T

P

R

G

G

A

F

S

G

G

A

I

M

L

L

T

S

F

I

G

G

V

V

K

K

G

G

G

D

A

A

T

S

A

A

G

G

E

S

K

K

F

V

I

V

D

D

A

G

C

L

E

K

F

L

L

V

S

S

H

N

L

L

A

A

N

N

I

V

G

G

D

D

A

A

K

K

T

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T

T

H

H

R

E

Q

Q

L

L

N

S

E

E

E

D

E

E

L

R

A

L

R

A

A

S

G

G

V

V

S

T

A

E

D

D

M

M

V

I

R
|
R

L

I

S

S

V

V

G

G

I

I

E

E

D

H

L

V

D

D

D

D

I

I

L

I

W

A

D

D

I

F

D

E

Q

Q

A

S

L

F

G

Q

R

K

T

A

G

Y

G

G

binding (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid: S83 (= S93), G84 (= G94), Q85 (≠ M95), Q88 (= Q98), Y109 (= Y119), N156 (= N166), D181 (= D191), S204 (= S213), T206 (= T215), K207 (= K216), R404 (= R416)

4omaA The crystal structure of methionine gamma-lyase from citrobacter freundii in complex with l-cycloserine pyridoxal-5'-phosphate (see paper)
43% identity, 97% coverage: 11:437/442 of query aligns to 4:394/396 of 4omaA

query
sites
4omaA

R

R

A

T

F

Y

G

G

F

F

G

N

T

T

R

Q

A

I

I

V

H

H

A

A

G

G

A

Q

Q

Q

P

P

D

D

P

P

V

S

T

T

G

G

A

A

R

L

A

S

T

T

P

P

I

I

H

F

Q

Q

T

T

T

S

S

T

F

F

V

V

F

F

D

D

N

S

A

A

E

E

H

Q

A

G

S

A

S

A

L

R

F

F

N

A

L

L

Q

E

T

E

F

S

G

G

N

Y

V

I

Y

Y

S

T

R
|
R

I

L

S

G

N

N

P

P

T

T

V

T

A

D

V

A

F

L

E

E

E

K

R

K

I

L

A

A

S

V

L

L

E

E

N

R

G

G

R

E

A

A

A

G

L

L

A

A

C

T

A

A

S

S

G
|
G

M
x
I

A

S

A

A

Q

I

M

T

A

T

A

T

L

L

L

L

A

T

I

L

L

C

K

Q

T

Q

G

G

D

D

H

H

I

I

V

V

A

S

A

A

S

S

T

A

L

I

Y
|
Y

G

G

G

C

T

T

V

H

G

A

Q

F

L

L

G

S

V

H

G

S

F

M

A

P

R

K

L

F

G

G

I

I

E

N

T

V

T

S

F

F

V

V

D

D

P

A

A

A

D

K

P

P

E

E

N

E

F

I

A

R

R

A

A

A

M

M

R

R

P

P

N

E

T

T

R

K

A

V

V

V

Y

Y

G

I

E

E

T

T

I

P

G

A

N

N

P

P

L

T

V

L

N

S

V

L

L

V

D

D

I

I

A

E

A

T

V

V

A

A

E

G

V

I

A

A

H

H

A

Q

H

Q

G

G

V

A

P

L

L

L

I

V

I

V

D
|
D

N

N

T

T

V

F

A

M

S

S

P

P

Y

Y

L

C

C

Q

N

Q

P

P

L

L

A

Q

L

L

G

G

A

A

D

D

I

I

V

V

V

V

H

H

S
|
S

A

V

T
|
T

K
|
K

Y

Y

I

I

G

N

G

G

H

H

G

G

T

D

T

V

M

I

G

G

G

G

V

I

V

I

V

V

E

G

G

K

G

Q

Q

E

F

F

P

-

W

I

D

D

N

Q

G

A

K

R

F

F

P

-

E

-

M

-

V

-

E

-

P

-

S

-

R

-

A

-

Y

-

H

-

G

-

V

-

K

-

F

-

Y

-

E

-

T

-

F

-

G

-

D

-

F

-

G

-

Y

-

T

-

M

-

K

-

A

-

R

-

M

V

E

G

V

L

N

K

R

D

T

I

F

T

G

G

G

G

V

C

L

M

S

S

P

P

M

F

N

N

A

A

W

W

Q

L

L

T

L

L

Q

R

G

G

A

V

E

K

T

T

L

L

H

G

L

I

R

R

M

M

R

E

E

R

H

H

C

C

R

E

N

N

A

A

L

L

A

K

V

I

A

A

K

R

F

F

L

L

Q

E

S

G

H

H

P

P

Q

S

V

I

A

T

W

R

V

V

N

Y

Y

Y

P

P

G

G

L

L

S

S

D

S

S

H

P

P

Y

Q

F

Y

D

E

L

L

A

G

Q

Q

K

R

Q

Q

F

M

R

-

A

-

V

-

D

-

G

S

A

L

P

P

G

G

A

-

S

-

G

G

I

I

L

I

T

S

F

F

G

E

V

I

K

A

G

G

G

G

A

L

T

E

A

A

G

G

E

R

K

R

F

M

I

I

D

N

A

S

C

V

E

E

F

L

L

C

S

L

H

L

L

A

A
x
V

N
x
S

I

L

G

G

D

D

A

T

K

E

T

T

L

L

V

I

I

Q

H

H

P

P

A

A

S

S

T

M

T

T

H

H

R

S

Q

P

L

V

N

A

E

P

E

E

E

E

L

R

A

L

R

K

A

A

G

G

V

I

S

T

A

D

D

G

M

L

V

I

R
|
R

L

L

S

S

V

V

G

G

I

L

E

E

D

D

L

P

D

E

D

D

I

I

L

I

W

N

D

D

I

L

D

E

Q

H

A

A

L

I

G

R

R

K

active site: R59 (= R66), Y112 (= Y119), D184 (= D191), K209 (= K216)
binding [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate: G87 (= G94), I88 (≠ M95), Y112 (= Y119), D184 (= D191), S206 (= S213), T208 (= T215), K209 (= K216), V337 (≠ A380), S338 (≠ N381), R373 (= R416)

3jwbA Crystal structure of l-methionine gamma-lyase from citrobacter freundii with norleucine (see paper)
43% identity, 97% coverage: 11:437/442 of query aligns to 4:394/396 of 3jwbA

query
sites
3jwbA

R

R

A

T

F

Y

G

G

F

F

G

N

T

T

R

Q

A

I

I

V

H

H

A

A

G

G

A

Q

Q

Q

P

P

D

D

P

P

V

S

T

T

G

G

A

A

R

L

A

S

T

T

P

P

I

I

H

F

Q

Q

T

T

T

S

S

T

F

F

V

V

F

F

D

D

N

S

A

A

E

E

H

Q

A

G

S

A

S

A

L

R

F

F

N

A

L

L

Q

E

T

E

F

S

G

G

N

Y

V

I

Y

Y

S

T

R
|
R

I

L

S

G

N

N

P

P

T

T

V

T

A

D

V

A

F

L

E

E

E

K

R

K

I

L

A

A

S

V

L

L

E

E

N

R

G

G

R

E

A

A

A

G

L

L

A

A

C

T

A

A

S

S

G

G

M

I

A

S

A

A

Q

I

M

T

A

T

A

T

L

L

L

L

A

T

I

L

L

C

K

Q

T

Q

G

G

D

D

H

H

I

I

V

V

A

S

A

A

S

S

T

A

L

I

Y
|
Y

G

G

G

C

T

T

V

H

G

A

Q

F

L

L

G

S

V

H

G

S

F

M

A

P

R

K

L

F

G

G

I

I

E

N

T

V

T

S

F

F

V

V

D

D

P

A

A

A

D

K

P

P

E

E

N

E

F

I

A

R

R

A

A

A

M

M

R

R

P

P

N

E

T

T

R

K

A

V

V

V

Y

Y

G

I

E

E

T

T

I

P

G

A

N

N

P

P

L

T

V

L

N

S

V

L

L

V

D

D

I

I

A

E

A

T

V

V

A

A

E

G

V

I

A

A

H

H

A

Q

H

Q

G

G

V

A

P

L

L

L

I

V

I

V

D
|
D

N

N

T

T

V

F

A

M

S

S

P

P

Y

Y

L

C

C

Q

N

Q

P

P

L

L

A

Q

L

L

G

G

A

A

D

D

I

I

V

V

V

V

H

H

S

S

A

V

T

T

K
|
K

Y

Y

I

I

G

N

G

G

H

H

G

G

T

D

T

V

M

I

G

G

G

G

V

I

V

I

V

V

E

G

G

K

G

Q

Q

E

F

F

P

-

W

I

D

D

N

Q

G

A

K

R

F

F

P

-

E

-

M

-

V

-

E

-

P

-

S

-

R

-

A

-

Y

-

H

-

G

-

V

-

K

-

F

-

Y

-

E

-

T

-

F

-

G

-

D

-

F

-

G

-

Y

-

T

-

M

-

K

-

A

-

R

-

M

V

E

G

V

L

N

K

R

D

T

I

F

T

G

G

G

G

V

C

L

M

S

S

P

P

M

F

N

N

A

A

W

W

Q

L

L

T

L

L

Q

R

G

G

A

V

E

K

T

T

L

L

H

G

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