SitesBLAST
Comparing Ac3H11_1486 FitnessBrowser__acidovorax_3H11:Ac3H11_1486 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
50% identity, 99% coverage: 5:484/485 of query aligns to 29:514/515 of 2d4eC
- active site: N173 (= N146), K196 (= K169), E271 (= E242), C305 (= C276), E409 (= E379), E486 (= E456)
- binding nicotinamide-adenine-dinucleotide: I169 (= I142), T170 (≠ S143), P171 (= P144), W172 (= W145), K196 (= K169), A198 (≠ S171), G229 (= G202), G233 (= G206), A234 (≠ E207), T248 (= T221), G249 (= G222), E250 (≠ S223), T253 (= T226), E271 (= E242), L272 (= L243), C305 (= C276), E409 (= E379), F411 (= F381), F475 (= F445)
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
43% identity, 98% coverage: 1:473/485 of query aligns to 8:485/487 of Q9H2A2
- R109 (= R102) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N146) mutation to A: Complete loss of activity.
- R451 (= R439) mutation to A: Complete loss of activity.
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
43% identity, 100% coverage: 1:483/485 of query aligns to 2:487/489 of 4o6rA
- active site: N150 (= N146), K173 (= K169), E248 (= E242), C282 (= C276), E383 (= E379), E460 (= E456)
- binding adenosine monophosphate: I146 (= I142), V147 (≠ S143), K173 (= K169), G206 (= G202), G210 (= G206), Q211 (≠ E207), F224 (= F220), G226 (= G222), S227 (= S223), T230 (= T226), R233 (= R229)
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
42% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4npiA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), W160 (= W154), E251 (= E242), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), P150 (= P144), W151 (= W145), K175 (= K169), E178 (= E172), G208 (= G202), G213 (= G206), E214 (= E207), F227 (= F220), G229 (= G222), E230 (≠ S223), T233 (= T226), G253 (= G244), C285 (= C276), K335 (= K326), E387 (= E379), F389 (= F381)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
42% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4i2rA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ S223), T233 (= T226), E251 (= E242), L252 (= L243), G253 (= G244), C285 (= C276), E387 (= E379), F389 (= F381)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
42% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4i25A
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), P150 (= P144), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), G213 (= G206), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ S223), T233 (= T226), E251 (= E242), L252 (= L243), C285 (= C276), E387 (= E379), F389 (= F381)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
42% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 5kllA
- active site: D152 (≠ N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (= R102), D152 (≠ N146), L157 (≠ T151), W160 (= W154), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
42% identity, 98% coverage: 2:475/485 of query aligns to 3:484/484 of 5kj5B
- active site: D153 (≠ N146), K176 (= K169), E252 (= E242), C286 (= C276), E388 (= E379), E465 (= E456)
- binding nicotinamide-adenine-dinucleotide: I149 (= I142), S150 (= S143), P151 (= P144), W152 (= W145), D153 (≠ N146), L158 (≠ T151), K176 (= K169), G209 (= G202), K210 (= K203), G214 (= G206), F228 (= F220), T229 (= T221), G230 (= G222), E231 (≠ S223), T234 (= T226), E252 (= E242), L253 (= L243), C286 (= C276), E388 (= E379), F390 (= F381), F454 (= F445)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
42% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4ou2A
- active site: N152 (= N146), K175 (= K169), A251 (≠ E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), P150 (= P144), W151 (= W145), N152 (= N146), K175 (= K169), G208 (= G202), G213 (= G206), E214 (= E207), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ S223), T233 (= T226), A251 (≠ E242), L252 (= L243), G253 (= G244), C285 (= C276), E387 (= E379), F389 (= F381)
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
42% identity, 97% coverage: 7:478/485 of query aligns to 10:485/489 of 4cazA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E379), E463 (= E456)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I142), G149 (≠ S143), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), T227 (= T221), G228 (= G222), G229 (≠ S223), T232 (= T226), V236 (≠ I230), E251 (= E242), L252 (= L243), C285 (= C276), E386 (= E379), F388 (= F381)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
42% identity, 97% coverage: 7:478/485 of query aligns to 10:485/489 of 2woxA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E379), E463 (= E456)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I142), G149 (≠ S143), W151 (= W145), N152 (= N146), K175 (= K169), S177 (= S171), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), T227 (= T221), G228 (= G222), G229 (≠ S223), T232 (= T226), V236 (≠ I230), E251 (= E242), L252 (= L243), C285 (= C276), E386 (= E379), F388 (= F381)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
42% identity, 97% coverage: 7:478/485 of query aligns to 10:485/489 of 2wmeA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E379), E463 (= E456)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ S143), W151 (= W145), K175 (= K169), S177 (= S171), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), G228 (= G222), G229 (≠ S223), T232 (= T226), V236 (≠ I230)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
42% identity, 97% coverage: 7:478/485 of query aligns to 11:486/490 of Q9HTJ1
- GAWN 150:153 (≠ SPWN 143:146) binding
- K162 (= K155) active site, Charge relay system
- KPSE 176:179 (≠ KMSE 169:172) binding
- G209 (= G202) binding
- GTST 230:233 (≠ STAT 223:226) binding
- E252 (= E242) active site, Proton acceptor
- C286 (= C276) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E379) binding
- E464 (= E456) active site, Charge relay system
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
42% identity, 95% coverage: 14:475/485 of query aligns to 53:515/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
41% identity, 96% coverage: 13:479/485 of query aligns to 44:511/512 of P47895
- R89 (≠ A55) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K169) binding
- E207 (= E172) binding
- GSTEVG 257:262 (≠ GSTATG 222:227) binding
- Q361 (≠ H323) binding
- E411 (= E379) binding
- A493 (≠ S461) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
41% identity, 96% coverage: 13:476/485 of query aligns to 25:489/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I142), T159 (≠ S143), P160 (= P144), W161 (= W145), K185 (= K169), E188 (= E172), G218 (= G202), G222 (= G206), F236 (= F220), S239 (= S223), V242 (≠ T226)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
41% identity, 95% coverage: 14:475/485 of query aligns to 29:491/496 of 4fr8C
- active site: N165 (= N146), K188 (= K169), Q264 (≠ E242), C298 (= C276), E395 (= E379), E472 (= E456)
- binding nicotinamide-adenine-dinucleotide: I161 (= I142), I162 (≠ S143), W164 (= W145), K188 (= K169), G221 (= G202), G225 (= G206), A226 (≠ E207), F239 (= F220), G241 (= G222), S242 (= S223), I245 (≠ T226), Q345 (≠ H323), E395 (= E379), F397 (= F381)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
41% identity, 95% coverage: 14:475/485 of query aligns to 26:488/493 of 4fr8A
- active site: N162 (= N146), K185 (= K169), Q261 (≠ E242), C295 (= C276), E392 (= E379), E469 (= E456)
- binding nicotinamide-adenine-dinucleotide: I158 (= I142), I159 (≠ S143), W161 (= W145), K185 (= K169), G218 (= G202), G222 (= G206), A223 (≠ E207), F236 (= F220), G238 (= G222), S239 (= S223), I242 (≠ T226), Q342 (≠ H323), K345 (= K326), E392 (= E379), F394 (= F381)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ V147), L166 (≠ M150), W170 (= W154), F289 (≠ S270), S294 (≠ R275), C295 (= C276), D450 (≠ N437), F452 (≠ R439)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
41% identity, 95% coverage: 14:475/485 of query aligns to 27:489/494 of 5l13A
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E379), E470 (= E456)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ V147), M168 (≠ T151), W171 (= W154), F290 (≠ S270), C295 (≠ R275), C296 (= C276), C297 (≠ T277), D451 (≠ N437), F453 (≠ R439)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
41% identity, 95% coverage: 14:475/485 of query aligns to 27:489/494 of 4kwgA
- active site: N163 (= N146), K186 (= K169), E262 (= E242), C296 (= C276), E393 (= E379), E470 (= E456)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ V147), M168 (≠ T151), C295 (≠ R275), C296 (= C276), C297 (≠ T277), D451 (≠ N437), F453 (≠ R439)
Query Sequence
>Ac3H11_1486 FitnessBrowser__acidovorax_3H11:Ac3H11_1486
MRIQHLIGGKPVESREYFETVNPATQEVLAEVASGGAAEVHAAVAAAKDAFPAWAGLPAP
ERAKLVRKLGDLIAAEVPTLALTETKDTGQVIGQTGKALIPRAADNFYYFAEMCTRVDGH
TYPTPTHLNYTLFHPVGVCALISPWNVPFMTSTWKVAPALAFGNTAVLKMSELSPLTAAR
LGELALEAGIPAGVLNVVHGYGKDAGEPLCTHPDVRAISFTGSTATGNRIVQAAGLKKFS
MELGGKSPFVVFADADLDRALDAALFMIFSNNGERCTAGSRILVQKSIYADFAEKFAARA
RRIVVGDPLDEKTIVGPMISQAHLAKVRSYIELGPKEGATLLCGGLGTPDLPAHLQKGNF
VLPTVFADVDNRMKIAQEEIFGPVACLIPFEDEAEAIRLANDIQYGLSSYVWTENIGRAH
RVAAGIEAGMCFVNSQNVRDLRQPFGGTKGSGTGREGGTWSYEVFLEPKNIAVSMGSHHI
PHWGV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory