Comparing Ac3H11_1530 FitnessBrowser__acidovorax_3H11:Ac3H11_1530 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7tcmA Crystal structure of aspartate-semialdehyde dehydrogenase from acinetobacter baumannii in complex with NADP
66% identity, 99% coverage: 5:384/385 of query aligns to 5:370/373 of 7tcmA
5bntC X-ray crystal structure of a aspartate-semialdehyde dehydrogenase bound to NADP from pseudomonas aeruginosa
64% identity, 99% coverage: 3:384/385 of query aligns to 3:370/371 of 5bntC
P44801 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 2 papers)
62% identity, 99% coverage: 3:383/385 of query aligns to 2:370/371 of P44801
1pquA Crystal structure of the h277n mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae bound with NADP, s-methyl cysteine sulfoxide and cacodylate (see paper)
62% identity, 99% coverage: 3:383/385 of query aligns to 2:370/371 of 1pquA
1gl3A Aspartate beta-semialdehyde dehydrogenase in complex with NADP and substrate analogue s-methyl cysteine sulfoxide (see paper)
62% identity, 99% coverage: 3:382/385 of query aligns to 2:366/367 of 1gl3A
P0A9Q9 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Escherichia coli (strain K12) (see 2 papers)
62% identity, 99% coverage: 3:382/385 of query aligns to 2:366/367 of P0A9Q9
1tb4A Crystal structure of aspartate-semialdehyde dehydrogenase from haemophilus influenzae with a bound periodate (see paper)
61% identity, 99% coverage: 3:383/385 of query aligns to 2:356/357 of 1tb4A
1ta4A Crystal structure of aspartate-semialdehyde dehydrogenase from haemophilus influenzae with a bound arsenate (see paper)
61% identity, 99% coverage: 3:383/385 of query aligns to 2:356/357 of 1ta4A
1nx6A Crystal structure of aspartate semialdehyde dehydrogenase from haemophilus influenzae as a tetrahedral hemithiocetal reaction intermediate with phosphate at 2.15 a (see paper)
61% identity, 99% coverage: 3:383/385 of query aligns to 2:356/357 of 1nx6A
1pqpA Crystal structure of the c136s mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae bound with aspartate semialdehyde and phosphate (see paper)
60% identity, 99% coverage: 3:383/385 of query aligns to 2:356/357 of 1pqpA
4r5mA Crystal structure of vc-aspartate beta-semialdehyde-dehydrogenase with NADP and 4-nitro-2-phosphono-benzoic acid (see paper)
60% identity, 98% coverage: 5:383/385 of query aligns to 3:367/369 of 4r5mA
1mb4A Crystal structure of aspartate semialdehyde dehydrogenase from vibrio cholerae with NADP and s-methyl-l-cysteine sulfoxide (see paper)
60% identity, 98% coverage: 5:383/385 of query aligns to 3:367/369 of 1mb4A
3pzrA Crystals structure of aspartate beta-semialdehyde dehydrogenase from vibrio cholerae with NADP and product of s-carbamoyl-l-cysteine (see paper)
60% identity, 98% coverage: 5:383/385 of query aligns to 3:367/370 of 3pzrA
Q9KQG2 Aspartate-semialdehyde dehydrogenase 1; ASA dehydrogenase 1; ASADH 1; Aspartate-beta-semialdehyde dehydrogenase 1; EC 1.2.1.11 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
60% identity, 98% coverage: 5:383/385 of query aligns to 3:367/370 of Q9KQG2
Q04797 Aspartate-semialdehyde dehydrogenase; ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase; EC 1.2.1.11 from Bacillus subtilis (strain 168) (see paper)
24% identity, 96% coverage: 5:372/385 of query aligns to 7:330/346 of Q04797
3tz6A Crystal structure of aspartate semialdehyde dehydrogenase complexed with inhibitor smcs (cys) and phosphate from mycobacterium tuberculosis h37rv (see paper)
26% identity, 96% coverage: 5:372/385 of query aligns to 4:330/342 of 3tz6A
Sites not aligning to the query:
2r00C Crystal structure of aspartate semialdehyde dehydrogenase ii complexed with asa from vibrio cholerae (see paper)
24% identity, 80% coverage: 5:311/385 of query aligns to 6:265/336 of 2r00C
Sites not aligning to the query:
P23247 Aspartate-semialdehyde dehydrogenase 2; ASA dehydrogenase 2; ASADH 2; Aspartate-beta-semialdehyde dehydrogenase 2; EC 1.2.1.11 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
24% identity, 80% coverage: 5:311/385 of query aligns to 7:266/337 of P23247
4r5hA Crystal structure of sp-aspartate-semialdehyde-dehydrogenase with nicotinamide-adenine-dinucleotide-phosphate and 3-carboxy-propenyl- phthalic acid (see paper)
23% identity, 96% coverage: 5:372/385 of query aligns to 4:330/359 of 4r5hA
4r4jA Crystal structure of complex sp_asadh with 3-carboxypropyl-phthalic acid and nicotinamide adenine dinucleotide phosphate (see paper)
23% identity, 96% coverage: 5:372/385 of query aligns to 4:330/359 of 4r4jA
>Ac3H11_1530 FitnessBrowser__acidovorax_3H11:Ac3H11_1530
MSKLVGLVGWRGMVGSVLMDRMEQEKDFDLIEPMFFSTSNAGGKAPAQAKNETALQDAFN
IEALKRCEIIITAQGGDYTSEVYPKLRAAGWNGHWIDAASSLRMEKNAVIVLDPVNMPVI
KNALANGGKDWIGGNCTVSCMLMGVGALYKAGLVEWMSTQTYQAASGGGAQHMRELLTQY
GTLNAEVRSLLDDPKSAILEIDRKVIAKQRALTGAETANFGVPLGGSLIPWIDKDLGIGK
SQDEPGWGMSKEEWKGMAETNKILGQGEGFSTAAIPVDGFCVRVGAMRCHSQALTFKLKK
DVPVADIEAMVAADNEWVKVVPNTREATIQDLTPVAVTGTMTIPVGRIRKLAMGPEYVGA
FTIGDQLLWGAAEPLRRMLRILLDA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory