SitesBLAST – Find functional sites

 

SitesBLAST

Comparing Ac3H11_1679 FitnessBrowser__acidovorax_3H11:Ac3H11_1679 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 6 hits to proteins with known functional sites (download)

Q02I31 Putative pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
26% identity, 78% coverage: 23:110/113 of query aligns to 23:110/118 of Q02I31

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Q02I31
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Sites not aligning to the query:

2v6tB Crystal structure of a complex of pterin-4a-carbinolamine dehydratase from toxoplasma gondii with 7,8-dihydrobiopterin (see paper)
32% identity, 84% coverage: 14:108/113 of query aligns to 1:93/100 of 2v6tB

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2v6tB
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P61459 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Rattus norvegicus (Rat) (see 2 papers)
32% identity, 73% coverage: 23:105/113 of query aligns to 15:94/104 of P61459

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P61459
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Sites not aligning to the query:

P61457 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Homo sapiens (Human) (see 6 papers)
32% identity, 73% coverage: 23:105/113 of query aligns to 15:94/104 of P61457

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P61457
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Sites not aligning to the query:

1f93A Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator dcoh (see paper)
32% identity, 73% coverage: 23:105/113 of query aligns to 14:93/103 of 1f93A

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1f93A
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1dcpA Dcoh, a bifunctional protein-binding transcriptional coactivator, complexed with biopterin (see paper)
32% identity, 73% coverage: 23:105/113 of query aligns to 10:89/99 of 1dcpA

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1dcpA
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Query Sequence

>Ac3H11_1679 FitnessBrowser__acidovorax_3H11:Ac3H11_1679
MTTTMLKKKDWSALARRALTATEVVANLAKLEGWSLSGDGANVAIEKTYHFANYYETISF
VNALAFVANAQDHHPDLSVHYNRCVVRLNTHDVNGISSTDFECATQFDALVAL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory