SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ac3H11_1692 FitnessBrowser__acidovorax_3H11:Ac3H11_1692 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
53% identity, 97% coverage: 8:241/242 of query aligns to 5:238/240 of 1ji0A

query
sites
1ji0A

V

I

L

V

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L

Q

E

V

V

K

Q

G

S

L

L

K

H

V

V

A

Y

Y
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Y

G

G

G

A

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A

A

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K

G

G

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G

E

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L

L

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S

A

N

N

G
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G

A

A

G
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G

K
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K

T
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T

T

T

M

L

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S

A

A

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T

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E
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E

G

G

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R

G

R

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I

F

F

A

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E

M

L

T

T

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Y

E

E

N

N

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L

Q

M

M

M

G

G

A

A

Y

Y

I

N

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R

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D

D

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E

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T

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E

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N

N

A

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G

G

binding adenosine-5'-triphosphate: Y16 (= Y19), G42 (= G45), G44 (= G47), K45 (= K48), T46 (= T49), T47 (= T50), E88 (= E91), E165 (= E168)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 97% coverage: 9:242/242 of query aligns to 4:254/254 of 1g6hA

query
sites
1g6hA

L

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L

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N

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x
F

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N

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G

A

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G

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K

T
x
S

T
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T

T

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E

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E

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K

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G

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E

binding adenosine-5'-diphosphate: F14 (≠ Y19), F17 (≠ I22), N39 (= N44), G40 (= G45), G42 (= G47), K43 (= K48), S44 (≠ T49), T45 (= T50)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 96% coverage: 9:241/242 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

L

I

L

L

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E

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N

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A

Y

Y
x
F

G

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x
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A

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D

G

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G

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L

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G
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G

A
x
S

G
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G

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K

T
x
S

T
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T

T

L

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I

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N

A

V

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T

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G

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F

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M

T

T

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E

E

N

N

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I

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G

A

E

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I

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G

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N

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E

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G

L

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A

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G

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R

G

G

Q

E

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E

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K

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N

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L

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D

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L

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G

binding adenosine-5'-diphosphate: F14 (≠ Y19), F17 (≠ I22), G40 (= G45), S41 (≠ A46), G42 (= G47), K43 (= K48), S44 (≠ T49), T45 (= T50)
binding magnesium ion: S44 (≠ T49), E176 (= E168)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
31% identity, 96% coverage: 10:242/242 of query aligns to 3:236/238 of 6s8nB

query
sites
6s8nB

L

L

Q

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N

N

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A

A

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x
R

R

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Y

E

D

N

N

L

L

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M

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A

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A

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D

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A

A

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N

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F

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E

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R

D

D

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L
x
M

A
x
G

G
x
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G

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A

E

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A

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R

A

A

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A

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N

P

P

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K

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F

L

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L

L

D

D

E

E

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F

M

A

G

G

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P

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V

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K

D

I

I

F

K

E

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R

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D

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Y

R

A

D

L

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G

G

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I

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L

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D

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H

N

N

A

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S

R

R

E

A

T

L

L

A

A

I

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A

C

D

E

R

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A

Y

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S

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G

L

H

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I

M

A

T

H

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G

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T

G

P

Q

T

Q

E

L

I

L

L

N

Q

D

D

P

E

K

H

V

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R

K

A

R

A

V

Y

Y

L

L

G

G

E

E

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ A97), M133 (≠ L139), G134 (≠ A140), Q135 (≠ G141)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
31% identity, 96% coverage: 10:242/242 of query aligns to 3:236/238 of 6s8gA

query
sites
6s8gA

L

L

Q

T

V

A

K

K

G

N

L

L

K

A

V

K

A

A

Y
|
Y

G

K

G

G

I
x
R

Q

R

A

V

V

V

K

E

G

D

V

V

D

S

F

L

E

T

V

V

R

N

E

S

G

G

E

E

L

I

V

V

S

G

L

L

I

L

G

G

S

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

T

T

M

F

K

Y

A

M

I

V

T

V

G

G

T

I

L

V

S

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M

R

N

D

D

A

G

G

N

N

I

I

E

I

Y

I

L

D

G

D

K

D

S

D

I

I

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S

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L

K

L

G

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A

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D

A

L

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A

K

R

E

R

G

G

L

I

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M

Y

V

L

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P

E
x
Q

G

E

R

A

G

S

V

I

F

F

A

R

R

R

M

L

T

S

I

V

T

Y

E

D

N

N

L

L

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M

-

A

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V

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L

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Q

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I

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R

-

D

Q

D

M

L

G

S

A

A

Y

E

I

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R

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K

E

D

D

K

R

A

A

G

N

I

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L

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A

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D

E

I

L

E

M

K

E

M

E

F

F

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I

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F

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P

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E

H

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D

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M

A

G

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T
x
S

M

L

S
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S

G

G

E
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E

Q

R

M

R

L

V

A

E

M

I

G

A

R

R

A

A

L

L

M

A

S

A

Q

N

P

P

K

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

S

D

P

P

I

I

M

S

V

V

D

I

K

D

I

I

F

K

E

R

V

I

R

E

D

H

V

L

Y

R

A

D

L

S

G

G

V

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

A

V

S

R

R

E

A

T

L

L

A

A

I

V

A

C

D

E

R

R

G

A

Y

Y

V

I

M

V

E

S

S

Q

G

G

L

H

I

L

T

I

M

A

T

H

G

G

P

T

G

P

Q

T

Q

E

L

I

L

L

N

Q

D

D

P

E

K

H

V

V

R

K

A

R

A

V

Y

Y

L

L

G

G

E

E

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y19), R15 (≠ I22), N37 (= N44), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50), Q84 (≠ E91), S136 (≠ T142), S138 (= S144), E141 (= E147)

6mbnA Lptb e163q in complex with atp (see paper)
30% identity, 96% coverage: 10:242/242 of query aligns to 4:237/241 of 6mbnA

query
sites
6mbnA

L

L

Q

T

V

A

K

K

G

N

L

L

K

A

V

K

A

A

Y
|
Y

G

K

G

G

I
x
R

Q

R

A
x
V

V

V

K

E

G

D

V

V

D

S

F

L

E

T

V

V

R

N

E

S

G

G

E

E

L

I

V

V

S

G

L

L

I

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T

T

M

F

K

Y

A

M

I

V

T

V

G

G

T

I

L

V

S

P

M

R

N

D

D

A

G

G

N

N

I

I

E

I

Y

I

L

D

G

D

K

D

S

D

I

I

K

S

G

L

K

L

G

P

A

L

W

H

D

A

L

R

V

A

K

R

E

R

G

G

L

I

V

G

M

Y

V

L

P

P

E

Q

G

E

R

A

G

S

V

I

F

F

A

R

R

R

M

L

T

S

I

V

T

Y

E

D

N

N

L

L

-

M

-

A

-

V

-

L

-

Q

-

I

-

R

-

D

Q

D

M

L

G

S

A

A

Y

E

I

Q

R

R

K

E

D

D

K

R

A

A

G

N

I

-

L

-

A

-

D

E

I

L

E

M

K

E

M

E

F

F

T

H

I

I

F

-

P

-

R

-

L

-

R

E

E

H

R

L

K

R

D

D

Q

S

L

M

A

G

G

Q

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

G

A

R

R

A

A

L

L

M

A

S

A

Q

N

P

P

K

K

V

F

L

I

L

L

D

D

E

Q

P

P

S

F

M

A

G

G

L

V

S

D

P

P

I

I

M

S

V

V

D

I

K

D

I

I

F

K

E

R

V

I

R

E

D

H

V

L

Y

R

A

D

L

S

G

G

V

L

T

G

I

V

V

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

S

R

R

E

A

T

L

L

A

A

I

V

A

C

D

E

R

R

G

A

Y

Y

V

I

M

V

E

S

S

Q

G

G

L

H

I

L

T

I

M

A

T

H

G

G

P

T

G

P

Q

T

Q

E

L

I

L

L

N

Q

D

D

P

E

K

H

V

V

R

K

A

R

A

V

Y

Y

L

L

G

G

E

E

binding adenosine-5'-triphosphate: Y13 (= Y19), R16 (≠ I22), V18 (≠ A24), N38 (= N44), G39 (= G45), G41 (= G47), K42 (= K48), T43 (= T49), T44 (= T50), H195 (≠ Q200)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
30% identity, 96% coverage: 10:241/242 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

Q

T

V

A

K

K

G

N

L

L

K

A

V

K

A

A

Y
|
Y

G

K

G

G

I

R

Q

R

A

V

V

V

K

E

G

D

V

V

D

S

F

L

E

T

V

V

R

N

E

S

G

G

E

E

L

I

V

V

S

G

L

L

I

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T

T

M

F

K

Y

A

M

I

V

T

V

G

G

T

I

L

V

S

P

M

R

N

D

D

A

G

G

N

N

I

I

E

I

Y

I

L

D

G

D

K

D

S

D

I

I

K

S

G

L

K

L

G

P

A

L

W

H

D

A

L

R

V

A

K

R

E

R

G

G

L

I

V

G

M

Y

V

L

P

P

E
x
Q

G

E

R

A

G

S

V

I

F

F

A

R

R

R

M

L

T

S

I

V

T

Y

E

D

N

N

L

L

-

M

-

A

-

V

-

L

-

Q

-

I

-

R

-

D

Q

D

M

L

G

S

A

A

Y

E

I

Q

R

R

K

E

D

D

K

R

A

A

G

N

I

-

L

-

A

-

D

E

I

L

E

M

K

E

M

E

F

F

T

H

I

I

F

-

P

-

R

-

L

-

R

E

E

H

R

L

K

R

D

D

Q

S

L

M

A

G

G

Q

T
x
S

M

L

S
|
S

G
|
G

E

E

Q

R

M

R

L

V

A

E

M

I

G

A

R

R

A

A

L

L

M

A

S

A

Q

N

P

P

K

K

V

F

L

I

L

L

D

D

E
|
E

P

P

S

F

M

A

G
|
G

L

V

S

D

P

P

I

I

M

S

V

V

D

I

K

D

I

I

F

K

E

R

V

I

R

E

D

H

V

L

Y

R

A

D

L

S

G

G

V

L

T

G

I

V

V

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

S

R

R

E

A

T

L

L

A

A

I

V

A

C

D

E

R

R

G

A

Y

Y

V

I

M

V

E

S

S

Q

G

G

L

H

I

L

T

I

M

A

T

H

G

G

P

T

G

P

Q

T

Q

E

L

I

L

L

N

Q

D

D

P

E

K

H

V

V

R

K

A

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y19), N37 (= N44), G38 (= G45), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50), Q84 (≠ E91), S136 (≠ T142), S138 (= S144), G139 (= G145), G140 (= G146), E162 (= E168), G166 (= G172), H194 (≠ Q200)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
30% identity, 95% coverage: 10:240/242 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

Q

T

V

A

K

K

G

N

L

L

K

A

V

K

A

A

Y
|
Y

G

K

G

G

I
x
R

Q

R

A
x
V

V

V

K

E

G

D

V

V

D

S

F

L

E

T

V

V

R

N

E

S

G

G

E

E

L

I

V

V

S

G

L

L

I

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T

T

M

F

K

Y

A

M

I

V

T

V

G

G

T

I

L

V

S

P

M

R

N

D

D

A

G

G

N

N

I

I

E

I

Y

I

L

D

G

D

K

D

S

D

I

I

K

S

G

L

K

L

G

P

A
x
L

W
x
H

D

A

L

R

V

A

K

R

E

R

G

G

L

I

V

G

M

Y

V

L

P
|
P

E
x
Q

G

E

R
x
A

G
x
S

V

I

F
|
F

A
x
R

R
|
R

M
x
L

T

S

I

V

T

Y

E

D

N

N

L

L

-

M

-

A

-
x
V

-

L

-

Q

-

I

-

R

-

D

Q

D

M

L

G

S

A

A

Y

E

I

Q

R

R

K

E

D

D

K

R

A

A

G

N

I

-

L

-

A

-

D

E

I

L

E

M

K

E

M

E

F

F

T

H

I

I

F

-

P

-

R

-

L

-

R

E

E

H

R

L

K

R

D

D

Q

S

L

M

A

G

G
x
Q

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

G

A

R
|
R

A

A

L

L

M

A

S

A

Q

N

P

P

K

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

S

D

P

P

I

I

M

S

V

V

D

I

K

D

I

I

F

K

E

R

V

I

R

E

D

H

V

L

Y

R

A

D

L

S

G

G

V

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

A

V

S

R

R

E

A

T

L

L

A

A

I

V

A

C

D

E

R

R

G

A

Y

Y

V

I

M

V

E

S

S

Q

G

G

L

H

I

L

T

I

M

A

T

H

G

G

P

T

G

P

Q

T

Q

E

L

I

L

L

N

Q

D

D

P

E

K

H

V

V

R

K

A

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y19), R15 (≠ I22), V17 (≠ A24), N37 (= N44), G38 (= G45), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50)
binding magnesium ion: T42 (= T49), Q84 (≠ E91)
binding novobiocin: L71 (≠ A78), H72 (≠ W79), P83 (= P90), A86 (≠ R93), S87 (≠ G94), F89 (= F96), R90 (≠ A97), R91 (= R98), L92 (≠ M99), V101 (vs. gap), Q135 (≠ G141), R149 (= R155)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
30% identity, 95% coverage: 10:240/242 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

Q

T

V

A

K

K

G

N

L

L

K

A

V

K

A

A

Y
|
Y

G

K

G

G

I
x
R

Q

R

A
x
V

V

V

K

E

G

D

V

V

D

S

F

L

E

T

V

V

R

N

E

S

G

G

E

E

L

I

V

V

S

G

L

L

I

L

G

G

S

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T

T

M

F

K

Y

A

M

I

V

T

V

G

G

T

I

L

V

S

P

M

R

N

D

D

A

G

G

N

N

I

I

E

I

Y

I

L

D

G

D

K

D

S

D

I

I

K

S

G

L

K

L

G

P

A

L

W

H

D

A

L

R

V

A

K

R

E

R

G

G

L

I

V

G

M

Y

V

L

P

P

E
x
Q

G

E

R

A

G

S

V

I

F

F

A

R

R

R

M

L

T

S

I

V

T

Y

E

D

N

N

L

L

-

M

-

A

-

V

-

L

-

Q

-

I

-

R

-

D

Q

D

M

L

G

S

A

A

Y

E

I

Q

R

R

K

E

D

D

K

R

A

A

G

N

I

-

L

-

A

-

D

E

I

L

E

M

K

E

M

E

F

F

T

H

I

I

F

-

P

-

R

-

L

-

R

E

E

H

R

L

K

R

D

D

Q

S

L

M

A

G

G

Q

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

G

A

R

R

A

A

L

L

M

A

S

A

Q

N

P

P

K

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

S

D

P

P

I

I

M

S

V

V

D

I

K

D

I

I

F

K

E

R

V

I

R

E

D

H

V

L

Y

R

A

D

L

S

G

G

V

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

A

V

S

R

R

E

A

T

L

L

A

A

I

V

A

C

D

E

R

R

G

A

Y

Y

V

I

M

V

E

S

S

Q

G

G

L

H

I

L

T

I

M

A

T

H

G

G

P

T

G

P

Q

T

Q

E

L

I

L

L

N

Q

D

D

P

E

K

H

V

V

R

K

A

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y19), R15 (≠ I22), V17 (≠ A24), G38 (= G45), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50)
binding magnesium ion: T42 (= T49), Q84 (≠ E91)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
30% identity, 95% coverage: 10:239/242 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

Q

T

V

A

K

K

G

N

L

L

K

A

V

K

A

A

Y
|
Y

G

K

G

G

I
x
R

Q

R

A
x
V

V

V

K

E

G

D

V

V

D

S

F

L

E

T

V

V

R

N

E

S

G

G

E

E

L

I

V

V

S

G

L

L

I

L

G

G

S

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T

T

M

F

K

Y

A

M

I

V

T

V

G

G

T

I

L

V

S

P

M

R

N

D

D

A

G

G

N

N

I

I

E

I

Y

I

L

D

G

D

K

D

S

D

I

I

K

S

G

L

K

L

G

P

A

L

W

H

D

A

L

R

V

A

K

R

E

R

G

G

L

I

V

G

M

Y

V

L

P

P

E

Q

G

E

R

A

G

S

V

I

F
|
F

A
x
R

R
|
R

M

L

T

S

I

V

T

Y

E

D

N

N

L

L

-

M

-

A

-

V

-

L

-

Q

-

I

-

R

-

D

Q

D

M

L

G

S

A

A

Y

E

I

Q

R

R

K

E

D

D

K

R

A

A

G

N

I

-

L

-

A

-

D

E

I

L

E

M

K

E

M

E

F

F

T

H

I

I

F

-

P

-

R

-

L

-

R

E

E

H

R

L

K

R

D

D

Q

S

L

M

A

G

G

Q

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

G

A

R

R

A

A

L

L

M

A

S

A

Q

N

P

P

K

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

S

D

P

P

I

I

M

S

V

V

D

I

K

D

I

I

F

K

E

R

V

I

R

E

D

H

V

L

Y

R

A

D

L

S

G

G

V

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

A

V

S

R

R

E

A

T

L

L

A

A

I

V

A

C

D

E

R

R

G

A

Y

Y

V

I

M

V

E

S

S

Q

G

G

L

H

I

L

T

I

M

A

T

H

G

G

P

T

G

P

Q

T

Q

E

L

I

L

L

N

Q

D

D

P

E

K

H

V

V

R

K

A

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y19), R15 (≠ I22), V17 (≠ A24), G38 (= G45), G40 (= G47), K41 (= K48), T42 (= T49), T43 (= T50)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F96), R90 (≠ A97), R91 (= R98)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
29% identity, 93% coverage: 9:234/242 of query aligns to 2:228/241 of 4u00A

query
sites
4u00A

L

I

Q

R

V

I

K

R

G

N

L

L

K

H

V

K

A

W

Y
x
F

G

G

G

P

I

L

Q

H

A
x
V

V

L

K

K

G

G

V

I

D

H

F

L

E

E

V

V

R

A

E

P

G

G

E

E

L

K

V

L

S

V

L

I

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

M

I

K

R

A

T

I

I

T

N

G

R

T

L

L

E

S

D

M

F

N

Q

D

E

G

G

N

E

I

V

E

V

Y

V

L

D

G

G

K

L

S

S

I

V

K

K

G

D

K

D

G

R

A

A

W

L

D

R

L

E

V

I

K

R

E

R

G

E

L

V

V

G

M

M

V

V

P

F

E

Q

G

Q

R

F

G

N

V

L

F

F

A

P

R

H

M

M

T

T

I

V

T

L

E

E

N

N

L

V

Q

T

M

L

G

-

A

A

Y

P

I

M

R

R

K

V

D

R

K

R

A

W

G

P

I

R

L

E

A

K

D

A

I

E

E

K

K

K

M

A

F

L

T

E

I

L

F

L

P

E

R

R

-

V

-

G

L

I

R

L

E

D

R

Q

K

A

D

R

Q

K

L

Y

A

P

G

A

T

Q

M

L

S

S

G

G

E

Q

Q

Q

M

R

L

V

A

A

M

I

G

A

R

R

A

A

L

L

M

A

S

M

Q

E

P

P

K

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

S

D

P

P

I

E

M

M

V

V

D

G

K

E

I

V

F

L

E

D

V

V

V

M

R

R

D

D

V

L

Y

A

A

Q

L

G

G

G

V

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

A

M

S

G

R

F

A

A

L

R

A

E

I

V

A

A

D

D

R

R

G

V

Y

V

V

F

M

M

E

D

S

G

G

G

L

Q

I

I

T

V

M

E

T

E

G

G

P

R

G

P

Q

E

L

I

L

F

N

T

D

R

P

P

K

K

binding adenosine-5'-diphosphate: F12 (≠ Y19), V17 (≠ A24), S37 (≠ N44), G38 (= G45), S39 (≠ A46), G40 (= G47), K41 (= K48), S42 (≠ T49), T43 (= T50)

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 93% coverage: 9:234/242 of query aligns to 3:230/242 of 3c4jA

query
sites
3c4jA

L

M

L

I

Q

D

V

V

K

H

G

Q

L

L

K

K

V

K

A

S

Y
x
F

G

G

G

S

I

L

Q

E

A
x
V

V

L

K

K

G

G

V

I

D

N

F

V

E

H

V

I

R

R

E

E

G

G

E

E

L

V

V

V

S

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

M

L

K

R

A

C

I

L

T

N

G

L

T

L

L

E

S

D

M

F

N

D

D

E

G

G

N

E

I

I

E

I

Y

I

L

D

G

G

K

I

S

N

I

L

K

K

G

A

K

K

G

D

A

T

-

N

W

L

D

N

L

K

V

V

K

R

E

E

G

E

L

V

V

G

M

M

V

V

P

F

E

Q

G

R

R

F

G

N

V

L

F

F

A

P

R

H

M

M

T

T

I

V

T

L

E

N

N

N

L

I

Q

T

M

L

G

A

A

P

Y

M

-

K

I

V

R

R

K

K

-

W

-

P

-

R

D

E

K

K

A

A

G

E

I

A

L

K

A

A

D

-

I

M

E

E

K

L

M

L

F

D

T

K

I

V

F

-

P

-

R

G

L

L

R

K

E

D

R

K

K

A

D

H

Q

A

L

Y

A

P

G

D

T

S

M

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

G

A

R

R

A

A

L

L

M

A

S

M

Q

E

P

P

K

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

S

D

P

P

I

E

M

M

V

V

D

G

K

E

I

V

F

L

E

S

V

V

V

M

R

K

D

Q

V

L

Y

A

A

N

L

E

G

G

V

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

A

M

S

G

R

F

A

A

L

R

A

E

I

V

A

G

D

D

R

R

G

V

Y

L

V

F

M

M

E

D

S

G

G

G

L

Y

I

I

T

I

M

E

T

E

G

G

P

K

G

P

Q

E

Q

D

L

L

L

F

N

D

D

R

P

P

K

Q

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), S40 (≠ A46), G41 (= G47), K42 (= K48), S43 (≠ T49), T44 (= T50)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 93% coverage: 9:234/242 of query aligns to 3:230/242 of 3c41J

query
sites
3c41J

L

M

L

I

Q

D

V

V

K

H

G

Q

L

L

K

K

V

K

A

S

Y
x
F

G

G

G

S

I

L

Q

E

A
x
V

V

L

K

K

G

G

V

I

D

N

F

V

E

H

V

I

R

R

E

E

G

G

E

E

L

V

V

V

S

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

M

L

K

R

A

C

I

L

T

N

G

L

T

L

L

E

S

D

M

F

N

D

D

E

G

G

N

E

I

I

E

I

Y

I

L

D

G

G

K

I

S

N

I

L

K

K

G

A

K

K

G

D

A

T

-

N

W

L

D

N

L

K

V

V

K

R

E

E

G

E

L

V

V

G

M

M

V

V

P

F

E

Q

G

R

R

F

G

N

V

L

F

F

A

P

R

H

M

M

T

T

I

V

T

L

E

N

N

N

L

I

Q

T

M

L

G

A

A

P

Y

M

-

K

I

V

R

R

K

K

-

W

-

P

-

R

D

E

K

K

A

A

G

E

I

A

L

K

A

A

D

-

I

M

E

E

K

L

M

L

F

D

T

K

I

V

F

-

P

-

R

G

L

L

R

K

E

D

R

K

K

A

D

H

Q

A

L

Y

A

P

G

D

T

S

M

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

G

A

R

R

A

A

L

L

M

A

S

M

Q

E

P

P

K

K

V

I

L

M

L

L

L

F

D
|
D

E

E

P

P

S

T

M

S

G

A

L

L

S

D

P

P

I

E

M

M

V

V

D

G

K

E

I

V

F

L

E

S

V

V

V

M

R

K

D

Q

V

L

Y

A

A

N

L

E

G

G

V

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

A

M

S

G

R

F

A

A

L

R

A

E

I

V

A

G

D

D

R

R

G

V

Y

L

V

F

M

M

E

D

S

G

G

G

L

Y

I

I

T

I

M

E

T

E

G

G

P

K

G

P

Q

E

Q

D

L

L

L

F

N

D

D

R

P

P

K

Q

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), G41 (= G47), K42 (= K48), S43 (≠ T49), T44 (= T50)
binding magnesium ion: S43 (≠ T49), D163 (= D167)

2olkA Abc protein artp in complex with adp-beta-s
30% identity, 93% coverage: 9:234/242 of query aligns to 3:230/242 of 2olkA

query
sites
2olkA

L

M

L

I

Q

D

V

V

K

H

G

Q

L

L

K

K

V

K

A

S

Y
x
F

G

G

G

S

I

L

Q

E

A
x
V

V

L

K

K

G

G

V

I

D

N

F

V

E

H

V

I

R

R

E

E

G

G

E

E

L

V

V

V

S

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

M

L

K

R

A

C

I

L

T

N

G

L

T

L

L

E

S

D

M

F

N

D

D

E

G

G

N

E

I

I

E

I

Y

I

L

D

G

G

K

I

S

N

I

L

K

K

G

A

K

K

G

D

A

T

-

N

W

L

D

N

L

K

V

V

K

R

E

E

G

E

L

V

V

G

M

M

V

V

P

F

E

Q

G

R

R

F

G

N

V

L

F

F

A

P

R

H

M

M

T

T

I

V

T

L

E

N

N

N

L

I

Q

T

M

L

G

A

A

P

Y

M

-

K

I

V

R

R

K

K

-

W

-

P

-

R

D

E

K

K

A

A

G

E

I

A

L

K

A

A

D

-

I

M

E

E

K

L

M

L

F

D

T

K

I

V

F

-

P

-

R

G

L

L

R

K

E

D

R

K

K

A

D

H

Q

A

L

Y

A

P

G

D

T

S

M

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

G

A

R

R

A

A

L

L

M

A

S

M

Q

E

P

P

K

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

S

D

P

P

I

E

M

M

V

V

D

G

K

E

I

V

F

L

E

S

V

V

V

M

R

K

D

Q

V

L

Y

A

A

N

L

E

G

G

V

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

A

M

S

G

R

F

A

A

L

R

A

E

I

V

A

G

D

D

R

R

G

V

Y

L

V

F

M

M

E

D

S

G

G

G

L

Y

I

I

T

I

M

E

T

E

G

G

P

K

G

P

Q

E

Q

D

L

L

L

F

N

D

D

R

P

P

K

Q

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), S40 (≠ A46), G41 (= G47), K42 (= K48), S43 (≠ T49), T44 (= T50)

2oljA Abc protein artp in complex with adp/mg2+
30% identity, 93% coverage: 9:234/242 of query aligns to 3:230/242 of 2oljA

query
sites
2oljA

L

M

L

I

Q

D

V

V

K

H

G

Q

L

L

K

K

V

K

A

S

Y
x
F

G

G

G

S

I

L

Q

E

A
x
V

V

L

K

K

G

G

V

I

D

N

F

V

E

H

V

I

R

R

E

E

G

G

E

E

L

V

V

V

S

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

M

L

K

R

A

C

I

L

T

N

G

L

T

L

L

E

S

D

M

F

N

D

D

E

G

G

N

E

I

I

E

I

Y

I

L

D

G

G

K

I

S

N

I

L

K

K

G

A

K

K

G

D

A

T

-

N

W

L

D

N

L

K

V

V

K

R

E

E

G

E

L

V

V

G

M

M

V

V

P

F

E

Q

G

R

R

F

G

N

V

L

F

F

A

P

R

H

M

M

T

T

I

V

T

L

E

N

N

N

L

I

Q

T

M

L

G

A

A

P

Y

M

-

K

I

V

R

R

K

K

-

W

-

P

-

R

D

E

K

K

A

A

G

E

I

A

L

K

A

A

D

-

I

M

E

E

K

L

M

L

F

D

T

K

I

V

F

-

P

-

R

G

L

L

R

K

E

D

R

K

K

A

D

H

Q

A

L

Y

A

P

G

D

T

S

M

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

G

A

R

R

A

A

L

L

M

A

S

M

Q

E

P

P

K

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

S

D

P

P

I

E

M

M

V

V

D

G

K

E

I

V

F

L

E

S

V

V

V

M

R

K

D

Q

V

L

Y

A

A

N

L

E

G

G

V

M

T

T

I

M

V

V

L

V

V

V

E

T

Q

H

N

E

A

M

S

G

R

F

A

A

L

R

A

E

I

V

A

G

D

D

R

R

G

V

Y

L

V

F

M

M

E

D

S

G

G

G

L

Y

I

I

T

I

M

E

T

E

G

G

P

K

G

P

Q

E

Q

D

L

L

L

F

N

D

D

R

P

P

K

Q

binding adenosine-5'-diphosphate: F13 (≠ Y19), V18 (≠ A24), S38 (≠ N44), G39 (= G45), S40 (≠ A46), G41 (= G47), K42 (= K48), S43 (≠ T49), T44 (= T50)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
29% identity, 88% coverage: 7:218/242 of query aligns to 2:217/501 of P04983

query
sites
P04983

K

E

V

A

L

L

Q

Q

V

L

K

K

G

G

L

I

K

D

V

K

A

A

Y

F

G

P

G

G

I

V

Q

K

A

A

V

L

K

S

G

G

V

A

D

A

F

L

E

N

V

V

R

Y

E

P

G

G

E

R

L

V

V

M

S

A

L

L

I

V

G

G

S

E

N

N

G

G

A

A

G

G

K
|
K

T

S

T

T

T

M

M

M

K

K

A

V

I

L

T

T

G

G

T

I

L

Y

S

T

M

R

N

D

D

A

G

G

N

T

I

L

E

L

Y

W

L

L

G

G

K

K

S

E

I

T

K

T

G

F

K

T

G

G

A

P

W

K

D

S

L

S

V

Q

K

E

E

A

G

G

L

I

V

G

M

I

V

I

P

H

E

Q

G

E

R

L

G

N

V

L

F

I

A

P

R

Q

M

L

T

T

I

I

T

A

E

E

N

N

L

I

Q

F

M

L

G

G

-

R

A

E

Y

F

I

V

R

N

K

R

-

F

-

G

-

K

-

I

D

D

K

W

A

K

G

T

I

M

L

Y

A

A

D

E

I

A

E

D

K

K

M

L

F

L

T

A

I

K

F

L

P

-

R

N

L

L

R

R

E

F

R

K

K

S

D

D

Q

K

L

L

A

V

G

G

T

D

M

L

S

S

G

I

G

G

E

D

Q

Q

M

M

L

V

A

E

M

I

G

A

R

K

A

V

L

L

M

S

S

F

Q

E

P

S

K

K

V

V

L

I

L

M

D

D

E

E

P

P

S

T

M

D

G

A

L

L

S

T

P

D

I

T

M

E

V

T

D

E

K

S

I

L

F

F

E

R

V

V

V

I

R

R

D

E

V

L

Y

K

A

S

L

Q

G

G

V

R

T

G

I

I

V

V

L

Y

V

I

E

S

Q

H

N

R

A

M

S

K

R

E

A

I

L

F

A

E

I

I

A

C

D

D

R

D

G

V

Y

T

V

V

M

F

E

R

S

D

G

G

K43 (= K48) mutation to R: Loss of transport.

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
26% identity, 97% coverage: 9:242/242 of query aligns to 2:236/240 of 6mjpA

query
sites
6mjpA

L

I

L

L

Q

K

V

A

K

Q

G

H

L

L

K

A

V

K

A

S

Y

Y

G

K

I

R

Q

K

A

V

V

V

K

S

G

D

V

V

D

S

F

L

E

Q

V

V

R

E

E

S

G

G

E

Q

L

I

V

V

S

G

L

L

I

L

G

G

S

P

N

N

G

G

A

A

G

G

K

K

T

T

T

S

M

F

K

Y

A

M

I

I

T

V

G

G

T

L

L

V

S

A

M

R

N

D

D

E

G

G

N

T

I

I

E

T

Y

I

L

D

G

D

K

N

S

D

I

I

K

S

G

I

K

L

G

P

A

M

W

H

D

S

L

R

V

S

K

R

E

M

G

G

L

I

V

G

M

Y

V

L

P

P

E

Q

G

E

R

A

G

S

V

I

F

F

A

R

R

K

M

L

T

S

I

V

T

E

E

D

N

N

L

I

-

M

-

A

-

V

-

L

-

Q

-

T

-

R

-

E

Q

E

M

L

G

T

A

H

Y
x
E

I

E

R

R

K

Q

D
|
D

K

K

A

-

G

-

I

-

L

L

A

E

D

D

I

L

E

L

K

E

M

E

F

F

T

H

I

I

F

-

P

-

R

-

L

-

R

Q

E

H

R

I

K

R

D

K

Q

S

L

A

A

G

G

M

T

A

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

M

I

G

A

R

R

A

A

L

L

M

A

S

A

Q

N

P

P

K

Q

V

F

L

I

L

L

D

D

E

Q

P

P

S

F

M

A

G

G

L

V

S

D

P

P

I

I

M

S

V

V

D

I

K

D

I

I

F

K

E

K

V

I

R

E

D

H

V

L

Y

R

A

D

L

R

G

G

V

L

T

G

I

V

V

L

L

I

V

T

E

D

Q

H

N

N

A

V

S

R

R

E

A

T

L

L

A

D

I

V

A

C

D

E

R

K

G

A

Y

Y

V

I

M

V

E

S

S

Q

G

G

L

R

I

L

T

I

M

A

T

E

G

G

P

T

G

P

Q

Q

Q

D

L

V

L

L

N

N

D

N

P

E

K

Q

V

V

R

K

A

Q

A

V

Y

Y

L

L

G

G

E

E

binding calcium ion: E111 (≠ Y110), D115 (= D114)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
31% identity, 88% coverage: 19:230/242 of query aligns to 11:224/240 of 4ymuJ

query
sites
4ymuJ

Y
x
F

G

G

G

S

I

L

Q

E

A
x
V

V

L

K

K

G

G

V

V

D

T

F

L

E

K

V

V

R

N

E

K

G

G

E

E

L

V

V

V

S

V

L

I

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

M

L

K

R

A

C

I

I

T

N

G

L

T

L

L

E

S

E

M

P

N

T

D

K

G

G

N

E

I

V

E

F

Y

I

L

D

G

G

K

V

S

K

I

I

K

N

-

N

G

G

K

K

G

V

A

N

W

I

D

N

L

K

V

V

K

R

E

Q

G

K

L

V

V

G

M

M

V

V

P

F

E

Q

G

H

R

F

G

N

V

L

F

F

A

P

R

H

M

L

T

T

I

A

T

I

E

E

N

N

L

I

Q

T

M

L

G

-

A

A

Y

P

I

V

R

K

K

V

D

K

K

K

A

M

G

N

I

K

L

K

A

E

D

A

I

E

E

E

K

L

M

A

F

V

T

D

I

L

F

L

P

A

R

K

-

V

-

G

L

L

R

L

E

D

R

K

K

K

D

D

Q

Q

L

Y

A

P

G

I

T

K

M

L

S

S

G

G

E

Q

Q

K

Q

Q

M

R

L

L

A

A

M

I

G

A

R

R

A

A

L

L

M

A

S

M

Q

Q

P

P

K

E

V

V

L

M

L

L

L

F

D

D

E
|
E

P

P

S

T

M

S

G

A

L

L

S

D

P

P

I

E

M

M

V

V

D

K

K

E

I

V

F

L

E

N

V

V

V

M

R

K

D

Q

V

L

Y

A

A

N

L

E

G

G

V

M

T

T

I

M

V

V

L

V

V

V

E

T

Q
x
H

N

E

A

M

S

G

R

F

A

A

L

R

A

E

I

V

A

G

D

D

R

R

G

V

Y

I

V

F

M

M

E

D

S

D

G

G

L

V

I

I

T

V

M

E

T

E

G

G

P

T

G

P

Q

E

L

I

L

F

binding adenosine-5'-triphosphate: F11 (≠ Y19), V16 (≠ A24), S36 (≠ N44), G37 (= G45), S38 (≠ A46), G39 (= G47), K40 (= K48), S41 (≠ T49), T42 (= T50), E162 (= E168), H194 (≠ Q200)
binding magnesium ion: S41 (≠ T49), E162 (= E168)

Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see 2 papers)
29% identity, 92% coverage: 3:224/242 of query aligns to 474:698/1624 of Q8IUA7

query
sites
Q8IUA7

E

E

K

F

S

C

N

G

K

K

V

E

L

A

L

I

Q

R

V

I

K

K

G

N

L

L

K

K

V

K

A

E

Y

Y

G

A

G

G

-

K

-

C

-

E

-

R

I

V

Q

E

A

A

V

L

K

K

G

G

V

V

D

V

F

F

E

D

V

I

R

Y

E

E

G

G

E

Q

L

I

V

T

S

A

L

L

I

L

G

G

S

H

N

S

G

G

A

A

G

G

K

K

T

T

T

L

M

L

K

N

A

I

I

L

T

S

G

G

T

L

L

S

S

V

M

P

N

T

D

S

G

G

N

S

I

V

E

T

Y

V

L

Y

G

N

K

H

S

T

I

L

K

S

G

R

K

M

G

A

A

D

W

I

D

E

L

N

V

I

K

S

E

K

G

F

L

T

V

G

M

F

V

C

P

P

E

Q

G

S

R

N

G

V

V

Q

F

F

A

G

R

F

M

L

T

T

I

V

T

K

E

E

N

N

L

L

Q

R

M

L

G

F

A

A

Y

K

I

I

R

K

K

-

D

-

K

-

A

-

G

G

I

I

L

L

A

P

-

H

D

E

I

V

E

E

K

K

M

E

F

V

T

Q

I

R

F

V

P

V

R

Q

-

E

-

L

-

E

L

M

R

E

E

N

R

I

K

Q

D

D

Q

I

L

L

A

A

G

Q

T

N

M

L

S

S

G

G

E

Q

Q

N

Q

R

M

K

L

L

A

T

M

F

G

G

R

I

A

A

L

I

M

L

S

G

Q

D

P

P

K

Q

V

V

L

L

D

D

E

E

P

P

S

T

M

A

G

G

L

L

S

D

P

P

I

L

M

S

V

R

D

H

K

R

I

I

F

W

E

N

V

L

R

K

D

E

V

G

Y

K

A

S

L

D

G

R

V

V

T

-

I

I

V

L

L

F

V

S

E

T

Q

Q

N

F

A

I

S

D

R

E

A

A

L

D

A

I

I

L

A

A