SitesBLAST
Comparing Ac3H11_1933 FitnessBrowser__acidovorax_3H11:Ac3H11_1933 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P51174 Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8 from Mus musculus (Mouse) (see paper)
56% identity, 98% coverage: 4:381/386 of query aligns to 50:424/430 of P51174
- K318 (= K275) modified: N6-acetyllysine; mutation to R: Reduces activity by 37%; reduces activity by 80% when associated with R-322.
- K322 (≠ Q279) modified: N6-acetyllysine; alternate; mutation to R: Reduces activity by 23%; reduces activity by 80% when associated with R-318.
Sites not aligning to the query:
- 42 modified: N6-acetyllysine; K→R: Reduces activity by 90% when associated with R-318 and R-322.
P28330 Long-chain specific acyl-CoA dehydrogenase, mitochondrial; LCAD; EC 1.3.8.8 from Homo sapiens (Human) (see 2 papers)
54% identity, 98% coverage: 4:381/386 of query aligns to 50:424/430 of P28330
- E291 (= E248) active site, Proton acceptor; mutation to Q: Loss of long-chain-acyl-CoA dehydrogenase activity. No effect on protein abundance. No effect on solubility. No effect on substrate binding.
- S303 (≠ A260) to T: in dbSNP:rs1801204
- K333 (≠ T290) to Q: in dbSNP:rs2286963
2pg0A Crystal structure of acyl-coa dehydrogenase from geobacillus kaustophilus
52% identity, 98% coverage: 7:385/386 of query aligns to 5:380/380 of 2pg0A
- active site: M124 (= M126), T125 (≠ S127), E243 (= E248), A364 (≠ G369), R376 (= R381)
- binding flavin-adenine dinucleotide: I122 (= I124), M124 (= M126), T125 (≠ S127), G130 (= G132), S131 (= S133), F155 (= F159), I156 (= I160), T157 (= T161), R269 (= R274), F272 (= F277), F279 (= F284), Q337 (= Q342), L338 (≠ M343), G340 (= G345), G341 (= G346), V359 (= V364), I362 (= I367), Y363 (= Y368), T366 (= T371), E368 (= E373), M369 (≠ I374)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
40% identity, 97% coverage: 6:380/386 of query aligns to 3:373/378 of 5ol2F
- active site: L124 (≠ M126), T125 (≠ S127), G241 (≠ E248)
- binding calcium ion: E29 (≠ D32), E33 (≠ Q36), R35 (≠ Y38)
- binding coenzyme a persulfide: L238 (= L245), R242 (= R249), E362 (≠ G369), G363 (= G370)
- binding flavin-adenine dinucleotide: F122 (≠ I124), L124 (≠ M126), T125 (≠ S127), P127 (= P129), T131 (≠ S133), F155 (= F159), I156 (= I160), T157 (= T161), E198 (≠ L202), R267 (= R274), F270 (= F277), L274 (≠ V281), F277 (= F284), Q335 (= Q342), L336 (≠ M343), G338 (= G345), G339 (= G346), Y361 (= Y368), T364 (= T371), E366 (= E373)
Sites not aligning to the query:
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
40% identity, 94% coverage: 19:381/386 of query aligns to 14:370/374 of 5lnxD
- active site: L122 (≠ M126), T123 (≠ S127), G239 (≠ E248), E358 (≠ G369), K370 (≠ R381)
- binding flavin-adenine dinucleotide: L122 (≠ M126), T123 (≠ S127), G128 (= G132), S129 (= S133), F153 (= F159), T155 (= T161), R265 (= R274), Q267 (≠ V276), F268 (= F277), I272 (≠ V281), N275 (≠ F284), I278 (≠ T287), Q331 (= Q342), I332 (≠ M343), G335 (= G346), Y357 (= Y368), T360 (= T371), E362 (= E373)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
39% identity, 97% coverage: 10:383/386 of query aligns to 8:377/380 of 4l1fA
- active site: L125 (≠ M126), T126 (≠ S127), G242 (≠ E248), E363 (≠ G369), R375 (= R381)
- binding coenzyme a persulfide: T132 (≠ S133), H179 (≠ K182), F232 (= F238), M236 (= M242), E237 (= E243), L239 (= L245), D240 (≠ P246), R243 (= R249), Y362 (= Y368), E363 (≠ G369), G364 (= G370), R375 (= R381)
- binding flavin-adenine dinucleotide: F123 (≠ I124), L125 (≠ M126), T126 (≠ S127), G131 (= G132), T132 (≠ S133), F156 (= F159), I157 (= I160), T158 (= T161), R268 (= R274), Q270 (≠ V276), F271 (= F277), I275 (≠ V281), F278 (= F284), L281 (≠ T287), Q336 (= Q342), I337 (≠ M343), G340 (= G346), I358 (≠ V364), Y362 (= Y368), T365 (= T371), Q367 (≠ E373)
- binding 1,3-propandiol: Q10 (= Q12)
Sites not aligning to the query:
3r7kA Crystal structure of a probable acyl coa dehydrogenase from mycobacterium abscessus atcc 19977 / dsm 44196 (see paper)
39% identity, 97% coverage: 9:384/386 of query aligns to 7:378/378 of 3r7kA
- active site: V126 (≠ M126), T127 (≠ S127), E242 (= E248), G363 (= G369), K375 (≠ R381)
- binding dihydroflavine-adenine dinucleotide: V126 (≠ M126), T127 (≠ S127), G132 (= G132), S133 (= S133), F157 (= F159), I158 (= I160), T159 (= T161), R268 (= R274), T270 (≠ V276), F271 (= F277), L275 (≠ V281), R278 (≠ F284), I281 (≠ T287), Q336 (= Q342), I337 (≠ M343), G340 (= G346), I358 (≠ V364), T365 (= T371), E367 (= E373)
8sgrA Isovaleryl-CoA dehydrogenase, mitochondrial (see paper)
37% identity, 96% coverage: 10:381/386 of query aligns to 15:386/393 of 8sgrA
- binding flavin-adenine dinucleotide: S135 (= S127), G140 (= G132), S141 (= S133), W165 (≠ F159), T167 (= T161), R279 (= R274), F282 (= F277), I286 (≠ V281), F289 (= F284), Q347 (= Q342), C348 (≠ M343), G351 (= G346), L369 (≠ V364), G375 (= G370), T376 (= T371), L382 (≠ E377)
1ivhA Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity (see paper)
37% identity, 96% coverage: 10:381/386 of query aligns to 11:382/387 of 1ivhA
- active site: M130 (= M126), S131 (= S127), E249 (= E248), A370 (≠ G369), R382 (= R381)
- binding coenzyme a persulfide: S137 (= S133), S185 (≠ A181), R186 (≠ K182), V239 (≠ F238), Y240 (≠ I239), M243 (= M242), E249 (= E248), R250 (= R249), G369 (≠ Y368), A370 (≠ G369), G371 (= G370), V375 (≠ I374)
- binding flavin-adenine dinucleotide: L128 (≠ I124), M130 (= M126), S131 (= S127), G136 (= G132), S137 (= S133), W161 (≠ F159), T163 (= T161), R275 (= R274), F278 (= F277), F285 (= F284), M288 (≠ T287), Q343 (= Q342), C344 (≠ M343), G347 (= G346), T372 (= T371), E374 (= E373)
P26440 Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; Butyryl-CoA dehydrogenase; EC 1.3.8.4; EC 1.3.8.1 from Homo sapiens (Human) (see 5 papers)
37% identity, 96% coverage: 10:381/386 of query aligns to 48:419/426 of P26440
- 165:174 (vs. 124:133, 80% identical) binding
- S174 (= S133) binding
- WIT 198:200 (≠ FIT 159:161) binding
- SR 222:223 (≠ AK 181:182) binding
- G250 (≠ A209) to A: in IVA; uncertain significance
- Y277 (≠ I239) binding
- DLER 284:287 (≠ PWER 246:249) binding
- E286 (= E248) active site, Proton acceptor; mutation to D: Residual isovaleryl-CoA dehydrogenase activity.; mutation to G: Loss of isovaleryl-CoA dehydrogenase activity. Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 407-E.; mutation to Q: Loss of isovaleryl-CoA dehydrogenase activity.
- A291 (= A253) to V: in IVA; uncertain significance; dbSNP:rs886042098
- R312 (= R274) binding
- Q323 (= Q285) binding
- I379 (≠ V341) to T: in IVA; uncertain significance
- QCFGG 380:384 (≠ QMFGG 342:346) binding
- R398 (≠ A360) to Q: in IVA; uncertain significance; dbSNP:rs1477527791
- Y403 (≠ Q365) to N: in IVA; uncertain significance
- A407 (≠ G369) mutation to E: Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 286-D.
- AG 407:408 (≠ GG 369:370) binding
- TSE 409:411 (≠ TNE 371:373) binding
Sites not aligning to the query:
- 1:32 modified: transit peptide, Mitochondrion
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
35% identity, 97% coverage: 11:383/386 of query aligns to 1:367/369 of 3pfdC
- active site: L116 (≠ M126), S117 (= S127), T233 (≠ E248), E353 (≠ G369), R365 (= R381)
- binding dihydroflavine-adenine dinucleotide: Y114 (≠ I124), L116 (≠ M126), S117 (= S127), G122 (= G132), S123 (= S133), W147 (≠ F159), I148 (= I160), T149 (= T161), R259 (= R274), F262 (= F277), V266 (= V281), N269 (≠ F284), Q326 (= Q342), L327 (≠ M343), G330 (= G346), I348 (≠ V364), Y352 (= Y368), T355 (= T371), Q357 (≠ E373)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
36% identity, 96% coverage: 9:380/386 of query aligns to 8:376/384 of 1jqiA
- binding acetoacetyl-coenzyme a: L95 (≠ I94), F125 (≠ I124), S134 (= S133), F234 (= F238), M238 (= M242), Q239 (≠ E243), L241 (= L245), D242 (≠ P246), R245 (= R249), Y364 (= Y368), E365 (≠ G369), G366 (= G370)
- binding flavin-adenine dinucleotide: F125 (≠ I124), L127 (≠ M126), S128 (= S127), G133 (= G132), S134 (= S133), W158 (≠ F159), T160 (= T161), R270 (= R274), F273 (= F277), L280 (≠ F284), Q338 (= Q342), I339 (≠ M343), G342 (= G346), I360 (≠ V364), T367 (= T371), E369 (= E373), I370 (= I374)
Sites not aligning to the query:
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
36% identity, 96% coverage: 9:380/386 of query aligns to 35:403/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
38% identity, 96% coverage: 10:381/386 of query aligns to 5:373/383 of 4iv6B
- active site: L121 (≠ M126), T122 (≠ S127), G240 (≠ E248), E361 (≠ G369), K373 (≠ R381)
- binding dihydroflavine-adenine dinucleotide: L121 (≠ M126), T122 (≠ S127), G126 (≠ A131), G127 (= G132), S128 (= S133), W152 (≠ F159), I153 (= I160), S154 (≠ T161), R266 (= R274), S268 (≠ V276), F269 (= F277), I273 (≠ V281), H276 (≠ F284), V279 (≠ T287), R334 (≠ Q342), V335 (≠ M343), G338 (= G346), L356 (≠ V364), G360 (≠ Y368), T363 (= T371), E365 (= E373), I366 (= I374)
2z1qB Crystal structure of acyl coa dehydrogenase
37% identity, 98% coverage: 7:386/386 of query aligns to 24:410/549 of 2z1qB
- active site: L144 (≠ M126), T145 (≠ S127), G259 (≠ E248), E394 (≠ G369), G406 (= G382)
- binding flavin-adenine dinucleotide: Y142 (≠ I124), L144 (≠ M126), T145 (≠ S127), G150 (= G132), S151 (= S133), W177 (≠ F159), S179 (≠ T161), R285 (= R274), F288 (= F277), I292 (≠ V281), F295 (= F284), I298 (≠ T287), H369 (≠ F344), G370 (= G345), F393 (≠ Y368), I399 (= I374)
Sites not aligning to the query:
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
35% identity, 97% coverage: 6:381/386 of query aligns to 5:376/378 of 4n5fA
- active site: L126 (≠ M126), T127 (≠ S127), G243 (≠ E248), E364 (≠ G369), R376 (= R381)
- binding dihydroflavine-adenine dinucleotide: L126 (≠ M126), T127 (≠ S127), G132 (= G132), S133 (= S133), F157 (= F159), T159 (= T161), T210 (= T212), Y363 (= Y368), T366 (= T371), E368 (= E373), M372 (≠ E377)
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
36% identity, 98% coverage: 7:386/386 of query aligns to 3:378/379 of 6fahD
- active site: L124 (≠ M126), T125 (≠ S127), G241 (≠ E248), G374 (= G382)
- binding flavin-adenine dinucleotide: F122 (≠ I124), L124 (≠ M126), T125 (≠ S127), R152 (≠ S156), F155 (= F159), T157 (= T161), E198 (≠ L202), R267 (= R274), Q269 (≠ V276), F270 (= F277), I274 (≠ V281), F277 (= F284), Q335 (= Q342), I336 (≠ M343), G339 (= G346), Y361 (= Y368), T364 (= T371), Q366 (≠ E373)
8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
35% identity, 97% coverage: 6:381/386 of query aligns to 3:377/381 of 8i4rA
- binding acetyl coenzyme *a: S132 (= S133), T134 (≠ L135), R180 (≠ K182), R234 (≠ I239), L237 (≠ M242), R238 (≠ E243), L240 (= L245), D241 (≠ P246), R244 (= R249), E365 (≠ G369), G366 (= G370), R377 (= R381)
- binding flavin-adenine dinucleotide: Y123 (≠ I124), L125 (≠ M126), S126 (= S127), G131 (= G132), S132 (= S133), W156 (≠ F159), I157 (= I160), T158 (= T161), I360 (≠ V364), T367 (= T371), Q369 (≠ E373)
8i4pA Crystal structure of acyl-coa dehydrogenase from thermobifida fusca
35% identity, 97% coverage: 6:381/386 of query aligns to 3:377/381 of 8i4pA
- binding flavin-adenine dinucleotide: Y123 (≠ I124), L125 (≠ M126), S126 (= S127), G131 (= G132), S132 (= S133), W156 (≠ F159), I157 (= I160), T158 (= T161), I360 (≠ V364), Y364 (= Y368), T367 (= T371), Q369 (≠ E373)
7w0jE Acyl-coa dehydrogenase, tfu_1647
35% identity, 97% coverage: 6:381/386 of query aligns to 4:378/382 of 7w0jE
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: S127 (= S127), W157 (≠ F159), R270 (= R274), Q272 (≠ V276), F273 (= F277), I277 (≠ V281), F280 (= F284), I283 (≠ T287), Q339 (= Q342), L340 (≠ M343), G343 (= G346), Y365 (= Y368), E366 (≠ G369), T368 (= T371), Q370 (≠ E373), I371 (= I374)
Query Sequence
>Ac3H11_1933 FitnessBrowser__acidovorax_3H11:Ac3H11_1933
MIERTLFQPEHQAFADSFRRFIEKEVTPHHADWEDQGYVAREVWSQAGANGFLCMSLPEE
YGGAGADKLYSVAQMEELARAGTTGIGFGLHSEIVAPYILHYGTEEQKRKYLPQMASGAV
VGAIAMSEPAAGSDLQGIKTTAIKSADGSHYVLNGSKTFITNGWHADLVIVVAKTDPAAG
AKGTSLLLVERGMPGFEKGQRLKKLGMKAQDTSELFFNDVKVPAENLLGGPAMEGRGFIC
LMEQLPWERLQIAITAVAAAQAAIDWTLDYVKERKVFGQPVASFQNTRYTLAELQTEVQV
ARVFVDKCCELIARDQLDTQTASMAKYWTTDLQCKVMDECVQMFGGYGYMWEYPITRAYA
DARVQRIYGGTNEIMKEVISRGMGLK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory