SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Ac3H11_1936 FitnessBrowser__acidovorax_3H11:Ac3H11_1936 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
53% identity, 86% coverage: 20:254/272 of query aligns to 6:239/240 of 1ji0A

query
sites
1ji0A

L

V

L

L

R

E

L

V

Q

Q

N

S

V

L

E

H

S

V

A

Y

Y
|
Y

G

G

P

A

I
|
I

K

H

A
|
A

I

I

R

K

G

G

V

I

S

D

L

L

Q

K

V

V

R

P

R

R

G

G

E

Q

I

I

A

V

A

T

V

L

L

I

G

G

S

A

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

I

T

L

L

K

S

T

A

I

I

S

A

G

G

I

L

I

V

D

R

P

A

R

Q

K

K

G

G

S

K

I

I

E

I

F

F

Q

N

G

G

Q

Q

D

D

I

I

T

T

A

N

R

K

D

P

P

A

A

H

A

V

I

I

V

N

R

R

R

M

G

G

L

I

M

A

H

L

V

V

P

P

E
|
E

G

G

R

R

E

R

V

I

F

F

P

P

L

E

L

L

S

T

V

V

R

Y

D

E

N

N

L

L

L

M

M

M

G

G

A

A

Y

Y

T

N

R

R

A

K

D

D

K

K

D

E

G

G

V

I

A

K

R

R

D

D

I

L

E

E

T

W

V

I

F

F

G

S

Y

L

F

F

P

P

I

R

L

L

K

K

E

E

R

R

A

L

A

K

Q

Q

D

L

A

G

G

G

L

T

L

L

S

S

G

G

Q

E

Q

Q

M

M

L

L

A

A

I

I

S

G

R

R

A

A

L

L

M

M

A

S

A

R

P

P

E

K

L

L

I

L

L

M

D
|
D

E
|
E

P

P

S

S

L

L

G

G

L

L

S

A

P

P

K

I

L

L

T

V

K

S

E

E

I

V

F

F

E

E

I

V

V

I

V

Q

R

K

I

I

N

N

R

Q

E

E

R

-

G

G

T

T

I

I

L

L

V

V

E

E

Q

Q

N

N

A

A

N

L

M

G

A

A

L

L

N

K

A

V

S

A

D

H

Y

Y

G

G

Y

Y

V

V

L

L

E

E

N

T

G

G

R

Q

I

I

V

V

M

L

E

E

D

G

S

K

C

A

E

S

R

E

L

L

R

L

E

D

K

N

D

E

D

M

I

V

K

R

E

K

F

A

Y

Y

L

L

G

G

M

V

binding adenosine-5'-triphosphate: Y16 (= Y30), I19 (= I33), A21 (= A35), N41 (= N55), G42 (= G56), A43 (= A57), G44 (= G58), K45 (= K59), T46 (= T60), T47 (= T61), E88 (= E102), D164 (= D178), E165 (= E179)

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
31% identity, 86% coverage: 20:253/272 of query aligns to 4:253/254 of 1g6hA

query
sites
1g6hA

L

I

L

L

R

R

L

T

Q

E

N

N

V

I

E

V

S

K

A

Y

Y
x
F

G

G

P

E

I
x
F

K

K

A

A

I

L

R

D

G

G

V

V

S

S

L

I

Q

S

V

V

R

N

R

K

G

G

E

D

I

V

A

T

A

L

V

I

L

I

G

G

S

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

I

K

N

T

V

I

I

S

T

G

G

I

F

I

L

D

K

P

A

R

D

K

E

G

G

S

R

I

V

E

Y

F

F

Q

E

G

N

Q

K

D

D

I

I

T

T

A

N

R

K

D

E

P

P

A

A

A

E

I

L

V

Y

R

H

R

Y

G

G

L

I

M

V

H

R

V

T

P

F

E

Q

G

T

R

P

E

Q

V

P

F

L

P

K

L

E

L

M

S

T

V

V

R

L

D

E

N

N

L

L

M

I

G

G

A

E

Y

I

T

C

R

P

A

G

D

E

-

S

-

P

-

L

-

N

-

S

-

L

-

F

-

Y

K

K

D

K

G

W

V

I

A

P

R

K

D

E

-

E

-

M

I

V

E

E

T

K

V

A

F

F

G

K

Y

I

F

L

P

E

I

F

L

L

K

K

E

L

R

S

A

H

A

L

Q

Y

D

D

-

R

-

K

A

A

G

G

L

E

L

L

S

S

G

G

Q

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

S

G

R

R

A

A

L

L

M

M

A

T

A

N

P

P

E

K

L

M

I

I

L

V

L

M

D

D

E

E

P

P

S

I

L

A

G

G

L

V

S

A

P

P

K

G

L

L

T

A

K

H

E

D

I

I

F

F

E

N

I

H

V

V

V

L

R

E

I

L

N

-

R

K

E

A

R

K

G

G

T

I

T

T

I

F

L

L

L

I

V

I

E

E

Q

H

N

R

A

L

N

D

M

I

A

V

L

L

N

N

A

Y

S

I

D

D

Y

H

G

L

Y

Y

V

V

L

M

E

F

N

N

G

G

R

Q

I

I

V

I

M

A

-

E

-

G

-

R

-

G

E

E

D

E

S

E

C

I

E

K

R

N

L

V

R

L

E

S

K

D

D

P

D

K

I

V

K

V

E

E

F

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y30), F17 (≠ I33), N39 (= N55), G40 (= G56), S41 (≠ A57), G42 (= G58), K43 (= K59), S44 (≠ T60), T45 (= T61)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 86% coverage: 20:253/272 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

L

I

L

L

R

R

L

T

Q

E

N

N

V

I

E

V

S

K

A

Y

Y
x
F

G

G

P

E

I
x
F

K

K

A

A

I

L

R

D

G

G

V

V

S

S

L

I

Q

S

V

V

R

C

R

K

G

G

E

D

I

V

A

T

A

L

V

I

L

I

G

G

S

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

I

K

N

T

V

I

I

S

T

G

G

I

F

I

L

D

K

P

A

R

D

K

E

G

G

S

R

I

V

E

Y

F

F

Q

E

G

N

Q

K

D

D

I

I

T

T

A

N

R

K

D

E

P

P

A

A

A

E

I

L

V

Y

R

H

R

Y

G

G

L

I

M

V

H

R

V

T

P

F

E

Q

G

T

R

P

E

Q

V

P

F

L

P

K

L

E

L

M

S

T

V

V

R

L

D

E

N

N

L

L

M

I

G

G

A

E

Y

I

T

N

R

P

A

G

D

E

-

S

-

P

-

L

-

N

-

S

-

L

-

F

-

Y

K

K

D

K

G

W

V

I

A

P

R

K

D

E

-

E

-

M

I

V

E

E

T

K

V

A

F

F

G

K

Y

I

F

L

P

E

I

F

L

L

K

K

E

L

R

S

A

H

A

L

Q

Y

D

D

-

R

-

K

A

A

G

G

L

E

L

L

S

S

G

G

Q

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

S

G

R

R

A

A

L

L

M

M

A

T

A

N

P

P

E

K

L

M

I

I

L

V

L

M

D

D

E
|
E

P

P

S

I

L

A

G

G

L

V

S

A

P

P

K

G

L

L

T

A

K

H

E

D

I

I

F

F

E

N

I

H

V

V

V

L

R

E

I

L

N

-

R

K

E

A

R

K

G

G

T

I

T

T

I

F

L

L

L

I

V

I

E

E

Q

H

N

R

A

L

N

D

M

I

A

V

L

L

N

N

A

Y

S

I

D

D

Y

H

G

L

Y

Y

V

V

L

M

E

F

N

N

G

G

R

Q

I

I

V

I

M

A

-

E

-

G

-

R

-

G

E

E

D

E

S

E

C

I

E

K

R

N

L

V

R

L

E

S

K

D

D

P

D

K

I

V

K

V

E

E

F

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y30), F17 (≠ I33), N39 (= N55), G40 (= G56), S41 (≠ A57), G42 (= G58), K43 (= K59), S44 (≠ T60), T45 (= T61)
binding magnesium ion: S44 (≠ T60), E176 (= E179)

6mjpB Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 86% coverage: 20:253/272 of query aligns to 2:235/240 of 6mjpB

query
sites
6mjpB

L

I

L

L

R

K

L

A

Q

Q

N

H

V

L

E

A

S

K

A

S

Y

Y

G

K

P

K

I

R

K

K

A

V

I

V

R

S

G

D

V

V

S

S

L

L

Q

Q

V

V

R

E

R

S

G

G

E

Q

I

I

A

V

A

G

V

L

L

L

G

G

S

P

N

N

G

G

A

A

G

G

K

K

T

T

I

S

L

F

K

Y

T

M

I

I

S

V

G

G

I

L

I

V

D

A

P

R

R

D

K

E

G

G

S

T

I

I

E

T

F

I

Q

D

G

D

Q

N

D

D

I

I

T

S

A

I

R

L

D

P

P

M

A

H

A

S

I

R

V

S

R

R

R

M

G

G

L

I

M

G

H

Y

V

L

P

P

E

Q

G

E

R

A

E

S

V

I

F

F

P
x
R

L
x
K

L

L

S

S

V

V

R

E

D

D

N

N

L

I

L

M

M

A

G

V

A

L

Y

Q

T

T

R

R

A

E

D

E

K

L

D

T

G

H

V

E

A

E

R

R

D

Q

-

D

-

K

I

L

E

E

T

D

V

L

F

L

G

E

Y

E

F

F

P

H

I

I

L

Q

K

H

E

I

R

R

A

K

A

S

Q

-

D

-

A

A

G

G

L

M

-

A

L

L

S

S

G

G

Q

E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

Q

L

F

I

I

L

L

D

D

E

Q

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

K

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

R

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

M

E

A

T

L

L

N

D

A

V

S

C

D

E

Y

K

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

R

I

L

V

I

M

A

E

E

D

G

S

T

C

P

E

Q

R

D

L

V

R

L

E

N

K

N

D

E

D

Q

I

V

K

K

E

Q

F

V

Y

Y

L

L

G

G

binding 6-cyclohexylhexyl beta-D-glucopyranoside: R90 (≠ P108), K91 (≠ L109)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 86% coverage: 20:253/272 of query aligns to 2:235/240 of 6mjpA

query
sites
6mjpA

L

I

L

L

R

K

L

A

Q

Q

N

H

V

L

E

A

S

K

A

S

Y

Y

G

K

P

K

I

R

K

K

A

V

I

V

R

S

G

D

V

V

S

S

L

L

Q

Q

V

V

R

E

R

S

G

G

E

Q

I

I

A

V

A

G

V

L

L

L

G

G

S

P

N

N

G

G

A

A

G

G

K

K

T

T

I

S

L

F

K

Y

T

M

I

I

S

V

G

G

I

L

I

V

D

A

P

R

R

D

K

E

G

G

S

T

I

I

E

T

F

I

Q

D

G

D

Q

N

D

D

I

I

T

S

A

I

R

L

D

P

P

M

A

H

A

S

I

R

V

S

R

R

R

M

G

G

L

I

M

G

H

Y

V

L

P

P

E

Q

G

E

R

A

E

S

V

I

F

F

P

R

L

K

L

L

S

S

V

V

R

E

D

D

N

N

L

I

L

M

M

A

G

V

A

L

Y

Q

T

T

R

R

A

E

D

E

K

L

D

T

G

H

V
x
E

A

E

R

R

D

Q

-
x
D

-

K

I

L

E

E

T

D

V

L

F

L

G

E

Y

E

F

F

P

H

I

I

L

Q

K

H

E

I

R

R

A

K

A

S

Q

-

D

-

A

A

G

G

L

M

-

A

L

L

S

S

G

G

Q

E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

Q

L

F

I

I

L

L

D

D

E

Q

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

K

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

R

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

M

E

A

T

L

L

N

D

A

V

S

C

D

E

Y

K

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

R

I

L

V

I

M

A

E

E

D

G

S

T

C

P

E

Q

R

D

L

V

R

L

E

N

K

N

D

E

D

Q

I

V

K

K

E

Q

F

V

Y

Y

L

L

G

G

binding calcium ion: E111 (≠ V129), D115 (vs. gap)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
32% identity, 86% coverage: 21:253/272 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

R

T

L

A

Q

K

N

N

V

L

E

A

S

K

A

A

Y
|
Y

G

K

P

G

I

R

K

R

A

V

I

V

R

E

G

D

V

V

S

S

L

L

Q

T

V

V

R

N

R

S

G

G

E

E

I

I

A

V

A

G

V

L

L

L

G

G

S
x
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

I

T

L

F

K

Y

T

M

I

V

S

V

G

G

I

I

I

V

D

P

P

R

R

D

K

A

G

G

S

N

I

I

E

I

F

I

Q

D

G

D

Q

D

D

D

I

I

T

S

A

L

R

L

D

P

P

L

A

H

A

A

I

R

V

A

R

R

G

G

L

I

M

G

H

Y

V

L

P

P

E
x
Q

G

E

R

A

E

S

V

I

F

F

P

R

L

R

L

L

S

S

V

V

R

Y

D

D

N

N

L

L

L

M

M

A

G

V

A

L

Y

Q

T

I

R

R

A

D

D

D

K

L

D

S

G

A

V

E

A

Q

R

R

D

E

-

D

-

R

I

A

E

N

T

E

V

L

F

M

G

E

Y

E

F

F

P

H

I

I

-

E

-

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

D
x
S

A

-

G

-

L

-

L

L

S
|
S

G
|
G

Q
x
E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

K

L

F

I

I

L

L

D

D

E
|
E

P

P

S

F

L

A

G
|
G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

R

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

S

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

N

R

M

E

A

T

L

L

N

A

A

V

S

C

D

E

Y

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

H

I

L

V

I

M

A

E

H

D

G

S

T

C

P

E

T

R

E

L

I

R

L

E

Q

K

D

D

E

D

H

I

V

K

K

E

R

F

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y30), P36 (≠ S54), N37 (= N55), G38 (= G56), A39 (= A57), G40 (= G58), K41 (= K59), T42 (= T60), T43 (= T61), Q84 (≠ E102), S136 (≠ D150), S138 (= S155), G139 (= G156), G140 (= G157), E141 (≠ Q158), E162 (= E179), G166 (= G183), H194 (≠ Q212)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
32% identity, 86% coverage: 21:253/272 of query aligns to 3:235/238 of 6s8nB

query
sites
6s8nB

L

L

R

T

L

A

Q

K

N

N

V

L

E

A

S

K

A

A

Y

Y

G

K

P

G

I

R

K

R

A

V

I

V

R

E

G

D

V

V

S

S

L

L

Q

T

V

V

R

N

R

S

G

G

E

E

I

I

A

V

A

G

V

L

L

L

G

G

S

P

N

N

G

G

A

A

G

G

K

K

T

T

I

T

L

F

K

Y

T

M

I

V

S

V

G

G

I

I

I

V

D

P

P

R

R

D

K

A

G

G

S

N

I

I

E

I

F

I

Q

D

G

D

Q

D

D

D

I

I

T

S

A

L

R

L

D

P

P

L

A

H

A

A

I

R

V

A

R

R

G

G

L

I

M

G

H

Y

V

L

P

P

E

Q

G

E

R

A

E

S

V

I

F

F

P
x
R

L

R

L

L

S

S

V

V

R

Y

D

D

N

N

L

L

L

M

M

A

G

V

A

L

Y

Q

T

I

R

R

A

D

D

D

-

L

-

S

-

A

-

E

-

Q

K

R

D

E

G

D

V

R

A

A

R

N

D

E

I

L

E

M

T

E

V

E

F

F

G

-

Y

H

F

I

P

E

I

H

L

L

K

R

E

D

R

S

A
x
M

A
x
G

Q
|
Q

D

S

A

-

G

-

L

-

L

L

S

S

G

G

Q

E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

K

L

F

I

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

R

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

S

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

M

E

A

T

L

L

N

A

A

V

S

C

D

E

Y

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

H

I

L

V

I

M

A

E

H

D

G

S

T

C

P

E

T

R

E

L

I

R

L

E

Q

K

D

D

E

D

H

I

V

K

K

E

R

F

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ P108), M133 (≠ A147), G134 (≠ A148), Q135 (= Q149)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
32% identity, 86% coverage: 21:253/272 of query aligns to 3:235/238 of 6s8gA

query
sites
6s8gA

L

L

R

T

L

A

Q

K

N

N

V

L

E

A

S

K

A

A

Y
|
Y

G

K

P

G

I
x
R

K

R

A
x
V

I

V

R

E

G

D

V

V

S

S

L

L

Q

T

V

V

R

N

R

S

G

G

E

E

I

I

A

V

A

G

V

L

L

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

I

T

L

F

K

Y

T

M

I

V

S

V

G

G

I

I

I

V

D

P

P

R

R

D

K

A

G

G

S

N

I

I

E

I

F

I

Q

D

G

D

Q

D

D

D

I

I

T

S

A

L

R

L

D

P

P

L

A

H

A

A

I

R

V

A

R

R

G

G

L

I

M

G

H

Y

V

L

P

P

E
x
Q

G

E

R

A

E

S

V

I

F

F

P

R

L

R

L

L

S

S

V

V

R

Y

D

D

N

N

L

L

L

M

M

A

G

V

A

L

Y

Q

T

I

R

R

A

D

D

D

-

L

-

S

-

A

-

E

-

Q

K

R

D

E

G

D

V

R

A

A

R

N

D

E

I

L

E

M

T

E

V

E

F

F

G

-

Y

H

F

I

P

E

I

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

D
x
S

A

-

G

-

L

-

L

L

S
|
S

G

G

Q
x
E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

K

L

F

I

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

R

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

S

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

N

R

M

E

A

T

L

L

N

A

A

V

S

C

D

E

Y

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

H

I

L

V

I

M

A

E

H

D

G

S

T

C

P

E

T

R

E

L

I

R

L

E

Q

K

D

D

E

D

H

I

V

K

K

E

R

F

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y30), R15 (≠ I33), V17 (≠ A35), N37 (= N55), G38 (= G56), G40 (= G58), K41 (= K59), T42 (= T60), T43 (= T61), Q84 (≠ E102), S136 (≠ D150), S138 (= S155), E141 (≠ Q158), H194 (≠ Q212)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
29% identity, 82% coverage: 19:241/272 of query aligns to 1:223/241 of 4u00A

query
sites
4u00A

P

P

L

I

R

R

L

I

Q

R

N

N

V

L

E

H

S

K

A

W

Y
x
F

G

G

P

P

I
x
L

K

H

A
x
V

I

L

R

K

G

G

V

I

S

H

L

L

Q

E

V

V

R

A

R

P

G

G

E

E

I

K

A

L

A

V

V

I

L

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

I

K

R

T

T

I

I

S

N

G

R

I

L

I

E

D

D

P

F

R

Q

K

E

G

G

S

E

I

V

E

V

F

V

Q

D

G

G

Q

-

D

-

I

L

T

S

A

V

R

K

D

D

P

D

A

R

A

A

I

L

-

R

-

E

V

I

R

R

G

E

L

V

M

G

H

M

V

V

P

F

E

Q

G

Q

R

F

E

N

V

L

F

F

P

P

L

H

L

M

S

T

V

V

R

L

D

E

N

N

L

V

L

T

M

L

G

A

A

P

-

M

-

R

-

V

-

R

Y

W

T

P

R

R

A

E

D

K

K

A

D

E

G

K

V

K

A

A

R

L

D

E

I

L

E

L

T

E

V

R

F

V

G

G

Y

I

F

L

P

D

I

Q

L

A

K

R

E

K

R

Y

A

P

A

A

Q

Q

D

-

A

-

G

-

L

-

L

L

S

S

G

G

Q

Q

M

R

L

V

A

A

I

I

S

A

R

R

A

A

L

L

M

A

A

M

A

E

P

P

E

K

L

I

I

M

L

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

S

D

P

P

K

E

L

M

T

V

K

G

E

E

I

V

F

L

E

D

I

-

V

V

V

M

R

R

I

D

N

L

R

A

E

Q

R

G

G

G

T

M

T

T

I

M

L

V

V

V

E

T

Q

H

N

E

A

M

N

G

M

F

A

A

L

R

N

E

A

V

S

A

D

D

Y

R

G

V

Y

V

V

F

L

M

E

D

N

G

G

G

R

Q

I

I

V

V

M

E

E

E

D

G

S

R

C

P

E

E

R

E

L

I

binding adenosine-5'-diphosphate: F12 (≠ Y30), L15 (≠ I33), V17 (≠ A35), S37 (≠ N55), G38 (= G56), S39 (≠ A57), G40 (= G58), K41 (= K59), S42 (≠ T60), T43 (= T61)

6mbnA Lptb e163q in complex with atp (see paper)
32% identity, 86% coverage: 21:253/272 of query aligns to 4:236/241 of 6mbnA

query
sites
6mbnA

L

L

R

T

L

A

Q

K

N

N

V

L

E

A

S

K

A

A

Y
|
Y

G

K

P

G

I
x
R

K

R

A
x
V

I

V

R

E

G

D

V

V

S

S

L

L

Q

T

V

V

R

N

R

S

G

G

E

E

I

I

A

V

A

G

V

L

L

L

G

G

S
x
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

I

T

L

F

K

Y

T

M

I

V

S

V

G

G

I

I

I

V

D

P

P

R

R

D

K

A

G

G

S

N

I

I

E

I

F

I

Q

D

G

D

Q

D

D

D

I

I

T

S

A

L

R

L

D

P

P

L

A

H

A

A

I

R

V

A

R

R

G

G

L

I

M

G

H

Y

V

L

P

P

E
x
Q

G

E

R

A

E

S

V

I

F

F

P

R

L

R

L

L

S

S

V

V

R

Y

D

D

N

N

L

L

L

M

M

A

G

V

A

L

Y

Q

T

I

R

R

A

D

D

D

K

L

D

S

G

A

V

E

A

Q

R

R

D

E

-

D

-

R

I

A

E

N

T

E

V

L

F

M

G

E

Y

E

F

F

P

H

I

I

-

E

-

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

D

S

A

-

G

-

L

-

L

L

S

S

G

G

Q

E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

K

L

F

I

I

L

L

D

D

E

Q

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

R

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

S

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

N

R

M

E

A

T

L

L

N

A

A

V

S

C

D

E

Y

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

H

I

L

V

I

M

A

E

H

D

G

S

T

C

P

E

T

R

E

L

I

R

L

E

Q

K

D

D

E

D

H

I

V

K

K

E

R

F

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (= Y30), R16 (≠ I33), V18 (≠ A35), P37 (≠ S54), N38 (= N55), G39 (= G56), A40 (= A57), G41 (= G58), K42 (= K59), T43 (= T60), T44 (= T61), Q85 (≠ E102), H195 (≠ Q212)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
29% identity, 82% coverage: 20:241/272 of query aligns to 1:223/240 of 4ymuJ

query
sites
4ymuJ

L

M

L

I

R

F

L

V

Q

N

N

D

V

V

E

Y

S

K

A

N

Y
x
F

G

G

P

S

I
x
L

K

E

A
x
V

I

L

R

K

G

G

V

V

S

T

L

L

Q

K

V

V

R

N

R

K

G

G

E

E

I

V

A

V

V

I

L

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

L

K

R

T

C

I

I

S

N

G

L

I

L

I
x
E

D

E

P

P

R

T

K

K

G

G

S

E

I

V

E

F

F

I

Q

D

G

G

Q

V

D

K

I

I

T

N

-

N

A

G

R

K

D

V

P

N

A

I

A

N

I

K

V

V

R

R

R

Q

G

K

L

V

M

G

H

M

V

V

P

F

E

Q

G

H

R

F

E

N

V

L

F

F

P

P

L

H

L

L

S

T

V

A

R

I

D

E

N

N

L

I

L

T

M

L

G

A

-

P

-

V

-

K

-

V

-

K

A

K

Y

M

T

N

R

K

A

K

D

E

K

A

D

E

G

E

V

L

A

A

R

V

D

D

I

L

E

L

T

A

V

K

F

V

G

G

Y

-

F

-

P

-

I

-

L

L

K

L

E

D

R

K

A

K

A

D

Q

Q

D

Y

A

P

G

I

L

K

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

M

R

L

L

A

A

I

I

S

A

R

R

A

A

L

L

M

A

A

M

A

Q

P

P

E

E

L

V

I

M

L

L

L

F

D

D

E
|
E

P

P

S

T

L

S

G

A

L

L

S

D

P

P

K

E

L

M

T

V

K

K

E

E

I

V

F

L

E

N

I

V

V

M

V

K

R

Q

I

L

N

A

R

N

E

E

R

-

G

G

T

M

T

T

I

M

L

V

V

V

E

T

Q
x
H

N

E

A

M

N

G

M

F

A

A

L

R

N

E

A

V

S

G

D

D

Y

R

G

V

Y

I

V

F

L

M

E

D

N

D

G

G

R

V

I

I

V

V

M

E

E

E

D

G

S

T

C

P

E

E

R

E

L

I

binding adenosine-5'-triphosphate: F11 (≠ Y30), L14 (≠ I33), V16 (≠ A35), S36 (≠ N55), G37 (= G56), S38 (≠ A57), G39 (= G58), K40 (= K59), S41 (≠ T60), T42 (= T61), E51 (≠ I70), E162 (= E179), H194 (≠ Q212)
binding magnesium ion: S41 (≠ T60), E162 (= E179)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
32% identity, 85% coverage: 21:252/272 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

R

T

L

A

Q

K

N

N

V

L

E

A

S

K

A

A

Y
|
Y

G

K

P

G

I
x
R

K

R

A
x
V

I

V

R

E

G

D

V

V

S

S

L

L

Q

T

V

V

R

N

R

S

G

G

E

E

I

I

A

V

A

G

V

L

L

L

G

G

S

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

I

T

L

F

K

Y

T

M

I

V

S

V

G

G

I

I

I

V

D

P

P

R

R

D

K

A

G

G

S

N

I

I

E

I

F

I

Q

D

G

D

Q

D

D

D

I

I

T

S

A

L

R

L

D

P

P
x
L

A
x
H

A

A

I

R

V

A

R

R

G

G

L

I

M

G

H
x
Y

V

L

P
|
P

E
x
Q

G
x
E

R
x
A

E
x
S

V

I

F
|
F

P
x
R

L
x
R

L
|
L

S

S

V

V

R

Y

D

D

N

N

L

L

L

M

M

A

G
x
V

A

L

Y

Q

T

I

R

R

A

D

D

D

K

L

D

S

G

A

V

E

A

Q

R

R

D

E

-

D

-

R

I

A

E

N

T

E

V

L

F

M

G

E

Y

E

F

F

P

H

I

I

-

E

-

H

L

L

K

R

E

D

R

S

A

M

A

G

Q
|
Q

D

S

A

-

G

-

L

-

L

L

S

S

G

G

Q

E

Q

R

M

R

L

V

A

E

I

I

S

A

R
|
R

A

A

L

L

M

A

A

A

A

N

P

P

E

K

L

F

I

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

R

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

S

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

M

E

A

T

L

L

N

A

A

V

S

C

D

E

Y

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

H

I

L

V

I

M

A

E

H

D

G

S

T

C

P

E

T

R

E

L

I

R

L

E

Q

K

D

D

E

D

H

I

V

K

K

E

R

F

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y30), R15 (≠ I33), V17 (≠ A35), N37 (= N55), G38 (= G56), A39 (= A57), G40 (= G58), K41 (= K59), T42 (= T60), T43 (= T61)
binding magnesium ion: T42 (= T60), Q84 (≠ E102)
binding novobiocin: L71 (≠ P89), H72 (≠ A90), Y81 (≠ H99), P83 (= P101), E85 (≠ G103), A86 (≠ R104), S87 (≠ E105), F89 (= F107), F89 (= F107), R90 (≠ P108), R91 (≠ L109), L92 (= L110), V101 (≠ G119), Q135 (= Q149), R149 (= R166)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
32% identity, 85% coverage: 21:252/272 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

R

T

L

A

Q

K

N

N

V

L

E

A

S

K

A

A

Y
|
Y

G

K

P

G

I
x
R

K

R

A
x
V

I

V

R

E

G

D

V

V

S

S

L

L

Q

T

V

V

R

N

R

S

G

G

E

E

I

I

A

V

A

G

V

L

L

L

G

G

S

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

I

T

L

F

K

Y

T

M

I

V

S

V

G

G

I

I

I

V

D

P

P

R

R

D

K

A

G

G

S

N

I

I

E

I

F

I

Q

D

G

D

Q

D

D

D

I

I

T

S

A

L

R

L

D

P

P

L

A

H

A

A

I

R

V

A

R

R

G

G

L

I

M

G

H

Y

V

L

P

P

E
x
Q

G

E

R

A

E

S

V

I

F

F

P

R

L

R

L

L

S

S

V

V

R

Y

D

D

N

N

L

L

L

M

M

A

G

V

A

L

Y

Q

T

I

R

R

A

D

D

D

K

L

D

S

G

A

V

E

A

Q

R

R

D

E

-

D

-

R

I

A

E

N

T

E

V

L

F

M

G

E

Y

E

F

F

P

H

I

I

-

E

-

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

D

S

A

-

G

-

L

-

L

L

S

S

G

G

Q

E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

K

L

F

I

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

R

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

S

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

M

E

A

T

L

L

N

A

A

V

S

C

D

E

Y

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

H

I

L

V

I

M

A

E

H

D

G

S

T

C

P

E

T

R

E

L

I

R

L

E

Q

K

D

D

E

D

H

I

V

K

K

E

R

F

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y30), R15 (≠ I33), V17 (≠ A35), N37 (= N55), G38 (= G56), A39 (= A57), G40 (= G58), K41 (= K59), T42 (= T60), T43 (= T61)
binding magnesium ion: T42 (= T60), Q84 (≠ E102)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
31% identity, 85% coverage: 21:251/272 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

R

T

L

A

Q

K

N

N

V

L

E

A

S

K

A

A

Y
|
Y

G

K

P

G

I
x
R

K

R

A
x
V

I

V

R

E

G

D

V

V

S

S

L

L

Q

T

V

V

R

N

R

S

G

G

E

E

I

I

A

V

A

G

V

L

L

L

G

G

S

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

I

T

L

F

K

Y

T

M

I

V

S

V

G

G

I

I

I

V

D

P

P

R

R

D

K

A

G

G

S

N

I

I

E

I

F

I

Q

D

G

D

Q

D

D

D

I

I

T

S

A

L

R

L

D

P

P

L

A

H

A

A

I

R

V

A

R

R

G

G

L

I

M

G

H

Y

V

L

P

P

E

Q

G

E

R

A

E

S

V

I

F
|
F

P
x
R

L
x
R

L

L

S

S

V

V

R

Y

D

D

N

N

L

L

L

M

M

A

G

V

A

L

Y

Q

T

I

R

R

A

D

D

D

K

L

D

S

G

A

V

E

A

Q

R

R

D

E

-

D

-

R

I

A

E

N

T

E

V

L

F

M

G

E

Y

E

F

F

P

H

I

I

-

E

-

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

D

S

A

-

G

-

L

-

L

L

S

S

G

G

Q

E

Q

R

M

R

L

V

A

E

I

I

S

A

R

R

A

A

L

L

M

A

A

A

A

N

P

P

E

K

L

F

I

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

S

D

P

P

K

I

L

S

T

V

K

I

E

D

I

I

F

K

E

R

I

I

V

I

V

E

R

H

I

L

N

-

R

R

E

D

R

S

G

G

T

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

M

E

A

T

L

L

N

A

A

V

S

C

D

E

Y

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

R

H

I

L

V

I

M

A

E

H

D

G

S

T

C

P

E

T

R

E

L

I

R

L

E

Q

K

D

D

E

D

H

I

V

K

K

E

R

F

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y30), R15 (≠ I33), V17 (≠ A35), N37 (= N55), G38 (= G56), A39 (= A57), G40 (= G58), K41 (= K59), T42 (= T60), T43 (= T61)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F107), R90 (≠ P108), R91 (≠ L109)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 80% coverage: 20:237/272 of query aligns to 1:224/343 of P30750

query
sites
P30750

L

M

L

I

R

K

L

L

Q

S

N

N

V

I

E

T

S

K

A

V

Y

F

G

H

-

Q

-

G

-

T

-

R

P

T

I

I

K

Q

A

A

I

L

R

N

G

N

V

V

S

S

L

L

Q

H

V

V

R

P

R

A

G

G

E

Q

I

I

A

Y

A

G

V

V

L

I

G

G

S

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

I

K

R

T

C

I

V

S

N

G

L

I

L

I

E

D

R

P

P

R

T

K

E

G

G

S

S

I

V

E

L

F

V

Q

D

G

G

Q

Q

D

E

I

L

T

T

A

T

R

L

D

S

P

E

A

S

A

E

I

L

V

T

-

K

-

A

R

R

G

Q

L

I

M

G

H

M

V

I

P

F

E

Q

G

H

R

-

E

-

V

-

F

F

P

N

L

L

S

S

V

S

R

R

D

T

N

V

L

F

-

G

-

N

-

V

-

A

L

L

M

P

G

L

A

E

Y

L

T

D

R

N

A

T

D

P

K

K

D

D

G

E

V

V

A

K

R

R

D

R

I

V

E

T

T

E

V

L

F

L

G

S

Y

L

F

V

P

G

I

L

L

G

K

D

E

K

R

H

A

D

A

S

Q

Y

D

P

A

S

G

N

L

L

L

-

S

S

G

G

Q

Q

Q

K

Q

Q

M

R

L

V

A

A

I

I

S

A

R

R

A

A

L

L

M

A

A

S

A

N

P

P

E

K

L

V

I

L

L

L

L

C

D

D

E
|
E

P

A

S

T

L

S

G

A

L

L

S

D

P

P

K

A

L

T

T

T

K

R

E

S

I

I

F

L

E

E

I

L

V

L

V

K

R

D

I

I

N

N

R

R

E

R

R

L

G

G

T

L

T

T

I

I

L

L

V

I

E

T

Q

H

N

E

A

M

N

D

M

V

A

V

L

K

N

R

A

I

S

C

D

D

Y

C

G

V

Y

A

V

V

L

I

E

S

N

N

G

G

R

E

I

L

V

I

M

E

E

Q

D

D

S

T

40:46 (vs. 55:61, 71% identical) binding
E166 (= E179) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
29% identity, 80% coverage: 20:237/272 of query aligns to 2:225/344 of 6cvlD

query
sites
6cvlD

L

M

L

I

R

K

L

L

Q

S

N

N

V

I

E

T

S

K

A

V

Y
x
F

G

H

-
x
Q

-

G

-

T

-

R

P

T

I
|
I

K

Q

A

A

I

L

R

N

G

N

V

V

S

S

L

L

Q

H

V

V

R

P

R

A

G

G

E

Q

I

I

A

Y

A

G

V

V

L

I

G

G

S

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

I

K

R

T

C

I

V

S

N

G

L

I

L

I

E

D

R

P

P

R

T

K

E

G

G

S

S

I

V

E

L

F

V

Q

D

G

G

Q

Q

D

E

I

L

T

T

A

T

R

L

D

S

P

E

A

S

A

E

I

L

V

T

-

K

-

A

R

R

G

Q

L

I

M

G

H

M

V

I

P

F

E

Q

G

H

R

-

E

-

V

-

F

F

P

N

L

L

S

S

V

S

R

R

D

T

N

V

L

F

-

G

-

N

-

V

-

A

L

L

M

P

G

L

A

E

Y

L

T

D

R

N

A

T

D

P

K

K

D

D

G

E

V

V

A

K

R

R

D

R

I

V

E

T

T

E

V

L

F

L

G

S

Y

L

F

V

P

G

I

L

L

G

K

D

E

K

R

H

A

D

A

S

Q

Y

D

P

A

S

G
x
N

L
|
L

L

-

S
|
S

G
|
G

Q
|
Q

Q

K

Q

Q

M

R

L

V

A

A

I

I

S

A

R

R

A

A

L

L

M

A

A

S

A

N

P

P

E

K

L

V

I

L

L

L

L

C

D

D

E

Q

P

A

S

T

L

S

G

A

L

L

S

D

P

P

K

A

L

T

T

T

K

R

E

S

I

I

F

L

E

E

I

L

V

L

V

K

R

D

I

I

N

N

R

R

E

R

R

L

G

G

T

L

T

T

I

I

L

L

V

I

E

T

Q
x
H

N

E

A

M

N

D

M

V

A

V

L

K

N

R

A

I

S

C

D

D

Y

C

G

V

Y

A

V

V

L

I

E

S

N

N

G

G

R

E

I

L

V

I

M

E

E

Q

D

D

S

T

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y30), Q14 (vs. gap), I19 (= I33), S41 (≠ N55), G42 (= G56), A43 (= A57), G44 (= G58), K45 (= K59), S46 (≠ T60), T47 (= T61), N141 (≠ G152), L142 (= L153), S143 (= S155), G144 (= G156), G145 (= G157), Q146 (= Q158), H200 (≠ Q212)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
29% identity, 80% coverage: 20:237/272 of query aligns to 2:225/344 of 3tuzC

query
sites
3tuzC

L

M

L

I

R

K

L

L

Q

S

N

N

V

I

E

T

S

K

A

V

Y
x
F

G

H

-
x
Q

-

G

-

T

-

R

P

T

I

I

K

Q

A
|
A

I

L

R

N

G

N

V

V

S

S

L

L

Q

H

V

V

R

P

R

A

G

G

E

Q

I

I

A

Y

A

G

V

V

L

I

G

G

S

A

N

S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

I

K

R

T

C

I

V

S

N

G

L

I

L

I

E

D

R

P

P

R

T

K

E

G

G

S

S

I

V

E

L

F

V

Q

D

G

G

Q

Q

D

E

I

L

T

T

A

T

R

L

D

S

P

E

A

S

A

E

I

L

V

T

-

K

-

A

R

R

G

Q

L

I

M

G

H

M

V

I

P

F

E

Q

G

H

R

-

E

-

V

-

F

F

P

N

L

L

S

S

V

S

R

R

D

T

N

V

L

F

-

G

-

N

-

V

-

A

L

L

M

P

G

L

A

E

Y

L

T

D

R

N

A

T

D

P

K

K

D

D

G

E

V

V

A

K

R

R

D

R

I

V

E

T

T

E

V

L

F

L

G

S

Y

L

F

V

P

G

I

L

L

G

K

D

E

K

R

H

A

D

A

S

Q

Y

D

P

A

S

G

N

L

L

L

-

S

S

G

G

Q

Q

Q

K

Q

Q

M

R

L

V

A

A

I

I

S

A

R

R

A

A

L

L

M

A

A

S

A

N

P

P

E

K

L

V

I

L

L

L

L

C

D

D

E

Q

P

A

S

T

L

S

G

A

L

L

S

D

P

P

K

A

L

T

T

T

K

R

E

S

I

I

F

L

E

E

I

L

V

L

V

K

R

D

I

I

N

N

R

R

E

R

R

L

G

G

T

L

T

T

I

I

L

L

V

I

E

T

Q

H

N

E

A

M

N

D

M

V

A

V

L

K

N

R

A

I

S

C

D

D

Y

C

G

V

Y

A

V

V

L

I

E

S

N

N

G

G

R

E

I

L

V

I

M

E

E

Q

D

D

S

T

binding adenosine-5'-diphosphate: F12 (≠ Y30), Q14 (vs. gap), A21 (= A35), G42 (= G56), A43 (= A57), G44 (= G58), K45 (= K59), S46 (≠ T60), T47 (= T61)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 312, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
29% identity, 80% coverage: 20:237/272 of query aligns to 2:225/344 of 3tuiC

query
sites
3tuiC

L

M

L

I

R

K

L

L

Q

S

N

N

V

I

E

T

S

K

A

V

Y
x
F

G

H

-
x
Q

-

G

-

T

-

R

P

T

I

I

K

Q

A

A

I

L

R

N

G

N

V

V

S

S

L

L

Q

H

V

V

R

P

R

A

G

G

E

Q

I

I

A

Y

A

G

V

V

L

I

G

G

S

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

I

L

L

I

K

R

T

C

I

V

S

N

G

L

I

L

I

E

D

R

P

P

R

T

K

E

G

G

S

S

I

V

E

L

F

V

Q

D

G

G

Q

Q

D

E

I

L

T

T

A

T

R

L

D

S

P

E

A

S

A

E

I

L

V

T

-

K

-

A

R

R

G

Q

L

I

M

G

H

M

V

I

P

F

E

Q

G

H

R

-

E

-

V

-

F

F

P

N

L

L

S

S

V

S

R

R

D

T

N

V

L

F

-

G

-

N

-

V

-

A

L

L

M

P

G

L

A

E

Y

L

T

D

R

N

A

T

D

P

K

K

D

D

G

E

V

V

A

K

R

R

D

R

I

V

E

T

T

E

V

L

F

L

G

S

Y

L

F

V

P

G

I

L

L

G

K

D

E

K

R

H

A

D

A

S

Q

Y

D

P

A

S

G

N

L

L

L

-

S

S

G

G

Q

Q

Q

K

Q

Q

M

R

L

V

A

A

I

I

S

A

R

R

A

A

L

L

M

A

A

S

A

N

P

P

E

K

L

V

I

L

L

L

L

C

D

D

E

Q

P

A

S

T

L

S

G

A

L

L

S

D

P

P

K

A

L

T

T

T

K

R

E

S

I

I

F

L

E

E

I

L

V

L

V

K

R

D

I

I

N

N

R

R

E

R

R

L

G

G

T

L

T

T

I

I

L

L

V

I

E

T

Q

H

N

E

A

M

N

D

M

V

A

V

L

K

N

R

A

I

S

C

D

D

Y

C

G

V

Y

A

V

V

L

I

E

S

N

N

G

G

R

E

I

L

V

I

M

E

E

Q

D

D

S

T

binding adenosine-5'-diphosphate: F12 (≠ Y30), Q14 (vs. gap), S41 (≠ N55), G42 (= G56), A43 (= A57), G44 (= G58), K45 (= K59), S46 (≠ T60), T47 (= T61)

3c4jA Abc protein artp in complex with atp-gamma-s
26% identity, 83% coverage: 20:244/272 of query aligns to 3:228/242 of 3c4jA

query
sites
3c4jA

L

M

L

I

R

D

L

V

Q

H

N

Q

V

L

E

K

S

K

A

S

Y
x
F

G

G

P

S

I

L

K

E

A
x
V

I

L

R

K

G

G

V

I

S

N

L

V

Q

H

V

I

R

R

R

E

G

G

E

E

I

V

A

V

V

V

L

I

G

G

S
x
P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

I

F

L

L

K

R

T

C

I

L

S

N

G

L

I

L

I

E

D

D

P

F

R

D

K

E

G

G

S

E

I

I

E

I

F

I

Q

D

G

G

Q

I

D

N

I

L

T

K

A

A

R

K

D

D

P

T

A

N

A

L

-

N

I

K

V

V

R

R

R

E

G

E

L

V

M

G

H

M

V

V

P

F

E

Q

G

R

R

F

E

N

V

L

F

F

P

P

L

H

L

M

S

T

V

V

R

L

D

N

N

N

L

I

L

T

M

L

G

A

-

P

-

M

-

K

-

V

-

R

A

K

Y

W

T

P

R

R

A

E

D

K

K

A

D

E

G

A

V

K

A

A

R

M

D

E

I

L

E

L

T

D

V

K

F

V

G

G