Comparing Ac3H11_2202 FitnessBrowser__acidovorax_3H11:Ac3H11_2202 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 17 hits to proteins with known functional sites (download)
4ga6A Crystal structure of amp phosphorylasE C-terminal deletion mutant in complex with substrates (see paper)
42% identity, 84% coverage: 62:510/535 of query aligns to 35:480/493 of 4ga6A
Q5JCX3 AMP phosphorylase; AMPpase; Nucleoside monophosphate phosphorylase; NMP phosphorylase; EC 2.4.2.57 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
42% identity, 86% coverage: 62:522/535 of query aligns to 35:492/503 of Q5JCX3
4ga4A Crystal structure of amp phosphorylase n-terminal deletion mutant (see paper)
44% identity, 76% coverage: 115:522/535 of query aligns to 1:408/418 of 4ga4A
1brwB The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation (see paper)
30% identity, 71% coverage: 123:504/535 of query aligns to 9:402/433 of 1brwB
1brwA The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation (see paper)
30% identity, 71% coverage: 123:504/535 of query aligns to 9:402/433 of 1brwA
7m7kB Crystal structure of uridine bound to geobacillus thermoglucosidasius pyrimidine nucleoside phosphorylase pynp
29% identity, 70% coverage: 129:502/535 of query aligns to 14:399/432 of 7m7kB
5olnB X-ray structure of the complex pyrimidine-nucleoside phosphorylase from bacillus subtilis at 1.88 a (see paper)
29% identity, 71% coverage: 121:502/535 of query aligns to 8:401/434 of 5olnB
P77836 Pyrimidine-nucleoside phosphorylase; PYNP; Py-NPase; EC 2.4.2.2 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
27% identity, 70% coverage: 130:502/535 of query aligns to 16:400/433 of P77836
P19971 Thymidine phosphorylase; TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase; EC 2.4.2.4 from Homo sapiens (Human) (see 3 papers)
29% identity, 73% coverage: 115:505/535 of query aligns to 33:446/482 of P19971
Sites not aligning to the query:
2wk6A Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil (see paper)
29% identity, 70% coverage: 129:505/535 of query aligns to 14:412/446 of 2wk6A
2j0fA Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design (see paper)
29% identity, 70% coverage: 129:505/535 of query aligns to 15:413/446 of 2j0fA
1uouA Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor (see paper)
29% identity, 73% coverage: 115:505/535 of query aligns to 1:404/438 of 1uouA
4lhmA Thymidine phosphorylase from e.Coli with 3'-azido-3'-deoxythymidine (see paper)
28% identity, 70% coverage: 130:501/535 of query aligns to 17:404/440 of 4lhmA
Sites not aligning to the query:
4eadA Thymidine phosphorylase from e.Coli with 3'-azido-2'-fluoro- dideoxyuridine
28% identity, 70% coverage: 130:501/535 of query aligns to 17:404/440 of 4eadA
5ey3A X-ray structure of the thymidine phosphorylase from salmonella typhimurium in complex with cytidine and sulphate
26% identity, 71% coverage: 130:508/535 of query aligns to 19:413/442 of 5ey3A
4yyyB X-ray structure of the thymidine phosphorylase from salmonella typhimurium in complex with uridine (see paper)
26% identity, 71% coverage: 130:508/535 of query aligns to 17:411/440 of 4yyyB
4yekA X-ray structure of the thymidine phosphorylase from salmonella typhimurium in complex with thymidine (see paper)
26% identity, 71% coverage: 130:508/535 of query aligns to 17:411/440 of 4yekA
>Ac3H11_2202 FitnessBrowser__acidovorax_3H11:Ac3H11_2202
MHAEPSSPALASAPVSALADAPPRSQLALRRVAIDTWRENVAYLHRDCAVYRAEGFQALS
KIEVRANGRRILATVNVVDDPAIVGCQELGLSEDAFAQLGVDNGHTVSVAQAEPPESMGA
LFRKIASERLTREDFGAIVRDIADHRYSKIELTAFVVACHRSELDREEVFFLTDAMVASG
RRLDWHEPLVVDKHCIGGIPGNRTTMLVVPIVAAHGMLCPKTSSRAITSPAGTADTMEVL
AKVELPLEQLADIVRDYRGCLAWGGTAHLSPADDVLISVERPLSIDSAGQMVASILSKKV
AAGATHLVLDIPIGPTAKVRSMPDAQRLRRLFEYVARRMGLSLDVVITDGRQPVGQGVGP
VLEARDVMRVLQNDPRAPDDLRQKALRLAGRLIECDPDVRGGDGYAIARDILDSGRALAR
MNAIIAAQGSTGFDHNHPALGALTLDVVAPASGVVSAIDNYQIACVARLAGAPKVPGAGV
DLMHKLGDTVAAGDLLYRVHASYPADLEFARHACERDSGYRLGTADEVPQVFVEF
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory