SitesBLAST

Comparing Ac3H11_2278 FitnessBrowser__acidovorax_3H11:Ac3H11_2278 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Found 20 (the maximum) hits to proteins with known functional sites (download)

query
sites
P22033

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Q50 (≠ S27) binding

I69 (≠ V46) to V: in MMAM; likely benign variant; dbSNP:rs115923556

P86 (= P65) to L: in MMAM; mut0 and mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs769348060

G87 (= G66) to E: in MMAM; mut0; dbSNP:rs1554160986

R93 (= R72) to H: in MMAM; mut0; decreased methylmalonyl-CoA mutase activity; dbSNP:rs121918251

G94 (= G73) to R: in MMAM; mut0; dbSNP:rs727504022; to V: in MMAM; mut- and mut0; dbSNP:rs535411418

P95 (= P74) to R: in MMAM; mut0; dbSNP:rs190834116

YPTM 96:99 (≠ QATM 75:78) binding

Y100 (= Y79) to C: in MMAM; mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs864309735

W105 (= W84) to R: in MMAM; mut0; dbSNP:rs121918249

TIRQY 106:110 (= TIRQY 85:89) binding

R108 (= R87) to C: in MMAM; mut0; dbSNP:rs121918257; to G: in MMAM; mut-; to H: in MMAM; mut0; dbSNP:rs483352778

Q109 (= Q88) to R: in MMAM; mut0; dbSNP:rs1461110052

G133 (= G112) to R: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs879253828

A137 (= A116) to V: in MMAM; mut0; dbSNP:rs941483851

D139 (= D118) to N: in MMAM; unknown pathological significance; dbSNP:rs879253829

L140 (= L119) to P: in MMAM; decreased protein expression; decreased methylmalonyl-CoA mutase activity

A141 (= A120) to T: in MMAM; decreased protein expression; dbSNP:rs1554160730

H143 (= H122) to Y: in MMAM; mut0

G145 (= G124) to S: in MMAM; mut0

S148 (= S127) to L: in MMAM; mut0; dbSNP:rs1300547552

D156 (= D135) to N: in MMAM; mut-

G158 (= G137) to V: in MMAM; mut0

G161 (= G140) to R: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; to V: in MMAM; decreased protein expression

F174 (= F153) to S: in MMAM; mut0; dbSNP:rs864309733

M186 (= M165) to V: in MMAM; mut-; dbSNP:rs148331800

T187 (= T166) to S: in MMAM; mut0; dbSNP:rs879253830

N189 (= N168) to I: in MMAM; mut-; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs200908035; to K: in MMAM; mut-; dbSNP:rs1561959114

A191 (= A170) to E: in MMAM; mut- and mut0; affects proper folding; reduced protein level; decreased methylmalonyl-CoA mutase activity; dbSNP:rs760782399

A197 (= A176) to E: in MMAM; mut0

G203 (≠ A182) to R: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs778702777

E205 (= E184) natural variant: Missing (in MMAM; mut0; dbSNP:rs879253831)

G215 (= G194) to C: in MMAM; mut- and mut0; dbSNP:rs121918258; to S: in MMAM; mut0; dbSNP:rs121918258

TIQ 216:218 (= TIQ 195:197) binding

Q218 (= Q197) to H: in MMAM; mut0 and mut-; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; alters thermodynamic stability; dbSNP:rs1446389693

N219 (= N198) to Y: in MMAM; mut0; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; dbSNP:rs121918256

R228 (= R207) binding ; to Q: in MMAM; mut0; dbSNP:rs770810987

T230 (= T209) to I: in MMAM; mut-; to R: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs879253833

Y231 (= Y210) to N: in MMAM; mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; strong decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs864309736

K255 (= K234) binding

S262 (= S241) to N: in MMAM; mut0

H265 (= H244) binding ; to Y: in MMAM; mut-

E276 (= E255) to D: in MMAM; mut-; unknown pathological significance; dbSNP:rs12175488

L281 (= L260) to S: in MMAM; mut0; dbSNP:rs796052007

G284 (= G263) to E: in MMAM; mut0; dbSNP:rs879253835; to R: in MMAM; mut0; dbSNP:rs761477436

S288 (≠ V267) to P: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs1179778233

G291 (≠ A270) to E: in MMAM; mut0

Q293 (≠ A272) to P: in MMAM; mut0

RLS 304:306 (= RLS 283:285) binding

L305 (= L284) to S: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs1554160246

S306 (= S285) to F: in MMAM; mut0; dbSNP:rs1085307929

W309 (= W288) to G: in MMAM; decreased protein expression

G312 (= G291) to V: in MMAM; mut0; dbSNP:rs864309734

Y316 (= Y295) to C: in MMAM; mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; no decreased affinity for adenosylcob(III)alamin; dbSNP:rs781474200

A324 (= A303) to T: in MMAM; mut-; dbSNP:rs780387525

R326 (= R305) to K: in MMAM; unknown pathological significance; dbSNP:rs758577372

L328 (= L307) to F: in MMAM; mut0; affects proper folding; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; dbSNP:rs796052002; to P: in MMAM; mut0; dbSNP:rs965316043

S344 (= S322) to F: in MMAM; mut-; affects proper folding; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin

L346 (≠ M324) natural variant: Missing (in MMAM; mut0)

L347 (= L325) to R: in MMAM; mut0; dbSNP:rs1026703654

H350 (= H328) to Y: in MMAM; mut0; dbSNP:rs1407914109

L358 (= L336) to P: in MMAM; mut0

N366 (= N344) to S: in MMAM; mut-; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs864309737

R369 (= R347) to C: in MMAM; mut0; dbSNP:rs772552898; to H: in MMAM; mut- and mut0; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; alters thermodynamic stability; dbSNP:rs564069299

T370 (= T348) to P: in MMAM; mut0; dbSNP:rs368790885

A377 (= A355) to E: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs121918250

Q383 (= Q361) to H: in MMAM; mut0; to P: in MMAM; mut0

H386 (= H364) to N: in MMAM; mut0; dbSNP:rs1554159937; to R: in MMAM; mut0; dbSNP:rs866933356

T387 (= T365) to I: in MMAM; mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability

N388 (= N366) to H: in MMAM; mut0; dbSNP:rs766010704; to K: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs879253840

S389 (≠ A367) natural variant: Missing (in MMAM; mut0)

I412 (= I390) natural variant: Missing (in MMAM; mut0)

P424 (= P402) to L: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs879253842

G426 (≠ A404) to E: in MMAM; mut-; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs533755473; to R: in MMAM; mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; strong decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs769922244

G427 (= G405) to D: in MMAM; mut0; dbSNP:rs753288303

G454 (= G432) to E: in MMAM; mut0

A499 (≠ P477) to T: in dbSNP:rs2229385

I505 (= I483) to T: in MMAM; decreased protein expression; decreased methylmalonyl-CoA mutase activity

Q514 (= Q492) to E: in MMAM; unknown pathological significance; to K: in MMAM; decreased protein expression

L518 (= L496) to P: in MMAM; mut0; dbSNP:rs864309738

R532 (≠ A510) to H: in dbSNP:rs1141321

A535 (≠ D513) to P: in MMAM; mut0; dbSNP:rs760183775

A552 (≠ S530) to V: in MMAM; unknown pathological significance; dbSNP:rs879253845

C560 (≠ A538) to Y: in MMAM; mut0; dbSNP:rs1238333040

T566 (≠ S544) to R: in MMAM; mut0

F573 (= F551) to S: in MMAM; mut-; affects proper folding; no effect on protein abundance; no effect on methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; does not alter thermodynamic stability; dbSNP:rs775593146

Y587 (= Y565) to C: in MMAM; mut-

I597 (≠ W575) to R: in MMAM; no changed in protein expression; decreased methylmalonyl-CoA mutase activity; dbSNP:rs1554158951

P615 (= P593) to L: in MMAM; mut0; affects proper folding; reduced strongly protein level; to R: in MMAM; mut0; dbSNP:rs1554158777; to T: in MMAM; mut0; affects proper folding; reduced strongly protein level; loss of methylmalonyl-CoA mutase activity; dbSNP:rs1302409621

R616 (= R594) to C: in MMAM; mut0; dbSNP:rs765284825

L617 (≠ V595) to R: in MMAM; mut0; dbSNP:rs1554158775

K621 (= K599) to N: in MMAM; mut0

G623 (= G601) to R: in MMAM; mut0; dbSNP:rs121918254

Q624 (= Q602) to R: in MMAM; no effect on protein abundance; dbSNP:rs768521956

D625 (= D603) to G: in MMAM; mut0; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs879253847; to V: in MMAM; mut0; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity

G626 (= G604) to C: in MMAM; mut-; dbSNP:rs982110849

H627 (= H605) binding axial binding residue; to R: in MMAM; mut0; dbSNP:rs372486357

G630 (= G608) to E: in MMAM; mut0; dbSNP:rs143023066

V633 (= V611) to G: in MMAM; mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; does not alter thermodynamic stability; dbSNP:rs200055428

G637 (≠ A615) to E: in MMAM; mut-; to R: in MMAM; mut0; dbSNP:rs781501004

F638 (= F616) to I: in MMAM; mut0

D640 (= D618) to Y: in MMAM; mut0; dbSNP:rs865815395

G642 (= G620) to R: in MMAM; mut-; dbSNP:rs747897332

G648 (= G626) to D: in MMAM; mut-; no effect on protein abundance; decreased methylmalonyl-CoA mutase activity; strong decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs766721811

I671 (≠ V649) to V: in dbSNP:rs8589

L674 (= L652) to F: in MMAM; decreased protein abundance; decreased methylmalonyl-CoA mutase activity; dbSNP:rs1164271240

H678 (= H656) to R: in MMAM; mut-; dbSNP:rs147094927

E684 (≠ A662) natural variant: E -> EL (in MMAM; mut-)

L685 (≠ I663) to R: in MMAM; mut-; dbSNP:rs864309739

R694 (≠ A672) to L: in MMAM; mut-; decreased protein abundance; loss of methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; to W: in MMAM; mut- and mut0; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs777758903

M700 (≠ F678) to K: in MMAM; mut-; no effect on protein abundance; loss of methylmalonyl-CoA mutase activity; decreased affinity for adenosylcob(III)alamin; alters thermodynamic stability; dbSNP:rs140600746

G703 (= G681) to R: in MMAM; mut0; dbSNP:rs121918255

G717 (= G695) to V: in MMAM; mut-; no effect on protein abundance; interfers with the binding of the cofactor to the apoenzyme; decreased methylmalonyl-CoA mutase activity; strong decreased affinity for adenosylcob(III)alamin; decreased thermodynamic stability; dbSNP:rs121918252

G723 (= G701) to D: in MMAM; decreased protein expression; decreased methylmalonyl-CoA mutase activity; dbSNP:rs755077681

Sites not aligning to the query:

1:32 modified: transit peptide, Mitochondrion

7:750 natural variant: Missing (in MMAM; mut-)

152:750 natural variant: Missing (in MMAM; mut0)

228:750 natural variant: Missing (in MMAM; mut0)

query
sites
2xiqA

W

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-

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query
sites
8dyjB

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SitesBLAST – Find functional sites

SitesBLAST