SitesBLAST
Comparing Ac3H11_444 FitnessBrowser__acidovorax_3H11:Ac3H11_444 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P31120 Phosphoglucosamine mutase; EC 5.4.2.10 from Escherichia coli (strain K12) (see 3 papers)
55% identity, 100% coverage: 2:443/444 of query aligns to 3:444/445 of P31120
- S100 (= S100) mutation to A: 2% of wild-type activity.; mutation to T: 20-fold increase in the non-specific phosphoglucomutase activity towards glucose-phosphate substrates (non aminated).
- S102 (= S102) active site, Phosphoserine intermediate; modified: Phosphoserine; by autocatalysis; mutation to A: Loss of activity in the absence or presence of glucosamine-1,6-diP.
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
7omlA Bacillus subtilis phosphoglucomutase glmm (metal bound) (see paper)
42% identity, 99% coverage: 4:443/444 of query aligns to 2:442/445 of 7omlA
7ojrA Bacillus subtilis phosphoglucomutase glmm (phosphate bound) (see paper)
42% identity, 99% coverage: 4:443/444 of query aligns to 2:442/445 of 7ojrA
3i3wA Structure of a phosphoglucosamine mutase from francisella tularensis
43% identity, 99% coverage: 4:442/444 of query aligns to 1:437/441 of 3i3wA
- active site: R9 (= R12), S99 (= S102), H100 (= H103), K109 (= K112), D237 (= D241), D239 (= D243), D241 (= D245), R242 (= R246), H324 (= H329)
- binding zinc ion: S99 (= S102), D237 (= D241), D239 (= D243), D241 (= D245)
1wqaA Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
34% identity, 97% coverage: 4:432/444 of query aligns to 3:441/455 of 1wqaA
- active site: R11 (= R12), S101 (= S102), H102 (= H103), K111 (= K112), D243 (= D241), D245 (= D243), D247 (= D245), R248 (= R246), G330 (≠ H329), R340 (vs. gap)
- binding magnesium ion: S101 (= S102), D243 (= D241), D245 (= D243), D247 (= D245)
6mlwA Crystal structure of x. Citri phosphoglucomutase in complex with 2- fluoro mannosyl-1-methyl-phosphonic acid (see paper)
30% identity, 100% coverage: 1:442/444 of query aligns to 2:448/449 of 6mlwA
- active site: R13 (= R12), S98 (= S102), H99 (= H103), K108 (= K112), D238 (= D241), D240 (= D243), D242 (= D245), R243 (= R246), H325 (= H329)
- binding 2,6-anhydro-5,7-dideoxy-5-fluoro-7-phosphono-D-glycero-D-manno-heptitol: R281 (≠ L284), G303 (= G307), H304 (≠ D308), E321 (= E325), S323 (= S327), H325 (= H329), R415 (= R410), S417 (= S412), N418 (≠ G413), T419 (= T414), R424 (= R419)
- binding magnesium ion: S98 (= S102), D238 (= D241), D240 (= D243), D242 (= D245)
5bmpA Crystal structure of phosphoglucomutase from xanthomonas citri complexed with glucose-1-phosphate (see paper)
30% identity, 100% coverage: 1:442/444 of query aligns to 2:448/449 of 5bmpA
- active site: R13 (= R12), S98 (= S102), H99 (= H103), K108 (= K112), D238 (= D241), D240 (= D243), D242 (= D245), R243 (= R246), H325 (= H329)
- binding 1-O-phosphono-alpha-D-glucopyranose: Y10 (≠ D9), R281 (≠ L284), G303 (= G307), H304 (≠ D308), E321 (= E325), S323 (= S327), H325 (= H329), R415 (= R410), S417 (= S412), N418 (≠ G413), T419 (= T414), R424 (= R419)
- binding magnesium ion: S98 (= S102), D238 (= D241), D240 (= D243), D242 (= D245)
6nqhA Xanthomonas citri dephospho-pgm in complex with xylose-1-phosphate
30% identity, 100% coverage: 1:442/444 of query aligns to 1:447/448 of 6nqhA
- active site: R12 (= R12), S97 (= S102), H98 (= H103), K107 (= K112), D237 (= D241), D239 (= D243), D241 (= D245), R242 (= R246), H324 (= H329)
- binding magnesium ion: D237 (= D241), D239 (= D243), D241 (= D245)
- binding 1-O-phosphono-alpha-D-xylopyranose: R12 (= R12), S97 (= S102), H98 (= H103), K107 (= K112), D237 (= D241), D239 (= D243), R242 (= R246), R280 (≠ L284), S301 (≠ V306), G302 (= G307), H303 (≠ D308), E320 (= E325), S322 (= S327), H324 (= H329), H324 (= H329), R414 (= R410), S416 (= S412), N417 (≠ G413), T418 (= T414), R423 (= R419)
6np8A Xanthomonas citri phospho-pgm in complex with mannose-6-phosphate (see paper)
30% identity, 100% coverage: 1:442/444 of query aligns to 1:447/448 of 6np8A
- active site: R12 (= R12), S97 (= S102), H98 (= H103), K107 (= K112), D237 (= D241), D239 (= D243), D241 (= D245), R242 (= R246), H324 (= H329)
- binding calcium ion: S97 (= S102), D237 (= D241), D239 (= D243), D241 (= D245)
- binding 6-O-phosphono-alpha-D-mannopyranose: Y9 (≠ D9), R280 (≠ L284), G302 (= G307), H303 (≠ D308), E320 (= E325), S322 (= S327), H324 (= H329), R414 (= R410), S416 (= S412), N417 (≠ G413), T418 (= T414), R423 (= R419)
6nolA Xanthomonas citri dephospho-pgm in complex with mannose-1-phosphate (see paper)
30% identity, 100% coverage: 1:442/444 of query aligns to 1:447/448 of 6nolA