SitesBLAST
Comparing Ac3H11_4557 FitnessBrowser__acidovorax_3H11:Ac3H11_4557 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5iduC Crystal structure of an acyl-coa dehydrogenase domain protein from burkholderia phymatum bound to fad
61% identity, 93% coverage: 27:410/411 of query aligns to 20:397/405 of 5iduC
- active site: L145 (= L149), S146 (= S150), F260 (= F272), E381 (= E394), R393 (≠ K406)
- binding flavin-adenine dinucleotide: F143 (= F147), L145 (= L149), S146 (= S150), G151 (= G155), S152 (= S156), W176 (= W188), S178 (= S190), R286 (= R298), M288 (= M300), F296 (= F308), Q354 (= Q367), L355 (= L368), G358 (= G371), A376 (≠ S389), Y380 (= Y393), A383 (= A396), E385 (= E398)
5jscA Crystal structure of a putative acyl-coa dehydrogenase from burkholderia xenovorans
61% identity, 93% coverage: 27:410/411 of query aligns to 8:381/388 of 5jscA
- active site: L129 (= L149), S130 (= S150), F244 (= F272), E365 (= E394), R377 (≠ K406)
- binding flavin-adenine dinucleotide: F127 (= F147), L129 (= L149), S130 (= S150), G135 (= G155), S136 (= S156), W160 (= W188), S162 (= S190), R270 (= R298), M272 (= M300), L277 (= L305), F280 (= F308), Q338 (= Q367), L339 (= L368), G341 (= G370), G342 (= G371), Y364 (= Y393), E369 (= E398)
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
39% identity, 91% coverage: 35:409/411 of query aligns to 16:377/379 of 1ukwB
- active site: L124 (= L149), S125 (= S150), T241 (≠ F272), E362 (= E394), R374 (≠ K406)
- binding cobalt (ii) ion: D145 (= D178), H146 (≠ S179)
- binding flavin-adenine dinucleotide: F122 (= F147), L124 (= L149), S125 (= S150), G130 (= G155), S131 (= S156), W155 (= W188), S157 (= S190), K200 (≠ V233), L357 (≠ S389), Y361 (= Y393), E362 (= E394), T364 (≠ A396), E366 (= E398), L370 (= L402)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
39% identity, 91% coverage: 35:409/411 of query aligns to 16:377/379 of 1ukwA
- active site: L124 (= L149), S125 (= S150), T241 (≠ F272), E362 (= E394), R374 (≠ K406)
- binding flavin-adenine dinucleotide: F122 (= F147), L124 (= L149), S125 (= S150), G130 (= G155), S131 (= S156), W155 (= W188), S157 (= S190), L357 (≠ S389), Y361 (= Y393), E362 (= E394), T364 (≠ A396), E366 (= E398), L370 (= L402)
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
36% identity, 91% coverage: 37:411/411 of query aligns to 15:379/379 of 6fahD
- active site: L124 (= L149), T125 (≠ S150), G241 (≠ F272), G374 (≠ K406)
- binding flavin-adenine dinucleotide: F122 (= F147), L124 (= L149), T125 (≠ S150), R152 (≠ T185), F155 (≠ W188), T157 (≠ S190), E198 (≠ I231), R267 (= R298), Q269 (≠ M300), F270 (= F301), I274 (≠ L305), F277 (= F308), Q335 (= Q367), I336 (≠ L368), G339 (= G371), Y361 (= Y393), T364 (≠ A396), Q366 (≠ E398)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
37% identity, 85% coverage: 62:411/411 of query aligns to 39:380/380 of 4l1fA
- active site: L125 (= L149), T126 (≠ S150), G242 (≠ F272), E363 (= E394), R375 (≠ K406)
- binding coenzyme a persulfide: T132 (≠ S156), H179 (≠ R211), F232 (= F262), M236 (= M266), E237 (≠ R267), L239 (= L269), D240 (= D270), R243 (= R273), Y362 (= Y393), E363 (= E394), G364 (= G395), R375 (≠ K406)
- binding flavin-adenine dinucleotide: F123 (= F147), L125 (= L149), T126 (≠ S150), G131 (= G155), T132 (≠ S156), F156 (≠ W188), I157 (= I189), T158 (≠ S190), R268 (= R298), Q270 (≠ M300), F271 (= F301), I275 (≠ L305), F278 (= F308), L281 (≠ T311), Q336 (= Q367), I337 (≠ L368), G340 (= G371), I358 (≠ S389), Y362 (= Y393), T365 (≠ A396), Q367 (≠ E398)
Sites not aligning to the query:
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
37% identity, 88% coverage: 47:409/411 of query aligns to 22:373/374 of 5lnxD
- active site: L122 (= L149), T123 (≠ S150), G239 (≠ F272), E358 (= E394), K370 (= K406)
- binding flavin-adenine dinucleotide: L122 (= L149), T123 (≠ S150), G128 (= G155), S129 (= S156), F153 (≠ W188), T155 (≠ S190), R265 (= R298), Q267 (≠ M300), F268 (= F301), I272 (≠ L305), N275 (≠ F308), I278 (≠ T311), Q331 (= Q367), I332 (≠ L368), G335 (= G371), Y357 (= Y393), T360 (≠ A396), E362 (= E398)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
37% identity, 88% coverage: 49:410/411 of query aligns to 27:378/378 of 5ol2F
- active site: L124 (= L149), T125 (≠ S150), G241 (≠ F272), G374 (≠ K406)
- binding calcium ion: E29 (= E51), E33 (≠ D57), R35 (≠ A59)
- binding coenzyme a persulfide: L238 (= L269), R242 (= R273), E362 (= E394), G363 (= G395)
- binding flavin-adenine dinucleotide: F122 (= F147), L124 (= L149), T125 (≠ S150), P127 (= P152), T131 (≠ S156), F155 (≠ W188), I156 (= I189), T157 (≠ S190), E198 (≠ I231), R267 (= R298), F270 (= F301), L274 (= L305), F277 (= F308), Q335 (= Q367), L336 (= L368), G338 (= G370), G339 (= G371), Y361 (= Y393), T364 (≠ A396), E366 (= E398)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
39% identity, 84% coverage: 65:410/411 of query aligns to 44:381/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ R372), T347 (≠ V376), E348 (≠ G377)
- binding flavin-adenine dinucleotide: F125 (= F147), L127 (= L149), S128 (= S150), G133 (= G155), S134 (= S156), W158 (= W188), T160 (≠ S190), R270 (= R298), F273 (= F301), L280 (≠ F308), V282 (≠ L310), Q338 (= Q367), I339 (≠ L368), G342 (= G371), I360 (≠ S389), Y364 (= Y393), T367 (≠ A396), E369 (= E398), I370 (≠ V399), L373 (= L402)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
39% identity, 84% coverage: 65:410/411 of query aligns to 71:408/412 of P16219
- G90 (= G84) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (≠ T100) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 147:156, 80% identical) binding in other chain
- R171 (= R172) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ WIS 188:190) binding in other chain
- A192 (= A195) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G212) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R298) binding
- Q308 (= Q309) binding in other chain
- R325 (≠ A326) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ T355) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QLHGG 367:371) binding
- R380 (≠ S382) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ ATE 396:398) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
39% identity, 84% coverage: 65:410/411 of query aligns to 41:378/381 of 8sgsA
- binding coenzyme a: S131 (= S156), A133 (≠ V158), N177 (≠ T210), F231 (= F262), M235 (= M266), L238 (= L269), I312 (≠ V343), E362 (= E394), G363 (= G395)
- binding flavin-adenine dinucleotide: F122 (= F147), L124 (= L149), S125 (= S150), G130 (= G155), S131 (= S156), W155 (= W188), T157 (≠ S190), R267 (= R298), F270 (= F301), L274 (= L305), L277 (≠ F308), Q335 (= Q367), I336 (≠ L368), G338 (= G370), G339 (= G371), I357 (≠ S389), I360 (= I392), Y361 (= Y393), T364 (≠ A396), E366 (= E398)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
39% identity, 84% coverage: 65:410/411 of query aligns to 47:384/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (= F147), L130 (= L149), S131 (= S150), G136 (= G155), S137 (= S156), W161 (= W188), T163 (≠ S190), T214 (≠ L239), R273 (= R298), F276 (= F301), L280 (= L305), L283 (≠ F308), V285 (≠ L310), Q341 (= Q367), I342 (≠ L368), G345 (= G371), I363 (≠ S389), Y367 (= Y393), T370 (≠ A396), E372 (= E398), L376 (= L402)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
38% identity, 91% coverage: 34:406/411 of query aligns to 15:376/378 of 4n5fA
- active site: L126 (= L149), T127 (≠ S150), G243 (≠ F272), E364 (= E394), R376 (≠ K406)
- binding dihydroflavine-adenine dinucleotide: L126 (= L149), T127 (≠ S150), G132 (= G155), S133 (= S156), F157 (≠ W188), T159 (≠ S190), T210 (= T241), Y363 (= Y393), T366 (≠ A396), E368 (= E398), M372 (≠ L402)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
39% identity, 84% coverage: 65:410/411 of query aligns to 44:381/384 of 1jqiA
- active site: G377 (≠ K406)
- binding acetoacetyl-coenzyme a: L95 (= L117), F125 (= F147), S134 (= S156), F234 (= F262), M238 (= M266), Q239 (≠ R267), L241 (= L269), D242 (= D270), R245 (= R273), Y364 (= Y393), E365 (= E394), G366 (= G395)
- binding flavin-adenine dinucleotide: F125 (= F147), L127 (= L149), S128 (= S150), G133 (= G155), S134 (= S156), W158 (= W188), T160 (≠ S190), R270 (= R298), F273 (= F301), L280 (≠ F308), Q338 (= Q367), I339 (≠ L368), G342 (= G371), I360 (≠ S389), T367 (≠ A396), E369 (= E398), I370 (≠ V399)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
40% identity, 69% coverage: 126:410/411 of query aligns to 105:383/383 of 1bucA
- active site: L128 (= L149), T129 (≠ S150), G246 (≠ F272), E367 (= E394), G379 (≠ K406)
- binding acetoacetyl-coenzyme a: F126 (= F147), G134 (= G155), T135 (≠ S156), T162 (≠ S190), N182 (≠ T210), H183 (≠ R211), F236 (= F262), M240 (= M266), M241 (≠ R267), L243 (= L269), D244 (= D270), T317 (= T344), Y366 (= Y393), E367 (= E394), G368 (= G395)
- binding flavin-adenine dinucleotide: F126 (= F147), L128 (= L149), T129 (≠ S150), G134 (= G155), T135 (≠ S156), F160 (≠ W188), T162 (≠ S190), Y366 (= Y393), T369 (≠ A396), E371 (= E398), M375 (≠ L402)
Sites not aligning to the query:
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
40% identity, 69% coverage: 126:410/411 of query aligns to 105:383/383 of Q06319
- E367 (= E394) active site, Proton acceptor; mutation to Q: Loss of activity.
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
39% identity, 84% coverage: 65:410/411 of query aligns to 71:408/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
P41367 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; MCAD; EC 1.3.8.7 from Sus scrofa (Pig) (see 2 papers)
34% identity, 97% coverage: 10:406/411 of query aligns to 22:413/421 of P41367
- 158:167 (vs. 147:156, 50% identical) binding in other chain
- S167 (= S156) binding
- WIT 191:193 (≠ WIS 188:190) binding in other chain
- S216 (≠ T210) binding
- D278 (= D270) binding
- R281 (= R273) binding
- RKT 306:308 (≠ RRM 298:300) binding
- HQ 316:317 (≠ FQ 308:309) binding in other chain
- R349 (= R342) binding
- T351 (= T344) binding
- QVFGG 374:378 (≠ QLHGG 367:371) binding
- E401 (= E394) active site, Proton acceptor; binding
- GTAQ 402:405 (≠ GATE 395:398) binding in other chain
3mdeA Crystal structures of medium chain acyl-coa dehydrogenase from pig liver mitochondria with and without substrate (see paper)
35% identity, 91% coverage: 35:406/411 of query aligns to 17:378/385 of 3mdeA
- active site: V125 (≠ L149), T126 (≠ S150), T245 (≠ F272), E366 (= E394), R378 (≠ K406)
- binding octanoyl-coenzyme a: T86 (≠ F110), E89 (≠ A113), L93 (= L117), S132 (= S156), V134 (= V158), S181 (≠ T210), F235 (= F262), M239 (= M266), F242 (≠ L269), R314 (= R342), Y365 (= Y393), E366 (= E394), G367 (= G395)
- binding flavin-adenine dinucleotide: Y123 (≠ F147), V125 (≠ L149), T126 (≠ S150), G131 (= G155), S132 (= S156), W156 (= W188), I157 (= I189), T158 (≠ S190), R271 (= R298), T273 (≠ M300), F274 (= F301), L278 (= L305), H281 (≠ F308), Q339 (= Q367), V340 (≠ L368), G343 (= G371), I361 (≠ S389), T368 (≠ A396), Q370 (≠ E398)
3mddA Crystal structures of medium chain acyl-coa dehydrogenase from pig liver mitochondria with and without substrate (see paper)
35% identity, 91% coverage: 35:406/411 of query aligns to 17:378/385 of 3mddA
- active site: V125 (≠ L149), T126 (≠ S150), T245 (≠ F272), E366 (= E394), R378 (≠ K406)
- binding flavin-adenine dinucleotide: Y123 (≠ F147), T126 (≠ S150), G131 (= G155), S132 (= S156), W156 (= W188), T158 (≠ S190), R271 (= R298), T273 (≠ M300), F274 (= F301), H281 (≠ F308), Q339 (= Q367), V340 (≠ L368), G343 (= G371), I361 (≠ S389), T368 (≠ A396), Q370 (≠ E398)
Query Sequence
>Ac3H11_4557 FitnessBrowser__acidovorax_3H11:Ac3H11_4557
VKFKQALSSTMHVATPPAPRPPSTAHLALPFFDDAHRALAEGLVPWAAAQEVDETDDRAA
CRDWVKRLGAGGWLRYCVPAAHGGALPALDSRALVLLRETLAYHSPLADFAFAMQGLGSG
AITLAGSPAQQAHYLQGVARGELIAAFALSEPEAGSDVGAMKTIAENAYLSRGNGPKDSY
SLTGTKTWISNGGIADFYCVFAKTDPAGGTRGISAFIVDANTPGLDASRHIHVMAPHPLA
TLQFDQCTVPATALLGEENGGFKLAMRTLDIFRASVAAAALGMARRALAEAVHHARQRRM
FGQTLADFQLTQAKIGEMAALVDSAALLTYRAAWLRDTGQARVTAEAAMAKMTATENAQR
VIDMALQLHGGRGVEVGSKVESLYRDIRSLRIYEGATEVQQLIIGKAVLQE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory