Comparing Ac3H11_4733 FitnessBrowser__acidovorax_3H11:Ac3H11_4733 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1h5yB Hisf protein from pyrobaculum aerophilum (see paper)
50% identity, 100% coverage: 1:250/250 of query aligns to 20:253/253 of 1h5yB
Sites not aligning to the query:
1gpwC Structural evidence for ammonia tunneling across the (beta/alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex. (see paper)
46% identity, 100% coverage: 1:250/250 of query aligns to 17:250/253 of 1gpwC
Sites not aligning to the query:
7ac8A Molecular basis for the unique allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex. (see paper)
46% identity, 100% coverage: 1:250/250 of query aligns to 17:250/252 of 7ac8A
Sites not aligning to the query:
Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
46% identity, 100% coverage: 1:250/250 of query aligns to 17:250/253 of Q9X0C6
Sites not aligning to the query:
7qc8A Imidazole glycerol phosphate synthase subunit HisF (see paper)
45% identity, 100% coverage: 1:250/250 of query aligns to 17:250/250 of 7qc8A
Sites not aligning to the query:
5d2tA Directed evolutionary changes in kemp eliminase ke07 - crystal 3 wild type
42% identity, 100% coverage: 1:250/250 of query aligns to 15:248/251 of 5d2tA
6dnjA Directed evolutionary changes in kemp eliminase ke07 - crystal 28 round 5 (see paper)
42% identity, 100% coverage: 1:250/250 of query aligns to 16:249/250 of 6dnjA
4ewnD Structure of hisf-d130v+d176v with bound rcdrp (see paper)
44% identity, 100% coverage: 1:250/250 of query aligns to 16:243/243 of 4ewnD
3zr4E Structural evidence for ammonia tunneling across the (beta-alpha)8 barrel of the imidazole glycerol phosphate synthase bienzyme complex (see paper)
45% identity, 95% coverage: 13:250/250 of query aligns to 20:241/244 of 3zr4E
Sites not aligning to the query:
2wjzE Crystal structure of (hish) k181a y138a mutant of imidazoleglycerolphosphate synthase (hish hisf) which displays constitutive glutaminase activity (see paper)
45% identity, 96% coverage: 11:250/250 of query aligns to 16:236/237 of 2wjzE
Sites not aligning to the query:
3iivB Evolutionary optimization of computationally designed enzymes: kemp eliminases of the ke07 series (see paper)
42% identity, 100% coverage: 1:250/250 of query aligns to 17:249/262 of 3iivB
P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12) (see paper)
39% identity, 100% coverage: 1:250/250 of query aligns to 17:257/258 of P60664
Sites not aligning to the query:
P33734 Imidazole glycerol phosphate synthase hisHF; IGP synthase; IGPS; ImGP synthase; EC 4.3.2.10; EC 3.5.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
36% identity, 96% coverage: 10:250/250 of query aligns to 273:549/552 of P33734
Sites not aligning to the query:
1ox4B Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
36% identity, 96% coverage: 12:250/250 of query aligns to 263:537/538 of 1ox4B
Sites not aligning to the query:
1ox5A Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerophosphate synthase (see paper)
36% identity, 95% coverage: 14:250/250 of query aligns to 263:531/532 of 1ox5A
Sites not aligning to the query:
3tdmA Computationally designed tim-barrel protein, halfflr (see paper)
44% identity, 46% coverage: 107:221/250 of query aligns to 1:99/120 of 3tdmA
Sites not aligning to the query:
5ab3A S.Enterica hisa mutant d7n, d10g, dup13-15, q24l, g102a (see paper)
30% identity, 93% coverage: 6:237/250 of query aligns to 23:235/241 of 5ab3A
Sites not aligning to the query:
5abtA S.Enterica hisa mutant d7n, g102a, v106m, d176a
31% identity, 93% coverage: 6:237/250 of query aligns to 20:238/246 of 5abtA
Sites not aligning to the query:
4tx9A Crystal structure of hisap from streptomyces sviceus with degraded profar (see paper)
29% identity, 78% coverage: 14:209/250 of query aligns to 37:210/246 of 4tx9A
Sites not aligning to the query:
5dn1A Crystal structure of phosphoribosyl isomerase a from streptomyces coelicolor (see paper)
28% identity, 90% coverage: 14:237/250 of query aligns to 32:235/240 of 5dn1A
Sites not aligning to the query:
>Ac3H11_4733 FitnessBrowser__acidovorax_3H11:Ac3H11_4733
VVKGVNFVELRDAGDPVEIAARYNAQGADELTFLDITATSDGRDLILHIIEAVASQVFIP
LTVGGGVRTVEDVRRLLNAGADKTSFNSAAIANPDLINAVSAKYGAQCIVVAIDAKRRSA
EDALRIGANGQPVGEGWDVYSHGGRKNTGLDAIAWATEMARRGAGEILLTSMDRDGTKSG
FDLALTRAVSDAVSVPVIASGGVGNLDHLADGVQQGGADAVLAASIFHYGEYTVGQAKAR
MAERGIPVRL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory