Comparing Ac3H11_4771 FitnessBrowser__acidovorax_3H11:Ac3H11_4771 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 13 hits to proteins with known functional sites (download)
P0A7B5 Glutamate 5-kinase; Gamma-glutamyl kinase; GK; EC 2.7.2.11 from Escherichia coli (strain K12) (see paper)
44% identity, 96% coverage: 10:379/384 of query aligns to 1:365/367 of P0A7B5
2j5tD Glutamate 5-kinase from escherichia coli complexed with glutamate (see paper)
45% identity, 96% coverage: 12:379/384 of query aligns to 1:363/365 of 2j5tD
2j5vB Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
39% identity, 96% coverage: 12:379/384 of query aligns to 1:323/325 of 2j5vB
2j5vA Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
39% identity, 96% coverage: 12:379/384 of query aligns to 1:321/323 of 2j5vA
7wx3B Gk domain of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
36% identity, 68% coverage: 8:268/384 of query aligns to 7:256/258 of 7wx3B
7f5xA Gk domain of drosophila p5cs filament with glutamate (see paper)
34% identity, 68% coverage: 8:268/384 of query aligns to 7:234/236 of 7f5xA
2akoA Crystal structure of glutamate 5-kinase from campylobacter jejuni
32% identity, 63% coverage: 14:254/384 of query aligns to 1:224/241 of 2akoA
2bmuB Ump kinase from pyrococcus furiosus complexed with its substrate ump and its substrate analog amppnp (see paper)
35% identity, 28% coverage: 162:268/384 of query aligns to 121:224/226 of 2bmuB
Sites not aligning to the query:
Q8U122 Uridylate kinase; UK; Uridine monophosphate kinase; UMP kinase; UMPK; EC 2.7.4.22 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see paper)
35% identity, 28% coverage: 162:268/384 of query aligns to 120:223/225 of Q8U122
Sites not aligning to the query:
2ji5A Structure of ump kinase from pyrococcus furiosus complexed with utp
32% identity, 28% coverage: 162:268/384 of query aligns to 122:217/219 of 2ji5A
Sites not aligning to the query:
3ll5A Crystal structure of t. Acidophilum isopentenyl phosphate kinase product complex (see paper)
35% identity, 17% coverage: 132:198/384 of query aligns to 113:180/233 of 3ll5A
Sites not aligning to the query:
3lkkB Crystal structure of the isopentenyl phosphate kinase substrate complex (see paper)
35% identity, 17% coverage: 132:198/384 of query aligns to 114:181/238 of 3lkkB
Sites not aligning to the query:
7n9dA I74a mutant of the isopentenyl phosphate kinase from candidatus methanomethylophilus alvus (see paper)
26% identity, 33% coverage: 137:264/384 of query aligns to 124:248/253 of 7n9dA
Sites not aligning to the query:
>Ac3H11_4771 FitnessBrowser__acidovorax_3H11:Ac3H11_4771
MIQTMVSSVLRDARRIVVKVGSSLVTNEGRGLDETAIGEWSRQLAALVRGDGGVAREVVM
VSSGAIAEGMKRLGWTTRPQEIHELQAAAAVGQMGLAQMYETKLREEGMGSAQVLLTHAD
LADRERYLNARSTLLTLLRLGVVPVINENDTVVNDEIKFGDNDTLGALVANLVEADALII
LTDQKGLYTADPRRDPAAQFVHEAKAGDLALEAMAGGAGSSIGRGGMITKILAAKRAAGS
GASTVIAWGREPDVLLRLVGGESLGTLLVAQTQKKQARKQWMADHLQLRGSVVVDAGAAA
KVRDEGKSLLPIGMTAVEGDFSRGDVIAVRDASGVEIARGLANYAAAEARLLCRKPSAEF
EKLLGYVAEPEMVHRDNLVLAVGA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory