SitesBLAST – Find functional sites

 

SitesBLAST

Comparing Ac3H11_4901 amino acid ABC transporter, permease protein to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
35% identity, 93% coverage: 5:213/224 of query aligns to 3:207/214 of 4ymwC

query
sites
4ymwC
L
 
V
D
 
D
F
 
F
S
 
L
A
 
S
V
 
M
L
 
V
S
 
K
A
 
Y
W
 
T
P
 
P
L
 
L
L
 
F
V
 
I
R
 
S
G
 
G
V
 
L
V
 
I
W
 
M
T
 
T
I
 
L
G
 
K
L
 
L
T
 
T
I
 
F
V
 
L
G
 
A
T
 
V
G
 
T
L
 
I
G
 
G
L
 
V
L
 
L
L
 
M
G
 
G
T
 
L
A
 
F
C
 
I
A
 
A
W
 
L
A
 
M
R
 
K
A
 
M
R
 
S
N
 
S
L
 
I
G
 
-
H
 
-
R
 
K
P
 
P
T
 
-
A
 
-
L
 
I
R
 
K
W
 
L
A
 
V
V
 
A
A
 
S
S
 
S
Y
 
Y
V
 
I
E
 
E
L
 
V
V
 
I
R
 
R
N
 
G
T
 
T
P
 
P
F
 
L
I
 
L
V
 
V
Q
 
Q
L
 
L
F
 
L
F
 
L
L
 
I
F
 
Y
F
 
N
G
 
G
L
 
L
P
 
M
A
 
Q
L
 
F
G
 
G
L
 
M
K
 
N
L
 
I
S
 
P
P
 
A
E
 
F
F
 
T
A
 
A
S
 
G
V
 
V
L
 
S
A
 
A
M
 
L
V
 
A
I
 
I
N
|
N
L
 
S
G
 
S
A
 
A
Y
|
Y
S
 
V
A
 
A
E
 
E
I
 
I
I
 
I
R
 
R
A
 
A
G
 
G
I
 
I
E
 
Q
A
 
A
T
 
V
P
 
D
R
 
P
G
 
G
Q
 
Q
I
 
N
E
 
E
A
 
A
A
 
A
H
 
R
S
 
S
L
 
L
A
 
G
L
 
M
T
 
T
P
 
H
G
 
A
Q
 
M
T
 
A
F
 
M
R
 
R
R
 
Y
V
 
V
V
 
I
L
 
I
P
 
P
P
 
Q
A
 
A
L
 
I
Q
 
K
K
 
N
V
 
I
W
 
L
P
 
P
A
 
A
M
 
L
V
 
G
S
 
N
Q
x
E
I
 
F
I
 
I
I
 
V
V
 
M
M
 
L
L
 
K
G
x
E
S
 
S
A
 
A
V
 
I
C
 
V
G
 
S
Q
 
V
I
 
I
S
 
G
T
 
F
P
 
A
E
 
D
L
 
L
S
 
T
Y
 
R
A
 
Q
A
 
A
N
 
D
L
 
I
I
 
I
S
 
Q
S
 
S
N
 
V
T
 
T
F
 
Y
R
 
R
A
 
Y
F
 
F
E
 
E
A
 
P
F
 
Y
I
 
I
L
 
I
A
 
I
T
 
A
A
 
A
V
 
I
Y
 
Y
L
 
F
V
 
V
L
 
M
S
 
T
M
 
L
L
 
T
T
 
F
R
 
S
R
 
K
L
 
L
L
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
35% identity, 93% coverage: 5:213/224 of query aligns to 3:207/215 of 4ymtC

query
sites
4ymtC
L
 
V
D
 
D
F
 
F
S
 
L
A
 
S
V
 
M
L
 
V
S
 
K
A
 
Y
W
 
T
P
 
P
L
 
L
L
 
F
V
 
I
R
 
S
G
 
G
V
 
L
V
 
I
W
 
M
T
 
T
I
 
L
G
 
K
L
 
L
T
 
T
I
 
F
V
 
L
G
 
A
T
 
V
G
 
T
L
 
I
G
 
G
L
 
V
L
 
L
L
 
M
G
 
G
T
 
L
A
 
F
C
 
I
A
 
A
W
 
L
A
 
M
R
 
K
A
 
M
R
 
S
N
 
S
L
 
I
G
 
-
H
 
-
R
 
K
P
 
P
T
 
-
A
 
-
L
 
I
R
 
K
W
 
L
A
 
V
V
 
A
A
 
S
S
 
S
Y
 
Y
V
 
I
E
 
E
L
 
V
V
 
I
R
 
R
N
 
G
T
 
T
P
|
P
F
x
L
I
 
L
V
 
V
Q
 
Q
L
 
L
F
 
L
F
 
L
L
 
I
F
 
Y
F
 
N
G
 
G
L
 
L
P
 
M
A
 
Q
L
 
F
G
 
G
L
 
M
K
 
N
L
 
I
S
 
P
P
 
A
E
 
F
F
 
T
A
 
A
S
 
G
V
 
V
L
 
S
A
 
A
M
 
L
V
 
A
I
 
I
N
|
N
L
 
S
G
 
S
A
 
A
Y
|
Y
S
 
V
A
 
A
E
 
E
I
 
I
I
 
I
R
 
R
A
 
A
G
 
G
I
 
I
E
 
Q
A
 
A
T
 
V
P
 
D
R
 
P
G
 
G
Q
 
Q
I
 
N
E
 
E
A
 
A
A
 
A
H
 
R
S
 
S
L
 
L
A
 
G
L
 
M
T
 
T
P
 
H
G
 
A
Q
 
M
T
 
A
F
 
M
R
 
R
R
 
Y
V
 
V
V
 
I
L
 
I
P
 
P
P
 
Q
A
 
A
L
 
I
Q
 
K
K
 
N
V
 
I
W
 
L
P
 
P
A
 
A
M
 
L
V
 
G
S
 
N
Q
x
E
I
 
F
I
 
I
I
 
V
V
x
M
M
 
L
L
x
K
G
x
E
S
 
S
A
 
A
V
 
I
C
 
V
G
 
S
Q
 
V
I
 
I
S
 
G
T
 
F
P
 
A
E
 
D
L
 
L
S
 
T
Y
 
R
A
 
Q
A
 
A
N
 
D
L
 
I
I
 
I
S
 
Q
S
 
S
N
 
V
T
 
T
F
 
Y
R
 
R
A
 
Y
F
 
F
E
 
E
A
 
P
F
 
Y
I
 
I
L
 
I
A
 
I
T
 
A
A
 
A
V
 
I
Y
 
Y
L
 
F
V
 
V
L
 
M
S
 
T
M
 
L
L
 
T
T
 
F
R
 
S
R
 
K
L
 
L
L
 
L

Query Sequence

>Ac3H11_4901 amino acid ABC transporter, permease protein
MLIQLDFSAVLSAWPLLVRGVVWTIGLTIVGTGLGLLLGTACAWARARNLGHRPTALRWA
VASYVELVRNTPFIVQLFFLFFGLPALGLKLSPEFASVLAMVINLGAYSAEIIRAGIEAT
PRGQIEAAHSLALTPGQTFRRVVLPPALQKVWPAMVSQIIIVMLGSAVCGQISTPELSYA
ANLISSNTFRAFEAFILATAVYLVLSMLTRRLLMWVGARFLVGR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory