Comparing Ac3H11_601 2-dehydro-3-deoxyphosphogalactonate aldolase (EC 4.1.2.21) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
Q6BF16 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; 2-oxo-3-deoxygalactonate 6-phosphate aldolase; 6-phospho-2-dehydro-3-deoxygalactonate aldolase; 6-phospho-2-keto-3-deoxygalactonate aldolase; KDPGal; EC 4.1.2.21 from Escherichia coli (strain K12) (see paper)
48% identity, 88% coverage: 17:209/219 of query aligns to 9:201/205 of Q6BF16
2v82A Kdpgal complexed to kdpgal (see paper)
48% identity, 88% coverage: 17:209/219 of query aligns to 8:200/205 of 2v82A
Sites not aligning to the query:
1wa3D Mechanism of the class i kdpg aldolase (see paper)
30% identity, 90% coverage: 10:206/219 of query aligns to 4:197/203 of 1wa3D
P00885 2-dehydro-3-deoxy-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase; EC 4.1.2.14 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
31% identity, 89% coverage: 11:205/219 of query aligns to 23:221/226 of P00885
Sites not aligning to the query:
1mxsA Crystal structure of 2-keto-3-deoxy-6-phosphogluconate (kdpg) aldolase from pseudomonas putida. (see paper)
31% identity, 89% coverage: 11:205/219 of query aligns to 13:211/216 of 1mxsA
3vcrA Crystal structure of a putative kdpg (2-keto-3-deoxy-6- phosphogluconate) aldolase from oleispira antarctica (see paper)
34% identity, 80% coverage: 32:206/219 of query aligns to 29:212/216 of 3vcrA
6oviA Crystal structure of kdpg aldolase from legionella pneumophila with pyruvate captured at low ph as a covalent carbinolamine intermediate
32% identity, 65% coverage: 32:173/219 of query aligns to 29:169/210 of 6oviA
1euaA Schiff base intermediate in kdpg aldolase from escherichia coli (see paper)
33% identity, 67% coverage: 30:175/219 of query aligns to 30:174/213 of 1euaA
P0A955 KHG/KDPG aldolase; EC 4.1.3.16; EC 4.1.2.14 from Escherichia coli (strain K12) (see 3 papers)
33% identity, 67% coverage: 30:175/219 of query aligns to 30:174/213 of P0A955
Sites not aligning to the query:
2c0aB Mechanism of the class i kdpg aldolase (see paper)
32% identity, 67% coverage: 30:175/219 of query aligns to 31:175/214 of 2c0aB
Sites not aligning to the query:
1wauA Structure of kdpg aldolase e45n mutant (see paper)
32% identity, 67% coverage: 30:175/219 of query aligns to 30:174/213 of 1wauA
Sites not aligning to the query:
5xsfA Crystal structure of the 2-keto-3-deoxy-6-phosphogluconate aldolase of zymomonas mobilis zm4 with 3-phosphoglycerate
33% identity, 80% coverage: 32:207/219 of query aligns to 29:206/209 of 5xsfA
Sites not aligning to the query:
>Ac3H11_601 2-dehydro-3-deoxyphosphogalactonate aldolase (EC 4.1.2.21)
MNPIDKALFHILQRCGLIAILRGVQPHEVVAIGHALYDAGFRIIEVPLNSPEPLASIRAL
RDALPADCLVGAGTVLSIDAVADVAAAGGQIIVMPHSDPDVIRAARAAGMACAPGVATLT
EAYAALAAGANMLKLFPAEALPPHVLKAWRAVITPPMALVPVGGIVPESIAPYAAAGASG
FGLGSALYRPGDQAPEVAHKAAAFARAWQASFGTAPATT
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory